RecruitingObservational

Molecular Analysis of Oncogenes and Resistance Mechanisms in Lung and Other Thoracic Cancers

NCT ID: NCT01580982Sponsor: University of Colorado, DenverLast updated: 2026-02-18

Summary

The mechanisms of sensitivity and resistance to oncogene-targeted therapy can be determined from tumor tissue or tumor cell lines derived from available archival samples and/or from standard-of-care re-biopsy upon suspected tumor progression.

Detailed description

To identify baseline and treatment-related somatic changes in the tumor tissue from patients with lung and other thoracic cancers. To estimate the proportion of patients that subsequent therapy is altered based on the information acquired from such biopsies.

Outcome measures

Primary

To identify baseline and treatment-related somatic changes in the tumor tissue from patients with lung and other thoracic cancers.
Time frame: To be determined upon funding

Secondary

To estimate the proportion of patients that subsequent therapy is altered based on the information acquired from such biopsies
Time frame: To be determined upon funding

Eligibility criteria

Sex: AllAge: 18 Years to 85 YearsHealthy volunteers: No

Inclusion Criteria: 1. Patients undergoing investigation or treatment for thoracic cancers with oncogene-targeted therapies 2. Aged 18 years or older 3. Either a) have suspected tumor progression or other condition that dictates a standard-of-care palliative, therapeutic, or diagnostic intervention including but not limited to procedures such as bronchoscopic biopsy, computed tomography (CT) or ultra-sound (US)-guided biopsy, thoracentesis, video assisted thoracoscopic (VATS) pleurodesis, lobectomy, adrenalectomy or pleural catheter placement, providing tumor specimen appropriate molecular analysis or b) have previously had biopsy/surgical intervention with tumor tissue at University of Colorado or an outside institution available for medullar analysis. 4. Patients must have the ability to understand and willingness to sign an informed consent document. Exclusion Criteria: \-

Study locations (1)

University of Colorado Cancer Center

Aurora, Colorado, 80045

Recruiting

Brandi Kubala · Contact

303-724-1657 brandi.kubala@cuanschutz.edu

Erin Schenk, MD,Ph.D · Principal Investigator