Intervention Strategies to Improve Cognitive Functioning in Hematologic Cancer Survivors After Hematopoietic Cell Transplantation
Summary
A pilot study to evaluate feasibility of enrollment of patients in an intervention to improve neurocognitive function in hematopoietic cell transplantation (HCT) survivors using the cognitive training Lumosity program. In addition, patients' interest in receiving information regarding genetic risk of cognitive impairment post-HCT will be measured.
Detailed description
The investigators propose using an "off-the-shelf" product - Lumosity (http://www.lumosity.com/) - an online cognitive training program, to address the cognitive impairment in outpatient HCT survivors. The program offers over 60 tasks in game-like format that cover the main cognitive domains: processing speed, working memory, and executive function. Training will involve a daily session of 5 training tasks for 12 weeks. Each time the patient is logged in for a session, a customized report will be generated by the Lumosity program to capture performance information. Ideally, targeting the intervention and offering it specifically to those at highest risk (integrating clinical and genetic markers) would ensure efficacy. However, evidence is lacking on whether patients are receptive to communication of individual genetic information and whether provision of such results would lead to enhanced intervention response. To realize the high expectations of personalized medicine, patients' preferences and attitudes need to be thoroughly investigated especially as more information on genetic risk becomes available. The investigators will examine patients' genetic knowledge to determine whether factual knowledge of genetics is essential for understanding genetic risk and for informing treatment decision making in this patient population.
Arms & interventions
- BehavioralLumosity
Computer-based online cognitive training program using the Lumosity cognitive training program.
- BehavioralLumosity (waitlist control)
Computer-based online cognitive training program using the Lumosity cognitive training program. The control group will receive the intervention after a waiting period of 12 weeks.
Outcome measures
Primary
Number of HCT patients completing the 2-arm wait-listed randomized trial of cognitive training intervention for a period of 3 months
Number of participants completing the 12 week intervention
Time frame: 12 weeks
Change in cognitive function between intervention and wait list control arms from baseline to 12 weeks.
Change in cognitive function will be measured using cognitive test scores at baseline and 12 weeks
Time frame: Baseline to 12 weeks
Secondary
16-item survey to measure genetic factual knowledge at baseline
Time frame: Baseline
Effect size of associations of key predictors with genetic factual knowledge at baseline
Time frame: Baseline
5 Likert scale survey questionnaire to measure importance of receiving genetic risk information
Time frame: baseline
5 Likert scale survey questionnaire to measure impact of receiving genetic risk information on intervention uptake
Time frame: baseline
5 Likert scale survey questionnaire to measure impact of receiving genetic risk information on intervention adherence
Time frame: baseline
Eligibility criteria
Study locations (1)
University of Alabama at Birmingham
Birmingham, Alabama, 35233