Exploring Outcomes and Characteristics of Myasthenia Gravis: The EXPLORE MG Registry
Summary
The purpose of this study is to create a Yale University Department of Neurology Myasthenia Gravis (MG) registry that will be used for current and future research projects involving the study of Myasthenia Gravis.
Detailed description
This registry will allow for the research of several mechanisms of Myasthenia Gravis (MG) by studying peripheral blood, stool, disease status and course, and treatment of subjects with MG. The EXPLORE-MG Registry focuses on varied aspects of MG such as disease management, health care utilization, health costs, disease characteristics, and diagnostic tools. As such, it will aid in a broader understanding of MG, while providing a registry from which questions about the disease may be better answered.
Arms & interventions
- OtherBlood Sample Draw
Approximately 100 cc (less than 1/2 cup) of blood will be drawn from both groups.
Outcome measures
Primary
The number of successful blood draws will be reported at the conclusion of the sample collection
Successful Collection of Blood
Time frame: 8 years
Secondary
The number of stool samples collected will be reported at the conclusion of the sample
Time frame: 8 years
Eligibility criteria
Study locations (1)
Yale-New Haven Hospital
New Haven, Connecticut, 06510
References
- Anil R, Kumar A, Alaparthi S, Sharma A, Nye JL, Roy B, O'Connor KC, Nowak RJ. Exploring outcomes and characteristics of myasthenia gravis: Rationale, aims and design of registry - The EXPLORE-MG registry. J Neurol Sci. 2020 Jul 15;414:116830. doi: 10.1016/j.jns.2020.116830. Epub 2020 Apr 16.(PubMed)
- McLaren N, Gutierrez AZ, Joo D, Roy B, Park M, Nowak RJ. Variations in clinical features and disease burden of myasthenia gravis between racial and ethnic groups: A retrospective cohort study of two national databases. J Neurol Sci. 2026 Feb 15;481:125740. doi: 10.1016/j.jns.2026.125740. Epub 2026 Jan 5.(PubMed)