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Melanoma Margins Trial-II - A Phase III, Multi-centre Randomised Controlled Trial Investigating 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma (02.18 MelMarT-II)

NCT ID: NCT03860883Sponsor: Melanoma and Skin Cancer Trials LimitedLast updated: 2024-11-27

Summary

Patients with a primary invasive melanoma are recommended to undergo excision of the primary lesion with a wide margin. There is evidence that less radical margins of excision may be just as safe. This is a randomised controlled trial of 1 cm versus 2 cm margin of excision of the primary lesion for adult patients with stage II primary invasive cutaneous melanomas (AJCC 8th edition) to determine differences in disease-free survival. A reduction in margins is expected to improve patient quality of life.

Detailed description

This study will determine whether there is a difference in disease-free survival rates for patients with primary cutaneous melanoma with Breslow thickness \> 2mm or 1-2mm with ulceration (pT2b-pT4b, AJCC 8th edition), treated with either a 1cm excision margin or 2cm margin. The study is designed to be able to prove or disprove that there is no difference in risk of the tumour recurring around the scar or anywhere else in the body between the two groups of patients. If the study shows no risk of tumour recurrence then we will also be able to determine how much of an impact the narrower excision has on patients in terms of improved quality of life and reduced side effects from the surgery and melanoma disease. This trial will also evaluate and determine the economic impact of narrower excision margins on the health services and society in general.

Arms & interventions

  • ProcedureWide Local Excision = 1cm Margin

    A wide local excision involves removing an extra "safety margin" of skin surrounding the original melanoma site, to ensure that any remaining scattered melanoma tumour cells that may have been left behind after the first initial biopsy/surgery are removed.

  • ProcedureWide Local Excision = 2cm Margin

    A wide local excision involves removing an extra "safety margin" of skin surrounding the original melanoma site, to ensure that any remaining scattered melanoma tumour cells that may have been left behind after the first initial biopsy/surgery are removed.

Outcome measures

Primary

  • Disease-Free Survival

    Time from randomisation until the first clinically, histologically or radiologically confirmed recurrence of melanoma at any body site, or death from any cause.

    Time frame: 0-60 months

Secondary

  • Local Recurrence

    Time frame: Day 0-Trial Completion (max. 120 months)

  • Distant Disease-Free Survival

    Time frame: Day 0-Trial Completion (max. 120 months)

  • Melanoma-Specific Survival

    Time frame: Day 0-Trial Completion (max. 120 months)

  • Overall Survival

    Time frame: Day 0-Trial Completion (max. 120 months)

  • Melanoma-specific Quality of Life: FACT-M questionnaire

    Time frame: Baseline, 3, 6, 12 & 24 months

  • Neuropathic Pain: PainDetect questionnaire

    Time frame: Baseline, 3, 6, 12 & 24 months

  • Health-related Quality of Life: EQ-5D-5L questionnaire

    Time frame: Baseline, 3, 6, 12 & 24 months

  • Surgery Related Adverse Events

    Time frame: Up to 12-months from the date of surgery

  • Health Economic Evaluation

    Time frame: Baseline, 3, 6, 12 & 24 months

  • Serious Adverse Events

    Time frame: from randomisation up to 12-months post-surgery

Eligibility criteria

Sex: AllAge: 18 Years and olderHealthy volunteers: No
Inclusion Criteria: Patients may be included in the study if they meet ALL of the following criteria: 1. 1\. Patients must have a Stage II primary invasive cutaneous melanoma (pT2b-pT4b, AJCC 8th edition) with Breslow thickness \>1.0mm to 2.0mm; \>2.0mm to 4.0mm or \>4.0mm with ulceration, or \>2.0mm to 4.0mm; or \>4.0mm without ulceration (Table 1) as determined by diagnostic biopsy (narrow excision, incision, shave or punch biopsy) and subsequent histopathological analysis. 2. Must have a primary melanoma that is cutaneous (including head, neck, trunk, extremity, scalp, palm or sole). 3. An uninterrupted 2cm margin must be technically feasible around biopsy scar or primary melanoma. 4. 4\. Surgical intervention (which refers to the staging -SLNB and WLE as these are both to be done on the same day) must be completed within 120 days of the original diagnosis. Surgical intervention must also be performed within 28 days of randomisation. 5. Patients must be 18 years or older at time of consent. 6. Patient must be able to give informed consent and comply with the treatment protocol and follow up plan. 7. Life expectancy of at least 5 years from the time of diagnosis, not considering the melanoma in question, as determined by the PI. 8. Patients must have an ECOG performance score between 0 and 1 at screening. 9. A survivor of prior cancer is eligible provided that ALL of the following criteria are met and documented: * The patient has undergone potentially curative therapy for all prior malignancies, * There has been no evidence of recurrence of any prior malignancies for at least FIVE years (with the exception of successfully treated uterine/cervical or non-melanoma skin cancers (SCCs/BCCs) with no evidence of recurrence), and * The patient is deemed by their treating physician to be at low risk of recurrence from previous malignancies. Exclusion Criteria: Patients will be excluded from the study for ANY of the following reasons: 1. Uncertain diagnosis of melanoma i.e., so-called 'melanocytic lesion of unknown malignant potential'. 2. Patient has already undergone WLE at the site of the primary index lesion. 3. Patient unable or ineligible to undergo staging SLNB of the primary index lesion. 4. Perineural invasion or neurotropic melanoma: Neurotropism or perineural invasion in any type of melanoma is an exclusion. Perineural invasion does not include entrapment of nerves within the main primary tumour mass. 5. Desmoplastic melanoma: with any patient where pathology determines melanoma as PURE desmoplastic (as per WHO definition of \>90% desmoplasia), they are not eligible for this study. However melanomas with less than 90% desmoplasia or mixed desmoplastic subtypes are eligible unless there is neurotropism present (perineural invasion). 6. Microsatellitosis (a nest of metastatic tumour cells found to be growing away from the primary tumour) as per AJCC 8th edition definition is an exclusion. 7. Subungual melanoma 8. Patient has already undergone a local flap reconstruction of the defect after excision of the primary and determination of an accurate excision margin is impossible. 9. History of previous or concurrent (i.e. \>1 primary melanoma) invasive melanoma. 10. Melanoma located distal to the metacarpophalangeal joint; on the tip of the nose; the eyelids or on the ear; genitalia, perineum or anus; mucous membranes or internal viscera. 11. Physical, clinical, radiographic or pathologic evidence of satellite, in-transit, regional, or distant metastatic melanoma. 12. Patient has undergone surgery on a separate occasion to clear the lymph nodes of the probable draining lymphatic field, including -SLNB, of the index melanoma. 13. Any additional solid tumour or hematologic malignancy during the past 5 years (with exception of non- melanoma skin cancers (T1 skin lesions of squamous cell carcinoma (SCCs), basal cell carcinoma (BCCs)), or uterine/cervical cancer). 14. Melanoma-related operative procedures not corresponding to criteria described in the protocol. 15. Planned adjuvant radiotherapy to the primary melanoma site after wide local excision is not permitted as part of the protocol and any patients given this treatment would be excluded from the study. 16. History of organ transplantation. 17. Oral or parenteral immunosuppressive agents (not topical or inhaled steroids) at enrolment or within 6 months prior to enrolment. Pregnancy is not a specific exclusion criterion for this trial, though it may not be clinically appropriate to perform a wide excision and SLNB until the pregnancy has been completed, which may exclude the patient due to violation of inclusion criterion 4. We would advise careful counselling of the patient prior to enrolling the patient, which would include a discussion at the treating centre's multidisciplinary team meeting or tumour board. We would strongly advise contacting the central trial office to discuss the case prior to enrolling on the study.

Study locations (130)

University of South Alabama Mitchell Cancer Institute

Mobile, Alabama, 36604

Recruiting
John H Howard, MD · Contact
jhoward@health.southalabama.edu
Tiffany Fulford · Contact
tfulford@health.southalabama.edu
John H Howard, MD · Principal Investigator

Banner MD Anderson Cancer Center

Gilbert, Arizona, 85234

Recruiting
Mark Gimbel · Contact
mark.gimbel@bannerhealth.com
Sandra Ortega · Contact
sandra.ortega@bannerhealth.com
Mark Gimbel · Principal Investigator

Mayo Clinic Phoenix

Phoenix, Arizona, 85054

Recruiting
Barbara A Pockaj, MD · Contact
pockaj.barbara@mayo.edu
Courtney Nelson · Contact
Nelson.Courtney4@mayo.edu

University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205

Recruiting
Michail Mavros · Contact
MMavros@uams.edu
Michail Mavros · Principal Investigator

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

Irvine, California, 92868

Recruiting
Maki Yamamoto, MD · Contact
Maki Yamamoto, MD · Principal Investigator

Los Angeles General Medical Center

Los Angeles, California, 90033

Recruiting
Gino In · Contact
gino.in@med.usc.edu
Gino In · Principal Investigator

Los Angeles General Medical Center

Los Angeles, California, 90033

Recruiting
Gino In, MD · Contact
gino.in@med.usc.edu
Gino In, MD · Principal Investigator

USC Norris Comprehensive Cancer Center

Los Angeles, California, 90033

Recruiting
Gino In · Contact
gino.in@med.usc.edu
Gino In · Principal Investigator

USC Norris Comprehensive Cancer Center

Los Angeles, California, 90033

Recruiting
Gino In, MD · Contact
gino.in@med.usc.edu
Gino In, MD · Principal Investigator

The Angeles (Cedars-Sinai Medical Center and its Affiliates)

Los Angeles, California, 90048-1804

Recruiting
Dr Mark Faries · Contact
Dr Mark Faries · Principal Investigator

UC Irvine Health - Chao Family Comprehensive Cancer Center

Orange, California, 92868

Recruiting
Jeremy Harris · Contact
jpharris1@hs.uci.edu
Jeremy Harris · Principal Investigator

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

Orange, California, 92868

Recruiting
Maki Yamamoto · Contact
myamamot@hs.uci.edu
Maki Yamamoto · Principal Investigator

Stanford Cancer Institute

Palo Alto, California, 94304

Recruiting
Amanda Kirane, MD FACS · Contact
650-725-4169akirane@stanford.edu
Patrick Yuan · Contact
+1 650-498-7061yuanp@stanford.edu

Huntington Memorial Hospital

Pasadena, California, 91105

Recruiting
Mark Faries · Contact
mfaries@theangelesclinic.org
Mark Faries · Principal Investigator

Stanford Cancer Center South Bay

San Jose, California, 95124

Recruiting
Amanda Kirane · Contact
Amanda Kirane · Principal Investigator

Kaiser Permanente - Vallejo Medical Center

Vallejo, California, 94589

Recruiting
Tatjana Kolevska, MD · Contact
Tatjana.Kolevska@kp.org
Desiree Goldstein · Contact
desiree.goldstein@kp.org
Tatjana Kolevska, MD · Principal Investigator

Kaiser Permanente - Walnut Creek Medical Center

Walnut Creek, California, 94596

Recruiting
Tatjana Kolevska, MD · Contact
Tatjana.Kolevska@kp.org
Desiree Goldstein · Contact
desiree.goldstein@kp.org
Tatjana Kolevska, MD · Principal Investigator

Smilow Hospital Care Center, Guilford

Guilford, Connecticut, 06437

Recruiting
James Clune · Contact
james.clune@yale.edu
James Clune · Principal Investigator

Yale University

New Haven, Connecticut, 06520

Recruiting
James Clune · Contact
james.clune@yale.edu
James Clune · Principal Investigator

MedStar Georgetown University Hospital

Washington D.C., District of Columbia, 20007

Recruiting
Geoffrey T Gibney · Contact
geofrey.t.gibney@gunet.georgetown.edu
Geoffrey T Gibney · Principal Investigator

MedStar Washington Hospital Center

Washington D.C., District of Columbia, 20010

Recruiting
Marc Boisvert, MD · Contact
Marc.E.Boisvert@medstar.net
Nicolas Rojas · Contact
Nicolas.Rojas@medstar.net
Marc Boisvert, MD · Principal Investigator

University of Miami Sylvester Comprehensive Cancer Center at Aventura

Aventura, Florida, 33180

Recruiting
Jessica S Crystal · Contact
jxc2521@med.miami.edu
Jessica S Crystal · Principal Investigator

University of Miami Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables, Florida, 33146

Recruiting
Jessica S Crystal · Contact
jxc2521@med.miami.edu
Jessica S Crystal · Principal Investigator

University of Miami Sylvester Cancer Center at Coral Springs

Coral Springs, Florida, 33065

Recruiting
Jessica S Crystal · Contact
jxc2521@med.miami.edu
Jessica S Crystal · Principal Investigator

University of Miami Sylvester Comprehensive Center at Deerfield Beach

Deerfield Beach, Florida, 33442

Recruiting
Jessica S Crystal · Contact
jxc2521@med.miami.edu
Jessica S Crystal · Principal Investigator

University of Miami Sylvester Comprehensive Center at Hollywood

Hollywood, Florida, 33021

Recruiting
Jessica S Crystal · Contact
jxc2521@med.miami.edu
Jessica S Crystal · Principal Investigator

Baptist MD Anderson Cancer Center

Jacksonville, Florida, 32207

Recruiting
Konstantinos Chouliaras · Contact
Konstantinos.Chouliaras@bmcjax.com
Konstantinos Chouliaras · Principal Investigator

Mayo Clinic in Florida

Jacksonville, Florida, 32224

Recruiting
James W Jakub · Contact
Jakub.James@mayo.edu
James W Jakub · Principal Investigator

Lakeland Regional Health Hollis Cancer Center

Lakeland, Florida, 33805

Recruiting
Manuel Molina · Contact
manuel.molina@mylrh.org
Manuel Molina · Principal Investigator

University of Miami Miller School of Medicine-Sylvester Cancer Centre

Miami, Florida, 33136

Recruiting
Jessica S Crystal · Contact
jxc2521@med.miami.edu
Jessica S Crystal · Principal Investigator

University of Miami Comprehensive Cancer Center at Kendall

Miami, Florida, 33176

Recruiting
Jessica S Crystal · Contact
jxc2521@med.miami.edu
Jessica S Crystal · Principal Investigator

University of Miami Comprehensive Cancer Center at Plantation

Plantation, Florida, 33324

Recruiting
Jessica S Crystal · Contact
jxc2521@med.miami.edu
Jessica S Crystal · Principal Investigator

Moffitt Cancer Center - McKinley Campus

Tampa, Florida, 33612

Recruiting
Jonathan Zager · Contact
Jonathan.zager@moffitt.org
Jonathan Zager · Principal Investigator

Moffitt Cancer Center, Magnolia Campus

Tampa, Florida, 33612

Recruiting
Jonathan Zager · Contact
Jonathan.zager@moffitt.org
Jonathan Zager · Principal Investigator

Emory University Hospital Midtown

Atlanta, Georgia, 30308

Recruiting
Michael Lowe, MD · Contact
mlowe3@emory.edu
Rachel Mock · Contact
rachel.ashley.mock@emory.edu
Michael Lowe, MD · Principal Investigator

Emory University

Atlanta, Georgia, 30322

Recruiting
Dr Michael Lowe · Contact
Dr Michael Lowe · Principal Investigator
Professor Keith Delman · Principal Investigator

Emory Saint Joseph's Hospital

Atlanta, Georgia, 30342

Recruiting
Michael Lowe, MD · Contact
mlowe3@emory.edu
Charisse Ellis · Contact
chariesse.aliyya.ellis@emory.edu
Michael Lowe, MD · Principal Investigator

Northside Hospital Atlanta

Atlanta, Georgia, 30342

Recruiting
Nicole Kounalakis · Contact
nicole.kounalakis@northside.com
Nicole Kounalakis · Principal Investigator

Northside Hospital Cancer Institute

Atlanta, Georgia, 30342

Not Yet Recruiting
Margaret Ferreira · Contact
Dr. Nicole Kounalakis · Contact
Dr. Nicole Kounalakis · Principal Investigator

Nancy N and JC Lewis Cancer & Research Pavilion St. Joseph's/Candler

Savannah, Georgia, 31405

Recruiting
Yana Puckett, MD · Contact
drpucketty@sjchs.org
Stephanie Reyes · Contact
smiths1@sjchs.org
Yana Puckett, MD · Principal Investigator

Advocate Illinois Masonic Medical Center

Chicago, Illinois, 60657

Recruiting
Sigrun Hallmeyer · Contact
sigrun.hallmeyer@aah.org
Sigrun Hallmeyer · Principal Investigator

Northwestern Medicine Cancer Center Kishwaukee

DeKalb, Illinois, 60115

Recruiting
Jeffrey Wayne · Contact
jeffrey.wayne@nm.org
Jeffrey Wayne · Principal Investigator

Northwestern University

Evanston, Illinois, 60208

Recruiting
Jeffrey Wayne · Contact
jeffrey.wayne@nm.org
Jeffrey Wayne · Principal Investigator

Northwestern Medicine Cancer Center Delnor

Geneva, Illinois, 60134

Recruiting
Jeffrey Wayne · Contact
jeffrey.wayne@nm.org
Jeffrey Wayne · Principal Investigator

Northwestern Medicine Cancer Center Lake Forest Hospital

Lake Forest, Illinois, 60045

Recruiting
Jeffrey Wayne · Contact
jeffrey.wayne@nm.org
Jeffrey Wayne · Principal Investigator

Advocate Lutheran General Hospital

Park Ridge, Illinois, 60068

Recruiting
Sigrun Hallmeyer, MD · Contact
sigrun.hallmeyer@aah.org
Cheryl Korabik · Contact
cheryl.korabik@aah.org
Sigrun Hallmeyer, MD · Principal Investigator

Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois, 60555

Recruiting
Jeffrey Wayne · Contact
jeffrey.wayne@nm.org
Jeffrey Wayne · Principal Investigator

Indiana University - Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202

Recruiting
Karl Bilimoria, MD · Contact
· Contact
karlb@iu.edu
Karl Bilimoria, MD · Principal Investigator

Indiana University Melvin and Bren Simon Comprehensive Cancer Center

Indianapolis, Indiana, 46202

Recruiting
Karl Bilimoria · Contact
karlb@iu.edu
Karl Bilimoria · Principal Investigator

Franciscan Health Indianapolis

Indianapolis, Indiana, 46237

Recruiting
Juliana Meyer · Contact
juliana.meyer@franciscanalliance.org
Juliana Meyer · Principal Investigator

University of Kansas Hospital - Indian Creek Campus

Overland Park, Kansas, 66211

Recruiting
Luke Selby · Contact
lselby@kumc.edu
Luke Selby · Principal Investigator

University of Kansas Hospital- Westwood Cancer Center

Westwood, Kansas, 66205

Recruiting
Luke Selby · Contact
lselby@kumc.edu
Luke Selby · Principal Investigator

University of Kentucky

Lexington, Kentucky, 40506

Recruiting
Erin Burke · Contact
erin.burke@uky.edu
Erin Burke · Principal Investigator

MedStar Franklin Square Medical Center

Baltimore, Maryland, 21237

Recruiting
Edward McCarron · Contact
edward.mccarron@medstar.net
Edward McCarron · Principal Investigator

University of Michigan Medical Center

Ann Arbor, Michigan, 48109

Recruiting
Christina Angeles · Contact
angelesc@med.umich.edu
Christina Angeles · Principal Investigator

University of Michigan - Brighton Center for Specialty Care

Brighton, Michigan, 48116

Recruiting
Christina Angeles · Contact
angelesc@med.umich.edu
Christina Angeles · Principal Investigator

Mercy Health Saint Mary's

Grand Rapids, Michigan, 49503

Recruiting
Kathleen Yost · Contact
kyost@crcwm.org
Renee Porter · Contact
renee.porter@crcwm.org
Kathleen Yost · Principal Investigator

Spectrum Health at Butterworth Campus

Grand Rapids, Michigan, 49503

Recruiting
Kathleen Yost · Contact
Kyost@chcwm.com
Kathleen Yost · Principal Investigator

West Michigan Cancer Centre

Kalamazoo, Michigan, 49007

Recruiting
Kathleen Yost · Contact
kyost@chcwm.com
Kathleen Yost · Principal Investigator

Siteman Cancer Centre, Barnes Jewish West County

Creve Coeur, Missouri, 63141

Recruiting
Ryan Fields · Contact
rcfields@wustl.edu
Ryan Fields · Principal Investigator

University of Kansas Cancer Center

Kansas City, Missouri, 64154

Recruiting
Luke Selby · Contact
lselby@kumc.edu
Luke Selby · Principal Investigator

Cox South Hospital

Springfield, Missouri, 65807

Recruiting
Srikant Nannapaneni · Contact
Srikant Nannapaneni · Principal Investigator

Washington University School of Medicine

St Louis, Missouri, 63110

Recruiting
Ryan Fields · Contact
rcfields@wustl.edu
Ryan Fields · Principal Investigator

Nebraska Medicine - Bellevue

Bellevue, Nebraska, 68123

Recruiting
Bradley Reames · Contact
bradley.reames@unmc.edu
Bradley Reames · Principal Investigator

Nebraska Medicine-Village Pointe

Omaha, Nebraska, 68118

Recruiting
Bradley Reames · Contact
bradley.reames@unmc.edu
Bradley Reames · Principal Investigator

University of Nebraska Medicine

Omaha, Nebraska, 68198

Recruiting
Bradley Reames · Contact
bradley.reames@unmc.edu
Bradley Reames · Principal Investigator

Cooperman Barnabas Medical Center

Livingston, New Jersey, 07039

Recruiting
Adam Berger · Contact
ab2047@cinj.rutgers.edu
Adam Berger · Principal Investigator

Rutgers Cancer Institute of New Jersey

Piscataway, New Jersey, 08854

Recruiting
Professor Adam Berger · Contact
Professor Adam Berger · Principal Investigator

Lovelace Medical Centre-Saint Joseph Square

Albuquerque, New Mexico, 87110

Recruiting
Bridget Fahy, MD · Contact
BFahy@salud.unm.edu

Lovelace Women's Hospital

Albuquerque, New Mexico, 87110

Recruiting
Bridget Fahy, MD · Contact
BFahy@salud.unm.edu
Bridget Fahy, MD · Principal Investigator

Northwell Health Imbert Cancer Center

Bay Shore, New York, 11706

Recruiting
Alan Kadison, MD · Contact
akadison@northwell.edu
Diane Delliliune · Contact
DDellili@northwell.edu
Alan Kadison, MD · Principal Investigator

Roswell Park Cancer Institute

Buffalo, New York, 14203

Recruiting
Shalana O'Brien · Contact
shalana.obrien@roswellpark.org
Shalana O'Brien · Principal Investigator

Northwell Health/Center for Advanced Medicine

Lake Success, New York, 11042

Recruiting
Alan Kadison, MD · Contact
akadison@northwell.edu
Alexa Amoroso · Contact
aamoroso1@northwell.edu
Alan Kadison, MD · Principal Investigator

NYU Langone Medical Center (Winthrop Hospital)

Mineola, New York, 11501

Recruiting
Erica Friedman · Contact
mailto:Erica.Friedman@nyulangone.org
Erica Friedman · Principal Investigator

Northern Westchester Hospital

Mount Kisco, New York, 10549

Recruiting
Alan Kadison · Contact
Akadison@northwell.edu
Alan Kadison · Principal Investigator

Laura & Isaac Perlmutter Cancer Center at NYU Langone Health

New York, New York, 10016

Recruiting
Erica Friedman · Contact
mailto:Erica.Friedman@nyulangone.org
Erica Friedman · Principal Investigator

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, New York, 10032

Recruiting
Bret Taback · Contact
bt2160@cumc.columbia.ed
Bret Taback · Principal Investigator

Memorial Sloan Kettering Cancer Center

New York, New York, 10065

Recruiting
Associate Professor Danielle Bello · Contact
Associate Professor Danielle Bello · Principal Investigator

Vassar Brothers Medical Center

Poughkeepsie, New York, 12601

Recruiting
James Nitzkorski · Contact
james.nitzkorski@nuvancehealth.org
Karley Flinn · Contact
Jameskarley.flinn@nuvancehealth.org
James Nitzkorski · Principal Investigator

University of Rochester

Rochester, New York, 14642

Recruiting
Paul Barr · Contact
paul_barr@urmc.rochester.edu
Paul Barr · Principal Investigator

Phelps Memorial Hospital Center

Sleepy Hollow, New York, 10591

Recruiting
Alan Kadison · Contact
akadison@northwell.edu
Alan Kadison · Principal Investigator

State University of New York Upstate Medical University

Syracuse, New York, 13210

Recruiting
Daniel Thomas, MD · Contact
ThomasDa@upstate.edu
Laine Abernathy · Contact
abernatl@upstate.edu
Daniel Thomas, MD · Principal Investigator

State University of New York Upstate Medical Center-Community Campus

Syracuse, New York, 13215

Recruiting
Daniel Thomas, MD · Contact
ThomasDa@upstate.edu
Laine Abernathy · Contact
abernatl@upstate.edu
Daniel Thomas, MD · Principal Investigator

Wilmont Cancer Institute at Webster

Webster, New York, 14580

Recruiting
Paul Barr, MD · Contact
paul_barr@urmc.rochester.edu
Sarah Cawley · Contact
sarah_cawley@urmc.rochester.edu
Paul Barr, MD · Principal Investigator

University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, 27599

Recruiting
David W Ollila · Contact
david_ollila@med.unc.edu
David W Ollila · Principal Investigator

Duke University Medical Center

Durham, North Carolina, 27710

Recruiting
Jay Lee · Contact
jay.lee@duke.edu
Jay Lee · Principal Investigator

East Carolina University

Greenville, North Carolina, 27858

Recruiting
Nasreen Vohra · Contact
joynersu@ecu.edu
Nasreen Vohra · Principal Investigator

University of North Carolina Hospitals - Hillsborough Campus

Hillsborough, North Carolina, 27278

Recruiting
David Ollila · Contact
david_ollila@med.unc.edu
David Ollila · Principal Investigator

Sanford Broadway Medical Centre

Fargo, North Dakota, 58102

Recruiting
Preston Steen · Contact
preston.steen@sanfordhealth.org
Preston Steen · Principal Investigator

Sanford Roger Maris Cancer Centre

Fargo, North Dakota, 58102

Recruiting
Preston Steen · Contact
preston.steen@sanfordhealth.org
Preston Steen · Principal Investigator

University Hospitals Avon Health Center

Avon, Ohio, 44011

Recruiting
Luke Rothermel · Contact
Luke.Rothermel@UHhospitals.org
Luke Rothermel · Principal Investigator

Miami Valley Hospital South

Centerville, Ohio, 45459

Recruiting
James Ouellette · Contact
jrouellett@premierhealth.com
James Ouellette · Principal Investigator

University Hospitals Geauga Medical Center

Chardon, Ohio, 44024

Recruiting
Luke Rothermel · Contact
Luke.Rothermel@UHhospitals.org
Luke Rothermel · Principal Investigator

University of Cincinnati

Cincinnati, Ohio, 45219

Recruiting
Jeffrey Sussman · Contact
sussmaj@ucmail.uc.edu
Jeffrey Sussman · Principal Investigator

University Hospitals Cleveland Medical Centre

Cleveland, Ohio, 44106

Recruiting
Luke Rothermel · Contact
Luke.Rothermel@UHhospitals.org
Luke Rothermel · Principal Investigator

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210

Recruiting
Joal Joal · Contact
Joal.Beane@osumc.edu
Joal Joal · Principal Investigator

University Hospitals Chagrin Highlands Medical Centre

Orange, Ohio, 44122

Recruiting
Luke Rothermel · Contact
Luke.Rothermel@UHhospitals.org
Luke Rothermel · Principal Investigator

West Chester Hospital (OH394)

West Chester, Ohio, 45069

Recruiting
Jeffrey Sussman · Contact
sussmaj@ucmail.uc.edu
Jeffrey Sussman · Principal Investigator

University Hospitals St. John Medical Center

Westlake, Ohio, 44145

Recruiting
Luke Rothermel · Contact
Luke.Rothermel@UHhospitals.org
Luke Rothermel · Principal Investigator

OUHSC Stephenson Cancer Center

Oklahoma City, Oklahoma, 73104

Recruiting
William Dooley · Contact
William-Dooley@ouhsc.edu
William Dooley · Principal Investigator

Mercy Health Center - Oncology Hematology

Oklahoma City, Oklahoma, 73120-8362

Recruiting
Christian Ellis, DO · Contact
christian.ellis@mercy.net
Trisha Strubhar · Contact
trisha.strubhar@mercy.net
Christian Ellis, DO · Principal Investigator

Kaiser Sunnyside Medical Center

Clackamas, Oregon, 97015

Recruiting
Sandeep Mashru · Contact
sandeep.h.mashru@kp.org
Sandeep Mashru · Principal Investigator

Kaiser Permanente Northwest - Oncology Clinic

Portland, Oregon, 97227

Recruiting
Sandeep Mashru · Contact
sandeep.h.mashru@kp.org
Sandeep Mashru · Principal Investigator

St. Luke's University Health Network - Allentown Cancer Center

Allentown, Pennsylvania, 18104

Recruiting
Darius Desai, MD · Contact
Darius.Desai@sluhn.org
Amy Grossman · Contact
Amy.Grossman@sluhn.org
Darius Desai, MD · Principal Investigator

St Luke's University Health Network, Bethlehem Campus

Bethlehem, Pennsylvania, 18015

Recruiting
Darius Desai · Contact
Darius.Desai@sluhn.org
Darius Desai · Principal Investigator

St Luke's University Health Network, Anderson Campus

Easton, Pennsylvania, 18045

Recruiting
Darius Desai · Contact
Darius.Desai@sluhn.org
Darius Desai · Principal Investigator

Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111

Recruiting
Dr Stephanie Greco · Contact
Dr Stephanie Greco · Principal Investigator

St Luke's University Health Network Quakertown Campus

Quakertown, Pennsylvania, 18951

Recruiting
Darius Desai · Contact
Darius.Desai@sluhn.org
Darius Desai · Principal Investigator

St. Luke's University Health Network - Upper Bucks

Quakertown, Pennsylvania, 18951

Recruiting
Darius Desai, MD · Contact
Darius.Desai@sluhn.org
Amy Grossman · Contact
Amy.Grossman@sluhn.org
Darius Desai, MD · Principal Investigator

Guthrie Medical Group PC-Robert Packer Hospital

Sayre, Pennsylvania, 18840

Recruiting
David Bertsch, MD · Contact
david.j.bertsch@guthrie.org
Susan Hadlock · Contact
susan.hadlock@guthrie.org
David Bertsch, MD · Principal Investigator

Medical University of South Carolina

Charleston, South Carolina, 29425

Recruiting
Andrea Abbott · Contact
abbottan@musc.edu
Andrea Abbott · Principal Investigator

Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, 57105,

Recruiting
Daniel Almquist, MD · Contact
daniel.almquist@sanfordhealth.org
Daniel Almquist, MD · Principal Investigator

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57105,

Recruiting
Daniel Almquist, MD · Contact
daniel.almquist@sanfordhealth.org
Daniel Almquist, MD · Principal Investigator

The University of Texas MD Anderson Cancer Center

Houston, Texas, 77030

Recruiting
Jeffrey Gershenwald · Contact
jgershen@mdanderson.org
Jeffrey Gershenwald · Principal Investigator

University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78284-7884

Recruiting
Fedrico Tozzi, MD · Contact
tozzi@uthscsa.edu
Samantha Bankston · Contact
bankstonsm@uthscsa.edu
Fedrico Tozzi, MD · Principal Investigator

Intermountain Medical Center

Murray, Utah, 84157

Recruiting
Tawnya Bowles · Contact
tawnya.bowles@imail.org
Kevin Adams · Contact
Kevin.Adams@imail.org
Tawnya Bowles · Principal Investigator

Huntsman Cancer Institute (The University of Utah)

Salt Lake City, Utah, 84112

Recruiting
Professor John Hynstrom · Contact
Professor John Hynstrom · Principal Investigator

University of Vermont Medical Center

Burlington, Vermont, 05401

Recruiting
Jessica Cintolo-Gonzalez, MD · Contact
jessica.cintolo-gonzalez@uvmhealth.org
Elizabeth Abrecht · Contact
elizabeth.abrecht@uvmhealth.org

University of Vermount and Sate Agricultural College

Burlington, Vermont, 05405

Recruiting
Jessica Cintolo-Gonzalez, MD · Contact
jessica.cintolo-gonzalez@uvmhealth.org
Elizabeth Abrecht · Contact
elizabeth.abrecht@uvmhealth.org

University of Virginia Health System

Charlottesville, Virginia, 22903

Recruiting
Lynn Dengel · Contact
LTD5B@uvahealth.org
Lynn Dengel · Principal Investigator

VCU Massey Cancer Center Peninsula Cancer Institute

Newport News, Virginia, 23601

Recruiting
Giao Phan · Contact
giao.phan@vcuhealth.org
Giao Phan · Principal Investigator

VCU Massey Cancer Center

Richmond, Virginia, 23298

Recruiting
Giao Phan · Contact
giao.phan@vcuhealth.org
Giao Phan · Principal Investigator

Carilion Roanoke Memorial Hospital

Roanoke, Virginia, 24014

Recruiting
Giao Phan · Contact
giao.phan@vcuhealth.org
Kristin Campbell · Contact
klcampbell@vcu.edu
Giao Phan · Principal Investigator

VCU Massey Cancer Center Affiliate Valley Health

Winchester, Virginia, 22601

Recruiting
Giao Phan · Contact
giao.phan@vcuhealth.org
Giao Phan · Principal Investigator

University of Winsconsin Carbone Cancer Center-Eastpark medical Center

Madison, Wisconsin, 53718

Recruiting
Heather Neuman · Contact
neuman@surgery.wisc.edu
Heather Neuman, MD · Contact
neuman@surgery.wisc.edu
Heather Neuman, MD · Principal Investigator

University of Wisconsin Carbone Cancer Center

Madison, Wisconsin, 53792

Recruiting
Heather Neuman · Contact
neuman@surgery.wisc.edu
Sam Hanson · Contact
shhanson@wisc.ed
Heather Neuman · Principal Investigator

Marshfield Medical Center - Marshfield

Marshfield, Wisconsin, 54449

Recruiting
Rohit Sharma · Contact
sharma.rohit@marshfieldclinic.org
Rohit Sharma · Principal Investigator

Aurora St Luke's Medical Center

Milwaukee, Wisconsin, 53215

Recruiting
Sigrun Hallmeyer · Contact
sigrun.hallmeyer@aah.org
Sigrun Hallmeyer · Principal Investigator

Medical College of Wisconsin

Milwaukee, Wisconsin, 53226

Recruiting
Jennifer Bruening · Contact
jbruening@mcw.edu
Chloe Papageorgio · Contact
cpapageorgio@mcw.edu
Jennifer Bruening · Principal Investigator

Marshfield Medical Center- Weston

Weston, Wisconsin, 54476

Recruiting
Rohit Sharma, MD · Contact
sharma.rohit@marshfieldclinic.org
Rohit Sharma, sharma.rohit@marshfieldclinic. · Principal Investigator