Comparing the Clinical Impact of Pancreatic Cyst Surveillance Programs and Associated Biomarkers
Summary
The purpose of this study is to compare two approaches for monitoring pancreatic cysts as well as to identify associated biomarkers. The study doctors want to compare more frequent monitoring versus less frequent monitoring as well as identify biomarkers which may improve risk detection of transformation to pancreatic cancer. The study doctors want to learn which monitoring method and which biomarkers lead to better outcomes for patients.
Detailed description
PRIMARY OBJECTIVE: I. Evaluate whether the protocol specified primary biomarkers (both blood and imaging-based) measured at baseline, are associated with the future development of worrisome features and/or high-risk stigmata. SECONDARY OBJECTIVES: I. Evaluate whether the imaging-based secondary biomarker implemented using baseline computed tomography (CT) scans and/or the blood-based secondary biomarker panel, is associated with the future development of worrisome features and/or high-risk stigmata. II. Estimate area under curve (AUC), sensitivity, specificity, negative, and positive predictive value of each biomarker. III. Evaluate the predictive ability of the longitudinal trajectory of each biomarker for prediction of worrisome features and/or high-risk stigmata. IV. Develop and evaluate risk scores that combine blood-based and imaging-based markers. V. Compare patient reported outcomes (PROs) between study arms (A and B): quality of life (QOL), financial distress, and situational anxiety. VI. Compare 5-year total cost between arms (A and B). PRIMARY OBJECTIVE (PRIOR TO ADDENDUM #5 08/13/2024): I. To compare the rates of unfavorable clinical outcomes in the two arms. SECONDARY OBJECTIVES (PRIOR TO ADDENDUM #5 08/13/2024): I. To compare rates of major surgical morbidity and/or mortality between arms. II. To compare pancreatic cancer incidence and all-cause mortality across arms. III. Compare institutional (direct) costs. IV. Compare healthcare utilization of imaging, invasive testing, surgical, and other procedures across the two surveillance arms. V. Compare patient (out-of-pocket and other indirect) costs. VI. Describe diagnostic test and treatment pathways by arm. VII. Compare patient reports of QOL, situational anxiety. VIII. Compare patient report of financial distress. IX. Compare rates of non-adherence by arm assignment. X. To evaluate and compare the predictive performance of known and future biomarkers for dysplasia or cancer. EXPLORATORY OBJECTIVE (PRIOR TO ADDENDUM #5 08/13/2024): I. To evaluate and compare the predictive accuracy of known and future radiomic markers for dysplasia and pancreatic cancer. OUTLINE: This is an observational study. Patients undergo magnetic resonance imaging (MRI) or CT scans as well as blood sample collection throughout the trial. Patients undergo endoscopic ultrasound (EUS), fine needle aspiration (FNA), biopsy and surgery as clinically indicated. Patients are followed up every 6 months or yearly for 5 years from the date of registration. OUTLINE (PRIOR TO ADDENDUM #5 08/13/2024): This is an observational study. Patients are randomized to 1 of 2 arms. ARM A (LOW INTENSITY SURVEILLANCE) (CLOSED TO ACCRUAL 08/13/2024): Patients undergo MRI, CT, or EUS at the beginning of the trial and MRI or CT again in 1 year. Following the first year, patients with no abnormalities repeat MRI or CT every 2 years. Patients with positive imaging features on MRI and CT at 1 or 2 years and with negative EUS, repeat MRI or CT in 1 year. Patients with negative imaging repeat MRI or CT in 2 years. ARM B (HIGH INTENSITY SURVEILLANCE) (CLOSED TO ACCRUAL 08/13/2024): Patients undergo MRI, CT, or EUS at the beginning of the trial. Patients with \>= 1 and \< 2 cm cyst undergo MRI or CT every 6 months for 1 year, then every 12 months for 2 years, and then every 24 months thereafter. Patients with \>= 2 and \< 3 cm cyst undergo EUS within 6 months, and if EUS is negative, patients repeat MRI or CT in 1 year. If second EUS is negative, patients undergo alternate MRI or CT and EUS every 12 months. Patients with cyst \>= 3 cm undergo alternate MRI or CT with EUS every 3-6 months. All patients may also optionally undergo blood sample collection, biopsy and/or EUS-FNA on study. After completion of imaging procedures, patients are followed up for 5 years from the date of registration.
Arms & interventions
- ProcedureBiopsy Procedure
Undergo biopsy
- ProcedureBiospecimen Collection
Undergo blood sample collection
- ProcedureComputed Tomography
Undergo CT
- ProcedureEndoscopic Ultrasound
Undergo EUS
- ProcedureEndoscopic Ultrasound-Guided Fine-Needle Aspiration
Undergo EUS-FNA
- ProcedureMagnetic Resonance Imaging
Undergo MRI
- OtherQuality-of-Life Assessment
Ancillary studies (PRIOR TO ADDENDUM #5 08/13/2024)
- OtherQuestionnaire Administration
Ancillary studies (PRIOR TO ADDENDUM #5 08/13/2024)
- ProcedureSurgical Procedure
Undergo surgery
Outcome measures
Primary
Time-to-finding of a worrisome feature and/or high-risk stigmata on computed tomography (CT) or magnetic resonance imaging (MRI)
Will assess the predictive performance of both primary markers separately. Time to first occurrence of worrisome features and/or high-risk stigmata will be measured from the time of baseline blood draw. Will use an overall significance level of 0.1. Will use a Bonferroni correction for multiplicity adjustment, the significance level applied to both primary biomarkers will be 0.05. Will evaluate using a two-sided log-rank test comparing time to occurrence of worrisome features and/or high-risk stigmata between the marker-positive and marker-negative subgroups. Will visually summarize time to occurrence of worrisome features and/or high-risk stigmata in both maker positive and marker negative using Kaplan-Meier curves. All biomarkers will come in with a predetermined threshold for determining marker positivity (as defined in their respective publications). The primary imaging marker is for MRI, the analysis of this biomarker will be restricted to participants with a pre-enrollment MRI.
Time frame: Up to 5 years
Occurrence of an "unfavorable" outcome (PRIOR TO ADDENDUM #5 08/13/2024)
Defined as a composite of: (1) any pancreatic cancer without surgery; (2) unresectable pancreatic cancer or cancer \> T1a, N0 at surgery, and (3) benign disease at surgery will be approached from the intent-to-treat perspective. Time to the first occurrence of the primary endpoint will be measured from randomization. Survival analysis methods will be used to estimate and compare distributions of time to an unfavorable event between the study arms. In particular Kaplan-Meier estimates will be developed for each arm and a log rank test will be used to compare the two arms.
Time frame: Up to 5 years
Secondary
Finding of a worrisome feature and/or high-risk stigmata on CT or MRI
Time frame: Up to 5 years
Situational anxiety
Time frame: Up to 5 years
Overall quality of life
Time frame: Up to 5 years
Financial distress
Time frame: Up to 5 years
Cost
Time frame: Up to 5 years
Surgical and all-cause mortality (PRIOR TO ADDENDUM #5 08/13/2024)
Time frame: Up to 5 years
Major surgical morbidity (PRIOR TO ADDENDUM #5 08/13/2024)
Time frame: Up to 5 years
Pancreatic cancer incidence (PRIOR TO ADDENDUM #5 08/13/2024)
Time frame: Up to 5 years
Institutional (direct) costs (PRIOR TO ADDENDUM #5 08/13/2024)
Time frame: Up to 5 years
Healthcare utilization of imaging, invasive testing, surgical, and other procedures (PRIOR TO ADDENDUM #5 08/13/2024)
Time frame: Up to 5 years
Patient (out-of-pocket and other indirect) costs (PRIOR TO ADDENDUM #5 08/13/2024)
Time frame: Up to 5 years
Diagnostic test and treatment pathways (PRIOR TO ADDENDUM #5 08/13/2024)
Time frame: Up to 5 years
Patient reports of quality of life (PRIOR TO ADDENDUM #5 08/13/2024)
Time frame: Up to 5 years
Patient reports of situational anxiety (PRIOR TO ADDENDUM #5 08/13/2024)
Time frame: Up to 5 years
Patient report of financial distress (PRIOR TO ADDENDUM #5 08/13/2024)
Time frame: Up to 5 years
Rates of non-adherence (PRIOR TO ADDENDUM #5 08/13/2024)
Time frame: Up to 5 years
Biomarker analysis (PRIOR TO ADDENDUM #5 08/13/2024)
Time frame: Up to 5 years
Eligibility criteria
Study locations (408)
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, 35233
University of South Alabama Mitchell Cancer Institute
Mobile, Alabama, 36688
Anchorage Associates in Radiation Medicine
Anchorage, Alaska, 98508
Anchorage Radiation Therapy Center
Anchorage, Alaska, 99504
Alaska Breast Care and Surgery LLC
Anchorage, Alaska, 99508
Alaska Oncology and Hematology LLC
Anchorage, Alaska, 99508
Alaska Women's Cancer Care
Anchorage, Alaska, 99508
Anchorage Oncology Centre
Anchorage, Alaska, 99508
Katmai Oncology Group
Anchorage, Alaska, 99508
Providence Alaska Medical Center
Anchorage, Alaska, 99508
Mayo Clinic Hospital in Arizona
Phoenix, Arizona, 85054
Mayo Clinic in Arizona
Scottsdale, Arizona, 85259
Baptist Health Medical Center - Little Rock
Little Rock, Arkansas, 72205
University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, California, 91505
UC San Diego Health System - Encinitas
Encinitas, California, 92024
UC San Diego Moores Cancer Center
La Jolla, California, 92093
Loma Linda University Medical Center
Loma Linda, California, 92354
Veterans Affairs Loma Linda Healthcare System
Loma Linda, California, 92357
UCLA / Jonsson Comprehensive Cancer Center
Los Angeles, California, 90095
University of California Davis Comprehensive Cancer Center
Sacramento, California, 95817
UC San Diego Medical Center - Hillcrest
San Diego, California, 92103
UCSF Medical Center-Mount Zion
San Francisco, California, 94115
UCSF Medical Center-Parnassus
San Francisco, California, 94143
UCSF Medical Center-Mission Bay
San Francisco, California, 94158
Smilow Cancer Hospital-Derby Care Center
Derby, Connecticut, 06418
Smilow Cancer Hospital Care Center-Fairfield
Fairfield, Connecticut, 06824
Smilow Cancer Hospital Care Center at Glastonbury
Glastonbury, Connecticut, 06033
Smilow Cancer Hospital Care Center at Greenwich
Greenwich, Connecticut, 06830
Smilow Cancer Hospital Care Center - Guilford
Guilford, Connecticut, 06437
Smilow Cancer Hospital-Hamden Care Center
Hamden, Connecticut, 06518
Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut, 06105
Smilow Cancer Center/Yale-New Haven Hospital
New Haven, Connecticut, 06510
Yale-New Haven Hospital Saint Raphael Campus
New Haven, Connecticut, 06511
Yale University
New Haven, Connecticut, 06520
Yale-New Haven Hospital North Haven Medical Center
North Haven, Connecticut, 06473
Smilow Cancer Hospital-Orange Care Center
Orange, Connecticut, 06477
Smilow Cancer Hospital-Torrington Care Center
Torrington, Connecticut, 06790
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut, 06611
Smilow Cancer Hospital-Waterbury Care Center
Waterbury, Connecticut, 06708
Smilow Cancer Hospital Care Center - Waterford
Waterford, Connecticut, 06385
Veterans Affairs Connecticut Healthcare System-West Haven Campus
West Haven, Connecticut, 06516
Beebe Medical Center
Lewes, Delaware, 19958
Beebe South Coastal Health Campus
Millville, Delaware, 19967
Helen F Graham Cancer Center
Newark, Delaware, 19713
Medical Oncology Hematology Consultants PA
Newark, Delaware, 19713
Christiana Care Health System-Christiana Hospital
Newark, Delaware, 19718
Beebe Health Campus
Rehoboth Beach, Delaware, 19971
Christiana Care Health System-Wilmington Hospital
Wilmington, Delaware, 19801
MedStar Georgetown University Hospital
Washington D.C., District of Columbia, 20007
Holy Cross Hospital
Fort Lauderdale, Florida, 33308
Regional Cancer Center-Lee Memorial Health System
Fort Myers, Florida, 33905
Mayo Clinic in Florida
Jacksonville, Florida, 32224-9980
Emory University Hospital Midtown
Atlanta, Georgia, 30308
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, 30322
Emory Saint Joseph's Hospital
Atlanta, Georgia, 30342
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho, 83706
Saint Luke's Cancer Institute - Boise
Boise, Idaho, 83712
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho, 83605
Saint Luke's Cancer Institute - Fruitland
Fruitland, Idaho, 83619
Idaho Urologic Institute-Meridian
Meridian, Idaho, 83642
Saint Luke's Cancer Institute - Meridian
Meridian, Idaho, 83642
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho, 83687
Saint Luke's Cancer Institute - Nampa
Nampa, Idaho, 83687
Saint Luke's Cancer Institute - Twin Falls
Twin Falls, Idaho, 83301
Advocate Outpatient Center - Aurora
Aurora, Illinois, 60506
Advocate Good Shepherd Hospital
Barrington, Illinois, 60010
Carle BroMenn Outpatient Center
Bloomington, Illinois, 61704
Illinois CancerCare-Bloomington
Bloomington, Illinois, 61704
Illinois CancerCare-Canton
Canton, Illinois, 61520
Memorial Hospital of Carbondale
Carbondale, Illinois, 62902
SIH Cancer Institute
Carterville, Illinois, 62918
Illinois CancerCare-Carthage
Carthage, Illinois, 62321
Centralia Oncology Clinic
Centralia, Illinois, 62801
Northwestern University
Chicago, Illinois, 60611
Advocate Illinois Masonic Medical Center
Chicago, Illinois, 60657
AMG Crystal Lake - Oncology
Crystal Lake, Illinois, 60014
Carle at The Riverfront
Danville, Illinois, 61832
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, 62526
Decatur Memorial Hospital
Decatur, Illinois, 62526
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois, 60115
Illinois CancerCare-Dixon
Dixon, Illinois, 61021
Advocate Good Samaritan Hospital
Downers Grove, Illinois, 60515
Carle Physician Group-Effingham
Effingham, Illinois, 62401
Crossroads Cancer Center
Effingham, Illinois, 62401
Advocate Sherman Hospital
Elgin, Illinois, 60123
Elmhurst Memorial Hospital
Elmhurst, Illinois, 60126
Illinois CancerCare-Eureka
Eureka, Illinois, 61530
NorthShore University HealthSystem-Evanston Hospital
Evanston, Illinois, 60201
Illinois CancerCare-Galesburg
Galesburg, Illinois, 61401
Western Illinois Cancer Treatment Center
Galesburg, Illinois, 61401
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois, 60134
NorthShore University HealthSystem-Glenbrook Hospital
Glenview, Illinois, 60026
Ingalls Memorial Hospital
Harvey, Illinois, 60426
Advocate South Suburban Hospital
Hazel Crest, Illinois, 60429
NorthShore University HealthSystem-Highland Park Hospital
Highland Park, Illinois, 60035
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois, 61443
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois, 60045
AMG Libertyville - Oncology
Libertyville, Illinois, 60048
Condell Memorial Hospital
Libertyville, Illinois, 60048
Illinois CancerCare-Macomb
Macomb, Illinois, 61455
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois, 61938
Edward Hospital/Cancer Center
Naperville, Illinois, 60540
Carle BroMenn Medical Center
Normal, Illinois, 61761
Carle Cancer Institute Normal
Normal, Illinois, 61761
Cancer Care Center of O'Fallon
O'Fallon, Illinois, 62269
HSHS Saint Elizabeth's Hospital
O'Fallon, Illinois, 62269
Northwestern Medicine Oak Brook
Oak Brook, Illinois, 60523
Advocate Christ Medical Center
Oak Lawn, Illinois, 60453-2699
Northwestern Medicine Orland Park
Orland Park, Illinois, 60462
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois, 61350
Advocate Lutheran General Hospital
Park Ridge, Illinois, 60068
Illinois CancerCare-Pekin
Pekin, Illinois, 61554
Illinois CancerCare-Peoria
Peoria, Illinois, 61615
Methodist Medical Center of Illinois
Peoria, Illinois, 61636
Illinois CancerCare-Peru
Peru, Illinois, 61354
Valley Radiation Oncology
Peru, Illinois, 61354
Edward Hospital/Cancer Center?Plainfield
Plainfield, Illinois, 60585
Illinois CancerCare-Princeton
Princeton, Illinois, 61356
Southern Illinois University School of Medicine
Springfield, Illinois, 62702
Springfield Clinic
Springfield, Illinois, 62702
Springfield Memorial Hospital
Springfield, Illinois, 62781
Southwest Illinois Health Services LLP
Swansea, Illinois, 62226
Carle Cancer Center
Urbana, Illinois, 61801
The Carle Foundation Hospital
Urbana, Illinois, 61801
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, 60555
Illinois CancerCare - Washington
Washington, Illinois, 61571
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, 46202
Reid Health
Richmond, Indiana, 47374
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, Iowa, 50023
Mercy Cancer Center-West Lakes
Clive, Iowa, 50325
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, Iowa, 50325
Greater Regional Medical Center
Creston, Iowa, 50801
Iowa Methodist Medical Center
Des Moines, Iowa, 50309
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, Iowa, 50309
Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, Iowa, 50314
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa, 52242
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee, Iowa, 50263
Mercy Medical Center-West Lakes
West Des Moines, Iowa, 50266
LSU Health Baton Rouge-North Clinic
Baton Rouge, Louisiana, 70805
Our Lady of the Lake Physician Group
Baton Rouge, Louisiana, 70808
Our Lady of The Lake
Baton Rouge, Louisiana, 70808
Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana, 70809
Christiana Care - Union Hospital
Elkton, Maryland, 21921
UM Baltimore Washington Medical Center/Tate Cancer Center
Glen Burnie, Maryland, 21061
MyMichigan Medical Center Gratiot
Alma, Michigan, 48801
MyMichigan Medical Center Alpena
Alpena, Michigan, 49707
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan, 48106
University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, 48109
Bronson Battle Creek
Battle Creek, Michigan, 49017
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, Michigan, 48114
Trinity Health Medical Center - Brighton
Brighton, Michigan, 48114
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, Michigan, 48188
Trinity Health Medical Center - Canton
Canton, Michigan, 48188
Chelsea Hospital
Chelsea, Michigan, 48118
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, Michigan, 48118
Hematology Oncology Consultants-Clarkston
Clarkston, Michigan, 48346
Newland Medical Associates-Clarkston
Clarkston, Michigan, 48346
Corewell Health Dearborn Hospital
Dearborn, Michigan, 48124
Henry Ford Health Saint John Hospital
Detroit, Michigan, 48236
Henry Ford River District Hospital
East China, Michigan, 48054
Corewell Health Farmington Hills Hospital
Farmington Hills, Michigan, 48336
Cancer Hematology Centers - Flint
Flint, Michigan, 48503
Genesee Hematology Oncology PC
Flint, Michigan, 48503
Genesys Hurley Cancer Institute
Flint, Michigan, 48503
Hurley Medical Center
Flint, Michigan, 48503
MyMichigan Medical Center Gladwin
Gladwin, Michigan, 48624
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids, Michigan, 49503
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
Grand Rapids, Michigan, 49503
Trinity Health Grand Rapids Hospital
Grand Rapids, Michigan, 49503
Henry Ford Saint John Hospital - Academic
Grosse Pointe Woods, Michigan, 48236
Henry Ford Saint John Hospital - Breast
Grosse Pointe Woods, Michigan, 48236
Henry Ford Saint John Hospital - Van Elslander
Grosse Pointe Woods, Michigan, 48236
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007
West Michigan Cancer Center
Kalamazoo, Michigan, 49007
Beacon Kalamazoo Cancer Center
Kalamazoo, Michigan, 49009
Beacon Kalamazoo
Kalamazoo, Michigan, 49048
University of Michigan Health - Sparrow Lansing
Lansing, Michigan, 48912
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan, 48154
Henry Ford Saint John Hospital - Macomb Medical
Macomb, Michigan, 48044
Henry Ford Warren Hospital - Breast Macomb
Macomb, Michigan, 48044
MyMichigan Medical Center Midland
Midland, Michigan, 48670
MyMichigan Medical Center Mount Pleasant
Mount Pleasant, Michigan, 48858
Trinity Health Muskegon Hospital
Muskegon, Michigan, 49444
Corewell Health Lakeland Hospitals - Niles Hospital
Niles, Michigan, 49120
Cancer and Hematology Centers of Western Michigan - Norton Shores
Norton Shores, Michigan, 49444
Hope Cancer Center
Pontiac, Michigan, 48341
Michigan Healthcare Professionals Pontiac
Pontiac, Michigan, 48341
Newland Medical Associates-Pontiac
Pontiac, Michigan, 48341
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan, 48341
Corewell Health Reed City Hospital
Reed City, Michigan, 49677
Oakland Colon Rectal Associates
Royal Oak, Michigan, 48067
Cancer Care Associates PC
Royal Oak, Michigan, 48073
Comprehensive Medical Center PLLC
Royal Oak, Michigan, 48073
Corewell Health William Beaumont University Hospital
Royal Oak, Michigan, 48073
Hematology Oncology Consultants PC-Royal Oak
Royal Oak, Michigan, 48073
Oakland Medical Group
Royal Oak, Michigan, 48073
MyMichigan Medical Center Saginaw
Saginaw, Michigan, 48601
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Saint Joseph, Michigan, 49085
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
Saint Joseph, Michigan, 49085
MyMichigan Medical Center Tawas
Tawas City, Michigan, 48764
Munson Medical Center
Traverse City, Michigan, 49684
Michigan Institute of Urology-Town Center
Troy, Michigan, 48084
Corewell Health Beaumont Troy Hospital
Troy, Michigan, 48085
Hematology Oncology Consultants PC-Troy
Troy, Michigan, 48098
Henry Ford Health Warren Hospital
Warren, Michigan, 48093
Henry Ford Madison Heights Hospital - Breast
Warren, Michigan, 48093
Henry Ford Warren Hospital - GLCMS
Warren, Michigan, 48093
University of Michigan Health - West
Wyoming, Michigan, 49519
Huron Gastroenterology PC
Ypsilanti, Michigan, 48106
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan, 48197
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota, 56601
Mayo Clinic in Rochester
Rochester, Minnesota, 55905
Sanford Thief River Falls Medical Center
Thief River Falls, Minnesota, 56701
Sanford Cancer Center Worthington
Worthington, Minnesota, 56187
Mercy Cancer Center - Cape Girardeau
Cape Girardeau, Missouri, 63703
Saint Francis Medical Center
Cape Girardeau, Missouri, 63703
Parkland Health Center - Farmington
Farmington, Missouri, 63640
MU Health Care Goldschmidt Cancer Center
Jefferson City, Missouri, 65109
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri, 63670
Washington University School of Medicine
St Louis, Missouri, 63110
Missouri Baptist Medical Center
St Louis, Missouri, 63131
Missouri Baptist Sullivan Hospital
Sullivan, Missouri, 63080
BJC Outpatient Center at Sunset Hills
Sunset Hills, Missouri, 63127
Saint Patrick Hospital - Community Hospital
Missoula, Montana, 59802
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire, 03756
Veterans Adminstration New Jersey Health Care System
East Orange, New Jersey, 07018-1095
CentraState Medical Center
Freehold, New Jersey, 07728
Morristown Medical Center
Morristown, New Jersey, 07960
Saint Peter's University Hospital
New Brunswick, New Jersey, 08901
Capital Health Medical Center-Hopewell
Pennington, New Jersey, 08534
Penn Medicine Princeton Health
Plainsboro, New Jersey, 08536
Overlook Hospital
Summit, New Jersey, 07902
University of New Mexico Cancer Center
Albuquerque, New Mexico, 87106
Roswell Park Cancer Institute
Buffalo, New York, 14263
Glens Falls Hospital
Glens Falls, New York, 12801
Northwell Health/Center for Advanced Medicine
Lake Success, New York, 11042
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York, 10016
Lenox Hill Hospital
New York, New York, 10075
Stony Brook University Medical Center
Stony Brook, New York, 11794
Montefiore Medical Center-Einstein Campus
The Bronx, New York, 10461
Montefiore Medical Center-Weiler Hospital
The Bronx, New York, 10461
Montefiore Medical Center - Moses Campus
The Bronx, New York, 10467
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, 27599
Durham VA Medical Center
Durham, North Carolina, 27705
East Carolina University
Greenville, North Carolina, 27834
Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157
Sanford Bismarck Medical Center
Bismarck, North Dakota, 58501
Sanford South University Medical Center
Fargo, North Dakota, 58103
Southpointe-Sanford Medical Center Fargo
Fargo, North Dakota, 58103
Sanford Medical Center Fargo
Fargo, North Dakota, 58104
Sanford Broadway Medical Center
Fargo, North Dakota, 58122
Sanford Roger Maris Cancer Center
Fargo, North Dakota, 58122
Indu and Raj Soin Medical Center
Beavercreek, Ohio, 45431
Saint Elizabeth Boardman Hospital
Boardman, Ohio, 44512
Dayton Physicians LLC-Miami Valley South
Centerville, Ohio, 45459
Miami Valley Hospital South
Centerville, Ohio, 45459
Oncology Hematology Care Inc-Kenwood
Cincinnati, Ohio, 45236
MetroHealth Medical Center
Cleveland, Ohio, 44109
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210
Miami Valley Hospital
Dayton, Ohio, 45409
Dayton Physician LLC - Englewood
Dayton, Ohio, 45415
Miami Valley Hospital North
Dayton, Ohio, 45415
Armes Family Cancer Center
Findlay, Ohio, 45840
Blanchard Valley Hospital
Findlay, Ohio, 45840
Orion Cancer Care
Findlay, Ohio, 45840
Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio, 45005-1066
Dayton Physicians LLC-Atrium
Franklin, Ohio, 45005
Dayton Physicians LLC-Wayne
Greenville, Ohio, 45331
Wayne Hospital
Greenville, Ohio, 45331
Greater Dayton Cancer Center
Kettering, Ohio, 45409
Kettering Medical Center
Kettering, Ohio, 45429
Springfield Regional Cancer Center
Springfield, Ohio, 45504
Springfield Regional Medical Center
Springfield, Ohio, 45504
Dayton Physicians LLC - Troy
Troy, Ohio, 45373
Upper Valley Medical Center
Troy, Ohio, 45373
Saint Joseph Warren Hospital
Warren, Ohio, 44484
Saint Elizabeth Youngstown Hospital
Youngstown, Ohio, 44501
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104
Saint Alphonsus Cancer Care Center-Baker City
Baker City, Oregon, 97814
Saint Charles Health System
Bend, Oregon, 97701
Clackamas Radiation Oncology Center
Clackamas, Oregon, 97015
Providence Cancer Institute Clackamas Clinic
Clackamas, Oregon, 97015
Bay Area Hospital
Coos Bay, Oregon, 97420
Providence Hood River Memorial Hospital
Hood River, Oregon, 97031
Providence Newberg Medical Center
Newberg, Oregon, 97132
Saint Alphonsus Cancer Care Center-Ontario
Ontario, Oregon, 97914
Providence Willamette Falls Medical Center
Oregon City, Oregon, 97045
Providence Portland Medical Center
Portland, Oregon, 97213
Providence Saint Vincent Medical Center
Portland, Oregon, 97225
Oregon Health and Science University
Portland, Oregon, 97239
Saint Charles Health System-Redmond
Redmond, Oregon, 97756
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania, 18103
Saint Luke's Cancer Center - Allentown
Allentown, Pennsylvania, 18104
Saint Luke's University Hospital-Bethlehem Campus
Bethlehem, Pennsylvania, 18015
Lehigh Valley Hospital - Muhlenberg
Bethlehem, Pennsylvania, 18017
Bryn Mawr Hospital
Bryn Mawr, Pennsylvania, 19010
Christiana Care Health System-Concord Health Center
Chadds Ford, Pennsylvania, 19317
Main Line Health Center-Collegeville
Collegeville, Pennsylvania, 19426
Geisinger Medical Center
Danville, Pennsylvania, 17822
Pocono Medical Center
East Stroudsburg, Pennsylvania, 18301
Saint Luke's Hospital-Anderson Campus
Easton, Pennsylvania, 18045
Main Line Health Center-Exton
Exton, Pennsylvania, 19341
Lehigh Valley Hospital-Hazleton
Hazleton, Pennsylvania, 18201
Riddle Memorial Hospital
Media, Pennsylvania, 19063
Paoli Memorial Hospital
Paoli, Pennsylvania, 19301
University of Pennsylvania/Abramson Cancer Center
Philadelphia, Pennsylvania, 19104
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107
Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111
Saint Luke's Hospital - Upper Bucks Campus
Quakertown, Pennsylvania, 18951
Saint Luke's Hospital-Quakertown Campus
Quakertown, Pennsylvania, 18951
Saint Luke's Hospital - Monroe Campus
Stroudsburg, Pennsylvania, 18360
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania, 18711
Lankenau Medical Center
Wynnewood, Pennsylvania, 19096
Smilow Cancer Hospital Care Center - Westerly
Westerly, Rhode Island, 02891
Prisma Health Cancer Institute - Spartanburg
Boiling Springs, South Carolina, 29316
Roper Hospital
Charleston, South Carolina, 29401
Bon Secours Saint Francis Hospital
Charleston, South Carolina, 29414
Prisma Health Cancer Institute - Laurens
Clinton, South Carolina, 29325
Prisma Health Richland Hospital
Columbia, South Carolina, 29203
Prisma Health Baptist Hospital
Columbia, South Carolina, 29220
Prisma Health Cancer Institute - Easley
Easley, South Carolina, 29640
Tidelands Georgetown Memorial Hospital
Georgetown, South Carolina, 29440
Prisma Health Cancer Institute - Butternut
Greenville, South Carolina, 29605
Prisma Health Cancer Institute - Faris
Greenville, South Carolina, 29605
Prisma Health Greenville Memorial Hospital
Greenville, South Carolina, 29605
Prisma Health Cancer Institute - Eastside
Greenville, South Carolina, 29615
Prisma Health Cancer Institute - Greer
Greer, South Carolina, 29650
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina, 29672
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota, 57104
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, 57117-5134
University of Tennessee - Knoxville
Knoxville, Tennessee, 37920
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee, 38120
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, 37232
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, 75390
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas, 77030
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78229
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, 84112
Central Vermont Medical Center/National Life Cancer Treatment
Berlin Corners, Vermont, 05602
University of Vermont Medical Center
Burlington, Vermont, 05401
University of Vermont and State Agricultural College
Burlington, Vermont, 05405
Inova Alexandria Hospital
Alexandria, Virginia, 22304
University of Virginia Cancer Center
Charlottesville, Virginia, 22908
Inova Schar Cancer Institute
Fairfax, Virginia, 22031
Inova Fair Oaks Hospital
Fairfax, Virginia, 22033
Inova Fairfax Hospital
Falls Church, Virginia, 22042
Inova Loudoun Hospital
Leesburg, Virginia, 20176
Sentara Norfolk General Hospital
Norfolk, Virginia, 23507
VCU Massey Cancer Center at Stony Point
Richmond, Virginia, 23235
VCU Massey Comprehensive Cancer Center
Richmond, Virginia, 23298
Carilion Roanoke Memorial Hospital
Roanoke, Virginia, 24033
Valley Health / Winchester Medical Center
Winchester, Virginia, 22601
Providence Regional Cancer System-Aberdeen
Aberdeen, Washington, 98520
PeaceHealth Saint Joseph Medical Center
Bellingham, Washington, 98225
Providence Regional Cancer System-Centralia
Centralia, Washington, 98531
Swedish Cancer Institute-Edmonds
Edmonds, Washington, 98026
Providence Regional Cancer Partnership
Everett, Washington, 98201
Swedish Cancer Institute-Issaquah
Issaquah, Washington, 98029
Kadlec Clinic Hematology and Oncology
Kennewick, Washington, 99336
Providence Regional Cancer System-Lacey
Lacey, Washington, 98503
PeaceHealth Saint John Medical Center
Longview, Washington, 98632
Skagit Regional Health Cancer Care Center
Mount Vernon, Washington, 98274
Virginia Mason Medical Center
Seattle, Washington, 98101
Pacific Gynecology Specialists
Seattle, Washington, 98104
Swedish Medical Center-Ballard Campus
Seattle, Washington, 98107
Swedish Medical Center-Cherry Hill
Seattle, Washington, 98122-5711
Swedish Medical Center-First Hill
Seattle, Washington, 98122
PeaceHealth United General Medical Center
Sedro-Woolley, Washington, 98284
Providence Regional Cancer System-Shelton
Shelton, Washington, 98584
Cancer Care Northwest - Spokane South
Spokane, Washington, 99202
Cancer Care Northwest-Valley
Spokane, Washington, 99216
Cancer Care Northwest-North Spokane
Spokane, Washington, 99218
PeaceHealth Southwest Medical Center
Vancouver, Washington, 98664
Providence Saint Mary Regional Cancer Center
Walla Walla, Washington, 99362
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima, Washington, 98902
Providence Regional Cancer System-Yelm
Yelm, Washington, 98597
United Hospital Center
Bridgeport, West Virginia, 26330
WVUH-Berkely Medical Center
Martinsburg, West Virginia, 25401
West Virginia University Healthcare
Morgantown, West Virginia, 26506
Camden Clark Medical Center
Parkersburg, West Virginia, 26101
Aurora Cancer Care-Southern Lakes VLCC
Burlington, Wisconsin, 53105
Aurora Saint Luke's South Shore
Cudahy, Wisconsin, 53110
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin, 54701
Aurora Health Care Germantown Health Center
Germantown, Wisconsin, 53022
Aurora Cancer Care-Grafton
Grafton, Wisconsin, 53024
Aurora BayCare Medical Center
Green Bay, Wisconsin, 54311
Mercyhealth Hospital and Cancer Center - Janesville
Janesville, Wisconsin, 53548
Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin, 53142
Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison, Wisconsin, 53718
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, 53792
Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin, 54143
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin, 54449
Aurora Cancer Care-Milwaukee
Milwaukee, Wisconsin, 53209
Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin, 53215
Aurora Sinai Medical Center
Milwaukee, Wisconsin, 53233
Marshfield Medical Center - Minocqua
Minocqua, Wisconsin, 54548
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin, 54904
Aurora Cancer Care-Racine
Racine, Wisconsin, 53406
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin, 54868
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin, 53081
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin, 54482
Aurora Medical Center in Summit
Summit, Wisconsin, 53066
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin, 54241
Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin, 53226
Aurora West Allis Medical Center
West Allis, Wisconsin, 53227
Marshfield Medical Center - Weston
Weston, Wisconsin, 54476
References
- Weinberg DS, Gatsonis C, Zeh HJ, Carlos RC, O'Dwyer PJ; EA2185 Team. Comparing the clinical impact of pancreatic cyst surveillance programs: A trial of the ECOG-ACRIN cancer research group (EA2185). Contemp Clin Trials. 2020 Oct;97:106144. doi: 10.1016/j.cct.2020.106144. Epub 2020 Sep 10.(PubMed)