Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer: The M&M Study
Summary
This study will examine the association between low muscle mass (myopenia) at diagnosis and chemotherapy toxicity in older adults with newly diagnosed advanced colorectal cancer.
Detailed description
This is a prospective cohort study that examines the impact of myopenia on chemotherapy toxicity in overall survival (OS) in older adults with newly diagnosed metastatic colorectal cancer (CRC) receiving 5-Fluouracil (5FU)systemic chemotherapy. The study also explores the mediating influence of genetic variation in the association between myopenia and chemotherapy toxicity.
Arms & interventions
Outcome measures
Primary
Number of Chemotherapy Toxicities (Grade 3 - 5)
Chemotoxicity will be measured after initiation of chemotherapy using the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE).
Time frame: Up to 6 months (after initiation of chemotherapy)
Secondary
Overall Survival
Time frame: 1 year
Eligibility criteria
Study locations (146)
Beebe South Coastal Health Campus
Millville, Delaware, 19967
Helen F Graham Cancer Center
Newark, Delaware, 19713
Medical Oncology Hematology Consultants PA
Newark, Delaware, 19713
Beebe Health Campus
Rehoboth Beach, Delaware, 19971
Christiana Care Health System-Wilmington Hospital
Wilmington, Delaware, 19801
MedStar Georgetown University Hospital
Washington D.C., District of Columbia, 20007
John B Amos Cancer Center
Columbus, Georgia, 31904
Illinois CancerCare-Bloomington
Bloomington, Illinois, 61704
Illinois CancerCare-Canton
Canton, Illinois, 61520
SIH Cancer Institute
Carterville, Illinois, 62918
John H Stroger Jr Hospital of Cook County
Chicago, Illinois, 60612
Carle at The Riverfront
Danville, Illinois, 61832
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, 62526
Crossroads Cancer Center
Effingham, Illinois, 62401
Illinois CancerCare-Galesburg
Galesburg, Illinois, 61401
Carle Physician Group - Mattoon/Charleston
Mattoon, Illinois, 61938
SSM Health Good Samaritan
Mount Vernon, Illinois, 62864
Carle BroMenn Medical Center
Normal, Illinois, 61761
Carle Cancer Institute Normal
Normal, Illinois, 61761
Cancer Care Center of O'Fallon
O'Fallon, Illinois, 62269
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois, 61350
Illinois CancerCare-Pekin
Pekin, Illinois, 61554
Illinois CancerCare-Peoria
Peoria, Illinois, 61615
Illinois CancerCare-Peru
Peru, Illinois, 61354
Southern Illinois University School of Medicine
Springfield, Illinois, 62702
Springfield Clinic
Springfield, Illinois, 62702
Carle Cancer Center
Urbana, Illinois, 61801
Illinois CancerCare - Washington
Washington, Illinois, 61571
The University of Iowa - Ankeny
Ankeny, Iowa, 50023
Saint Anthony Regional Hospital
Carroll, Iowa, 51401
Physicians' Clinic of Iowa PC
Cedar Rapids, Iowa, 52402
Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa, 52403
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, Iowa, 50325
Iowa Methodist Medical Center
Des Moines, Iowa, 50309
The University of Iowa-Des Moines
Des Moines, Iowa, 50309
Broadlawns Medical Center
Des Moines, Iowa, 50314
Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, Iowa, 50314
UI Healthcare Mission Cancer and Blood - Fort Dodge
Fort Dodge, Iowa, 50501
Saint Joseph Hospital East
Lexington, Kentucky, 40509
Louisiana Hematology Oncology Associates LLC
Baton Rouge, Louisiana, 70809
Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana, 70809
MBP Cancer Center - Baton Rouge General
Baton Rouge, Louisiana, 70809
Terrebonne General Medical Center
Houma, Louisiana, 70360
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan, 48106
Trinity Health IHA Medical Group Hematology Oncology-Brighton
Brighton, Michigan, 48114
Trinity Health Medical Center-Brighton
Brighton, Michigan, 48114
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, Michigan, 48188
Trinity Health Medical Center - Canton
Canton, Michigan, 48188
Chelsea Hospital
Chelsea, Michigan, 48118
Trinity Health IHA Hematology Oncology Consultants-Chelsea Hospital
Chelsea, Michigan, 48118
Cancer Hematology Centers - Flint
Flint, Michigan, 48503
Genesee Hematology Oncology PC
Flint, Michigan, 48503
Genesys Hurley Cancer Institute
Flint, Michigan, 48503
Marshfield Medical Center Dickinson
Iron Mountain, Michigan, 49801
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan, 48154
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan, 48341
Corewell Health Reed City Hospital
Reed City, Michigan, 49677
University of Michigan Health - West
Wyoming, Michigan, 49519
Trinity Health IHA Medical Group Hematology Oncology -Ann Arbor
Ypsilanti, Michigan, 48197
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota, 56601
Essentia Health Saint Joseph's Medical Center
Brainerd, Minnesota, 56401
Mercy Hospital
Coon Rapids, Minnesota, 55433
Essentia Health - Deer River Clinic
Deer River, Minnesota, 56636
Essentia Health Saint Mary's - Detroit Lakes Clinic
Detroit Lakes, Minnesota, 56501
Essentia Health Cancer Center
Duluth, Minnesota, 55805
Fairview Southdale Hospital
Edina, Minnesota, 55435
Essentia Health Hibbing Clinic
Hibbing, Minnesota, 55746
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota, 55109
Saint John's Hospital - Healtheast
Maplewood, Minnesota, 55109
Abbott-Northwestern Hospital
Minneapolis, Minnesota, 55407
Health Partners Inc
Minneapolis, Minnesota, 55454
New Ulm Medical Center
New Ulm, Minnesota, 56073
Essentia Health - Park Rapids
Park Rapids, Minnesota, 56470
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota, 55416
Regions Hospital
Saint Paul, Minnesota, 55101
United Hospital
Saint Paul, Minnesota, 55102
Essentia Health Sandstone
Sandstone, Minnesota, 55072
Saint Francis Regional Medical Center
Shakopee, Minnesota, 55379
Essentia Health Virginia Clinic
Virginia, Minnesota, 55792
Rice Memorial Hospital
Willmar, Minnesota, 56201
Saint Francis Medical Center
Cape Girardeau, Missouri, 63703
Parkland Health Center - Farmington
Farmington, Missouri, 63640
Mercy Clinic-Rolla-Cancer and Hematology
Rolla, Missouri, 65401
Heartland Regional Medical Center
Saint Joseph, Missouri, 64506
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri, 63670
Mercy Hospital Springfield
Springfield, Missouri, 65804
CoxHealth South Hospital
Springfield, Missouri, 65807
Missouri Baptist Medical Center
St Louis, Missouri, 63131
Missouri Baptist Sullivan Hospital
Sullivan, Missouri, 63080
BJC Outpatient Center at Sunset Hills
Sunset Hills, Missouri, 63127
Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina, 28203
Atrium Health Pineville/LCI-Pineville
Charlotte, North Carolina, 28210
Levine Cancer Institute-SouthPark
Charlotte, North Carolina, 28211
Atrium Health University City/LCI-University
Charlotte, North Carolina, 28262
Wake Forest University at Clemmons
Clemmons, North Carolina, 27012
Atrium Health Cabarrus/LCI-Concord
Concord, North Carolina, 28025
Levine Cancer Institute-Gaston
Gastonia, North Carolina, 28054
Wake Forest Baptist Health - Wilkes Medical Center
Wilkesboro, North Carolina, 28659
Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157
Sanford Bismarck Medical Center
Bismarck, North Dakota, 58501
Essentia Health Cancer Center-South University Clinic
Fargo, North Dakota, 58103
Sanford Broadway Medical Center
Fargo, North Dakota, 58122
Sanford Roger Maris Cancer Center
Fargo, North Dakota, 58122
Adena Regional Medical Center
Chillicothe, Ohio, 45601
The Mark H Zangmeister Center
Columbus, Ohio, 43219
Armes Family Cancer Center
Findlay, Ohio, 45840
Knox Community Hospital
Mount Vernon, Ohio, 43050
Licking Memorial Hospital
Newark, Ohio, 43055
Southern Ohio Medical Center
Portsmouth, Ohio, 45662
Springfield Regional Cancer Center
Springfield, Ohio, 45504
Genesis Healthcare System Cancer Care Center
Zanesville, Ohio, 43701
Geisinger Medical Center
Danville, Pennsylvania, 17822
Geisinger Medical Center-Cancer Center Hazleton
Hazleton, Pennsylvania, 18201
Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania, 17837
Lewistown Hospital
Lewistown, Pennsylvania, 17044
Geisinger Cancer Services-Pottsville
Pottsville, Pennsylvania, 17901
Community Medical Center
Scranton, Pennsylvania, 18510
Geisinger Medical Oncology-Selinsgrove
Selinsgrove, Pennsylvania, 17870
Geisinger Medical Group
State College, Pennsylvania, 16801
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania, 18711
Prisma Health Cancer Institute - Spartanburg
Boiling Springs, South Carolina, 29316
Prisma Health Cancer Institute - Easley
Easley, South Carolina, 29640
Gibbs Cancer Center-Gaffney
Gaffney, South Carolina, 29341
Prisma Health Cancer Institute - Butternut
Greenville, South Carolina, 29605
Prisma Health Cancer Institute - Faris
Greenville, South Carolina, 29605
Prisma Health Cancer Institute - Eastside
Greenville, South Carolina, 29615
Self Regional Healthcare
Greenwood, South Carolina, 29646
Prisma Health Cancer Institute - Greer
Greer, South Carolina, 29650
Gibbs Cancer Center-Pelham
Greer, South Carolina, 29651
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina, 29672
Spartanburg Medical Center
Spartanburg, South Carolina, 29303
MGC Hematology Oncology-Union
Union, South Carolina, 29379
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota, 57104
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, 57117-5134
Duluth Clinic Ashland
Ashland, Wisconsin, 54806
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin, 54701
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin, 54301
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin, 54303
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin, 54449
Marshfield Medical Center - Minocqua
Minocqua, Wisconsin, 54548
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin, 54868
Essentia Health-Spooner Clinic
Spooner, Wisconsin, 54801
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin, 54482
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, Wisconsin, 54235-1495
Marshfield Medical Center - Weston
Weston, Wisconsin, 54476