Dr. Paul E. Oberstein

Dr. Paul E. Oberstein, MD, is a highly regarded medical oncologist specializing in gastrointestinal malignancies, with particular expertise in pancreatic, esophageal, and colorectal cancers. He serves as Director of the Gastrointestinal Medical Oncology Program at NYU Langone Health’s Perlmutter Cancer Center and holds an academic appointment as Associate Professor in the Department of Medicine at NYU Grossman School of Medicine. Dr. Oberstein earned his medical degree from the University of Medicine and Dentistry of New Jersey, followed by a residency in internal medicine at NewYork-Presbyterian/Columbia University Irving Medical Center and a fellowship in hematology and oncology at Columbia University.

Dr. Oberstein is recognized for his translational research focused on improving treatment strategies and patient outcomes in gastrointestinal cancers. His research portfolio includes early-phase clinical trials, immunotherapy, and biomarker development, with a focus on understanding resistance mechanisms and personalizing care for patients with advanced disease. He has authored numerous peer-reviewed publications and serves as a principal investigator on several clinical trials evaluating cutting-edge therapies.

In addition to his research and clinical leadership, Dr. Oberstein is a committed educator and mentor, actively guiding medical students, residents, and fellows in oncology. Known for his meticulous, patient-focused approach, he works closely with multidisciplinary teams to deliver comprehensive cancer care. Through his contributions to clinical research, education, and patient advocacy, Dr. Oberstein continues to advance the field of gastrointestinal oncology.