Local 5-Fluorouracil Injection for the Treatment of Chalazia: A Prospective, Comparative Study

Summary

Local injection of 5-fluorouracil into a chalazion (stye) is as effective as local injection of triamcinolone (steroid) and incision and curettage for treatment of chalazia.

Detailed description

This is a prospective randomized interventional study comparing four current standard-of-care treatments for chalazia: incision and curettage, local injection of triamcinolone, local injection of 5-FU, and local injection of combination triamcinolone/5-FU.

Arms & interventions

• Drug5-fluorouracil Injection

  If the chalazion is present at follow-up visit, another injection of 5-FU will be given.

• DrugTriamcinolone Acetonide

  If chalazion present at follow-up, another Triamcinolone injection will be done.

• ProcedureIncision and Curettage

  If chalazion present at follow-up visit, patient will be randomized to receive local injection of either triamcinolone, 5-FU, or triamcinolone/5-FU mixture.

• DrugTriamcinolone Acetonide/5-fluorouracil mixture

  If chalazion persists at follow-up visit, another injection of triamcinolone/5-FU mixture will be done.

Outcome measures

Eligibility criteria