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RecruitingInterventionalPhase 3

Phase III Randomized Trial of Standard Systemic Therapy (SST) Versus Standard Systemic Therapy Plus Definitive Treatment (Surgery or Radiation) of the Primary Tumor in Metastatic Prostate Cancer

NCT ID: NCT03678025Sponsor: SWOG Cancer Research NetworkLast updated: 2025-09-11

Summary

This phase III trial studies how well standard systemic therapy with or without definitive treatment (prostate removal surgery or radiation therapy) works in treating participants with prostate cancer that has spread to other places in the body. Addition of prostate removal surgery or radiation therapy to standard systemic therapy for prostate cancer may lower the chance of the cancer growing or spreading.

Detailed description

PRIMARY OBJECTIVES: I. To compare overall survival in metastatic prostate cancer patients who are randomized to standard systemic therapy (SST) plus definitive treatment of the primary tumor versus standard systemic therapy alone. SECONDARY OBJECTIVES: I. To compare overall survival in metastatic prostate cancer patients who received SST plus surgical excision of the primary tumor versus SST alone in the subset who specify the surgical intent stratification factor. II. To compare the rate of symptomatic local progression between the treatment arms. III. To compare progression-free survival (PFS) between the two treatment arms. IV. To compare rates of progression-free survival between arms for the subsets of patients with and without metastasis directed therapy (MDT) to oligometastatic sites. QUALITY OF LIFE OBJECTIVES: I. To compare between arms patient-reported urinary function and urinary bother over time (after initiation of SST at 6 months, 1, 2, and 3 years) using the Expanded Prostate Cancer Index Composite (EPIC) and patient-reported pain and physical functioning using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) between patients receiving standard systemic therapy and those receiving systemic therapy and definitive management of the primary prostate cancer. OTHER OBJECTIVES: I. To bank tissue and whole blood specimens for future use. OUTLINE: INDUCTION: Participants receive 1 of 6 acceptable forms of SST for 22-28 weeks. I. Participants undergo a bilateral orchiectomy. II. Participants receive goserelin acetate subcutaneously (SC) every 28 days or 12 weeks, histrelin acetate SC every 12 months, leuprolide acetate SC or intramuscularly (IM) every 1, 3, 4, or 6 months, and triptorelin every 1, 3, or 6 months. III. Participants receive goserelin acetate SC every 28 days or 12 weeks, histrelin acetate SC every 12 months, leuprolide acetate SC or IM every 1, 3, 4, or 6 months, and triptorelin every 1, 3, or 6 months. Participants also receive nilutamide orally (PO) daily, flutamide PO every 8 hours, and bicalutamide PO daily. IV. Participants receive degarelix via injection for 2 doses and then every 28 days. V. Participants receive nilutamide PO daily, flutamide PO every 8 hours, and bicalutamide PO daily. Participants also receive docetaxel over 1 hour every 3 weeks with or without prednisone PO every 12 hours. VI. Participants receive nilutamide PO daily, flutamide PO every 8 hours, and bicalutamide PO daily. Participants also receive abiraterone PO daily or prednisone PO every 12 hours. After completion of 22-28 weeks of SST, participants are then randomized to 1 of 2 arms. ARM I: Participants receive 1 acceptable form of SST as in Induction except for treatment with docetaxel and prednisone. ARM II: Participants receive 1 acceptable form of SST as in Induction except for treatment with docetaxel and prednisone. Participants undergo prostatectomy within 8 weeks after randomization or radiation therapy within 4 weeks of randomization. After completion of study treatment, participants are followed up for 8 years.

Arms & interventions

  • DrugAbiraterone

    Given PO

  • DrugBicalutamide

    Given PO

  • DrugDegarelix

    Given via injection

  • DrugDocetaxel

    intravenous

  • DrugFlutamide

    Given PO

  • DrugGoserelin Acetate

    Given SC

  • DrugHistrelin Acetate

    Receive SC

  • DrugLeuprolide Acetate

    Receive SC or IM

  • DrugNilutamide

    Given PO

  • ProcedureOrchiectomy

    Undergo bilateral orchiectomy

  • DrugPrednisone

    Given PO

  • OtherQuality-of-Life Assessment

    Ancillary studies

  • RadiationRadiation Therapy

    Standard radiation

  • ProcedureRadical Prostatectomy

    Standard surgery

  • DrugTriptorelin

    injection

Outcome measures

Primary

  • Overall survival (OS)

    Time frame: From date of randomization to date of death due to any cause, assessed up to 8 years

Secondary

  • Media OS

    Time frame: From date of randomization to date of death due to any cause, assessed up to 8 years

  • Rate of symptomatic local progression

    Time frame: Up to 8 years

  • Progression-free survival (PFS)

    Time frame: From date of randomization to date of first documentation of progression, or death due to any cause, assessed up to 8 years

Eligibility criteria

Sex: MaleAge: 18 Years and olderHealthy volunteers: No
Inclusion Criteria: * STEP 1 REGISTRATION: DISEASE-RELATED CRITERIA: All patients must have a histologically or cytologically proven diagnosis of adenocarcinoma of the prostate. Patients with pure small cell carcinoma\* (SCC), sarcomatoid, or squamous cell carcinoma are not eligible. (\*morphology must be consistent with SCC; synaptophysin or chromogranin positive by immunohistochemical staining is insufficient to diagnose SCC). * STEP 1 REGISTRATION: DISEASE-RELATED CRITERIA: Patients must have an intact prostate. No prior local therapy for prostate adenocarcinoma is allowed (e.g., brachytherapy, high-intensity focused ultrasound \[HIFU\], cryotherapy, laser ablative therapies). Any prior therapy for benign conditions, such as obstruction, are acceptable (e.g., transurethral resection of the prostate, greenlight laser ablation, microwave ablation). * STEP 1 REGISTRATION: DISEASE-RELATED CRITERIA: Patients must have evidence of metastatic disease on technetium bone scan and computed tomography (CT) or magnetic resonance imaging (MRI) within 42 days prior to starting standard systemic therapy. Metastatic disease that is detected by positron emission tomography (PET) scan only (sodium fluoride \[NaF\], prostate-specific membrane antigen \[PSMA\], anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid \[FACBC\], carbon \[C\]11) but not conventional imaging (technetium \[Tc\]99 bone scan, CT or MRI) or solitary metastases by conventional imaging, must be confirmed histologically or cytologically. * STEP 1 REGISTRATION: DISEASE-RELATED CRITERIA: Patients with known brain metastases are not eligible. Brain imaging studies are not required for eligibility if the patient has no neurologic signs or symptoms suggestive of brain metastasis. If brain imaging studies are performed, they must be negative for disease. * STEP 1 REGISTRATION: PRIOR/CONCURRENT THERAPY CRITERIA: Patients must have received no more than 28 weeks of standard systemic therapy (SST). SST is defined as current National Comprehensive Cancer Network (NCCN) guidelines for metastatic prostate cancer. * STEP 1 REGISTRATION: PRIOR/CONCURRENT THERAPY CRITERIA: Patients must not have progressed while on SST. * STEP 1 REGISTRATION: PRIOR/CONCURRENT THERAPY CRITERIA: Patients with oligometastatic prostate cancer may receive metastasis directed therapy to up to four sites of disease prior to randomization. * STEP 1 REGISTRATION: CLINICAL/LABORATORY CRITERIA: Patients must have a complete physical examination and medical history within 28 days prior to registration. * STEP 1 REGISTRATION: CLINICAL/LABORATORY CRITERIA: Patients must have a PSA documented prior to initiation of SST and within 28 days prior to registration. Any additional PSAs measured while receiving SST should be recorded. * STEP 1 REGISTRATION: CLINICAL/LABORATORY CRITERIA: Patients must have a testosterone lab documented within 28 days prior to randomization. Any additional testosterone labs measured while receiving SST should be recorded as well as pretreatment initiation if available. * STEP 1 REGISTRATION: CLINICAL/LABORATORY CRITERIA: No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, adequately treated stage 0, I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for three years. * STEP 1 REGISTRATION: SPECIMEN SUBMISSION CRITERIA: Patients must be offered the opportunity to participate in translational medicine studies and specimen banking for future studies. * STEP 1 REGISTRATION: QUALITY OF LIFE CRITERIA: Patients who can complete Patient-Reported Outcome instruments in English, Spanish or French, must participate in the quality of life studies. * STEP 1 REGISTRATION: REGULATORY CRITERIA: Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines. * STEP 2 RANDOMIZATION: DISEASE-RELATED CRITERIA: As a part of the OPEN registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system. * STEP 2 RANDOMIZATION: DISEASE-RELATED CRITERIA: Patients must have no evidence of disease progression during the 28 weeks of SST by PSA measure, bone scan and CT or MRI or symptomatic deterioration (as defined by physician discretion) within 28 days prior to randomization. * STEP 2 RANDOMIZATION: DISEASE-RELATED CRITERIA: Patients must have consultation with a urologist and have surgically resectable disease regardless of definitive treatment intent or randomization. * STEP 2 RANDOMIZATION: PRIOR/CONCURRENT THERAPY CRITERIA: Patients must have received between 22 and 28 weeks of SST as measured from the date of first hormonal therapy or surgical castration. SST is defined by current NCCN guidelines for metastatic prostate cancer. * STEP 2 RANDOMIZATION: PRIOR/CONCURRENT THERAPY CRITERIA: Patients must not be planning to receive docetaxel after randomization. * STEP 2 RANDOMIZATION: PRIOR/CONCURRENT THERAPY CRITERIA: Any toxicities from SST must have resolved to =\< grade 1 (Common Terminology Criteria for Adverse Events \[CTCAE\] version 5.0) prior to randomization. * STEP 2 RANDOMIZATION: PRIOR/CONCURRENT THERAPY CRITERIA: Patients may have received elective metastasis directed therapy to oligometastatic sites (=\< 4 sites). All treatment must be completed prior to randomization. * STEP 2 RANDOMIZATION: CLINICAL/LABORATORY CRITERIA: Patients must have a PSA performed within 28 days prior to randomization. * STEP 2 RANDOMIZATION: CLINICAL/LABORATORY CRITERIA: Patients must have a testosterone \< 50 ng/dL within 28 days prior to randomization. * STEP 2 RANDOMIZATION: CLINICAL/LABORATORY CRITERIA: Patients must have a Zubrod performance status of 0 ? 1 within 28 days prior to randomization.

Study locations (334)

Banner MD Anderson Cancer Center

Gilbert, Arizona, 85234

Recruiting
Site Public Contact · Contact
602-747-9738
Chinedu Mmeje · Principal Investigator

Cancer Center at Saint Joseph's

Phoenix, Arizona, 85004

Recruiting
Site Public Contact · Contact
602-406-0777CancerInstitute@DignityHealth.org
Shahzad Siddique · Principal Investigator

Mayo Clinic Hospital in Arizona

Phoenix, Arizona, 85054

Suspended

Mayo Clinic in Arizona

Scottsdale, Arizona, 85259

Suspended

University of Arizona Cancer Center-Orange Grove Campus

Tucson, Arizona, 85704

Recruiting
Site Public Contact · Contact
520-694-8900
Juan Chipollini · Principal Investigator

University of Arizona Cancer Center-North Campus

Tucson, Arizona, 85719

Recruiting
Site Public Contact · Contact
UACC-IIT@uacc.arizona.edu
Juan Chipollini · Principal Investigator

University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205

Recruiting
Site Public Contact · Contact
501-686-8274
Shi-Ming Tu · Principal Investigator

Kaiser Permanente-Deer Valley Medical Center

Antioch, California, 94531

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

Community Cancer Institute

Clovis, California, 93611

Recruiting
Site Public Contact · Contact
559-387-1827
Uzair B. Chaudhary · Principal Investigator

University Oncology Associates

Clovis, California, 93611

Suspended

City of Hope Comprehensive Cancer Center

Duarte, California, 91010

Recruiting
Site Public Contact · Contact
800-826-4673becomingapatient@coh.org
Tanya B. Dorff · Principal Investigator

Kaiser Permanente Dublin

Dublin, California, 94568

Recruiting
Site Public Contact · Contact
877-642-4691
Andrea L. Harzstark · Principal Investigator

Kaiser Permanente-Fremont

Fremont, California, 94538

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

Fresno Cancer Center

Fresno, California, 93720

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

Kaiser Permanente-Fresno

Fresno, California, 93720

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

UC San Diego Moores Cancer Center

La Jolla, California, 92093

Recruiting
Site Public Contact · Contact
858-822-5354cancercto@ucsd.edu
Aditya Bagrodia · Principal Investigator

Tibor Rubin VA Medical Center

Long Beach, California, 90822

Recruiting
Site Public Contact · Contact
562-826-8000
Greg Gin · Principal Investigator

Los Angeles County-USC Medical Center

Los Angeles, California, 90033

Recruiting
Site Public Contact · Contact
323-865-0451
Siamak Daneshmand · Principal Investigator

USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033

Recruiting
Site Public Contact · Contact
323-865-0451
Siamak Daneshmand · Principal Investigator

Fremont - Rideout Cancer Center

Marysville, California, 95901

Recruiting
Site Public Contact · Contact
530-749-4400
Richard K. Valicenti · Principal Investigator

Kaiser Permanente-Modesto

Modesto, California, 95356

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

Kaiser Permanente Oakland-Broadway

Oakland, California, 94611

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

Kaiser Permanente-Oakland

Oakland, California, 94611

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

Desert Regional Medical Center

Palm Springs, California, 92262

Recruiting
Site Public Contact · Contact
760-416-4730
Amir Lavaf · Principal Investigator

Stanford Cancer Institute Palo Alto

Palo Alto, California, 94304

Recruiting
Site Public Contact · Contact
650-498-7061ccto-office@stanford.edu
Geoffrey A. Sonn · Principal Investigator

Kaiser Permanente-Rancho Cordova Cancer Center

Rancho Cordova, California, 95670

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

Kaiser Permanente-Redwood City

Redwood City, California, 94063

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

Kaiser Permanente-Richmond

Richmond, California, 94801

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

Rohnert Park Cancer Center

Rohnert Park, California, 94928

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

Kaiser Permanente-Roseville

Roseville, California, 95661

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

The Permanente Medical Group-Roseville Radiation Oncology

Roseville, California, 95678

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

Kaiser Permanente Downtown Commons

Sacramento, California, 95814

Recruiting
Site Public Contact · Contact
877-642-4691kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

Mercy Cancer Center - Sacramento

Sacramento, California, 95816

Recruiting
Site Public Contact · Contact
916-556-3301OncologyResearch@DignityHealth.org
Shahzad Siddique · Principal Investigator

University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817

Recruiting
Site Public Contact · Contact
916-734-3089
Richard K. Valicenti · Principal Investigator

Kaiser Permanente-South Sacramento

Sacramento, California, 95823

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

South Sacramento Cancer Center

Sacramento, California, 95823

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

Kaiser Permanente-San Francisco

San Francisco, California, 94115

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

Kaiser Permanente-Santa Teresa-San Jose

San Jose, California, 95119

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

Kaiser Permanente San Leandro

San Leandro, California, 94577

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

Pacific Central Coast Health Center-San Luis Obispo

San Luis Obispo, California, 93401

Recruiting
Site Public Contact · Contact
805-219-4673ResearchInstituteInquiries@CommonSpirit.org
Shahzad Siddique · Principal Investigator

Kaiser San Rafael-Gallinas

San Rafael, California, 94903

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

Kaiser Permanente Medical Center - Santa Clara

Santa Clara, California, 95051

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

Kaiser Permanente-Santa Rosa

Santa Rosa, California, 95403

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

Kaiser Permanente Cancer Treatment Center

South San Francisco, California, 94080

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

Kaiser Permanente-South San Francisco

South San Francisco, California, 94080

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

Kaiser Permanente-Stockton

Stockton, California, 95210

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

Gene Upshaw Memorial Tahoe Forest Cancer Center

Truckee, California, 96161

Recruiting
Site Public Contact · Contact
530-582-6450
Richard K. Valicenti · Principal Investigator

Kaiser Permanente Medical Center-Vacaville

Vacaville, California, 95688

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

Kaiser Permanente-Vallejo

Vallejo, California, 94589

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

Kaiser Permanente-Walnut Creek

Walnut Creek, California, 94596

Recruiting
Site Public Contact · Contact
877-642-4691Kpoct@kp.org
Andrea L. Harzstark · Principal Investigator

University of Colorado Hospital

Aurora, Colorado, 80045

Recruiting
Site Public Contact · Contact
720-848-0650
Paul D. Maroni · Principal Investigator

Rocky Mountain Cancer Centers-Boulder

Boulder, Colorado, 80304

Recruiting
Site Public Contact · Contact
303-777-2663info@westernstatesncorp.org
Nicholas DiBella · Principal Investigator

UCHealth Memorial Hospital Central

Colorado Springs, Colorado, 80909

Recruiting
Site Public Contact · Contact
719-365-2406
Paul D. Maroni · Principal Investigator

Memorial Hospital North

Colorado Springs, Colorado, 80920

Recruiting
Site Public Contact · Contact
719-364-6700
Paul D. Maroni · Principal Investigator

Porter Adventist Hospital

Denver, Colorado, 80210

Recruiting
Site Public Contact · Contact
719-776-6550ResearchTracking@Centura.Org
Shahzad Siddique · Principal Investigator

Shaw Cancer Center

Edwards, Colorado, 81632

Recruiting
Site Public Contact · Contact
970-569-7429
Patricia H. Hardenbergh · Principal Investigator

Poudre Valley Hospital

Fort Collins, Colorado, 80524

Recruiting
Site Public Contact · Contact
970-297-6150
Paul D. Maroni · Principal Investigator

North Colorado Medical Center

Greeley, Colorado, 80631

Recruiting
Site Public Contact · Contact
970-810-3046BMDACCResearchCOMailbox@bannerhealth.com
Supriya Jain · Principal Investigator

Littleton Adventist Hospital

Littleton, Colorado, 80122

Recruiting
Site Public Contact · Contact
719-776-6550ResearchTracking@Centura.Org
Shahzad Siddique · Principal Investigator

McKee Medical Center

Loveland, Colorado, 80539

Recruiting
Site Public Contact · Contact
970-810-3046BMDACCResearchCOMailbox@bannerhealth.com
Supriya Jain · Principal Investigator

Parker Adventist Hospital

Parker, Colorado, 80138

Recruiting
Site Public Contact · Contact
719-776-6550ResearchTracking@Centura.Org
Shahzad Siddique · Principal Investigator

Smilow Cancer Hospital Care Center - Guilford

Guilford, Connecticut, 06437

Recruiting
Site Public Contact · Contact
203-785-5702canceranswers@yale.edu
Preston C. Sprenkle · Principal Investigator

Yale University

New Haven, Connecticut, 06520

Recruiting
Site Public Contact · Contact
203-785-5702canceranswers@yale.edu
Preston C. Sprenkle · Principal Investigator

Stamford Hospital/Bennett Cancer Center

Stamford, Connecticut, 06904

Recruiting
Site Public Contact · Contact
203-323-8944
Anthony P. Gulati · Principal Investigator

Smilow Cancer Hospital Care Center-Trumbull

Trumbull, Connecticut, 06611

Recruiting
Site Public Contact · Contact
203-785-5702canceranswers@yale.edu
Preston C. Sprenkle · Principal Investigator

Smilow Cancer Hospital Care Center - Waterford

Waterford, Connecticut, 06385

Recruiting
Site Public Contact · Contact
203-785-5702canceranswers@yale.edu
Preston C. Sprenkle · Principal Investigator

Veterans Affairs Connecticut Healthcare System-West Haven Campus

West Haven, Connecticut, 06516

Recruiting
Site Public Contact · Contact
203-937-3421
Preston C. Sprenkle · Principal Investigator

Helen F Graham Cancer Center

Newark, Delaware, 19713

Recruiting
Site Public Contact · Contact
302-623-4450lbarone@christianacare.org
Gregory A. Masters · Principal Investigator

Christiana Care Health System-Christiana Hospital

Newark, Delaware, 19718

Recruiting
Site Public Contact · Contact
302-623-4450lbarone@christianacare.org
Gregory A. Masters · Principal Investigator

MedStar Georgetown University Hospital

Washington D.C., District of Columbia, 20007

Active Not Recruiting

MedStar Washington Hospital Center

Washington D.C., District of Columbia, 20010

Active Not Recruiting

George Washington University Medical Center

Washington D.C., District of Columbia, 20037

Recruiting
Site Public Contact · Contact
202-741-2981
Michael J. Whalen · Principal Investigator

Mount Sinai Comprehensive Cancer Center at Aventura

Aventura, Florida, 33180

Recruiting
Site Public Contact · Contact
305-674-2625yenrique@msmc.com
Michael A. Schwartz · Principal Investigator

UM Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables, Florida, 33146

Recruiting
Site Public Contact · Contact
305-243-2647
Chad R. Ritch · Principal Investigator

UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, 33442

Recruiting
Site Public Contact · Contact
305-243-2647
Chad R. Ritch · Principal Investigator

Baptist MD Anderson Cancer Center

Jacksonville, Florida, 32207

Recruiting
Site Public Contact · Contact
904-202-7468
Jonathan J. Melquist · Principal Investigator

University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136

Recruiting
Site Public Contact · Contact
305-243-2647
Chad R. Ritch · Principal Investigator

UM Sylvester Comprehensive Cancer Center at Kendall

Miami, Florida, 33176

Recruiting
Site Public Contact · Contact
305-243-2647
Chad R. Ritch · Principal Investigator

Mount Sinai Medical Center

Miami Beach, Florida, 33140

Recruiting
Site Public Contact · Contact
305-674-2625yenrique@msmc.com
Michael A. Schwartz · Principal Investigator

Orlando Health Cancer Institute

Orlando, Florida, 32806

Active Not Recruiting

UM Sylvester Comprehensive Cancer Center at Plantation

Plantation, Florida, 33324

Recruiting
Site Public Contact · Contact
305-243-2647
Chad R. Ritch · Principal Investigator

Grady Health System

Atlanta, Georgia, 30303

Recruiting
Site Public Contact · Contact
404-489-9164
Shreyas Joshi · Principal Investigator

Emory University Hospital Midtown

Atlanta, Georgia, 30308

Recruiting
Site Public Contact · Contact
888-946-7447
Shreyas Joshi · Principal Investigator

Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322

Recruiting
Site Public Contact · Contact
404-778-1868
Shreyas Joshi · Principal Investigator

Emory Saint Joseph's Hospital

Atlanta, Georgia, 30342

Recruiting
Site Public Contact · Contact
404-851-7115
Shreyas Joshi · Principal Investigator

Augusta University Medical Center

Augusta, Georgia, 30912

Recruiting
Site Public Contact · Contact
706-721-2388ga_cares@augusta.edu
Sharad A. Ghamande · Principal Investigator

Atlanta VA Medical Center

Decatur, Georgia, 30033

Recruiting
Site Public Contact · Contact
404-321-6111
Wayne B. Harris · Principal Investigator

Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, 83605

Recruiting
Site Public Contact · Contact
734-712-3671stephanie.couch@stjoeshealth.org
John M. Schallenkamp · Principal Investigator

Saint Alphonsus Cancer Care Center-Nampa

Nampa, Idaho, 83687

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, 83854

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Rush - Copley Medical Center

Aurora, Illinois, 60504

Recruiting
Site Public Contact · Contact
630-978-6212Cancer.Research@rushcopley.com
Sinisa Stanic · Principal Investigator

Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Canton

Canton, Illinois, 61520

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Carthage

Carthage, Illinois, 62321

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Northwestern University

Chicago, Illinois, 60611

Active Not Recruiting

Rush University Medical Center

Chicago, Illinois, 60612

Recruiting
Site Public Contact · Contact
312-942-5498clinical_trials@rush.edu
Srinivas Vourganti · Principal Investigator

University of Illinois

Chicago, Illinois, 60612

Recruiting
Site Public Contact · Contact
312-355-3046
Daniel Moreira · Principal Investigator

University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637

Active Not Recruiting

Decatur Memorial Hospital

Decatur, Illinois, 62526

Recruiting
Site Public Contact · Contact
217-876-4762morganthaler.jodi@mhsil.com
Bryan A. Faller · Principal Investigator

Crossroads Cancer Center

Effingham, Illinois, 62401

Recruiting
Site Public Contact · Contact
217-876-4762morganthaler.jodi@mhsil.com
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Eureka

Eureka, Illinois, 61530

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Macomb

Macomb, Illinois, 61455

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Loyola University Medical Center

Maywood, Illinois, 60153

Recruiting
Site Public Contact · Contact
708-226-4357
Ami Badami · Principal Investigator

Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Pekin

Pekin, Illinois, 61554

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Peoria

Peoria, Illinois, 61615

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Methodist Medical Center of Illinois

Peoria, Illinois, 61636

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

OSF Saint Francis Medical Center

Peoria, Illinois, 61637

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Peru

Peru, Illinois, 61354

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Princeton

Princeton, Illinois, 61356

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Southwest Illinois Health Services LLP

Swansea, Illinois, 62226

Suspended

Carle Cancer Center

Urbana, Illinois, 61801

Recruiting
Site Public Contact · Contact
800-446-5532Research@carle.com
Sinisa Stanic · Principal Investigator

Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202

Active Not Recruiting

Reid Health

Richmond, Indiana, 47374

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Howard M. Gross · Principal Investigator

McFarland Clinic - Ames

Ames, Iowa, 50010

Recruiting
Site Public Contact · Contact
515-239-4734ksoder@mcfarlandclinic.com
Joseph J. Merchant · Principal Investigator

Iowa Methodist Medical Center

Des Moines, Iowa, 50309

Recruiting
Site Public Contact · Contact
515-241-6727
Joshua Lukenbill · Principal Investigator

University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, 52242

Recruiting
Site Public Contact · Contact
800-237-1225
Yousef Zakharia · Principal Investigator

University of Kansas Cancer Center

Kansas City, Kansas, 66160

Recruiting
Site Public Contact · Contact
913-588-3671KUCC_Navigation@kumc.edu
William Parker · Principal Investigator

Olathe Health Cancer Center

Olathe, Kansas, 66061

Recruiting
Site Public Contact · Contact
913-355-8000Jeni.wakefield@olathehealth.org
William Parker · Principal Investigator

University of Kansas Cancer Center-Overland Park

Overland Park, Kansas, 66210

Recruiting
Site Public Contact · Contact
913-588-3671KUCC_Navigation@kumc.edu
William Parker · Principal Investigator

University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205

Recruiting
Site Public Contact · Contact
913-588-3671KUCC_Navigation@kumc.edu
William Parker · Principal Investigator

Saint Joseph Radiation Oncology Resource Center

Lexington, Kentucky, 40504

Recruiting
Site Public Contact · Contact
859-629-7169ResearchInstituteInquiries@CommonSpirit.org
Shahzad Siddique · Principal Investigator

Saint Joseph Hospital East

Lexington, Kentucky, 40509

Recruiting
Site Public Contact · Contact
859-629-7169ResearchInstituteInquiries@CommonSpirit.org
Shahzad Siddique · Principal Investigator

University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536

Not Yet Recruiting
Site Public Contact · Contact
859-257-3379
Patrick J. Hensley · Principal Investigator

The James Graham Brown Cancer Center at University of Louisville

Louisville, Kentucky, 40202

Recruiting
Site Public Contact · Contact
502-562-3429
Scott R. Silva · Principal Investigator

East Jefferson General Hospital

Metairie, Louisiana, 70006

Recruiting
Site Public Contact · Contact
504-210-3539emede1@lsuhsc.edu
Scott E. Delacroix · Principal Investigator

LSU Healthcare Network / Metairie Multi-Specialty Clinic

Metairie, Louisiana, 70006

Recruiting
Site Public Contact · Contact
504-210-3539emede1@lsuhsc.edu
Scott E. Delacroix · Principal Investigator

MaineHealth Coastal Cancer Treatment Center

Bath, Maine, 04530

Recruiting
Site Public Contact · Contact
888-823-5923ctsucontact@westat.com
Matthew H. Hayn · Principal Investigator

Lafayette Family Cancer Center-EMMC

Brewer, Maine, 04412

Recruiting
Site Public Contact · Contact
800-987-3005
Sarah J. Sinclair · Principal Investigator

Maine Medical Center-Bramhall Campus

Portland, Maine, 04102

Recruiting
Site Public Contact · Contact
207-885-7565
Matthew H. Hayn · Principal Investigator

MaineHealth Cancer Care Center of York County

Sanford, Maine, 04073

Recruiting
Site Public Contact · Contact
207-459-1600
Matthew H. Hayn · Principal Investigator

MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford

Sanford, Maine, 04073

Recruiting
Site Public Contact · Contact
LLemire@mmc.org
Matthew H. Hayn · Principal Investigator

Maine Medical Center- Scarborough Campus

Scarborough, Maine, 04074

Recruiting
Site Public Contact · Contact
207-396-8090wrighd@mmc.org
Matthew H. Hayn · Principal Investigator

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287

Active Not Recruiting

Lahey Hospital and Medical Center

Burlington, Massachusetts, 01805

Active Not Recruiting

Saint Joseph Mercy Hospital

Ann Arbor, Michigan, 48106

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Christopher M. Reynolds · Principal Investigator

University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, 48109

Recruiting
Site Public Contact · Contact
800-865-1125
Samuel D. Kaffenberger · Principal Investigator

Saint Joseph Mercy Brighton

Brighton, Michigan, 48114

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Christopher M. Reynolds · Principal Investigator

Henry Ford Cancer Institute-Downriver

Brownstown, Michigan, 48183

Recruiting
Site Public Contact · Contact
313-916-3721CTOResearch@hfhs.org
Haythem Y. Ali · Principal Investigator

Saint Joseph Mercy Canton

Canton, Michigan, 48188

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Christopher M. Reynolds · Principal Investigator

Saint Joseph Mercy Chelsea

Chelsea, Michigan, 48118

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Christopher M. Reynolds · Principal Investigator

GenesisCare USA - Clarkston

Clarkston, Michigan, 48346

Recruiting
Site Public Contact · Contact
941-833-5700Rudi.Ross@usa.genesiscare.com
Frank A. Vicini · Principal Investigator

Henry Ford Macomb Hospital-Clinton Township

Clinton Township, Michigan, 48038

Recruiting
Site Public Contact · Contact
313-916-3721CTOResearch@hfhs.org
Haythem Y. Ali · Principal Investigator

Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201

Recruiting
Site Public Contact · Contact
313-576-9790ctoadmin@karmanos.org
Elisabeth I. Heath · Principal Investigator

Henry Ford Hospital

Detroit, Michigan, 48202

Recruiting
Site Public Contact · Contact
313-916-3721CTOResearch@hfhs.org
Haythem Y. Ali · Principal Investigator

GenesisCare USA - Farmington Hills

Farmington Hills, Michigan, 48334

Recruiting
Site Public Contact · Contact
941-833-5700Rudi.Ross@usa.genesiscare.com
Frank A. Vicini · Principal Investigator

Spectrum Health at Butterworth Campus

Grand Rapids, Michigan, 49503

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen J. Yost · Principal Investigator

West Michigan Cancer Center

Kalamazoo, Michigan, 49007

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen J. Yost · Principal Investigator

Sparrow Hospital

Lansing, Michigan, 48912

Recruiting
Site Public Contact · Contact
517-364-9400
Christopher M. Reynolds · Principal Investigator

GenesisCare USA - Macomb

Macomb, Michigan, 48044

Recruiting
Site Public Contact · Contact
941-833-5700Rudi.Ross@usa.genesiscare.com
Frank A. Vicini · Principal Investigator

GenesisCare USA - Madison Heights

Madison Heights, Michigan, 48071

Recruiting
Site Public Contact · Contact
941-833-5700Rudi.Ross@usa.genesiscare.com
Frank A. Vicini · Principal Investigator

21st Century Oncology-Pontiac

Pontiac, Michigan, 48341

Recruiting
Site Public Contact · Contact
734-712-3671stephanie.couch@stjoeshealth.org
Christopher M. Reynolds · Principal Investigator

Ascension Saint Mary's Hospital

Saginaw, Michigan, 48601

Recruiting
Site Public Contact · Contact
989-907-8411lori.srebinski@ascension.org
Christopher M. Reynolds · Principal Investigator

Munson Medical Center

Traverse City, Michigan, 49684

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen J. Yost · Principal Investigator

GenesisCare USA - Troy

Troy, Michigan, 48098

Recruiting
Site Public Contact · Contact
941-833-5700Rudi.Ross@usa.genesiscare.com
Frank A. Vicini · Principal Investigator

Henry Ford West Bloomfield Hospital

West Bloomfield, Michigan, 48322

Recruiting
Site Public Contact · Contact
313-916-3721CTOResearch@hfhs.org
Haythem Y. Ali · Principal Investigator

Mercy Hospital

Coon Rapids, Minnesota, 55433

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Fairview Southdale Hospital

Edina, Minnesota, 55435

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Unity Hospital

Fridley, Minnesota, 55432

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Hennepin County Medical Center

Minneapolis, Minnesota, 55415

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Health Partners Inc

Minneapolis, Minnesota, 55454

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Mayo Clinic in Rochester

Rochester, Minnesota, 55905

Suspended

Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Regions Hospital

Saint Paul, Minnesota, 55101

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Saint Francis Regional Medical Center

Shakopee, Minnesota, 55379

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

University of Mississippi Medical Center

Jackson, Mississippi, 39216

Suspended

Saint Francis Medical Center

Cape Girardeau, Missouri, 63703

Recruiting
Site Public Contact · Contact
573-334-2230sfmc@sfmc.net
Bryan A. Faller · Principal Investigator

Southeast Cancer Center

Cape Girardeau, Missouri, 63703

Recruiting
Site Public Contact · Contact
573-651-5550
Bryan A. Faller · Principal Investigator

Siteman Cancer Center at Saint Peters Hospital

City of Saint Peters, Missouri, 63376

Recruiting
Site Public Contact · Contact
800-600-3606info@siteman.wustl.edu
Jeff M. Michalski · Principal Investigator

University of Missouri - Ellis Fischel

Columbia, Missouri, 65212

Recruiting
Site Public Contact · Contact
573-882-7440
Kushal Naha · Principal Investigator

Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, 63141

Recruiting
Site Public Contact · Contact
800-600-3606info@siteman.wustl.edu
Jeff M. Michalski · Principal Investigator

Freeman Health System

Joplin, Missouri, 64804

Recruiting
Site Public Contact · Contact
417-347-4030LJCrockett@freemanhealth.com
Jay W. Carlson · Principal Investigator

University of Kansas Cancer Center - North

Kansas City, Missouri, 64154

Recruiting
Site Public Contact · Contact
913-588-3671KUCC_Navigation@kumc.edu
William Parker · Principal Investigator

Delbert Day Cancer Institute at PCRMC

Rolla, Missouri, 65401

Recruiting
Site Public Contact · Contact
573-458-7504research@phelpshealth.org
Jay W. Carlson · Principal Investigator

Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, 63670

Recruiting
Site Public Contact · Contact
314-996-5569
Bryan A. Faller · Principal Investigator

Mercy Hospital Springfield

Springfield, Missouri, 65804

Recruiting
Site Public Contact · Contact
417-269-4520
Jay W. Carlson · Principal Investigator

CoxHealth South Hospital

Springfield, Missouri, 65807

Recruiting
Site Public Contact · Contact
417-269-4520
Jay W. Carlson · Principal Investigator

Washington University School of Medicine

St Louis, Missouri, 63110

Recruiting
Site Public Contact · Contact
800-600-3606info@siteman.wustl.edu
Jeff M. Michalski · Principal Investigator

Siteman Cancer Center-South County

St Louis, Missouri, 63129

Recruiting
Site Public Contact · Contact
800-600-3606info@siteman.wustl.edu
Jeff M. Michalski · Principal Investigator

Missouri Baptist Medical Center

St Louis, Missouri, 63131

Recruiting
Site Public Contact · Contact
314-996-5569
Bryan A. Faller · Principal Investigator

Siteman Cancer Center at Christian Hospital

St Louis, Missouri, 63136

Recruiting
Site Public Contact · Contact
800-600-3606info@siteman.wustl.edu
Jeff M. Michalski · Principal Investigator

Mercy Hospital Saint Louis

St Louis, Missouri, 63141

Recruiting
Site Public Contact · Contact
314-251-7066
Jay W. Carlson · Principal Investigator

Billings Clinic Cancer Center

Billings, Montana, 59101

Recruiting
Site Public Contact · Contact
800-996-2663research@billingsclinic.org
John M. Schallenkamp · Principal Investigator

Bozeman Deaconess Hospital

Bozeman, Montana, 59715

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Saint James Community Hospital and Cancer Treatment Center

Butte, Montana, 59701

Recruiting
Site Public Contact · Contact
406-723-2621
Troy A. Fiddler · Principal Investigator

Benefis Healthcare- Sletten Cancer Institute

Great Falls, Montana, 59405

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Kalispell Regional Medical Center

Kalispell, Montana, 59901

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Nebraska Medicine-Bellevue

Bellevue, Nebraska, 68123

Recruiting
Site Public Contact · Contact
402-559-6941unmcrsa@unmc.edu
Benjamin A. Teply · Principal Investigator

Nebraska Methodist Hospital

Omaha, Nebraska, 68114

Recruiting
Site Public Contact · Contact
402-354-5144
Ralph J. Hauke · Principal Investigator

Nebraska Medicine-Village Pointe

Omaha, Nebraska, 68118

Recruiting
Site Public Contact · Contact
402-559-5600
Benjamin A. Teply · Principal Investigator

University of Nebraska Medical Center

Omaha, Nebraska, 68198

Recruiting
Site Public Contact · Contact
402-559-6941unmcrsa@unmc.edu
Benjamin A. Teply · Principal Investigator

Comprehensive Cancer Centers of Nevada - Henderson

Henderson, Nevada, 89052

Recruiting
Site Public Contact · Contact
702-384-0013research@sncrf.org
John A. Ellerton · Principal Investigator

Radiation Oncology Centers of Nevada Central

Las Vegas, Nevada, 89106

Recruiting
Site Public Contact · Contact
702-384-0013research@sncrf.org
John A. Ellerton · Principal Investigator

Comprehensive Cancer Centers of Nevada - Northwest

Las Vegas, Nevada, 89128

Recruiting
Site Public Contact · Contact
702-384-0013research@sncrf.org
John A. Ellerton · Principal Investigator

Comprehensive Cancer Centers of Nevada-Summerlin

Las Vegas, Nevada, 89144

Recruiting
Site Public Contact · Contact
702-384-0013research@sncrf.org
John A. Ellerton · Principal Investigator

Comprehensive Cancer Centers of Nevada

Las Vegas, Nevada, 89148

Recruiting
Site Public Contact · Contact
702-384-0013research@sncrf.org
John A. Ellerton · Principal Investigator

Comprehensive Cancer Centers of Nevada - Central Valley

Las Vegas, Nevada, 89169

Recruiting
Site Public Contact · Contact
702-384-0013research@sncrf.org
John A. Ellerton · Principal Investigator

New Hampshire Oncology Hematology PA-Concord

Concord, New Hampshire, 03301

Recruiting
Site Public Contact · Contact
603-224-2556
Douglas J. Weckstein · Principal Investigator

Wentworth-Douglass Hospital

Dover, New Hampshire, 03820

Active Not Recruiting

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, New Hampshire, 03756

Recruiting
Site Public Contact · Contact
800-639-6918cancer.research.nurse@dartmouth.edu
Rodwell Mabaera · Principal Investigator

Elliot Hospital

Manchester, New Hampshire, 03103

Active Not Recruiting

Solinsky Center for Cancer Care

Manchester, New Hampshire, 03103

Recruiting
Site Public Contact · Contact
800-339-6484
Douglas J. Weckstein · Principal Investigator

Hackensack University Medical Center

Hackensack, New Jersey, 07601

Recruiting
Site Public Contact · Contact
201-996-2879
Robert S. Alter · Principal Investigator

Holy Name Hospital

Teaneck, New Jersey, 07666

Active Not Recruiting

Albany Medical Center

Albany, New York, 12208

Recruiting
Site Public Contact · Contact
518-262-5513
Badar M. Mian · Principal Investigator

Roswell Park Cancer Institute

Buffalo, New York, 14263

Recruiting
Site Public Contact · Contact
800-767-9355askroswell@roswellpark.org
Gurkamal S. Chatta · Principal Investigator

Noyes Memorial Hospital/Myers Cancer Center

Dansville, New York, 14437

Recruiting
Site Public Contact · Contact
WCICTOresearch@urmc.rochester.edu
Paul M. Barr · Principal Investigator

Glens Falls Hospital

Glens Falls, New York, 12801

Recruiting
Site Public Contact · Contact
518-926-6700
Nataniel H. Lester-Coll · Principal Investigator

Northwell Health/Center for Advanced Medicine

Lake Success, New York, 11042

Active Not Recruiting

NYP/Weill Cornell Medical Center

New York, New York, 10065

Recruiting
Site Public Contact · Contact
212-746-1848
Douglas Scherr · Principal Investigator

Upstate Cancer Center Radiation Oncology at Oneida

Oneida, New York, 13421

Recruiting
Site Public Contact · Contact
315-464-3603BinghamE@upstate.edu
Gennady Bratslavsky · Principal Investigator

Upstate Cancer Center Radiation Oncology at Oswego

Oswego, New York, 13126

Recruiting
Site Public Contact · Contact
315-464-3603BinghamE@upstate.edu
Gennady Bratslavsky · Principal Investigator

Highland Hospital

Rochester, New York, 14620

Recruiting
Site Public Contact · Contact
585-341-8113
Paul M. Barr · Principal Investigator

University of Rochester

Rochester, New York, 14642

Recruiting
Site Public Contact · Contact
585-275-5830
Paul M. Barr · Principal Investigator

Stony Brook University Medical Center

Stony Brook, New York, 11794

Recruiting
Site Public Contact · Contact
800-862-2215
Massimiliano Spaliviero · Principal Investigator

State University of New York Upstate Medical University

Syracuse, New York, 13210

Recruiting
Site Public Contact · Contact
315-464-5476
Gennady Bratslavsky · Principal Investigator

Montefiore Medical Center-Einstein Campus

The Bronx, New York, 10461

Recruiting
Site Public Contact · Contact
718-379-6866eskwak@montefiore.org
Ahmed A. Aboumohamed · Principal Investigator

Montefiore Medical Center - Moses Campus

The Bronx, New York, 10467

Recruiting
Site Public Contact · Contact
718-379-6866eskwak@montefiore.org
Ahmed A. Aboumohamed · Principal Investigator

James J Peters VA Medical Center

The Bronx, New York, 10468

Active Not Recruiting

Atrium Health Stanly/LCI-Albemarle

Albemarle, North Carolina, 28002

Recruiting
Site Public Contact · Contact
800-804-9376
Earle F. Burgess · Principal Investigator

Mission Hospital

Asheville, North Carolina, 28801

Active Not Recruiting

Carolinas Medical Center/Levine Cancer Institute

Charlotte, North Carolina, 28203

Recruiting
Site Public Contact · Contact
800-804-9376
Earle F. Burgess · Principal Investigator

Atrium Health Pineville/LCI-Pineville

Charlotte, North Carolina, 28210

Recruiting
Site Public Contact · Contact
980-442-2000
Earle F. Burgess · Principal Investigator

Atrium Health University City/LCI-University

Charlotte, North Carolina, 28262

Recruiting
Site Public Contact · Contact
800-804-9376
Earle F. Burgess · Principal Investigator

Levine Cancer Institute-Ballantyne

Charlotte, North Carolina, 28277

Recruiting
Site Public Contact · Contact
800-804-9376
Earle F. Burgess · Principal Investigator

Atrium Health Cabarrus/LCI-Concord

Concord, North Carolina, 28025

Recruiting
Site Public Contact · Contact
800-804-9376
Earle F. Burgess · Principal Investigator

Levine Cancer Institute-Gaston

Gastonia, North Carolina, 28054

Recruiting
Site Public Contact · Contact
800-804-9376
Earle F. Burgess · Principal Investigator

Margaret R Pardee Memorial Hospital

Hendersonville, North Carolina, 28791

Recruiting
Site Public Contact · Contact
828-696-4716pardeecancerresearch@unchealth.unc.edu
Praveen Vashist · Principal Investigator

Atrium Health Union/LCI-Union

Monroe, North Carolina, 28112

Recruiting
Site Public Contact · Contact
980-442-2000
Earle F. Burgess · Principal Investigator

CarolinaEast Medical Center

New Bern, North Carolina, 28561

Recruiting
Site Public Contact · Contact
252-634-6589lharrison@carolinaeasthealth.com
Sarah B. Carroll · Principal Investigator

Cleveland Clinic Mercy Hospital

Canton, Ohio, 44708

Recruiting
Site Public Contact · Contact
888-293-4673
Mitchell Haut · Principal Investigator

Miami Valley Hospital South

Centerville, Ohio, 45459

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Tarek M. Sabagh · Principal Investigator

University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, 45219

Recruiting
Site Public Contact · Contact
513-584-7698cancer@uchealth.com
Abhinav Sidana · Principal Investigator

MetroHealth Medical Center

Cleveland, Ohio, 44109

Recruiting
Site Public Contact · Contact
216-778-8526dstrater@metrohealth.org
William Tse · Principal Investigator

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210

Recruiting
Site Public Contact · Contact
800-293-5066Jamesline@osumc.edu
Steven K. Clinton · Principal Investigator

Miami Valley Hospital North

Dayton, Ohio, 45415

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Tarek M. Sabagh · Principal Investigator

Greater Dayton Cancer Center

Kettering, Ohio, 45409

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Howard M. Gross · Principal Investigator

Kettering Medical Center

Kettering, Ohio, 45429

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Howard M. Gross · Principal Investigator

ProMedica Flower Hospital

Sylvania, Ohio, 43560

Recruiting
Site Public Contact · Contact
419-824-1842PCIOncResearch@promedica.org
Jeffrey A. Forquer · Principal Investigator

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

Toledo, Ohio, 43606

Recruiting
Site Public Contact · Contact
419-824-1842PCIOncResearch@promedica.org
Jeffrey A. Forquer · Principal Investigator

University of Toledo

Toledo, Ohio, 43614

Suspended

University of Cincinnati Cancer Center-West Chester

West Chester, Ohio, 45069

Recruiting
Site Public Contact · Contact
513-584-7698cancer@uchealth.com
Abhinav Sidana · Principal Investigator

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104

Recruiting
Site Public Contact · Contact
405-271-8777ou-clinical-trials@ouhsc.edu
Kelly L. Stratton · Principal Investigator

Legacy Mount Hood Medical Center

Gresham, Oregon, 97030

Active Not Recruiting

Legacy Good Samaritan Hospital and Medical Center

Portland, Oregon, 97210

Active Not Recruiting

Oregon Health and Science University

Portland, Oregon, 97239

Active Not Recruiting

Chambersburg Hospital

Chambersburg, Pennsylvania, 17201

Recruiting
Site Public Contact · Contact
888-823-5923ctsucontact@westat.com
Sherif F. Yacoub · Principal Investigator

Geisinger Medical Center

Danville, Pennsylvania, 17822

Recruiting
Site Public Contact · Contact
570-271-5251HemonCCTrials@geisinger.edu
Ahmad Hanif · Principal Investigator

Ephrata Cancer Center

Ephrata, Pennsylvania, 17522

Recruiting
Site Public Contact · Contact
717-721-4840
Sherif F. Yacoub · Principal Investigator

Adams Cancer Center

Gettysburg, Pennsylvania, 17325

Recruiting
Site Public Contact · Contact
877-441-7957
Sherif F. Yacoub · Principal Investigator

Sechler Family Cancer Center

Lebanon, Pennsylvania, 17042

Recruiting
Site Public Contact · Contact
717-741-8303doxenberg@wellspan.org
Sherif F. Yacoub · Principal Investigator

Geisinger Medical Oncology-Lewisburg

Lewisburg, Pennsylvania, 17837

Recruiting
Site Public Contact · Contact
570-374-8555HemonCCTrials@geisinger.edu
Ahmad Hanif · Principal Investigator

Temple University Hospital

Philadelphia, Pennsylvania, 19140

Withdrawn

University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, 15232

Recruiting
Site Public Contact · Contact
412-647-8073
Benjamin J. Davies · Principal Investigator

UPMC-Shadyside Hospital

Pittsburgh, Pennsylvania, 15232

Recruiting
Site Public Contact · Contact
412-621-2334
Benjamin J. Davies · Principal Investigator

Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, 18711

Recruiting
Site Public Contact · Contact
570-271-5251HemonCCTrials@geisinger.edu
Ahmad Hanif · Principal Investigator

WellSpan Health-York Cancer Center

York, Pennsylvania, 17403

Recruiting
Site Public Contact · Contact
877-441-7957
Sherif F. Yacoub · Principal Investigator

Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, 29316

Recruiting
Site Public Contact · Contact
864-241-6251
Ki Y. Chung · Principal Investigator

Medical University of South Carolina

Charleston, South Carolina, 29425

Recruiting
Site Public Contact · Contact
843-792-9321hcc-clinical-trials@musc.edu
David T. Marshall · Principal Investigator

Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605

Recruiting
Site Public Contact · Contact
864-241-6251
Ki Y. Chung · Principal Investigator

Saint Francis Cancer Center

Greenville, South Carolina, 29607

Recruiting
Site Public Contact · Contact
864-603-6213melissa_beckman@bshsi.org
Jennifer Vogel · Principal Investigator

Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, 29615

Recruiting
Site Public Contact · Contact
864-241-6251
Ki Y. Chung · Principal Investigator

Prisma Health Cancer Institute - Greer

Greer, South Carolina, 29650

Recruiting
Site Public Contact · Contact
864-241-6251
Ki Y. Chung · Principal Investigator

Carolina Regional Cancer Center

Myrtle Beach, South Carolina, 29577

Recruiting
Site Public Contact · Contact
877-460-2657
Frank A. Vicini · Principal Investigator

Rock Hill Radiation Therapy Center

Rock Hill, South Carolina, 29730

Recruiting
Site Public Contact · Contact
800-804-9376
Earle F. Burgess · Principal Investigator

Levine Cancer Institute-Rock Hill

Rock Hill, South Carolina, 29732

Recruiting
Site Public Contact · Contact
800-804-9376
Earle F. Burgess · Principal Investigator

Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, 29672

Recruiting
Site Public Contact · Contact
864-241-6251
Ki Y. Chung · Principal Investigator

Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232

Recruiting
Site Public Contact · Contact
800-811-8480
Kerry R. Schaffer · Principal Investigator

MD Anderson in The Woodlands

Conroe, Texas, 77384

Recruiting
Site Public Contact · Contact
866-632-6789askmdanderson@mdanderson.org
Brian F. Chapin · Principal Investigator

Parkland Memorial Hospital

Dallas, Texas, 75235

Recruiting
Site Public Contact · Contact
214-590-5582canceranswerline@UTSouthwestern.edu
Suzanne M. Cole · Principal Investigator

UT Southwestern Simmons Cancer Center - RedBird

Dallas, Texas, 75237

Recruiting
Site Public Contact · Contact
214-648-7097canceranswerline@utsouthwestern.edu
Suzanne M. Cole · Principal Investigator

UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390

Recruiting
Site Public Contact · Contact
214-648-7097canceranswerline@UTSouthwestern.edu
Suzanne M. Cole · Principal Investigator

UT Southwestern/Simmons Cancer Center-Fort Worth

Fort Worth, Texas, 76104

Recruiting
Site Public Contact · Contact
214-648-7097canceranswerline@UTSouthwestern.edu
Suzanne M. Cole · Principal Investigator

Lyndon Baines Johnson General Hospital

Houston, Texas, 77026-1967

Recruiting
Site Public Contact · Contact
713-566-5000
Brian F. Chapin · Principal Investigator

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, Texas, 77030

Recruiting
Site Public Contact · Contact
713-798-1354burton@bcm.edu
Martha P. Mims · Principal Investigator

Ben Taub General Hospital

Houston, Texas, 77030

Recruiting
Site Public Contact · Contact
713-873-2000
Martha P. Mims · Principal Investigator

Houston Methodist Hospital

Houston, Texas, 77030

Active Not Recruiting

M D Anderson Cancer Center

Houston, Texas, 77030

Recruiting
Site Public Contact · Contact
877-632-6789askmdanderson@mdanderson.org
Brian F. Chapin · Principal Investigator

Michael E DeBakey VA Medical Center

Houston, Texas, 77030

Recruiting
Site Public Contact · Contact
800-553-2278
Aihua E. Yen · Principal Investigator

MD Anderson West Houston

Houston, Texas, 77079

Recruiting
Site Public Contact · Contact
877-632-6789askmdanderson@mdanderson.org
Brian F. Chapin · Principal Investigator

MD Anderson League City

League City, Texas, 77573

Recruiting
Site Public Contact · Contact
877-632-6789askmdanderson@mdanderson.org
Brian F. Chapin · Principal Investigator

UT Southwestern Clinical Center at Richardson/Plano

Richardson, Texas, 75080

Recruiting
Site Public Contact · Contact
972-669-7044Suzanne.cole@utsouthwestern.edu
Suzanne M. Cole · Principal Investigator

Audie L Murphy VA Hospital

San Antonio, Texas, 78229

Recruiting
Site Public Contact · Contact
877-469-5300
Michael A. Liss · Principal Investigator

University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229

Active Not Recruiting

MD Anderson in Sugar Land

Sugar Land, Texas, 77478

Recruiting
Site Public Contact · Contact
877-632-6789askmdanderson@mdanderson.org
Brian F. Chapin · Principal Investigator

Scott and White Memorial Hospital

Temple, Texas, 76508

Active Not Recruiting

American Fork Hospital / Huntsman Intermountain Cancer Center

American Fork, Utah, 84003

Suspended

Sandra L Maxwell Cancer Center

Cedar City, Utah, 84720

Suspended

Logan Regional Hospital

Logan, Utah, 84321

Suspended

Intermountain Medical Center

Murray, Utah, 84107

Suspended

McKay-Dee Hospital Center

Ogden, Utah, 84403

Suspended

Utah Valley Regional Medical Center

Provo, Utah, 84604

Suspended

Riverton Hospital

Riverton, Utah, 84065

Suspended

University of Utah Sugarhouse Health Center

Salt Lake City, Utah, 84106

Recruiting
Site Public Contact · Contact
888-424-2100cancerinfo@hci.utah.edu
Alejandro Sanchez · Principal Investigator

Utah Cancer Specialists-Salt Lake City

Salt Lake City, Utah, 84106

Suspended

Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112

Recruiting
Site Public Contact · Contact
888-424-2100cancerinfo@hci.utah.edu
Alejandro Sanchez · Principal Investigator

LDS Hospital

Salt Lake City, Utah, 84143

Suspended

George E Wahlen Department of Veterans Affairs Medical Center

Salt Lake City, Utah, 84148

Recruiting
Site Public Contact · Contact
801-582-1565
Sumati V. Gupta · Principal Investigator

Saint George Regional Medical Center

St. George, Utah, 84770

Suspended

Central Vermont Medical Center/National Life Cancer Treatment

Berlin Corners, Vermont, 05602

Recruiting
Site Public Contact · Contact
802-225-5400
Nataniel H. Lester-Coll · Principal Investigator

University of Vermont Medical Center

Burlington, Vermont, 05401

Recruiting
Site Public Contact · Contact
802-656-4101rpo@uvm.edu
Nataniel H. Lester-Coll · Principal Investigator

Bon Secours Saint Francis Medical Center

Midlothian, Virginia, 23114

Recruiting
Site Public Contact · Contact
804-893-8978anne_carmellat@bshsi.org
William J. Irvin · Principal Investigator

Bon Secours Cancer Institute at Reynolds Crossing

Richmond, Virginia, 23230

Recruiting
Site Public Contact · Contact
804-893-8978Anne_caramella@bshsi.org
William J. Irvin · Principal Investigator

VCU Massey Cancer Center at Stony Point

Richmond, Virginia, 23235

Recruiting
Site Public Contact · Contact
ctoclinops@vcu.edu
Asit K. Paul · Principal Investigator

Virginia Commonwealth University/Massey Cancer Center

Richmond, Virginia, 23298

Recruiting
Site Public Contact · Contact
CTOclinops@vcu.edu
Asit K. Paul · Principal Investigator

VCU Community Memorial Health Center

South Hill, Virginia, 23970

Recruiting
Site Public Contact · Contact
nemer.elmouallem@vcuhealth.org
Asit K. Paul · Principal Investigator

FHCC Overlake

Bellevue, Washington, 98004

Recruiting
Site Public Contact · Contact
425-454-2148
Jason Comer · Principal Investigator

Seattle Cancer Care Alliance at EvergreenHealth

Kirkland, Washington, 98034

Recruiting
Site Public Contact · Contact
425-899-6000
Eric W. Dean · Principal Investigator

FHCC South Lake Union

Seattle, Washington, 98109

Recruiting
Site Public Contact · Contact
800-804-8824
Daniel W. Lin · Principal Investigator

FHCC at Northwest Hospital

Seattle, Washington, 98133

Recruiting
Site Public Contact · Contact
206-606-5800
Nikhil V. Kamat · Principal Investigator

University of Washington Medical Center - Montlake

Seattle, Washington, 98195

Recruiting
Site Public Contact · Contact
800-804-8824
Daniel W. Lin · Principal Investigator

Legacy Salmon Creek Hospital

Vancouver, Washington, 98686

Active Not Recruiting

West Virginia University Healthcare

Morgantown, West Virginia, 26506

Recruiting
Site Public Contact · Contact
304-293-7374cancertrialsinfo@hsc.wvu.edu
Danh C. Pham · Principal Investigator

Langlade Hospital and Cancer Center

Antigo, Wisconsin, 54409

Recruiting
Site Public Contact · Contact
715-623-9869Juli.Alford@aspirus.org
Christopher S. Platta · Principal Investigator

Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Seth O. Fagbemi · Principal Investigator

Mayo Clinic Health System-Franciscan Healthcare

La Crosse, Wisconsin, 54601

Active Not Recruiting

Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Seth O. Fagbemi · Principal Investigator

Froedtert Menomonee Falls Hospital

Menomonee Falls, Wisconsin, 53051

Recruiting
Site Public Contact · Contact
262-257-5100
Scott Johnson · Principal Investigator

Medical College of Wisconsin

Milwaukee, Wisconsin, 53226

Recruiting
Site Public Contact · Contact
414-805-3666
Scott Johnson · Principal Investigator

Zablocki Veterans Administration Medical Center

Milwaukee, Wisconsin, 53295

Recruiting
Site Public Contact · Contact
888-469-6614
Elizabeth M. Gore · Principal Investigator

Marshfield Clinic-Minocqua Center

Minocqua, Wisconsin, 54548

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Seth O. Fagbemi · Principal Investigator

Cancer Center of Western Wisconsin

New Richmond, Wisconsin, 54017

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Drexel Town Square Health Center

Oak Creek, Wisconsin, 53154

Recruiting
Site Public Contact · Contact
414-805-0505
Scott Johnson · Principal Investigator

Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Seth O. Fagbemi · Principal Investigator

Ascension Saint Michael's Hospital

Stevens Point, Wisconsin, 54481

Recruiting
Site Public Contact · Contact
715-847-2353Beth.Knetter@aspirus.org
Christopher S. Platta · Principal Investigator

Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Seth O. Fagbemi · Principal Investigator

Aspirus Regional Cancer Center

Wausau, Wisconsin, 54401

Recruiting
Site Public Contact · Contact
877-405-6866
Christopher S. Platta · Principal Investigator

Froedtert West Bend Hospital/Kraemer Cancer Center

West Bend, Wisconsin, 53095

Recruiting
Site Public Contact · Contact
414-805-0505
Scott Johnson · Principal Investigator

Diagnostic and Treatment Center

Weston, Wisconsin, 54476

Recruiting
Site Public Contact · Contact
888-799-3989oncology.clinical.trials@marshfieldresearch.org
Seth O. Fagbemi · Principal Investigator

Marshfield Medical Center - Weston

Weston, Wisconsin, 54476

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Seth O. Fagbemi · Principal Investigator

Aspirus Cancer Care - Wisconsin Rapids

Wisconsin Rapids, Wisconsin, 54494

Recruiting
Site Public Contact · Contact
715-422-7718
Christopher S. Platta · Principal Investigator