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RecruitingInterventionalPhase 2

Phase II Study of Osimertinib (AZD9291) in Advanced NSCLC Patients With Exon 20 Insertion Mutations in EGFR

NCT ID: NCT03191149Sponsor: National Cancer Institute (NCI)Last updated: 2026-06-11

Summary

This phase II trial studies how well osimertinib works in treating patients with non-small cell lung cancer with EGFR exon 20 insertion mutation that is stage IIIB-IV or has come back after a period of improvement (recurrent). Osimertinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Detailed description

PRIMARY OBJECTIVE: I. To evaluate the best objective response rate of osimertinib (AZD9291) among patients with EGFR exon 20 insertions. SECONDARY OBJECTIVES: I. To determine the safety profile of 160 mg once daily (QD) dose of osimertinib (AZD9291) in patients with EGFR Exon 20 insertion mutations. II. To determine the progression-free survival. III. To determine the overall survival. TERTIARY OBJECTIVES: I. To characterize molecular markers of response to treatment in circulating tumor deoxyribonucleic acid (DNA). II. To evaluate biomarkers of response to treatment through retrospective analyses of pre-treatment tumor tissue. III. To identify resistance mechanisms to osimertinib (AZD9291) through post-progression tumor biopsies and circulating tumor (ct)DNA. OUTLINE: Patients receive osimertinib orally (PO) once daily (QD) on days 1-21 of each cycle. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity. Patients undergo echocardiography (ECHO) or multigated acquisition scan (MUGA), magnetic resonance imaging (MRI) or computed tomography (CT) with contrast, and collection of blood samples throughout the trial. After completion of study treatment, patients are followed up at 30 days and every 3 months for up to 5 years.

Arms & interventions

  • ProcedureBiospecimen Collection

    Undergo collection of blood samples

  • ProcedureComputed Tomography with Contrast

    Undergo CT with contrast

  • ProcedureEchocardiography Test

    Undergo ECHO

  • ProcedureMagnetic Resonance Imaging

    Undergo MRI

  • ProcedureMultigated Acquisition Scan

    Undergo MUGA

  • DrugOsimertinib

    Given PO

Outcome measures

Primary

  • Best objective response

    Will be evaluated via Response Evaluation Criteria in Solid Tumors 1.1 criteria. Categorical data, such as response rates (complete response + partial response), will be compared using Fisher's exact tests with a one-sided type I error rate of 10%; multivariable logistic regression modeling will be used to adjust for the effect of any covariates that are associated with these categorical outcomes. Any continuous outcomes will be analyzed using Wilcoxon rank sum test, and multivariable linear regression models may be used to adjust for multiple associations with outcome. Point estimates of all endpoints will be accompanied by the corresponding two-sided 80% confidence intervals. The method of Atkinson and Brown will be used for the estimation of the confidence interval for response.

    Time frame: Up to 5 years

Secondary

  • Progression-free survival (PFS)

    Time frame: From registration to documented disease progression or death from any cause, whichever occurs first, assessed up to 5 years

  • Overall survival (OS)

    Time frame: From registration to death from any cause, assessed up to 5 years

  • Incidence of adverse events

    Time frame: Up to 5 years

Eligibility criteria

Sex: AllAge: 18 Years and olderHealthy volunteers: No
Inclusion Criteria: * Participants must have a pathologically-confirmed diagnosis of non-small cell lung cancer (NSCLC) * Participants must have advanced disease - either stage IV disease, stage IIIB disease not amenable to definitive multi-modality therapy, or recurrent disease after a prior diagnosis of stage I-III disease. All staging is via the American Joint Committee on Cancer (AJCC)/International Association for the Study of Lung Cancer (IASLC) 7th edition staging criteria * An EGFR exon 20 insertion mutation must be detected in the tumor tissue. Patients may be enrolled in the study based on an exon 20 insertion EGFR mutation detected by any Clinical Laboratory Improvement Act (CLIA)-certified tissue assay * NOTE: Testing results are to be submitted via Medidata Rave and the study chair or delegate will review the reports * Patients must have measurable disease; baseline measurements and ALL sites of disease must be obtained within 4 weeks to registration * Patients must have previously received at least one line of therapy for their advanced lung cancer; there are no restrictions on the maximum number of prior therapies allowed * Participants must not have previously received osimertinib * Participants must have not previously received therapies targeting PDL1, PD1 or CTLA4 within 6 months (180 days) prior to registration * Age \>= 18 years * Eastern Cooperative Oncology Group (ECOG) performance status =\< 1 * Hemoglobin \>= 9.0 g/L (within 4 weeks before registration) * Leukocytes/white blood cells \>= 3,000/mcL (within 4 weeks before registration) * Absolute neutrophil count \>= 1,500/mcL (within 4 weeks before registration) * Platelets \>= 100,000/mcL (within 4 weeks before registration) * Total bilirubin =\< 1.5 x upper limit of normal (ULN) if no liver metastases or =\< 3 times ULN in the presence of documented Gilbert's syndrome (unconjugated hyperbilirubinemia) or liver metastases (within 4 weeks before registration) * Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase \[SGOT\])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) =\< 3 x institutional upper limit of normal; for patients with known hepatic metastases AST and/or ALT =\< 5 x ULN (within 4 weeks before registration) * Creatinine =\< 1.5 x institutional upper limit of normal (within 4 weeks before registration) * Participants may not have clinically active or symptomatic interstitial lung disease or interstitial pneumonitis (i.e., affecting activities of daily living or requiring therapeutic intervention), or a history of clinically significant interstitial lung disease or radiation pneumonitis * Participants may not have had radiation to the lung fields within four weeks (28 days) of starting treatment. For patients receiving palliative radiation to thoracic vertebrae, ribs or other sites where the radiation field includes the lungs, radiation must be completed at least two weeks before starting treatment. For all palliative radiation to all other sites, at least 7 days must have elapsed prior to starting treatment. At least six months (180 days) must have elapsed prior to starting treatment for radiation given with curative intent. Palliative radiotherapy to control symptoms (including gamma knife technique) is permitted. For stereotactic radiosurgery (SRS) to central nervous system (CNS) lesions, osimertinib can be held on the day of radiation only. For palliative radiotherapy (RT) to other sites of disease outside of the thorax osimertinib (osi) should be held for a minimum of 3 days before radiation and 3 days after RT is completed, but the duration of washout can be adjusted at the investigator's discretion with the approval of the study principal investigator (PI). For thoracic radiation, a 7-10 day washout period before the procedure and one week period after procedure before restarting osimertinib is advised to minimize the risk of pneumonitis. All radiotherapy related toxicities should be managed and ideally resolved before restarting osimertinib. Investigators should consider the radiotherapy when assessing causality if there are any localized adverse events (AEs) following the procedure * Participants may not have clinically symptomatic brain metastases, leptomeningeal disease, or spinal cord compression. Patients may be on a stable dose of corticosteroids to control brain metastases if they have been on a stable dose for two weeks (14 days) prior to study treatment and are clinically asymptomatic * Patients must have an ECHO or a nuclear study (MUGA or first pass) within 4 weeks (28 days) prior to registration to treatment and must not have a left ventricular ejection fraction (LVEF) \< institutional lower limit of normal (LLN). If the LLN is not defined at a site, the LVEF must be \>= 50% for the patient to be eligible * Participants may not have any of the following cardiac criteria: * Mean resting corrected QT interval (QTc) \>= 470 msec obtained from 3 electrocardiograms (ECGs) using the screening clinic ECG machine-derived QTc value * No history of QT prolongation associated with other medications that required discontinuation of that medication * Patient must not be receiving any concomitant medications that are known to be associated with Torsades de Pointes * Any clinically important abnormalities in rhythm, conduction or morphology of resting ECG e.g., complete left bundle branch block, third degree heart block, second degree heart block, any factors that increase the risk of QTc prolongation or risk of arrhythmic events such as heart failure, electrolyte abnormalities (including: serum/plasma potassium \< LLN; serum/plasma magnesium \< LLN; serum/plasma calcium \< LLN), congenital long QT syndrome, family history of long QT syndrome or unexplained sudden death under 40 years of age in first degree relatives or any concomitant medication known to prolong the QT interval * Symptomatic heart failure - New York Heart Association (NYHA) grade II-IV * Participants may not have a second, clinically active, cancer. Patients with second cancers which have been treated with curative intent and/or are currently inactive are allowed * Participants may not be receiving any other investigational agents. Patients previously treated with investigational agents must complete a washout period of at least two weeks or five half-lives, whichever is longer, before starting treatment * Participants may not have uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements * Patients must have no history of hypersensitivity active or inactive excipients of osimertinib (AZD9291) or drugs with a similar chemical structure or class to osimertinib (AZD9291) * Patients must not currently be receiving (or unable to stop use prior to receiving the first dose of study treatment) medications or herbal supplements known to be potent inducers of CYP3A4 (at least 3 week prior). All patients must try to avoid concomitant use of any medications, herbal supplements and/or ingestion of foods with known inducer effects on CYP3A4 * If medically feasible, patients taking regular medication, with the exception of potent inducers of CYP3A4, should be maintained on it throughout the study period. Patients taking concomitant medications whose disposition is dependent upon breast cancer resistance protein (BCRP) or P-glycoprotein (Pgp) and which have a narrow therapeutic index should be closely monitored for signs of changed tolerability as a result of increased exposure of the concomitant medication whilst receiving osimertinib (AZD9291) * NOTE: Use of St John's wort is a contra-indication for osimertinib (AZD9291) use * If applicable, it is recommended that the starting and maintenance dose of rosuvastatin (due to BCRP inhibition by AZD9291 \[osimertinib\]) should be as low as possible and should be guided by the statin label. Monitoring of low-density lipoprotein (LDL) cholesterol levels is advised. If the subject experiences any potentially relevant adverse events suggestive of muscle toxicity including unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever, the statin should be stopped, creatine kinase (CK) levels should be checked, and any appropriate further management should be taken * Subjects taking warfarin should be monitored regularly for changes in prothrombin time or international normalized ratio (INR) * No unresolved toxicities from prior therapy greater than Common Terminology Criteria for Adverse Events (CTCAE) grade 1 at the time of starting study treatment, with the exception of alopecia and grade 2, prior platinum-therapy-related neuropathy * Patients with refractory nausea and vomiting, chronic gastrointestinal diseases, inability to swallow the formulated product or previous significant bowel resection that would preclude adequate absorption of osimertinib (AZD9291) are ineligible * Women must not be pregnant or breast-feeding because osimertinib (AZD9291) has been shown to cause fetal harm in animal models. All females of childbearing potential must have a blood test or urine study within 2 weeks prior to registration to rule out pregnancy. A female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months) * Women of childbearing potential (WOCBP) and sexually active males must use an accepted and effective method of contraception while receiving protocol treatment or abstain from sexual intercourse for the duration of their participation in the study. WOCBP must use birth control for two weeks prior to the start of the treatment and continue for 6 weeks after the last dose of the study drug. Sexually active male patients must use effective contraception from day 1 of treatment and continue for 4 months after the last dose of the study drug * Other anticancer agents and investigational agents should not be given while the subject is on study treatment * Supportive care and other medications that are considered necessary for the subject's wellbeing may be given at the discretion of the investigator * A guidance regarding potential interactions with concomitant medications is provided

Study locations (345)

Anchorage Associates in Radiation Medicine

Anchorage, Alaska, 98508

Active Not Recruiting

Anchorage Radiation Therapy Center

Anchorage, Alaska, 99504

Active Not Recruiting

Alaska Breast Care and Surgery LLC

Anchorage, Alaska, 99508

Active Not Recruiting

Alaska Oncology and Hematology LLC

Anchorage, Alaska, 99508

Active Not Recruiting

Alaska Women's Cancer Care

Anchorage, Alaska, 99508

Active Not Recruiting

Anchorage Oncology Centre

Anchorage, Alaska, 99508

Active Not Recruiting

Katmai Oncology Group

Anchorage, Alaska, 99508

Active Not Recruiting

Providence Alaska Medical Center

Anchorage, Alaska, 99508

Active Not Recruiting

Fairbanks Memorial Hospital

Fairbanks, Alaska, 99701

Recruiting
Site Public Contact · Contact
907-458-3043Veronica.Stevenson@foundationhealth.org
John M. Schallenkamp · Principal Investigator

Mercy Hospital Fort Smith

Fort Smith, Arkansas, 72903

Recruiting
Site Public Contact · Contact
800-378-9373
Jay W. Carlson · Principal Investigator

CARTI Cancer Center

Little Rock, Arkansas, 72205

Recruiting
Site Public Contact · Contact
501-906-4199Research@CARTI.com
Jay W. Carlson · Principal Investigator

Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, 91505

Active Not Recruiting

MedStar Georgetown University Hospital

Washington D.C., District of Columbia, 20007

Recruiting
Site Public Contact · Contact
202-444-2223
Chul Kim · Principal Investigator

Holy Cross Hospital

Fort Lauderdale, Florida, 33308

Recruiting
Site Public Contact · Contact
eileen.georgi@holy-cross.com
Christopher M. Reynolds · Principal Investigator

Emory University Hospital Midtown

Atlanta, Georgia, 30308

Recruiting
Site Public Contact · Contact
888-946-7447
Ticiana A. Leal · Principal Investigator

Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322

Recruiting
Site Public Contact · Contact
404-778-1868
Ticiana A. Leal · Principal Investigator

Emory Saint Joseph's Hospital

Atlanta, Georgia, 30342

Recruiting
Site Public Contact · Contact
404-851-7115
Ticiana A. Leal · Principal Investigator

Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, 83706

Recruiting
Site Public Contact · Contact
734-712-3671stephanie.couch@stjoeshealth.org
Christopher M. Reynolds · Principal Investigator

Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712

Active Not Recruiting

Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, 83605

Recruiting
Site Public Contact · Contact
734-712-3671stephanie.couch@stjoeshealth.org
Christopher M. Reynolds · Principal Investigator

Kootenai Health - Coeur d'Alene

Coeur d'Alene, Idaho, 83814

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Walter Knox Memorial Hospital

Emmett, Idaho, 83617

Suspended

Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, 83619

Active Not Recruiting

Idaho Urologic Institute-Meridian

Meridian, Idaho, 83642

Recruiting
Site Public Contact · Contact
734-712-3671stephanie.couch@stjoeshealth.org
Christopher M. Reynolds · Principal Investigator

Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642

Active Not Recruiting

Saint Alphonsus Cancer Care Center-Nampa

Nampa, Idaho, 83687

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
Christopher M. Reynolds · Principal Investigator

Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83687

Active Not Recruiting

Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, 83854

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Kootenai Clinic Cancer Services - Sandpoint

Sandpoint, Idaho, 83864

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301

Active Not Recruiting

OSF Saint Anthony's Health Center

Alton, Illinois, 62002

Recruiting
Site Public Contact · Contact
618-463-5623
Jay W. Carlson · Principal Investigator

Rush-Copley Medical Center

Aurora, Illinois, 60504

Recruiting
Site Public Contact · Contact
630-978-6212RCMC_Cancer_Research@rush.edu
Priyank P. Patel · Principal Investigator

Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Canton

Canton, Illinois, 61520

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Memorial Hospital of Carbondale

Carbondale, Illinois, 62902

Recruiting
Site Public Contact · Contact
618-457-5200clinical.research@sih.net
Bryan A. Faller · Principal Investigator

SIH Cancer Institute

Carterville, Illinois, 62918

Recruiting
Site Public Contact · Contact
618-985-3333clinical.research@sih.net
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Carthage

Carthage, Illinois, 62321

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Centralia Oncology Clinic

Centralia, Illinois, 62801

Recruiting
Site Public Contact · Contact
217-876-4762morganthaler.jodi@mhsil.com
Bryan A. Faller · Principal Investigator

Saint Mary's Hospital

Centralia, Illinois, 62801

Suspended

Carle at The Riverfront

Danville, Illinois, 61832

Recruiting
Site Public Contact · Contact
800-446-5532Research@Carle.com
Priyank P. Patel · Principal Investigator

Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526

Recruiting
Site Public Contact · Contact
217-876-4762morganthaler.jodi@mhsil.com
Bryan A. Faller · Principal Investigator

Decatur Memorial Hospital

Decatur, Illinois, 62526

Recruiting
Site Public Contact · Contact
217-876-4762morganthaler.jodi@mhsil.com
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Dixon

Dixon, Illinois, 61021

Recruiting
Site Public Contact · Contact
815-285-7800
Bryan A. Faller · Principal Investigator

Carle Physician Group-Effingham

Effingham, Illinois, 62401

Recruiting
Site Public Contact · Contact
800-446-5532Research@carle.com
Priyank P. Patel · Principal Investigator

Crossroads Cancer Center

Effingham, Illinois, 62401

Recruiting
Site Public Contact · Contact
217-876-4762morganthaler.jodi@mhsil.com
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Eureka

Eureka, Illinois, 61530

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

NorthShore University HealthSystem-Evanston Hospital

Evanston, Illinois, 60201

Active Not Recruiting

Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Western Illinois Cancer Treatment Center

Galesburg, Illinois, 61401

Suspended

NorthShore University HealthSystem-Glenbrook Hospital

Glenview, Illinois, 60026

Active Not Recruiting

NorthShore University HealthSystem-Highland Park Hospital

Highland Park, Illinois, 60035

Active Not Recruiting

Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Macomb

Macomb, Illinois, 61455

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938

Recruiting
Site Public Contact · Contact
800-446-5532Research@carle.com
Priyank P. Patel · Principal Investigator

SSM Health Good Samaritan

Mount Vernon, Illinois, 62864

Recruiting
Site Public Contact · Contact
618-899-1894gayla.hall@ssmhealth.com
Jay W. Carlson · Principal Investigator

Cancer Care Center of O'Fallon

O'Fallon, Illinois, 62269

Recruiting
Site Public Contact · Contact
217-876-4762morganthaler.jodi@mhsil.com
Bryan A. Faller · Principal Investigator

HSHS Saint Elizabeth's Hospital

O'Fallon, Illinois, 62269

Recruiting
Site Public Contact · Contact
217-876-4762morganthaler.jodi@mhsil.com
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Pekin

Pekin, Illinois, 61554

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Peoria

Peoria, Illinois, 61615

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Methodist Medical Center of Illinois

Peoria, Illinois, 61636

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Peru

Peru, Illinois, 61354

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Valley Radiation Oncology

Peru, Illinois, 61354

Recruiting
Site Public Contact · Contact
815-664-4141
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Princeton

Princeton, Illinois, 61356

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

North Shore Medical Center

Skokie, Illinois, 60076

Active Not Recruiting

Southern Illinois University School of Medicine

Springfield, Illinois, 62702

Recruiting
Site Public Contact · Contact
217-545-7929
Bryan A. Faller · Principal Investigator

Springfield Clinic

Springfield, Illinois, 62702

Recruiting
Site Public Contact · Contact
800-444-7541
Bryan A. Faller · Principal Investigator

Springfield Memorial Hospital

Springfield, Illinois, 62781

Recruiting
Site Public Contact · Contact
217-528-7541pallante.beth@mhsil.com
Bryan A. Faller · Principal Investigator

Southwest Illinois Health Services LLP

Swansea, Illinois, 62226

Suspended

Carle Cancer Center

Urbana, Illinois, 61801

Recruiting
Site Public Contact · Contact
800-446-5532Research@carle.com
Priyank P. Patel · Principal Investigator

The Carle Foundation Hospital

Urbana, Illinois, 61801

Recruiting
Site Public Contact · Contact
800-446-5532Research@carle.com
Priyank P. Patel · Principal Investigator

Illinois CancerCare - Washington

Washington, Illinois, 61571

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Rush-Copley Healthcare Center

Yorkville, Illinois, 60560

Recruiting
Site Public Contact · Contact
630-978-6212Cancer.Research@rushcopley.com
Priyank P. Patel · Principal Investigator

Midwestern Regional Medical Center

Zion, Illinois, 60099

Active Not Recruiting

Reid Health

Richmond, Indiana, 47374

Active Not Recruiting

Heartland Oncology and Hematology LLP

Council Bluffs, Iowa, 51503

Recruiting
Site Public Contact · Contact
712-322-4136
Robert M. Langdon · Principal Investigator

Methodist Jennie Edmundson Hospital

Council Bluffs, Iowa, 51503

Recruiting
Site Public Contact · Contact
402-354-7939kathryn.bartz@nmhs.org
Robert M. Langdon · Principal Investigator

Nebraska Cancer Specialists/Oncology Hematology West PC - MEJ

Council Bluffs, Iowa, 51503

Recruiting
Site Public Contact · Contact
402-354-5892Liza.brandes@nmhs.org
Robert M. Langdon · Principal Investigator

Iowa Methodist Medical Center

Des Moines, Iowa, 50309

Active Not Recruiting

UI Health Care Mission Cancer and Blood - Des Moines Clinic

Des Moines, Iowa, 50309

Active Not Recruiting

Broadlawns Medical Center

Des Moines, Iowa, 50314

Active Not Recruiting

Iowa Lutheran Hospital

Des Moines, Iowa, 50316

Active Not Recruiting

UI Healthcare Mission Cancer and Blood - Fort Dodge

Fort Dodge, Iowa, 50501

Active Not Recruiting

Methodist West Hospital

West Des Moines, Iowa, 50266-7700

Active Not Recruiting

Central Care Cancer Center - Garden City

Garden City, Kansas, 67846

Recruiting
Site Public Contact · Contact
913-948-5588aroland@kccop.org
Jay W. Carlson · Principal Investigator

Central Care Cancer Center - Great Bend

Great Bend, Kansas, 67530

Recruiting
Site Public Contact · Contact
913-948-5588aroland@kccop.org
Jay W. Carlson · Principal Investigator

Mercy Hospital Pittsburg

Pittsburg, Kansas, 66762

Recruiting
Site Public Contact · Contact
888-446-3729
Jay W. Carlson · Principal Investigator

Ochsner Health Center-Summa

Baton Rouge, Louisiana, 70809

Active Not Recruiting

Medical Center of Baton Rouge

Baton Rouge, Louisiana, 70816

Active Not Recruiting

Ochsner High Grove

Baton Rouge, Louisiana, 70836

Active Not Recruiting

Ochsner Medical Center Jefferson

New Orleans, Louisiana, 70121

Active Not Recruiting

MedStar Franklin Square Medical Center/Weinberg Cancer Institute

Baltimore, Maryland, 21237

Active Not Recruiting

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287

Active Not Recruiting

Massachusetts General Hospital Cancer Center

Boston, Massachusetts, 02114

Recruiting
Site Public Contact · Contact
877-726-5130
Zofia Piotrowska · Principal Investigator

Brigham and Women's Hospital

Boston, Massachusetts, 02115

Suspended

Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215

Suspended

Dana-Farber Cancer Institute

Boston, Massachusetts, 02215

Suspended

Mercy Medical Center

Springfield, Massachusetts, 01104

Suspended

MyMichigan Medical Center Gratiot

Alma, Michigan, 48801

Recruiting
Site Public Contact · Contact
989-631-2469CVResearch@mymichigan.org
Christopher M. Reynolds · Principal Investigator

MyMichigan Medical Center Alpena

Alpena, Michigan, 49707

Recruiting
Site Public Contact · Contact
989-631-2469CVResearch@mymichigan.org
Christopher M. Reynolds · Principal Investigator

Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, 48106

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Christopher M. Reynolds · Principal Investigator

Bronson Battle Creek

Battle Creek, Michigan, 49017

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen Y. Butler · Principal Investigator

Trinity Health IHA Medical Group Hematology Oncology - Brighton

Brighton, Michigan, 48114

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Christopher M. Reynolds · Principal Investigator

Trinity Health Medical Center - Brighton

Brighton, Michigan, 48114

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Christopher M. Reynolds · Principal Investigator

Trinity Health IHA Medical Group Hematology Oncology - Canton

Canton, Michigan, 48188

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Christopher M. Reynolds · Principal Investigator

Trinity Health Medical Center - Canton

Canton, Michigan, 48188

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Christopher M. Reynolds · Principal Investigator

Caro Cancer Center

Caro, Michigan, 48723

Suspended

Chelsea Hospital

Chelsea, Michigan, 48118

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Christopher M. Reynolds · Principal Investigator

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

Chelsea, Michigan, 48118

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Christopher M. Reynolds · Principal Investigator

Hematology Oncology Consultants-Clarkston

Clarkston, Michigan, 48346

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Christopher M. Reynolds · Principal Investigator

Newland Medical Associates-Clarkston

Clarkston, Michigan, 48346

Suspended

Henry Ford Hospital

Detroit, Michigan, 48202

Recruiting
Site Public Contact · Contact
313-916-3721CTOResearch@hfhs.org
Adam M. Forman · Principal Investigator

Henry Ford Health Saint John Hospital

Detroit, Michigan, 48236

Recruiting
Site Public Contact · Contact
313-343-3166Kkeenan1@hfhs.org
Christopher M. Reynolds · Principal Investigator

Henry Ford River District Hospital

East China Township, Michigan, 48054

Recruiting
Site Public Contact · Contact
313-343-3166kforman1@hfhs.org
Christopher M. Reynolds · Principal Investigator

Cancer Hematology Centers - Flint

Flint, Michigan, 48503

Recruiting
Site Public Contact · Contact
810-762-8038wstrong@ghci.org
Christopher M. Reynolds · Principal Investigator

Genesee Hematology Oncology PC

Flint, Michigan, 48503

Recruiting
Site Public Contact · Contact
810-762-8038wstrong@ghci.org
Christopher M. Reynolds · Principal Investigator

Genesys Hurley Cancer Institute

Flint, Michigan, 48503

Recruiting
Site Public Contact · Contact
810-762-8038wstrong@ghci.org
Christopher M. Reynolds · Principal Investigator

Hurley Medical Center

Flint, Michigan, 48503

Recruiting
Site Public Contact · Contact
810-762-8038wstrong@ghci.org
Christopher M. Reynolds · Principal Investigator

MyMichigan Medical Center Gladwin

Gladwin, Michigan, 48624

Recruiting
Site Public Contact · Contact
989-631-2469CVResearch@mymichigan.org
Christopher M. Reynolds · Principal Investigator

Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Grand Rapids, Michigan, 49503

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen Y. Butler · Principal Investigator

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital

Grand Rapids, Michigan, 49503

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen Y. Butler · Principal Investigator

Trinity Health Grand Rapids Hospital

Grand Rapids, Michigan, 49503

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen Y. Butler · Principal Investigator

Henry Ford Saint John Hospital - Academic

Grosse Pointe Woods, Michigan, 48236

Recruiting
Site Public Contact · Contact
313-343-3166kforman1@hfhs.org
Christopher M. Reynolds · Principal Investigator

Henry Ford Saint John Hospital - Breast

Grosse Pointe Woods, Michigan, 48236

Recruiting
Site Public Contact · Contact
313-343-3166karen.forman@ascension.org
Christopher M. Reynolds · Principal Investigator

Henry Ford Saint John Hospital - Van Elslander

Grosse Pointe Woods, Michigan, 48236

Recruiting
Site Public Contact · Contact
313-343-3166kforman1@hfhs.org
Christopher M. Reynolds · Principal Investigator

Bronson Methodist Hospital

Kalamazoo, Michigan, 49007

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen Y. Butler · Principal Investigator

West Michigan Cancer Center

Kalamazoo, Michigan, 49007

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen Y. Butler · Principal Investigator

Beacon Kalamazoo Cancer Center

Kalamazoo, Michigan, 49009

Recruiting
Site Public Contact · Contact
574-647-7370
Kathleen Y. Butler · Principal Investigator

Beacon Kalamazoo

Kalamazoo, Michigan, 49048

Recruiting
Site Public Contact · Contact
574-647-7370
Kathleen Y. Butler · Principal Investigator

University of Michigan Health - Sparrow Lansing

Lansing, Michigan, 48912

Recruiting
Site Public Contact · Contact
517-364-3712harsha.trivedi@umhsparrow.org
Christopher M. Reynolds · Principal Investigator

Hope Cancer Clinic

Livonia, Michigan, 48154

Suspended

Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, 48154

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Christopher M. Reynolds · Principal Investigator

Henry Ford Saint John Hospital - Macomb Medical

Macomb, Michigan, 48044

Recruiting
Site Public Contact · Contact
313-343-3166kforman1@hfhs.org
Christopher M. Reynolds · Principal Investigator

Henry Ford Warren Hospital - Breast Macomb

Macomb, Michigan, 48044

Recruiting
Site Public Contact · Contact
313-343-3166kforman1@hfhs.org
Christopher M. Reynolds · Principal Investigator

Saint Mary's Oncology/Hematology Associates of Marlette

Marlette, Michigan, 48453

Suspended

MyMichigan Medical Center Midland

Midland, Michigan, 48670

Recruiting
Site Public Contact · Contact
989-631-2469CVResearch@mymichigan.org
Christopher M. Reynolds · Principal Investigator

MyMichigan Medical Center Mount Pleasant

Mount Pleasant, Michigan, 48858

Recruiting
Site Public Contact · Contact
989-631-2469CVResearch@mymichigan.org
Christopher M. Reynolds · Principal Investigator

Trinity Health Muskegon Hospital

Muskegon, Michigan, 49444

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen Y. Butler · Principal Investigator

Corewell Health Lakeland Hospitals - Niles Hospital

Niles, Michigan, 49120

Recruiting
Site Public Contact · Contact
616-391-1230
Kathleen Y. Butler · Principal Investigator

Cancer and Hematology Centers of Western Michigan - Norton Shores

Norton Shores, Michigan, 49444

Recruiting
Site Public Contact · Contact
616-391-1230connie.szczepanek@crcwm.org
Kathleen Y. Butler · Principal Investigator

Henry Ford Health Providence Novi Hospital

Novi, Michigan, 48374

Recruiting
Site Public Contact · Contact
248-849-5332kfife3@hfhs.org
Susan E. Lyons · Principal Investigator

Hope Cancer Center

Pontiac, Michigan, 48341

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Christopher M. Reynolds · Principal Investigator

Michigan Healthcare Professionals Pontiac

Pontiac, Michigan, 48341

Recruiting
Site Public Contact · Contact
248-858-6215Emily.Crofts@trinity-health.org
Christopher M. Reynolds · Principal Investigator

Newland Medical Associates-Pontiac

Pontiac, Michigan, 48341

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Christopher M. Reynolds · Principal Investigator

Trinity Health Saint Joseph Mercy Oakland Hospital

Pontiac, Michigan, 48341

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Christopher M. Reynolds · Principal Investigator

Corewell Health Reed City Hospital

Reed City, Michigan, 49677

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen Y. Butler · Principal Investigator

Henry Ford Rochester Hospital

Rochester Hills, Michigan, 48309

Suspended

MyMichigan Medical Center Saginaw

Saginaw, Michigan, 48601

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Christopher M. Reynolds · Principal Investigator

Oncology Hematology Associates of Saginaw Valley PC

Saginaw, Michigan, 48604

Suspended

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

Saint Joseph, Michigan, 49085

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen Y. Butler · Principal Investigator

Corewell Health Lakeland Hospitals - Saint Joseph Hospital

Saint Joseph, Michigan, 49085

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen Y. Butler · Principal Investigator

Henry Ford Health Providence Southfield Hospital

Southfield, Michigan, 48075

Recruiting
Site Public Contact · Contact
248-849-5332kfife3@hfhs.org
Susan E. Lyons · Principal Investigator

Bhadresh Nayak MD PC-Sterling Heights

Sterling Heights, Michigan, 48312

Suspended

MyMichigan Medical Center Tawas

Tawas City, Michigan, 48764

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Christopher M. Reynolds · Principal Investigator

Munson Medical Center

Traverse City, Michigan, 49684

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen Y. Butler · Principal Investigator

Advanced Breast Care Center PLLC

Warren, Michigan, 48088

Suspended

Henry Ford Health Warren Hospital

Warren, Michigan, 48093

Recruiting
Site Public Contact · Contact
313-343-3166kforman1@hfhs.org
Christopher M. Reynolds · Principal Investigator

Henry Ford Madison Heights Hospital - Breast

Warren, Michigan, 48093

Recruiting
Site Public Contact · Contact
313-343-3166kforman1@hfhs.org
Christopher M. Reynolds · Principal Investigator

Henry Ford Warren Hospital - GLCMS

Warren, Michigan, 48093

Recruiting
Site Public Contact · Contact
313-343-3166kforman1@hfhs.org
Christopher M. Reynolds · Principal Investigator

Macomb Hematology Oncology PC

Warren, Michigan, 48093

Suspended

Saint Mary's Oncology/Hematology Associates of West Branch

West Branch, Michigan, 48661

Suspended

University of Michigan Health - West

Wyoming, Michigan, 49519

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen Y. Butler · Principal Investigator

Huron Gastroenterology PC

Ypsilanti, Michigan, 48106

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Christopher M. Reynolds · Principal Investigator

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

Ypsilanti, Michigan, 48197

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Christopher M. Reynolds · Principal Investigator

Fairview Ridges Hospital

Burnsville, Minnesota, 55337

Suspended

Minnesota Oncology - Burnsville

Burnsville, Minnesota, 55337

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Cambridge Medical Center

Cambridge, Minnesota, 55008

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Minnesota Oncology Hematology PA-Chaska

Chaska, Minnesota, 55318

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Mercy Hospital

Coon Rapids, Minnesota, 55433

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Minnesota Oncology - Coon Rapids

Coon Rapids, Minnesota, 55433

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Fairview Southdale Hospital

Edina, Minnesota, 55435

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Minnesota Oncology - Edina

Edina, Minnesota, 55435

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Unity Hospital

Fridley, Minnesota, 55432

Active Not Recruiting

Fairview Clinics and Surgery Center Maple Grove

Maple Grove, Minnesota, 55369

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Minnesota Oncology - Maple Grove

Maple Grove, Minnesota, 55369

Recruiting
Site Public Contact · Contact
952-993-1572mmcorc@healthpartners.com
David M. King · Principal Investigator

Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Health Partners Inc

Minneapolis, Minnesota, 55454

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Monticello Cancer Center

Monticello, Minnesota, 55362

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

New Ulm Medical Center

New Ulm, Minnesota, 56073

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Fairview Northland Medical Center

Princeton, Minnesota, 55371

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Regions Hospital

Saint Paul, Minnesota, 55101

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

United Hospital

Saint Paul, Minnesota, 55102

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Saint Francis Regional Medical Center

Shakopee, Minnesota, 55379

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Lakeview Hospital

Stillwater, Minnesota, 55082

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Ridgeview Medical Center

Waconia, Minnesota, 55387

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Rice Memorial Hospital

Willmar, Minnesota, 56201

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, 55125

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Fairview Lakes Medical Center

Wyoming, Minnesota, 55092

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Mercy Oncology and Hematology - Clayton-Clarkson

Ballwin, Missouri, 63011

Recruiting
Site Public Contact · Contact
888-446-3729
Jay W. Carlson · Principal Investigator

Central Care Cancer Center - Bolivar

Bolivar, Missouri, 65613

Recruiting
Site Public Contact · Contact
913-948-5588aroland@kccop.org
Jay W. Carlson · Principal Investigator

Parkland Health Center-Bonne Terre

Bonne Terre, Missouri, 63628

Suspended

Cox Cancer Center Branson

Branson, Missouri, 65616

Recruiting
Site Public Contact · Contact
417-269-4520
Jay W. Carlson · Principal Investigator

Mercy Cancer Center - Cape Girardeau

Cape Girardeau, Missouri, 63703

Recruiting
Site Public Contact · Contact
888-446-3729
Jay W. Carlson · Principal Investigator

Saint Francis Medical Center

Cape Girardeau, Missouri, 63703

Recruiting
Site Public Contact · Contact
573-334-2230sfmc@sfmc.net
Bryan A. Faller · Principal Investigator

Parkland Health Center - Farmington

Farmington, Missouri, 63640

Recruiting
Site Public Contact · Contact
314-996-5569
Bryan A. Faller · Principal Investigator

MU Health Care Goldschmidt Cancer Center

Jefferson City, Missouri, 65109

Suspended

Freeman Health System

Joplin, Missouri, 64804

Recruiting
Site Public Contact · Contact
417-347-4030LJCrockett@freemanhealth.com
Jay W. Carlson · Principal Investigator

Mercy Hospital Joplin

Joplin, Missouri, 64804

Recruiting
Site Public Contact · Contact
417-556-3074esmeralda.carrillo@mercy.net
Jay W. Carlson · Principal Investigator

Lake Regional Hospital

Osage Beach, Missouri, 65065

Recruiting
Site Public Contact · Contact
573-302-2768clinicaltrials@lakeregional.com
Jay W. Carlson · Principal Investigator

Mercy Clinic-Rolla-Cancer and Hematology

Rolla, Missouri, 65401

Recruiting
Site Public Contact · Contact
573-458-6379
Jay W. Carlson · Principal Investigator

Phelps Health Delbert Day Cancer Institute

Rolla, Missouri, 65401

Recruiting
Site Public Contact · Contact
573-458-7504research@phelpshealth.org
Jay W. Carlson · Principal Investigator

Heartland Regional Medical Center

Saint Joseph, Missouri, 64506

Recruiting
Site Public Contact · Contact
816-271-7937Trisha.England2@mymlc.com
Jay W. Carlson · Principal Investigator

Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, 63670

Recruiting
Site Public Contact · Contact
314-996-5569
Bryan A. Faller · Principal Investigator

Mercy Hospital Springfield

Springfield, Missouri, 65804

Recruiting
Site Public Contact · Contact
417-269-4520
Jay W. Carlson · Principal Investigator

CoxHealth South Hospital

Springfield, Missouri, 65807

Recruiting
Site Public Contact · Contact
417-269-4520
Jay W. Carlson · Principal Investigator

Mercy Infusion Center - Chippewa

St Louis, Missouri, 63109

Recruiting
Site Public Contact · Contact
888-446-3729
Jay W. Carlson · Principal Investigator

Mercy Hospital South

St Louis, Missouri, 63128

Recruiting
Site Public Contact · Contact
314-525-6042Danielle.Werle@mercy.net
Jay W. Carlson · Principal Investigator

Missouri Baptist Medical Center

St Louis, Missouri, 63131

Recruiting
Site Public Contact · Contact
314-996-5569
Bryan A. Faller · Principal Investigator

Mercy Hospital Saint Louis

St Louis, Missouri, 63141

Recruiting
Site Public Contact · Contact
314-251-7066
Jay W. Carlson · Principal Investigator

Missouri Baptist Sullivan Hospital

Sullivan, Missouri, 63080

Recruiting
Site Public Contact · Contact
314-996-5569
Bryan A. Faller · Principal Investigator

BJC Outpatient Center at Sunset Hills

Sunset Hills, Missouri, 63127

Recruiting
Site Public Contact · Contact
314-996-5569
Bryan A. Faller · Principal Investigator

Mercy Hospital Washington

Washington, Missouri, 63090

Recruiting
Site Public Contact · Contact
636-390-1600
Jay W. Carlson · Principal Investigator

Community Hospital of Anaconda

Anaconda, Montana, 59711

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Billings Clinic Cancer Center

Billings, Montana, 59101

Recruiting
Site Public Contact · Contact
800-996-2663research@billingsclinic.org
John M. Schallenkamp · Principal Investigator

Bozeman Health Deaconess Hospital

Bozeman, Montana, 59715

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Benefis Sletten Cancer Institute

Great Falls, Montana, 59405

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Great Falls Clinic

Great Falls, Montana, 59405

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Hi-Line Sletten Cancer Center

Havre, Montana, 59501

Recruiting
Site Public Contact · Contact
ecog.rss@jimmy.harvard.edu
John M. Schallenkamp · Principal Investigator

Benefis Helena Specialty Center

Helena, Montana, 59601

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Saint Peter's Community Hospital

Helena, Montana, 59601

Suspended

Logan Health Medical Center

Kalispell, Montana, 59901

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Saint Patrick Hospital - Community Hospital

Missoula, Montana, 59802

Active Not Recruiting

Community Medical Center

Missoula, Montana, 59804

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Nebraska Cancer Specialists/Oncology Hematology West PC - MECC

Omaha, Nebraska, 68114

Recruiting
Site Public Contact · Contact
402-334-4773
Robert M. Langdon · Principal Investigator

Nebraska Methodist Hospital

Omaha, Nebraska, 68114

Recruiting
Site Public Contact · Contact
402-354-5144
Robert M. Langdon · Principal Investigator

Oncology Associates PC

Omaha, Nebraska, 68114

Suspended

Roswell Park Cancer Institute

Buffalo, New York, 14263

Active Not Recruiting

Garnet Health Medical Center

Middletown, New York, 10940

Suspended

Dickstein Cancer Treatment Center

White Plains, New York, 10601

Active Not Recruiting

Margaret R Pardee Memorial Hospital

Hendersonville, North Carolina, 28791

Active Not Recruiting

FirstHealth of the Carolinas-Moore Regional Hospital

Pinehurst, North Carolina, 28374

Recruiting
Site Public Contact · Contact
910-715-3500jcwilliams@firsthealth.org
Charles S. Kuzma · Principal Investigator

Indu and Raj Soin Medical Center

Beavercreek, Ohio, 45431

Active Not Recruiting

Saint Elizabeth Boardman Hospital

Boardman, Ohio, 44512

Active Not Recruiting

Dayton Physicians LLC-Miami Valley South

Centerville, Ohio, 45459

Active Not Recruiting

Miami Valley Hospital South

Centerville, Ohio, 45459

Active Not Recruiting

Oncology Hematology Care Inc-Kenwood

Cincinnati, Ohio, 45236

Active Not Recruiting

MetroHealth Medical Center

Cleveland, Ohio, 44109

Active Not Recruiting

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210

Recruiting
Site Public Contact · Contact
800-293-5066Jamesline@osumc.edu
Regan M. Memmott · Principal Investigator

Good Samaritan Hospital - Dayton

Dayton, Ohio, 45406

Suspended

Miami Valley Hospital

Dayton, Ohio, 45409

Active Not Recruiting

Dayton Physician LLC - Englewood

Dayton, Ohio, 45415

Active Not Recruiting

Miami Valley Hospital North

Dayton, Ohio, 45415

Active Not Recruiting

Armes Family Cancer Center

Findlay, Ohio, 45840

Active Not Recruiting

Blanchard Valley Hospital

Findlay, Ohio, 45840

Active Not Recruiting

Orion Cancer Care

Findlay, Ohio, 45840

Active Not Recruiting

Atrium Medical Center-Middletown Regional Hospital

Franklin, Ohio, 45005-1066

Active Not Recruiting

Dayton Physicians LLC-Atrium

Franklin, Ohio, 45005

Active Not Recruiting

Dayton Physicians LLC-Wayne

Greenville, Ohio, 45331

Active Not Recruiting

Wayne Hospital

Greenville, Ohio, 45331

Active Not Recruiting

Greater Dayton Cancer Center

Kettering, Ohio, 45409

Active Not Recruiting

First Dayton Cancer Care

Kettering, Ohio, 45420

Active Not Recruiting

Kettering Medical Center

Kettering, Ohio, 45429

Active Not Recruiting

Springfield Regional Cancer Center

Springfield, Ohio, 45504

Active Not Recruiting

Springfield Regional Medical Center

Springfield, Ohio, 45504

Active Not Recruiting

Dayton Physicians LLC - Troy

Troy, Ohio, 45373

Active Not Recruiting

Upper Valley Medical Center

Troy, Ohio, 45373

Active Not Recruiting

Saint Joseph Warren Hospital

Warren, Ohio, 44484

Active Not Recruiting

Saint Elizabeth Youngstown Hospital

Youngstown, Ohio, 44501

Active Not Recruiting

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104

Recruiting
Site Public Contact · Contact
405-271-8777ou-clinical-trials@ouhsc.edu
Raid Aljumaily · Principal Investigator

Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, 73120

Recruiting
Site Public Contact · Contact
405-752-3402
Jay W. Carlson · Principal Investigator

Saint Alphonsus Cancer Care Center-Baker City

Baker City, Oregon, 97814

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
Christopher M. Reynolds · Principal Investigator

Saint Charles Health System

Bend, Oregon, 97701

Active Not Recruiting

Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015

Active Not Recruiting

Providence Cancer Institute Clackamas Clinic

Clackamas, Oregon, 97015

Active Not Recruiting

Bay Area Hospital

Coos Bay, Oregon, 97420

Active Not Recruiting

Good Samaritan Hospital

Corvallis, Oregon, 97330

Recruiting
Site Public Contact · Contact
541-768-4352stmock@samhealth.org
John Strother · Principal Investigator

Providence Newberg Medical Center

Newberg, Oregon, 97132

Active Not Recruiting

Saint Alphonsus Cancer Care Center-Ontario

Ontario, Oregon, 97914

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
Christopher M. Reynolds · Principal Investigator

Providence Willamette Falls Medical Center

Oregon City, Oregon, 97045

Active Not Recruiting

Providence Portland Medical Center

Portland, Oregon, 97213

Active Not Recruiting

Providence Saint Vincent Medical Center

Portland, Oregon, 97225

Active Not Recruiting

Saint Charles Health System-Redmond

Redmond, Oregon, 97756

Active Not Recruiting

Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, 18103

Recruiting
Site Public Contact · Contact
610-402-9543Morgan_M.Horton@lvhn.org
Christopher M. Reynolds · Principal Investigator

Lehigh Valley Hospital - Muhlenberg

Bethlehem, Pennsylvania, 18017

Recruiting
Site Public Contact · Contact
610-402-9543Morgan_M.Horton@lvhn.org
Christopher M. Reynolds · Principal Investigator

Bryn Mawr Hospital

Bryn Mawr, Pennsylvania, 19010

Recruiting
Site Public Contact · Contact
484-476-2649turzoe@mlhs.org
Paul B. Gilman · Principal Investigator

Main Line Health Center-Collegeville

Collegeville, Pennsylvania, 19426

Suspended

Pocono Medical Center

East Stroudsburg, Pennsylvania, 18301

Recruiting
Site Public Contact · Contact
610-402-9543Morgan_M.Horton@lvhn.org
Christopher M. Reynolds · Principal Investigator

Main Line Health Center-Exton

Exton, Pennsylvania, 19341

Suspended

Lehigh Valley Hospital-Hazleton

Hazleton, Pennsylvania, 18201

Recruiting
Site Public Contact · Contact
610-402-9543Morgan_M.Horton@lvhn.org
Christopher M. Reynolds · Principal Investigator

Riddle Memorial Hospital

Media, Pennsylvania, 19063

Recruiting
Site Public Contact · Contact
484-476-2649turzoe@mlhs.org
Paul B. Gilman · Principal Investigator

Bryn Mawr Health Center

Newtown Square, Pennsylvania, 19073

Suspended

Paoli Memorial Hospital

Paoli, Pennsylvania, 19301

Recruiting
Site Public Contact · Contact
484-476-2649turzoe@mlhs.org
Paul B. Gilman · Principal Investigator

Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111

Active Not Recruiting

Temple University Hospital

Philadelphia, Pennsylvania, 19140

Active Not Recruiting

Penn State Health Saint Joseph Medical Center

Reading, Pennsylvania, 19605

Suspended

Lankenau Medical Center

Wynnewood, Pennsylvania, 19096

Recruiting
Site Public Contact · Contact
484-476-2649turzoe@mlhs.org
Paul B. Gilman · Principal Investigator

University of Virginia Cancer Center

Charlottesville, Virginia, 22908

Recruiting
Site Public Contact · Contact
434-243-6303uvacancertrials@hscmail.mcc.virginia.edu
Richard D. Hall · Principal Investigator

Providence Regional Cancer System-Aberdeen

Aberdeen, Washington, 98520

Active Not Recruiting

PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, 98225

Active Not Recruiting

Providence Regional Cancer System-Centralia

Centralia, Washington, 98531

Active Not Recruiting

Swedish Cancer Institute-Edmonds

Edmonds, Washington, 98026

Active Not Recruiting

Providence Regional Cancer Partnership

Everett, Washington, 98201

Active Not Recruiting

Swedish Cancer Institute-Issaquah

Issaquah, Washington, 98029

Active Not Recruiting

Kadlec Clinic Hematology and Oncology

Kennewick, Washington, 99336

Active Not Recruiting

Providence Regional Cancer System-Lacey

Lacey, Washington, 98503

Active Not Recruiting

PeaceHealth Saint John Medical Center

Longview, Washington, 98632

Active Not Recruiting

Pacific Gynecology Specialists

Seattle, Washington, 98104

Suspended

Swedish Medical Center-Ballard Campus

Seattle, Washington, 98107

Active Not Recruiting

Fred Hutchinson Cancer Center

Seattle, Washington, 98109

Recruiting
Site Public Contact · Contact
800-804-8824
Christina S. Baik · Principal Investigator

Kaiser Permanente Washington

Seattle, Washington, 98112

Active Not Recruiting

Swedish Medical Center-Cherry Hill

Seattle, Washington, 98122-5711

Active Not Recruiting

Swedish Medical Center-First Hill

Seattle, Washington, 98122

Active Not Recruiting

University of Washington Medical Center - Montlake

Seattle, Washington, 98195

Recruiting
Site Public Contact · Contact
800-804-8824
Christina S. Baik · Principal Investigator

PeaceHealth United General Medical Center

Sedro-Woolley, Washington, 98284

Active Not Recruiting

Providence Regional Cancer System-Shelton

Shelton, Washington, 98584

Active Not Recruiting

PeaceHealth Southwest Medical Center

Vancouver, Washington, 98664

Active Not Recruiting

Providence Saint Mary Regional Cancer Center

Walla Walla, Washington, 99362

Active Not Recruiting

Providence Regional Cancer System-Yelm

Yelm, Washington, 98597

Active Not Recruiting

Aurora Cancer Care-Southern Lakes VLCC

Burlington, Wisconsin, 53105

Recruiting
Site Public Contact · Contact
414-302-2304ncorp@aurora.org
Shamsuddin Virani · Principal Investigator

Marshfield Clinic-Chippewa Center

Chippewa Falls, Wisconsin, 54729

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Chady A. Leon · Principal Investigator

Aurora Saint Luke's South Shore

Cudahy, Wisconsin, 53110

Recruiting
Site Public Contact · Contact
414-302-2304ncorp@aurora.org
Shamsuddin Virani · Principal Investigator

Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Chady A. Leon · Principal Investigator

Aurora Health Center-Fond du Lac

Fond du Lac, Wisconsin, 54937

Recruiting
Site Public Contact · Contact
414-302-2304ncorp@aurora.org
Shamsuddin Virani · Principal Investigator

Aurora Health Care Germantown Health Center

Germantown, Wisconsin, 53022

Recruiting
Site Public Contact · Contact
414-302-2304ncorp@aurora.org
Shamsuddin Virani · Principal Investigator

Aurora Cancer Care-Grafton

Grafton, Wisconsin, 53024

Recruiting
Site Public Contact · Contact
414-302-2304ncorp@aurora.org
Shamsuddin Virani · Principal Investigator

Aurora BayCare Medical Center

Green Bay, Wisconsin, 54311

Recruiting
Site Public Contact · Contact
414-302-2304ncorp@aurora.org
Shamsuddin Virani · Principal Investigator

Aurora Cancer Care-Kenosha South

Kenosha, Wisconsin, 53142

Recruiting
Site Public Contact · Contact
414-302-2304ncorp@aurora.org
Shamsuddin Virani · Principal Investigator

Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601

Recruiting
Site Public Contact · Contact
608-775-2385cancerctr@gundersenhealth.org
Kurt Oettel · Principal Investigator

Marshfield Medical Center - Ladysmith

Ladysmith, Wisconsin, 54848

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Chady A. Leon · Principal Investigator

Aurora Bay Area Medical Group-Marinette

Marinette, Wisconsin, 54143

Recruiting
Site Public Contact · Contact
414-302-2304ncorp@aurora.org
Shamsuddin Virani · Principal Investigator

Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Chady A. Leon · Principal Investigator

Aurora Cancer Care-Milwaukee

Milwaukee, Wisconsin, 53209

Recruiting
Site Public Contact · Contact
414-302-2304ncorp@aurora.org
Shamsuddin Virani · Principal Investigator

Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, 53215

Recruiting
Site Public Contact · Contact
414-302-2304ncorp@aurora.org
Shamsuddin Virani · Principal Investigator

Aurora Sinai Medical Center

Milwaukee, Wisconsin, 53233

Recruiting
Site Public Contact · Contact
414-302-2304ncorp@aurora.org
Shamsuddin Virani · Principal Investigator

Marshfield Medical Center - Minocqua

Minocqua, Wisconsin, 54548

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Chady A. Leon · Principal Investigator

Cancer Center of Western Wisconsin

New Richmond, Wisconsin, 54017

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Vince Lombardi Cancer Clinic - Oshkosh

Oshkosh, Wisconsin, 54904

Recruiting
Site Public Contact · Contact
414-302-2304ncorp@aurora.org
Shamsuddin Virani · Principal Investigator

Aurora Cancer Care-Racine

Racine, Wisconsin, 53406

Recruiting
Site Public Contact · Contact
414-302-2304ncorp@aurora.org
Shamsuddin Virani · Principal Investigator

Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Chady A. Leon · Principal Investigator

Vince Lombardi Cancer Clinic-Sheboygan

Sheboygan, Wisconsin, 53081

Recruiting
Site Public Contact · Contact
414-302-2304ncorp@aurora.org
Shamsuddin Virani · Principal Investigator

Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Chady A. Leon · Principal Investigator

Aurora Medical Center in Summit

Summit, Wisconsin, 53066

Recruiting
Site Public Contact · Contact
414-302-2304ncorp@aurora.org
Shamsuddin Virani · Principal Investigator

Vince Lombardi Cancer Clinic-Two Rivers

Two Rivers, Wisconsin, 54241

Recruiting
Site Public Contact · Contact
414-302-2304ncorp@aurora.org
Shamsuddin Virani · Principal Investigator

Marshfield Clinic-Wausau Center

Wausau, Wisconsin, 54401

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Chady A. Leon · Principal Investigator

Aurora Cancer Care-Milwaukee West

Wauwatosa, Wisconsin, 53226

Recruiting
Site Public Contact · Contact
414-302-2304ncorp@aurora.org
Shamsuddin Virani · Principal Investigator

Aurora West Allis Medical Center

West Allis, Wisconsin, 53227

Recruiting
Site Public Contact · Contact
414-302-2304ncorp@aurora.org
Shamsuddin Virani · Principal Investigator

Marshfield Medical Center - Weston

Weston, Wisconsin, 54476

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Chady A. Leon · Principal Investigator

Marshfield Clinic - Wisconsin Rapids Center

Wisconsin Rapids, Wisconsin, 54494

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Chady A. Leon · Principal Investigator

Memorial Hospital of Laramie County

Cheyenne, Wyoming, 82001

Recruiting
Site Public Contact · Contact
ecog.rss@jimmy.harvard.edu
John M. Schallenkamp · Principal Investigator

Billings Clinic-Cody

Cody, Wyoming, 82414

Recruiting
Site Public Contact · Contact
800-996-2663research@billingsclinic.org
John M. Schallenkamp · Principal Investigator

Welch Cancer Center

Sheridan, Wyoming, 82801

Suspended
Testing Osimertinib as a Treatment for Lung Cancers With an EGFR Exon 20 Change | Cancerify