Childhood Cancer Survivor Study
Summary
The Childhood Cancer Survivor Study (CCSS) will investigate the long-term effects of cancer and its associated therapies. A retrospective cohort study will be conducted through a multi-institutional collaboration, which will involve the identification and active follow-up of a cohort of approximately 50,000 survivors of cancer, diagnosed before 21 years of age, between 1970 and 1999 and 10,000 sibling controls. This project will study children and young adults exposed to specific therapeutic modalities, including radiation, chemotherapy, and/or surgery, who are at increased risk of late-occurring adverse health outcomes. A group of sibling controls will be identified and data collected for comparison purposes.
Detailed description
The study will focus on the following objectives: * Characterize survivors' health with respect to disease- and treatment-related factors. * Investigate the consequences of various intensities of exposure to chemotherapy and/or radiation on health outcomes (e.g., cardiovascular, reproductive, second cancers, etc…). * Compare the mortality experience of survivors with the general population. * Characterize the health-related behaviors, patterns of medical care, and medical follow-up needs of survivors. * Describe patterns of familial aggregation of cancer, including known (and variations of) cancer family syndromes. * Collect and store biologic samples (saliva, blood, second tumor tissue) to correlate with health outcomes and use for future research.
Arms & interventions
Outcome measures
Primary
To characterize survivors' health outcomes with respect to disease-, treatment, and genetic-related factors.
Time frame: 25 years
Eligibility criteria
Study locations (30)
University of Alabama at Birmingham/Children's of Alabama
Birmingham, Alabama, 35294
City of Hope National Medical Center
Duarte, California, 91010
Children's Hospital Los Angeles
Los Angeles, California, 90027
University of California-Los Angeles
Los Angeles, California, 90095
Children's Hospital of Orange County
Orange, California, 92868
University of California-San Francisco
San Francisco, California, 94143
Stanford University School of Medicine
Stanford, California, 94305
Children's Hospital Colorado
Aurora, Colorado, 80045
Children's National Medical Center
Washington D.C., District of Columbia, 20010
Emory University/Children's Health Care of Atlanta
Atlanta, Georgia, 30322
Ana & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, 60611-2605
University of Chicago
Chicago, Illinois, 60637
Indiana University/Riley Hospital for Children
Indianapolis, Indiana, 46202
Dana-Farber Cancer Institute
Boston, Massachusetts, 02215
University of Michigan/Mott Children's Hospital
Ann Arbor, Michigan, 48109
Children's Hospitals & Clinics of Minnesota
Minneapolis, Minnesota, 55404
University of Minnesota
Minneapolis, Minnesota, 55455
Mayo Clinic
Rochester, Minnesota, 55905
St. Louis Children's Hospital/The Washington University
St Louis, Missouri, 63130
Roswell Park Cancer Institute
Buffalo, New York, 14263
Memorial-Sloan Kettering Cancer Center
New York, New York, 10065
Nationwide Children's Hospital
Columbus, Ohio, 43205
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104
Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, 15213
St. Jude Children's Research Hospital
Memphis, Tennessee, 38105
University of Texas Southwestern Medical Center
Dallas, Texas, 75390
Cook Children's Medical Center
Fort Worth, Texas, 76104
M.D. Anderson Cancer Center
Houston, Texas, 77030
Texas Children's Hospital
Houston, Texas, 77030
Seattle Children's Hospital
Seattle, Washington, 98105
References
- Webster R, Chambers EO, Qiu W, Dhaduk R, Wang L, Yasui Y, Yuan Y, Nathan PC, Leisenring W, Armstrong GT, Howell R, Schulte T, Yalch M, Cordova M, Krull KR, Brinkman TM, Edelstein K. Neurocognitive impairment and substance use in adult survivors of childhood cancer: a cross-sectional analysis from the Childhood Cancer Survivor Study. EClinicalMedicine. 2026 Apr 29;95:103924. doi: 10.1016/j.eclinm.2026.103924. eCollection 2026 May.(PubMed)
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- Mulrooney DA, Hyun G, Ness KK, Ehrhardt MJ, Yasui Y, Duprez D, Howell RM, Leisenring WM, Constine LS, Tonorezos E, Gibson TM, Robison LL, Oeffinger KC, Hudson MM, Armstrong GT. Major cardiac events for adult survivors of childhood cancer diagnosed between 1970 and 1999: report from the Childhood Cancer Survivor Study cohort. BMJ. 2020 Jan 15;368:l6794. doi: 10.1136/bmj.l6794.(PubMed)
- Ness KK, Hudson MM, Jones KE, Leisenring W, Yasui Y, Chen Y, Stovall M, Gibson TM, Green DM, Neglia JP, Henderson TO, Casillas J, Ford JS, Effinger KE, Krull KR, Armstrong GT, Robison LL, Oeffinger KC, Nathan PC. Effect of Temporal Changes in Therapeutic Exposure on Self-reported Health Status in Childhood Cancer Survivors. Ann Intern Med. 2017 Jan 17;166(2):89-98. doi: 10.7326/M16-0742. Epub 2016 Nov 8.(PubMed)
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