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RecruitingObservational
Clinical and Pathologic Studies in Non-Hodgkin's Lymphoma and Hodgkin's Disease
NCT ID: NCT00398177Sponsor: Stanford UniversityLast updated: 2025-12-24
Summary
The purpose of this study is to characterize the molecular and cell biology of the tumor cells in lymphoma.
Detailed description
This research involves the study of lymphoma cells in order to better understand how the disease grows and spreads. This study may lead to the development of special materials that could be used, in the future, to treat lymphoma or to follow the response of lymphoma to treatment.
Outcome measures
Primary
Collection of tumor tissue to characterize the molecular and cell biology of tumor cells in lymphoma.
Time frame: The study will continue indefinitely.
Eligibility criteria
Sex: AllAge: 18 Years and olderHealthy volunteers: No
Inclusion Criteria:
* Diagnosis of Hodgkin's disease or non-Hodgkin's lymphoma, any cellular classification, any stage, any grade.
* Adult or pediatric patients receiving lymph node excision for purposes other than cancer therapy (i.e. tonsillectomy, sleep apnea).
* A routine procedure for tissue collection is planned.
* Ability to understand and the willingness to sign a written informed consent.
Exclusion Criteria:
* Patients without NHL or Hodgkin's disease
Study locations (1)
Stanford University School of Medicine
Stanford, California, 94305
Ronald Levy · Principal Investigator
Shoshana Levy · Sub Investigator
References
- Roschewski M, Kurtz DM, Westin JR, Lynch RC, Gopal AK, Alig SK, Sworder BJ, Cherng HJ, Kuffer C, Blair D, Brown K, Goldstein JS, Schultz A, Close S, Chabon JJ, Diehn M, Wilson WH, Alizadeh AA. Remission Assessment by Circulating Tumor DNA in Large B-Cell Lymphoma. J Clin Oncol. 2025 Dec;43(34):3652-3661. doi: 10.1200/JCO-25-01534. Epub 2025 Aug 13.(PubMed)
- Kurtz DM, Scherer F, Jin MC, Soo J, Craig AFM, Esfahani MS, Chabon JJ, Stehr H, Liu CL, Tibshirani R, Maeda LS, Gupta NK, Khodadoust MS, Advani RH, Levy R, Newman AM, Duhrsen U, Huttmann A, Meignan M, Casasnovas RO, Westin JR, Roschewski M, Wilson WH, Gaidano G, Rossi D, Diehn M, Alizadeh AA. Circulating Tumor DNA Measurements As Early Outcome Predictors in Diffuse Large B-Cell Lymphoma. J Clin Oncol. 2018 Oct 1;36(28):2845-2853. doi: 10.1200/JCO.2018.78.5246. Epub 2018 Aug 20.(PubMed)