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RecruitingObservational

Germ Cell Tumor and Testicular Tumor DNA Registry

NCT ID: NCT02099734Sponsor: Memorial Sloan Kettering Cancer CenterLast updated: 2026-02-04

Summary

This study is being done to create a registry to help us learn more about germ cell tumors (GCT) and other testicular tumors. The registry will include people with these tumors and also relatives and unrelated people without these tumors. This study will help us learn more about the prevention, diagnosis, treatment and outcome of these tumors. Studying relatives of patients and people unrelated to patients with GCT and other testicular tumors will help us understand why some people get these tumors and why some people don't.

Arms & interventions

  • BehavioralQuestionnaires
  • Othersample of blood or saliva

    A sample of blood or saliva will be obtained for DNA extraction. Approximately 2-4 tubes of blood will be collected or one tablespoon of saliva. If a participant has already provided a DNA sample for another MSKCC IRB approved protocol, they may not need to provide an additional sample.

Outcome measures

Primary

  • creation of a Germ Cell Tumor and testicular tumor registry

    We will collect clinical data including diagnosis date, pathology, family history, and risk factors in patients with GCT-TT.

    Time frame: 5 years

Eligibility criteria

Sex: AllAge: 18 Years and olderHealthy volunteers: Yes
Inclusion Criteria: Case Cohort * Must be ≥ 18 years of age AND * Must be an English-speaker AND * Must have a diagnosis or suspicion of germ cell tumor and/or a testicular mass Family Member Cohort * Must be ≥ 18 years of age AND * Must be an English-speaker AND * Must be a blood relative of the proband. Family members of probands are eligible. These individuals need not have a diagnosis of GCT-TT, as they will be used for segregation analysis of suspected variants found in the proband. Control Cohort * Must be ≥ 18 years of age AND * Must be an English-speaker AND * Must not have a personal history of cancer, with the exception of non-melanoma skin cancer, AND * Must not have a family history of germ cell tumor or testicular tumor AND * Must not be a blood relative of controls enrolled in this study Exclusion Criteria:

Study locations (8)

Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey

Recruiting
Darren Feldman, MD · Contact
646-422-4491

Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748

Recruiting
Darren Feldman, MD · Contact
646-422-4491

Memorial Sloan Kettering Bergen

Montvale, New Jersey, 07645

Recruiting
Darren Feldman, MD · Contact
646-422-4491

Cold Springs Harbor Laboratory (Specimen Analysis)

Cold Spring Harbor, New York, 11724

Not Yet Recruiting
Richard McCombie, PhD · Contact
516-367-8800

Memorial Sloan Kettering Commack

Commack, New York, 11725

Recruiting
Darren Feldman, MD · Contact
646-422-4491

Memorial Sloan Kettering Westchester

Harrison, New York, 10604

Recruiting
Darren Feldman, MD · Contact
646-422-4491

Memorial Sloan Kettering Cancer Center

New York, New York, 10065

Recruiting
Darren Feldman, MD · Contact
646-422-4491
Joel Sheinfeld, MD · Contact
646-422-4311
Darren Feldman, MD · Principal Investigator

Memorial Sloan Kettering Nassau

Uniondale, New York, 11553

Not Yet Recruiting
Darren Feldman, MD · Contact
646-422-4491
Germ Cell Tumor and Testicular Tumor DNA Registry | Cancerify