Dr. Minesh P. Mehta

Dr. Minesh P. Mehta directs Radiation Oncology and serves as Deputy Director of Miami Cancer Institute at Baptist Health South Florida, coordinating a multidimensional team that includes neurosurgeons, thoracic surgeons, neuro-oncologists, medical physicists, neuroradiologists, speech therapists, dietitians, social-work navigators, and bilingual nurse coordinators. Every morning the group studies magnetic-resonance spectroscopy, positron-emission tomography overlays, genomic sequencing reports, and real-time symptom dashboards before the first patient arrives. That single conference fixes stereotactic-radiotherapy timing, systemic-therapy sequencing, rehabilitation referrals, and psychosocial support, saving families repeated drives on the Palmetto Expressway. Dedicated coordinators merge imaging, tele-visits, and insurance approvals into one call, while a secure portal posts appointment calendars, laboratory trends, educational videos, and direct-message links so questions receive answers within hours. People leave the initial visit knowing that every recommendation reflects daily consensus among experts focused on their exact diagnosis, transforming anxiety into a clear and compassionate plan. 

Dr. Mehta’s translational laboratory interrogates DNA-damage-response kinetics, tumor-associated microglia phenotypes, and hypoxia-driven metabolic shifts in glioblastoma, brain metastasis, and thoracic malignancies. His flagship ACCLAIM study combines a hypoxia-modulating radioprotector with proton therapy for newly diagnosed glioblastoma, embedding serial circulating-tumor-DNA assays, perfusion-weighted imaging, and spatial-transcriptomic mapping that detect resistant clones long before volumetric progression. Parallel patient-derived organoids and immune-competent mouse models evaluate ATR inhibition, antibody-drug conjugates, and oncolytic-virus infusions, with single-cell RNA readouts guiding dose refinement. Tissue, plasma, and radiomic data feed the Institute’s Precision Oncology Biobank, linking genomic, epigenomic, and metabolomic profiles to longitudinal outcomes while powering bedside dashboards clinicians consult in real time. Participants therefore receive therapies calibrated to evolving tumor biology while shaping protocols adopted beyond South Florida.

Education and outreach progress alongside discovery. Dr. Mehta mentors residents through a curriculum that blends Monte Carlo dose-calculation workshops, biostatistics boot camps, quality-of-life methodology, and narrative-medicine seminars, ensuring technical rigor never eclipses empathy. Quarterly Brain Tumor and Lung Cancer Forums, streamed in English, Spanish, and Haitian Creole, explain genomic testing, proton-therapy options, caregiver resilience, and financial navigation, reaching community clinics from Little Havana to the Everglades. Partnerships with regional colleges host bilingual smoking-cessation and HPV-vaccination drives, while mobile low-dose CT units visit underserved zip codes where late-stage presentation is common. Policy advocacy within national societies secures coverage for tumor-agnostic sequencing, tele-radiation consultations, and rehabilitation, proving that discovery, training, and equity can move forward together. Families know their physician invents, teaches, and listens with equal commitment.