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RecruitingInterventionalPhase 2

A Randomized Phase 2 Trial of Encorafenib + Binimetinib + Nivolumab vs Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

NCT ID: NCT04511013Sponsor: SWOG Cancer Research NetworkLast updated: 2025-09-11

Summary

This phase II trial compares the effect of encorafenib, binimetinib, and nivolumab versus ipilimumab and nivolumab in treating patients with BRAF- V600 mutant melanoma that has spread to the brain (brain metastases). Encorafenib and binimetinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Ipilimumab and nivolumab are monoclonal antibodies that may interfere with the ability of tumor cells to grow and spread. This trial aims to find out which approach is more effective in shrinking and controlling brain metastases from melanoma.

Detailed description

PRIMARY OBJECTIVE: I. To compare progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 between participants randomized to the triplet combination of encorafenib + binimetinib + nivolumab versus the doublet combination of ipilimumab + nivolumab among participants with BRAF-V600 mutant melanoma that has metastasized to the brain. SECONDARY OBJECTIVES: I. To estimate the overall survival (OS) of participants in each treatment arm. II. To estimate the objective response rate (ORR) (confirmed and unconfirmed, complete and partial responses) per RECIST 1.1 in each treatment arm. III. To estimate the intracranial response rate (ICRR), defined as confirmed and unconfirmed complete and partial response per modified RECIST for brain metastases (mRECIST). IV. To evaluate the duration of response, per RECIST 1.1 and the duration of ICRR per mRECIST, and per Response Assessment in Neuro-Oncology (RANO)-Brain Metastases (BM) (and immunotherapy \[i\]RANO) in each treatment arm. V. To evaluate the toxicity profile of each treatment arm. VI. To evaluate current and emerging radiographic response criteria (modified RECIST 1.1, modified RANO-BM and iRANO) by a retrospective blinded independent centralized review (BICR) of banked images. BANKING OBJECTIVE: I. To bank tumor tissue, cerebral spinal fluid (CSF), stool and blood samples for future correlative studies. OUTLINE: Patients are randomized to 1 of 2 arms. ARM I: Patients receive encorafenib orally (PO) once daily (QD) on days 1-28, binimetinib PO twice daily (BID) on days 1-28, and nivolumab intravenously (IV) on day 1. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. ARM II: Patients receive nivolumab IV on day 1 of all cycles and ipilimumab IV over 30 minutes on day 1 of cycles 1-4. Cycles repeat every 21 days for 4 cycles and then every 28 days in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up every 6 months for 2 years, and then annually until 3 years after randomization.

Arms & interventions

  • DrugBinimetinib

    Given PO

  • DrugEncorafenib

    Given PO

  • BiologicalIpilimumab

    Given IV

  • BiologicalNivolumab

    Given IV

Outcome measures

Primary

  • Progression-free survival

    Will be assessed by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1.

    Time frame: From date of registration to date of first documentation of progression, or symptomatic deterioration, or death due to any cause, assessed up to 3 years after randomization

Secondary

  • Overall survival (OS)

    Time frame: From date of registration to date of death due to any cause, assessed up to 3 years after randomization

  • Intracranial response rate (ICRR)

    Time frame: Up to 3 years after randomization

  • Objective response rate

    Time frame: Up to 3 years after randomization

  • Duration of response

    Time frame: Up to 3 years after randomization

Eligibility criteria

Sex: AllAge: 18 Years and olderHealthy volunteers: No
Inclusion Criteria: * Participants must have histologically and pathologically confirmed melanoma that has metastasized to the brain * Any primary (cutaneous, acral/mucosal, etc) or unknown origin are permitted, except that participants with uveal primary are not eligible * Participants must have BRAF-V600 mutant melanoma documented by a Clinical Laboratory Improvement Act (CLIA)-certified laboratory * All participants must have an magnetic resonance imaging (MRI) of the brain within 28 days prior to registration and must have central nervous system metastases with at least one measurable brain metastasis \>= 0.5 cm in size (per modified RECIST 1.1) that has not been irradiated, or progressed (in the opinion of the treating physician) after prior radiation therapy. Participating sites MUST use MRI slice thickness of =\< 1.5 mm and are recommended to adhere to the 'minimum' Brain Tumor Imaging Protocol for Clinical Trials in Brain Metastases (BTIP-BM) compliant MRI acquisition protocol. Computed tomography (CT) of the head cannot substitute for brain MRI. (NOTE: All central nervous system \[CNS\] disease must be documented on BOTH the Brain Metastases Baseline Tumor Assessment Form, using modified RECIST, and the Baseline Tumor Assessment Form \[RECIST 1.1\] using RECIST 1.1.) * Participants may have measurable or non-measurable extracranial disease. All measurable disease must be assessed within 28 days prior to randomization; all non-measurable disease must be assessed within 42 days prior to randomization. Please note, while any extracranial disease will also be assessed and followed, participants are NOT required to have extracranial disease for randomization. NOTE: All disease must be assessed and documented on the Baseline Tumor Assessment Form (RECIST 1.1). CNS disease must be documented on BOTH the Brain Metastases Baseline Tumor Assessment Form, using modified RECIST, and the Baseline Tumor Assessment Form (RECIST 1.1) using RECIST 1.1 * Participants may have leptomeningeal disease * Participants may be receiving corticosteroids for brain metastases at a dose of up to 8 mg of dexamethasone per day. The dose must not have exceeded 8 mg per day for at least 7 days prior to randomization * Participants must have Zubrod performance status =\< 2 * Participants must have complete history and physical examination within 28 days prior to randomization * Participants must be able to swallow and retain pills * Hemoglobin \>= 8.0 g/dL (within 28 days prior to randomization) * Absolute neutrophil count \>= 1,500/mcL (within 28 days prior to randomization) * Platelets \>= 75,000/mcL (within 28 days prior to randomization) * Total bilirubin =\< 1.5 institutional upper limit of normal (ULN) (within 28 days prior to randomization) * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =\< 2.5 x institutional ULN (in participants with liver metastases =\< 5 x ULN) (within 28 days prior to randomization) * Creatinine =\< 2.0 institutional ULN (within 28 days prior to randomization) * Participants with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, must have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, participants must be class 2B or better * Participants with a prior or concurrent malignancy whose natural history or treatment (in the opinion of the treating physician) does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial * Participants with known human immunodeficiency virus (HIV)-infection are eligible providing they are on effective anti-retroviral therapy and have undetectable viral load at their most recent viral load test and within 90 days prior to randomization * Participants with a known history of hepatitis C virus (HCV) infection must have been treated and cured. Participants with HCV infection who are currently on treatment must have an undetectable HCV viral load prior to randomization * Participants must agree to participate in image banking. Images must be submitted via the Triad System * Participants must be offered the opportunity to participate in specimen and blood collections * Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines * As a part of the OPEN registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system Exclusion Criteria: * Participants must not have received prior systemic therapy for metastatic disease. Prior systemic therapy received only in the neoadjuvant and/or adjuvant setting (e.g., BRAF/MEK inhibitor therapy, anti-PD-1 therapy or anti-CTLA4 therapy, alfa-interferon, etc.) is permitted. If patients received prior neoadjuvant/adjuvant therapy, they must have had eventual disease relapse prior to randomization * Participants must not have had prior radiation therapy within 7 days prior to randomization * Participants must not be planning to require any additional form of systemic anti-tumor therapy for melanoma while on protocol treatment * Participants must not be planning to use hormonal contraceptives * Participants must not have a serious active infection requiring systemic therapy at time of randomization in the opinion of the treating physician * Participants must not have active autoimmune disease that has required treatment in the past 6 months with use of biologic disease modifying agents (.e.g. infliximab, adalimumab). Patients on non-biologic disease modifying agents (e.g. methotrexate) or patients on corticosteroids =\< 10 mg prednisone daily or equivalent (to treat auto-immune disease), or on replacement therapy (e.g., thyroxine, insulin) are eligible if deemed in the best interest of the patient by treating physician * Participants must not have had grade 3 or 4 immune-related adverse events on ipilimumab or nivolumab that required more than 12 weeks of immune suppression with corticosteroids * Participants must not have had adverse events related to encorafenib and/or binimetinib specifically, that required discontinuation of one or both drugs. (Please note this does not apply to other BRAF/MEK inhibitor drugs.) * Participants must not be pregnant or nursing. Women/men of reproductive potential must have agreed to use an effective method of contraception. (NOTE: Patients must agree to not use hormonal contraceptives, as encorafenib can result in decreased concentration and loss of efficacy.) A woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate participant chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures

Study locations (331)

University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233

Recruiting
Site Public Contact · Contact
205-934-0220tmyrick@uab.edu
Maya Khalil · Principal Investigator

Thomas Hospital

Fairhope, Alabama, 36532

Recruiting
Site Public Contact · Contact
251-435-4584
Furhan Yunus · Principal Investigator

Mobile Infirmary Medical Center

Mobile, Alabama, 36607

Recruiting
Site Public Contact · Contact
251-435-3942
Furhan Yunus · Principal Investigator

Anchorage Associates in Radiation Medicine

Anchorage, Alaska, 98508

Recruiting
Site Public Contact · Contact
907-212-6871AKPAMC.OncologyResearchSupport@providence.org
Charles W. Drescher · Principal Investigator

Anchorage Radiation Therapy Center

Anchorage, Alaska, 99504

Recruiting
Site Public Contact · Contact
907-212-6871AKPAMC.OncologyResearchSupport@providence.org
Charles W. Drescher · Principal Investigator

Alaska Breast Care and Surgery LLC

Anchorage, Alaska, 99508

Recruiting
Site Public Contact · Contact
907-212-6871AKPAMC.OncologyResearchSupport@providence.org
Charles W. Drescher · Principal Investigator

Alaska Oncology and Hematology LLC

Anchorage, Alaska, 99508

Recruiting
Site Public Contact · Contact
907-212-6871AKPAMC.OncologyResearchSupport@providence.org
Charles W. Drescher · Principal Investigator

Alaska Women's Cancer Care

Anchorage, Alaska, 99508

Recruiting
Site Public Contact · Contact
907-212-6871AKPAMC.OncologyResearchSupport@providence.org
Charles W. Drescher · Principal Investigator

Anchorage Oncology Centre

Anchorage, Alaska, 99508

Recruiting
Site Public Contact · Contact
907-212-6871AKPAMC.OncologyResearchSupport@providence.org
Charles W. Drescher · Principal Investigator

Katmai Oncology Group

Anchorage, Alaska, 99508

Recruiting
Site Public Contact · Contact
907-212-6871AKPAMC.OncologyResearchSupport@providence.org
Charles W. Drescher · Principal Investigator

Providence Alaska Medical Center

Anchorage, Alaska, 99508

Recruiting
Site Public Contact · Contact
907-212-6871AKPAMC.OncologyResearchSupport@providence.org
Charles W. Drescher · Principal Investigator

Fairbanks Memorial Hospital

Fairbanks, Alaska, 99701

Recruiting
Site Public Contact · Contact
907-458-3043Veronica.Stevenson@foundationhealth.org
Nicholas DiBella · Principal Investigator

Mercy Hospital Fort Smith

Fort Smith, Arkansas, 72903

Recruiting
Site Public Contact · Contact
800-378-9373
Jay W. Carlson · Principal Investigator

Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, 91505

Recruiting
Site Public Contact · Contact
818-847-4793Najee.Boucher@providence.org
Charles W. Drescher · Principal Investigator

Epic Care-Dublin

Dublin, California, 94568

Recruiting
Site Public Contact · Contact
925-875-1677
Lisa Bailey · Principal Investigator

Bay Area Breast Surgeons Inc

Emeryville, California, 94608

Recruiting
Site Public Contact · Contact
510-835-9900
Lisa Bailey · Principal Investigator

Epic Care Partners in Cancer Care

Emeryville, California, 94608

Recruiting
Site Public Contact · Contact
510-629-6682
Lisa Bailey · Principal Investigator

UCLA / Jonsson Comprehensive Cancer Center

Los Angeles, California, 90095

Recruiting
Site Public Contact · Contact
888-798-0719
Bartosz Chmielowski · Principal Investigator

Contra Costa Regional Medical Center

Martinez, California, 94553-3156

Recruiting
Site Public Contact · Contact
925-957-5400
Lisa Bailey · Principal Investigator

Providence Queen of The Valley

Napa, California, 94558

Recruiting
Site Public Contact · Contact
707-521-3830
Charles W. Drescher · Principal Investigator

Alta Bates Summit Medical Center - Summit Campus

Oakland, California, 94609

Suspended

Bay Area Tumor Institute

Oakland, California, 94609

Recruiting
Site Public Contact · Contact
510-465-2242lradke@bati.org
Lisa Bailey · Principal Investigator

Sharp Memorial Hospital

San Diego, California, 92123

Recruiting
Site Public Contact · Contact
858-939-5062cathy.wood@sharp.com
Charles H. Redfern · Principal Investigator

Providence Medical Foundation - Santa Rosa

Santa Rosa, California, 95403

Recruiting
Site Public Contact · Contact
707-521-3830
Charles W. Drescher · Principal Investigator

Providence Santa Rosa Memorial Hospital

Santa Rosa, California, 95405

Recruiting
Site Public Contact · Contact
707-521-3830
Charles W. Drescher · Principal Investigator

Epic Care Cyberknife Center

Walnut Creek, California, 94597

Recruiting
Site Public Contact · Contact
510-465-8016somega@bati.org
Lisa Bailey · Principal Investigator

Rocky Mountain Cancer Centers-Aurora

Aurora, Colorado, 80012

Recruiting
Site Public Contact · Contact
303-777-2663info@westernstatesncorp.org
Nicholas DiBella · Principal Investigator

The Medical Center of Aurora

Aurora, Colorado, 80012

Suspended

University of Colorado Hospital

Aurora, Colorado, 80045

Recruiting
Site Public Contact · Contact
720-848-0650
Theresa M. Medina · Principal Investigator

Boulder Community Foothills Hospital

Boulder, Colorado, 80303

Recruiting
Site Public Contact · Contact
303-777-2663info@westernstatesncorp.org
Nicholas DiBella · Principal Investigator

Rocky Mountain Cancer Centers-Boulder

Boulder, Colorado, 80304

Recruiting
Site Public Contact · Contact
303-777-2663info@westernstatesncorp.org
Nicholas DiBella · Principal Investigator

Rocky Mountain Cancer Centers - Centennial

Centennial, Colorado, 80112

Recruiting
Site Public Contact · Contact
303-777-2663info@westernstatesncorp.org
Nicholas DiBella · Principal Investigator

The Women's Imaging Center

Denver, Colorado, 80209

Recruiting
Site Public Contact · Contact
303-777-2663info@westernstatesncorp.org
Nicholas DiBella · Principal Investigator

Colorado Blood Cancer Institute

Denver, Colorado, 80218

Recruiting
Site Public Contact · Contact
303-777-2663info@westernstatesncorp.org
Nicholas DiBella · Principal Investigator

Presbyterian - Saint Lukes Medical Center - Health One

Denver, Colorado, 80218

Recruiting
Site Public Contact · Contact
303-777-2663info@westernstatesncorp.org
Nicholas DiBella · Principal Investigator

Rocky Mountain Cancer Centers-Midtown

Denver, Colorado, 80218

Recruiting
Site Public Contact · Contact
303-777-2663info@westernstatesncorp.org
Nicholas DiBella · Principal Investigator

Rocky Mountain Cancer Centers-Rose

Denver, Colorado, 80220

Recruiting
Site Public Contact · Contact
303-777-2663info@westernstatesncorp.org
Nicholas DiBella · Principal Investigator

Rose Medical Center

Denver, Colorado, 80220

Suspended

Western Surgical Care

Denver, Colorado, 80220

Suspended

Mountain Blue Cancer Care Center - Swedish

Englewood, Colorado, 80113

Recruiting
Site Public Contact · Contact
303-777-2663info@westernstatesncorp.org
Nicholas DiBella · Principal Investigator

Rocky Mountain Cancer Centers - Swedish

Englewood, Colorado, 80113

Recruiting
Site Public Contact · Contact
303-777-2663info@westernstatesncorp.org
Nicholas DiBella · Principal Investigator

Swedish Medical Center

Englewood, Colorado, 80113

Recruiting
Site Public Contact · Contact
303-777-2663info@westernstatesncorp.org
Nicholas DiBella · Principal Investigator

The Melanoma and Skin Cancer Institute

Englewood, Colorado, 80113

Recruiting
Site Public Contact · Contact
ryan.weight@theskincancerinstitute.com
Nicholas DiBella · Principal Investigator

North Colorado Medical Center

Greeley, Colorado, 80631

Suspended

Rocky Mountain Cancer Centers-Lakewood

Lakewood, Colorado, 80228

Recruiting
Site Public Contact · Contact
303-777-2663info@westernstatesncorp.org
Nicholas DiBella · Principal Investigator

Rocky Mountain Cancer Centers-Littleton

Littleton, Colorado, 80120

Recruiting
Site Public Contact · Contact
303-777-2663info@westernstatesncorp.org
Nicholas DiBella · Principal Investigator

Rocky Mountain Cancer Centers-Sky Ridge

Lone Tree, Colorado, 80124

Recruiting
Site Public Contact · Contact
303-777-2663info@westernstatesncorp.org
Nicholas DiBella · Principal Investigator

Sky Ridge Medical Center

Lone Tree, Colorado, 80124

Suspended

McKee Medical Center

Loveland, Colorado, 80539

Suspended

Rocky Mountain Cancer Centers-Thornton

Thornton, Colorado, 80260

Recruiting
Site Public Contact · Contact
303-777-2663info@westernstatesncorp.org
Nicholas DiBella · Principal Investigator

UM Sylvester Comprehensive Cancer Center at Aventura

Aventura, Florida, 33180

Active Not Recruiting

UM Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables, Florida, 33146

Active Not Recruiting

UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, 33442

Active Not Recruiting

University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136

Active Not Recruiting

UM Sylvester Comprehensive Cancer Center at Kendall

Miami, Florida, 33176

Active Not Recruiting

Orlando Health Cancer Institute

Orlando, Florida, 32806

Recruiting
Site Public Contact · Contact
321-841-7246CancerClinicalTrials@orlandohealth.com
Sajeve S. Thomas · Principal Investigator

UM Sylvester Comprehensive Cancer Center at Plantation

Plantation, Florida, 33324

Active Not Recruiting

Moffitt Cancer Center-International Plaza

Tampa, Florida, 33607

Recruiting
Site Public Contact · Contact
800-679-0775ClinicalTrials@moffitt.org
Zeynep Eroglu · Principal Investigator

Moffitt Cancer Center - McKinley Campus

Tampa, Florida, 33612

Recruiting
Site Public Contact · Contact
800-679-0775ClinicalTrials@moffitt.org
Zeynep Eroglu · Principal Investigator

Moffitt Cancer Center

Tampa, Florida, 33612

Recruiting
Site Public Contact · Contact
800-679-0775ClinicalTrials@moffitt.org
Zeynep Eroglu · Principal Investigator

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405

Active Not Recruiting

Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, 83706

Recruiting
Site Public Contact · Contact
734-712-3671stephanie.couch@stjoeshealth.org
John M. Schallenkamp · Principal Investigator

Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712

Recruiting
Site Public Contact · Contact
208-381-2774eslinget@slhs.org
Charles W. Drescher · Principal Investigator

Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, 83605

Recruiting
Site Public Contact · Contact
734-712-3671stephanie.couch@stjoeshealth.org
John M. Schallenkamp · Principal Investigator

Kootenai Health - Coeur d'Alene

Coeur d'Alene, Idaho, 83814

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Walter Knox Memorial Hospital

Emmett, Idaho, 83617

Recruiting
Site Public Contact · Contact
734-712-3671stephanie.couch@stjoeshealth.org
John M. Schallenkamp · Principal Investigator

Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, 83619

Recruiting
Site Public Contact · Contact
208-381-2774eslinget@slhs.org
Charles W. Drescher · Principal Investigator

Idaho Urologic Institute-Meridian

Meridian, Idaho, 83642

Recruiting
Site Public Contact · Contact
734-712-3671stephanie.couch@stjoeshealth.org
John M. Schallenkamp · Principal Investigator

Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642

Recruiting
Site Public Contact · Contact
208-381-2774eslinget@slhs.org
Charles W. Drescher · Principal Investigator

Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83686

Recruiting
Site Public Contact · Contact
208-381-2774eslinget@slhs.org
Charles W. Drescher · Principal Investigator

Saint Alphonsus Cancer Care Center-Nampa

Nampa, Idaho, 83687

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, 83854

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Kootenai Cancer Clinic

Sandpoint, Idaho, 83864

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301

Recruiting
Site Public Contact · Contact
208-381-2774eslinget@slhs.org
Charles W. Drescher · Principal Investigator

Saint Anthony's Health

Alton, Illinois, 62002

Recruiting
Site Public Contact · Contact
618-463-5623
Jay W. Carlson · Principal Investigator

Rush - Copley Medical Center

Aurora, Illinois, 60504

Recruiting
Site Public Contact · Contact
630-978-6212Cancer.Research@rushcopley.com
Maria T. Grosse-Perdekamp · Principal Investigator

Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Canton

Canton, Illinois, 61520

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Memorial Hospital of Carbondale

Carbondale, Illinois, 62902

Recruiting
Site Public Contact · Contact
618-457-5200clinical.research@sih.net
Bryan A. Faller · Principal Investigator

SIH Cancer Institute

Carterville, Illinois, 62918

Recruiting
Site Public Contact · Contact
618-985-3333clinical.research@sih.net
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Carthage

Carthage, Illinois, 62321

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Centralia Oncology Clinic

Centralia, Illinois, 62801

Recruiting
Site Public Contact · Contact
217-876-4762morganthaler.jodi@mhsil.com
Bryan A. Faller · Principal Investigator

Saint Mary's Hospital

Centralia, Illinois, 62801

Recruiting
Site Public Contact · Contact
protocols@swog.org
Jay W. Carlson · Principal Investigator

Northwestern University

Chicago, Illinois, 60611

Active Not Recruiting

Carle at The Riverfront

Danville, Illinois, 61832

Recruiting
Site Public Contact · Contact
800-446-5532Research@Carle.com
Maria T. Grosse-Perdekamp · Principal Investigator

Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526

Recruiting
Site Public Contact · Contact
217-876-4762morganthaler.jodi@mhsil.com
Bryan A. Faller · Principal Investigator

Decatur Memorial Hospital

Decatur, Illinois, 62526

Recruiting
Site Public Contact · Contact
217-876-4762morganthaler.jodi@mhsil.com
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Dixon

Dixon, Illinois, 61021

Recruiting
Site Public Contact · Contact
815-285-7800
Bryan A. Faller · Principal Investigator

Carle Physician Group-Effingham

Effingham, Illinois, 62401

Recruiting
Site Public Contact · Contact
800-446-5532Research@carle.com
Maria T. Grosse-Perdekamp · Principal Investigator

Crossroads Cancer Center

Effingham, Illinois, 62401

Recruiting
Site Public Contact · Contact
217-876-4762morganthaler.jodi@mhsil.com
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Eureka

Eureka, Illinois, 61530

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Western Illinois Cancer Treatment Center

Galesburg, Illinois, 61401

Recruiting
Site Public Contact · Contact
309-344-2831
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Northwestern Medicine Lake Forest Hospital

Lake Forest, Illinois, 60045

Active Not Recruiting

Illinois CancerCare-Macomb

Macomb, Illinois, 61455

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Good Samaritan Regional Health Center

Mount Vernon, Illinois, 62864

Recruiting
Site Public Contact · Contact
618-242-4600
Jay W. Carlson · Principal Investigator

Cancer Care Center of O'Fallon

O'Fallon, Illinois, 62269

Recruiting
Site Public Contact · Contact
217-876-4762morganthaler.jodi@mhsil.com
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Pekin

Pekin, Illinois, 61554

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Peoria

Peoria, Illinois, 61615

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Methodist Medical Center of Illinois

Peoria, Illinois, 61636

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Peru

Peru, Illinois, 61354

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Valley Radiation Oncology

Peru, Illinois, 61354

Recruiting
Site Public Contact · Contact
815-664-4141
Bryan A. Faller · Principal Investigator

Illinois CancerCare-Princeton

Princeton, Illinois, 61356

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Southern Illinois University School of Medicine

Springfield, Illinois, 62702

Recruiting
Site Public Contact · Contact
217-545-7929
Bryan A. Faller · Principal Investigator

Springfield Clinic

Springfield, Illinois, 62702

Recruiting
Site Public Contact · Contact
800-444-7541
Bryan A. Faller · Principal Investigator

Memorial Medical Center

Springfield, Illinois, 62781

Recruiting
Site Public Contact · Contact
217-528-7541pallante.beth@mhsil.com
Bryan A. Faller · Principal Investigator

Southwest Illinois Health Services LLP

Swansea, Illinois, 62226

Suspended

Carle Cancer Center

Urbana, Illinois, 61801

Recruiting
Site Public Contact · Contact
800-446-5532Research@carle.com
Maria T. Grosse-Perdekamp · Principal Investigator

The Carle Foundation Hospital

Urbana, Illinois, 61801

Recruiting
Site Public Contact · Contact
800-446-5532Research@carle.com
Maria T. Grosse-Perdekamp · Principal Investigator

Illinois CancerCare - Washington

Washington, Illinois, 61571

Recruiting
Site Public Contact · Contact
309-243-3605andersonj@illinoiscancercare.com
Bryan A. Faller · Principal Investigator

Rush-Copley Healthcare Center

Yorkville, Illinois, 60560

Recruiting
Site Public Contact · Contact
630-978-6212Cancer.Research@rushcopley.com
Maria T. Grosse-Perdekamp · Principal Investigator

Reid Health

Richmond, Indiana, 47374

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Howard M. Gross · Principal Investigator

Mary Greeley Medical Center

Ames, Iowa, 50010

Recruiting
Site Public Contact · Contact
515-956-4132
Joseph J. Merchant · Principal Investigator

McFarland Clinic - Ames

Ames, Iowa, 50010

Recruiting
Site Public Contact · Contact
515-239-4734ksoder@mcfarlandclinic.com
Joseph J. Merchant · Principal Investigator

McFarland Clinic - Boone

Boone, Iowa, 50036

Recruiting
Site Public Contact · Contact
515-956-4132
Joseph J. Merchant · Principal Investigator

Saint Anthony Regional Hospital

Carroll, Iowa, 51401

Recruiting
Site Public Contact · Contact
515-689-7658sbenson@iora.org
Joshua Lukenbill · Principal Investigator

Iowa Methodist Medical Center

Des Moines, Iowa, 50309

Recruiting
Site Public Contact · Contact
515-241-6727
Joshua Lukenbill · Principal Investigator

Medical Oncology and Hematology Associates-Des Moines

Des Moines, Iowa, 50309

Recruiting
Site Public Contact · Contact
515-241-3305
Joshua Lukenbill · Principal Investigator

Broadlawns Medical Center

Des Moines, Iowa, 50314

Recruiting
Site Public Contact · Contact
515-282-2200
Joshua Lukenbill · Principal Investigator

Iowa Lutheran Hospital

Des Moines, Iowa, 50316

Recruiting
Site Public Contact · Contact
515-241-8704
Joshua Lukenbill · Principal Investigator

McFarland Clinic - Trinity Cancer Center

Fort Dodge, Iowa, 50501

Recruiting
Site Public Contact · Contact
515-956-4132
Joseph J. Merchant · Principal Investigator

Trinity Regional Medical Center

Fort Dodge, Iowa, 50501

Recruiting
Site Public Contact · Contact
515-574-8302
Joshua Lukenbill · Principal Investigator

McFarland Clinic - Jefferson

Jefferson, Iowa, 50129

Recruiting
Site Public Contact · Contact
515-956-4132
Joseph J. Merchant · Principal Investigator

McFarland Clinic - Marshalltown

Marshalltown, Iowa, 50158

Recruiting
Site Public Contact · Contact
515-956-4132
Joseph J. Merchant · Principal Investigator

Methodist West Hospital

West Des Moines, Iowa, 50266-7700

Recruiting
Site Public Contact · Contact
515-343-1000
Joshua Lukenbill · Principal Investigator

Central Care Cancer Center - Garden City

Garden City, Kansas, 67846

Recruiting
Site Public Contact · Contact
913-948-5588aroland@kccop.org
Jay W. Carlson · Principal Investigator

Central Care Cancer Center - Great Bend

Great Bend, Kansas, 67530

Recruiting
Site Public Contact · Contact
913-948-5588aroland@kccop.org
Jay W. Carlson · Principal Investigator

Mercy Health - Paducah Medical Oncology and Hematology

Paducah, Kentucky, 42003

Recruiting
Site Public Contact · Contact
270-538-5632BJWarner@mercy.com
Nicholas DiBella · Principal Investigator

University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, 48109

Recruiting
Site Public Contact · Contact
800-865-1125
Christopher D. Lao · Principal Investigator

Bronson Battle Creek

Battle Creek, Michigan, 49017

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen J. Yost · Principal Investigator

University of Michigan - Brighton Center for Specialty Care

Brighton, Michigan, 48116

Recruiting
Site Public Contact · Contact
800-865-1125
Christopher D. Lao · Principal Investigator

Helen DeVos Children's Hospital at Spectrum Health

Grand Rapids, Michigan, 49503

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen J. Yost · Principal Investigator

Spectrum Health at Butterworth Campus

Grand Rapids, Michigan, 49503

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen J. Yost · Principal Investigator

Trinity Health Grand Rapids Hospital

Grand Rapids, Michigan, 49503

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen J. Yost · Principal Investigator

Bronson Methodist Hospital

Kalamazoo, Michigan, 49007

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen J. Yost · Principal Investigator

West Michigan Cancer Center

Kalamazoo, Michigan, 49007

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen J. Yost · Principal Investigator

Ascension Borgess Cancer Center

Kalamazoo, Michigan, 49009

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen J. Yost · Principal Investigator

Borgess Medical Center

Kalamazoo, Michigan, 49048

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen J. Yost · Principal Investigator

Trinity Health Muskegon Hospital

Muskegon, Michigan, 49444

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen J. Yost · Principal Investigator

Lakeland Hospital Niles

Niles, Michigan, 49120

Recruiting
Site Public Contact · Contact
616-391-1230
Kathleen J. Yost · Principal Investigator

Cancer and Hematology Centers of Western Michigan - Norton Shores

Norton Shores, Michigan, 49444

Recruiting
Site Public Contact · Contact
616-391-1230connie.szczepanek@crcwm.org
Kathleen J. Yost · Principal Investigator

Spectrum Health Reed City Hospital

Reed City, Michigan, 49677

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen J. Yost · Principal Investigator

Lakeland Medical Center Saint Joseph

Saint Joseph, Michigan, 49085

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen J. Yost · Principal Investigator

Marie Yeager Cancer Center

Saint Joseph, Michigan, 49085

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen J. Yost · Principal Investigator

Munson Medical Center

Traverse City, Michigan, 49684

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen J. Yost · Principal Investigator

University of Michigan Health - West

Wyoming, Michigan, 49519

Recruiting
Site Public Contact · Contact
616-391-1230crcwm-regulatory@crcwm.org
Kathleen J. Yost · Principal Investigator

Fairview Ridges Hospital

Burnsville, Minnesota, 55337

Suspended

Minnesota Oncology - Burnsville

Burnsville, Minnesota, 55337

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Cambridge Medical Center

Cambridge, Minnesota, 55008

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Mercy Hospital

Coon Rapids, Minnesota, 55433

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Fairview Southdale Hospital

Edina, Minnesota, 55435

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Unity Hospital

Fridley, Minnesota, 55432

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Fairview Clinics and Surgery Center Maple Grove

Maple Grove, Minnesota, 55369

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Hennepin County Medical Center

Minneapolis, Minnesota, 55415

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Health Partners Inc

Minneapolis, Minnesota, 55454

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Monticello Cancer Center

Monticello, Minnesota, 55362

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

New Ulm Medical Center

New Ulm, Minnesota, 56073

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Fairview Northland Medical Center

Princeton, Minnesota, 55371

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Regions Hospital

Saint Paul, Minnesota, 55101

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

United Hospital

Saint Paul, Minnesota, 55102

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Saint Francis Regional Medical Center

Shakopee, Minnesota, 55379

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Lakeview Hospital

Stillwater, Minnesota, 55082

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Ridgeview Medical Center

Waconia, Minnesota, 55387

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Rice Memorial Hospital

Willmar, Minnesota, 56201

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, 55125

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Fairview Lakes Medical Center

Wyoming, Minnesota, 55092

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Saint Louis Cancer and Breast Institute-Ballwin

Ballwin, Missouri, 63011

Recruiting
Site Public Contact · Contact
314-251-7058
Jay W. Carlson · Principal Investigator

Central Care Cancer Center - Bolivar

Bolivar, Missouri, 65613

Recruiting
Site Public Contact · Contact
913-948-5588aroland@kccop.org
Jay W. Carlson · Principal Investigator

Cox Cancer Center Branson

Branson, Missouri, 65616

Recruiting
Site Public Contact · Contact
417-269-4520
Jay W. Carlson · Principal Investigator

Saint Francis Medical Center

Cape Girardeau, Missouri, 63703

Recruiting
Site Public Contact · Contact
573-334-2230sfmc@sfmc.net
Bryan A. Faller · Principal Investigator

Southeast Cancer Center

Cape Girardeau, Missouri, 63703

Recruiting
Site Public Contact · Contact
573-651-5550
Bryan A. Faller · Principal Investigator

Parkland Health Center - Farmington

Farmington, Missouri, 63640

Recruiting
Site Public Contact · Contact
314-996-5569
Bryan A. Faller · Principal Investigator

Capital Region Southwest Campus

Jefferson City, Missouri, 65109

Recruiting
Site Public Contact · Contact
573-632-4814swooden@mail.crmc.org
Bryan A. Faller · Principal Investigator

Freeman Health System

Joplin, Missouri, 64804

Recruiting
Site Public Contact · Contact
417-347-4030LJCrockett@freemanhealth.com
Jay W. Carlson · Principal Investigator

Mercy Hospital Joplin

Joplin, Missouri, 64804

Recruiting
Site Public Contact · Contact
417-556-3074esmeralda.carrillo@mercy.net
Jay W. Carlson · Principal Investigator

Delbert Day Cancer Institute at PCRMC

Rolla, Missouri, 65401

Recruiting
Site Public Contact · Contact
573-458-7504research@phelpshealth.org
Jay W. Carlson · Principal Investigator

Mercy Clinic-Rolla-Cancer and Hematology

Rolla, Missouri, 65401

Recruiting
Site Public Contact · Contact
573-458-6379
Jay W. Carlson · Principal Investigator

Heartland Regional Medical Center

Saint Joseph, Missouri, 64506

Recruiting
Site Public Contact · Contact
816-271-7937linda.schumacher@mymlc.com
Jay W. Carlson · Principal Investigator

Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, 63670

Recruiting
Site Public Contact · Contact
314-996-5569
Bryan A. Faller · Principal Investigator

Mercy Hospital Springfield

Springfield, Missouri, 65804

Recruiting
Site Public Contact · Contact
417-269-4520
Jay W. Carlson · Principal Investigator

CoxHealth South Hospital

Springfield, Missouri, 65807

Recruiting
Site Public Contact · Contact
417-269-4520
Jay W. Carlson · Principal Investigator

Saint Louis Cancer and Breast Institute-South City

St Louis, Missouri, 63109

Recruiting
Site Public Contact · Contact
314-353-1870
Jay W. Carlson · Principal Investigator

Mercy Hospital South

St Louis, Missouri, 63128

Recruiting
Site Public Contact · Contact
janet.lesko@mercy.net
Jay W. Carlson · Principal Investigator

Missouri Baptist Medical Center

St Louis, Missouri, 63131

Recruiting
Site Public Contact · Contact
314-996-5569
Bryan A. Faller · Principal Investigator

Mercy Hospital Saint Louis

St Louis, Missouri, 63141

Recruiting
Site Public Contact · Contact
314-251-7066
Jay W. Carlson · Principal Investigator

Missouri Baptist Sullivan Hospital

Sullivan, Missouri, 63080

Recruiting
Site Public Contact · Contact
314-996-5569
Bryan A. Faller · Principal Investigator

Missouri Baptist Outpatient Center-Sunset Hills

Sunset Hills, Missouri, 63127

Recruiting
Site Public Contact · Contact
314-996-5569
Bryan A. Faller · Principal Investigator

Mercy Hospital Washington

Washington, Missouri, 63090

Recruiting
Site Public Contact · Contact
636-390-1600
Jay W. Carlson · Principal Investigator

Community Hospital of Anaconda

Anaconda, Montana, 59711

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Billings Clinic Cancer Center

Billings, Montana, 59101

Recruiting
Site Public Contact · Contact
800-996-2663research@billingsclinic.org
John M. Schallenkamp · Principal Investigator

Bozeman Deaconess Hospital

Bozeman, Montana, 59715

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Benefis Healthcare- Sletten Cancer Institute

Great Falls, Montana, 59405

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Great Falls Clinic

Great Falls, Montana, 59405

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Kalispell Regional Medical Center

Kalispell, Montana, 59901

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Saint Patrick Hospital - Community Hospital

Missoula, Montana, 59802

Recruiting
Site Public Contact · Contact
406-327-3118amy.hanneman@providence.org
Charles W. Drescher · Principal Investigator

Community Medical Hospital

Missoula, Montana, 59804

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Cancer Partners of Nebraska - Pine Lake

Lincoln, Nebraska, 68516

Recruiting
Site Public Contact · Contact
402-327-7363research@cancerpartners.com
Joni A. Tilford · Principal Investigator

Southeast Nebraska Cancer Center - 68th Street Place

Lincoln, Nebraska, 68516

Recruiting
Site Public Contact · Contact
402-327-7363research@cancerpartners.com
Joni A. Tilford · Principal Investigator

Roswell Park Cancer Institute

Buffalo, New York, 14263

Active Not Recruiting

Wake Forest University at Clemmons

Clemmons, North Carolina, 27012

Recruiting
Site Public Contact · Contact
888-716-9259
Pierre L. Triozzi · Principal Investigator

Southeastern Medical Oncology Center-Clinton

Clinton, North Carolina, 28328

Recruiting
Site Public Contact · Contact
919-587-9084jfields@cancersmoc.com
Samer S. Kasbari · Principal Investigator

Southeastern Medical Oncology Center-Goldsboro

Goldsboro, North Carolina, 27534

Recruiting
Site Public Contact · Contact
919-587-9084jfields@cancersmoc.com
Samer S. Kasbari · Principal Investigator

Southeastern Medical Oncology Center-Jacksonville

Jacksonville, North Carolina, 28546

Recruiting
Site Public Contact · Contact
910-587-9084jfields@cancersmoc.com
Samer S. Kasbari · Principal Investigator

Wake Forest Baptist Health - Hematology Oncology - Statesville

Statesville, North Carolina, 28677

Recruiting
Site Public Contact · Contact
704-872-3630
Pierre L. Triozzi · Principal Investigator

Wake Forest Baptist Health - Wilkes Medical Center

Wilkesboro, North Carolina, 28659

Recruiting
Site Public Contact · Contact
888-716-9253
Pierre L. Triozzi · Principal Investigator

Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157

Recruiting
Site Public Contact · Contact
336-713-6771
Pierre L. Triozzi · Principal Investigator

UHHS-Chagrin Highlands Medical Center

Beachwood, Ohio, 44122

Recruiting
Site Public Contact · Contact
800-641-2422CTUReferral@UHhospitals.org
Ankit Mangla · Principal Investigator

Indu and Raj Soin Medical Center

Beavercreek, Ohio, 45431

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Howard M. Gross · Principal Investigator

Strecker Cancer Center-Belpre

Belpre, Ohio, 45714

Recruiting
Site Public Contact · Contact
800-523-3977sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

Saint Elizabeth Boardman Hospital

Boardman, Ohio, 44512

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Howard M. Gross · Principal Investigator

Dayton Physicians LLC-Miami Valley South

Centerville, Ohio, 45459

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Howard M. Gross · Principal Investigator

Miami Valley Hospital South

Centerville, Ohio, 45459

Suspended

Geauga Hospital

Chardon, Ohio, 44024

Recruiting
Site Public Contact · Contact
800-641-2422CTUReferral@UHhospitals.org
Ankit Mangla · Principal Investigator

Adena Regional Medical Center

Chillicothe, Ohio, 45601

Recruiting
Site Public Contact · Contact
877-779-7585sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, 45219

Active Not Recruiting

Oncology Hematology Care Inc-Kenwood

Cincinnati, Ohio, 45236

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Howard M. Gross · Principal Investigator

Case Western Reserve University

Cleveland, Ohio, 44106

Recruiting
Site Public Contact · Contact
800-641-2422CTUReferral@UHhospitals.org
Ankit Mangla · Principal Investigator

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210

Recruiting
Site Public Contact · Contact
800-293-5066Jamesline@osumc.edu
Kari L. Kendra · Principal Investigator

Mount Carmel East Hospital

Columbus, Ohio, 43213

Recruiting
Site Public Contact · Contact
614-488-2118sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

Columbus Oncology and Hematology Associates Inc

Columbus, Ohio, 43214

Recruiting
Site Public Contact · Contact
614-488-2118sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

Riverside Methodist Hospital

Columbus, Ohio, 43214

Recruiting
Site Public Contact · Contact
614-566-4475sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

Grant Medical Center

Columbus, Ohio, 43215

Recruiting
Site Public Contact · Contact
614-566-4475sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

The Mark H Zangmeister Center

Columbus, Ohio, 43219

Recruiting
Site Public Contact · Contact
614-488-2118sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

Mount Carmel Health Center West

Columbus, Ohio, 43222

Recruiting
Site Public Contact · Contact
614-234-5433sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

Doctors Hospital

Columbus, Ohio, 43228

Recruiting
Site Public Contact · Contact
614-566-3275sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

Miami Valley Hospital

Dayton, Ohio, 45409

Suspended

Dayton Physician LLC-Miami Valley Hospital North

Dayton, Ohio, 45415

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Howard M. Gross · Principal Investigator

Miami Valley Hospital North

Dayton, Ohio, 45415

Suspended

Delaware Health Center-Grady Cancer Center

Delaware, Ohio, 43015

Recruiting
Site Public Contact · Contact
740-615-0227sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

Grady Memorial Hospital

Delaware, Ohio, 43015

Recruiting
Site Public Contact · Contact
740-615-2403sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

Columbus Oncology and Hematology Associates

Dublin, Ohio, 43016

Recruiting
Site Public Contact · Contact
614-566-3275sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

Dublin Methodist Hospital

Dublin, Ohio, 43016

Recruiting
Site Public Contact · Contact
800-752-9119sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

Armes Family Cancer Center

Findlay, Ohio, 45840

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Howard M. Gross · Principal Investigator

Blanchard Valley Hospital

Findlay, Ohio, 45840

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Howard M. Gross · Principal Investigator

Orion Cancer Care

Findlay, Ohio, 45840

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Howard M. Gross · Principal Investigator

Atrium Medical Center-Middletown Regional Hospital

Franklin, Ohio, 45005-1066

Suspended

Dayton Physicians LLC-Atrium

Franklin, Ohio, 45005

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Howard M. Gross · Principal Investigator

Central Ohio Breast and Endocrine Surgery

Gahanna, Ohio, 43230

Recruiting
Site Public Contact · Contact
614-488-2745sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

Dayton Physicians LLC-Wayne

Greenville, Ohio, 45331

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Howard M. Gross · Principal Investigator

Wayne Hospital

Greenville, Ohio, 45331

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Howard M. Gross · Principal Investigator

Mount Carmel Grove City Hospital

Grove City, Ohio, 43123

Recruiting
Site Public Contact · Contact
877-779-7585sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

Zangmeister Center Grove City

Grove City, Ohio, 43123

Recruiting
Site Public Contact · Contact
614-488-2745sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

Greater Dayton Cancer Center

Kettering, Ohio, 45409

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Howard M. Gross · Principal Investigator

Kettering Medical Center

Kettering, Ohio, 45429

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Howard M. Gross · Principal Investigator

Fairfield Medical Center

Lancaster, Ohio, 43130

Recruiting
Site Public Contact · Contact
740-687-8863sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

Saint Rita's Medical Center

Lima, Ohio, 45801

Recruiting
Site Public Contact · Contact
419-226-9617
Timothy D. Moore · Principal Investigator

OhioHealth Mansfield Hospital

Mansfield, Ohio, 44903

Recruiting
Site Public Contact · Contact
419-526-8018sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

Marietta Memorial Hospital

Marietta, Ohio, 45750

Recruiting
Site Public Contact · Contact
800-523-3977sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

OhioHealth Marion General Hospital

Marion, Ohio, 43302

Recruiting
Site Public Contact · Contact
614-488-2118sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

UH Seidman Cancer Center at Southwest General Hospital

Middleburg Heights, Ohio, 44130

Recruiting
Site Public Contact · Contact
800-641-2422CTUReferral@UHhospitals.org
Ankit Mangla · Principal Investigator

Knox Community Hospital

Mount Vernon, Ohio, 43050

Recruiting
Site Public Contact · Contact
740-393-9000sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

Mount Carmel New Albany Surgical Hospital

New Albany, Ohio, 43054

Recruiting
Site Public Contact · Contact
614-488-2745sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

Licking Memorial Hospital

Newark, Ohio, 43055

Recruiting
Site Public Contact · Contact
740-348-4000sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

Newark Radiation Oncology

Newark, Ohio, 43055

Recruiting
Site Public Contact · Contact
614-488-2118sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

University Hospitals Parma Medical Center

Parma, Ohio, 44129

Recruiting
Site Public Contact · Contact
800-641-2422CTUReferral@UHhospitals.org
Ankit Mangla · Principal Investigator

Mercy Health Perrysburg Cancer Center

Perrysburg, Ohio, 43551

Recruiting
Site Public Contact · Contact
614-488-2118sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

Southern Ohio Medical Center

Portsmouth, Ohio, 45662

Recruiting
Site Public Contact · Contact
614-488-2118sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

University Hospitals Portage Medical Center

Ravenna, Ohio, 44266

Recruiting
Site Public Contact · Contact
800-641-2422CTUReferral@UHhospitals.org
Ankit Mangla · Principal Investigator

UH Seidman Cancer Center at Firelands Regional Medical Center

Sandusky, Ohio, 44870

Recruiting
Site Public Contact · Contact
800-641-2422CTUReferral@UHhospitals.org
Ankit Mangla · Principal Investigator

Springfield Regional Cancer Center

Springfield, Ohio, 45504

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Timothy D. Moore · Principal Investigator

Springfield Regional Medical Center

Springfield, Ohio, 45505

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Timothy D. Moore · Principal Investigator

Saint Vincent Mercy Medical Center

Toledo, Ohio, 43608

Recruiting
Site Public Contact · Contact
614-488-2118sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

Mercy Health - Saint Anne Hospital

Toledo, Ohio, 43623

Recruiting
Site Public Contact · Contact
614-488-2118sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

Dayton Physicians LLC - Troy

Troy, Ohio, 45373

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Howard M. Gross · Principal Investigator

Upper Valley Medical Center

Troy, Ohio, 45373

Suspended

University Hospitals Sharon Health Center

Wadsworth, Ohio, 44281

Recruiting
Site Public Contact · Contact
800-641-2422CTUReferral@UHhospitals.org
Ankit Mangla · Principal Investigator

Saint Joseph Warren Hospital

Warren, Ohio, 44484

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Howard M. Gross · Principal Investigator

University of Cincinnati Cancer Center-West Chester

West Chester, Ohio, 45069

Active Not Recruiting

Saint Ann's Hospital

Westerville, Ohio, 43081

Recruiting
Site Public Contact · Contact
614-234-5433sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

UH Seidman Cancer Center at Saint John Medical Center

Westlake, Ohio, 44145

Recruiting
Site Public Contact · Contact
800-641-2422CTUReferral@UHhospitals.org
Ankit Mangla · Principal Investigator

Saint Elizabeth Youngstown Hospital

Youngstown, Ohio, 44501

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Howard M. Gross · Principal Investigator

Genesis Healthcare System Cancer Care Center

Zanesville, Ohio, 43701

Recruiting
Site Public Contact · Contact
740-454-5232sheree@columbusccop.org
Timothy D. Moore · Principal Investigator

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104

Recruiting
Site Public Contact · Contact
405-271-8777ou-clinical-trials@ouhsc.edu
Abdul Rafeh Naqash · Principal Investigator

Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, 73120

Recruiting
Site Public Contact · Contact
405-752-3402
Jay W. Carlson · Principal Investigator

Saint Alphonsus Medical Center-Baker City

Baker City, Oregon, 97814

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Saint Charles Health System

Bend, Oregon, 97701

Recruiting
Site Public Contact · Contact
541-706-2909nosall@stcharleshealthcare.org
Charles W. Drescher · Principal Investigator

Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015

Recruiting
Site Public Contact · Contact
503-215-2614CanRsrchStudies@providence.org
Charles W. Drescher · Principal Investigator

Providence Cancer Institute Clackamas Clinic

Clackamas, Oregon, 97015

Recruiting
Site Public Contact · Contact
503-215-2614CanRsrchStudies@providence.org
Charles W. Drescher · Principal Investigator

Bay Area Hospital

Coos Bay, Oregon, 97420

Recruiting
Site Public Contact · Contact
541-269-8392cherie.cox@bayareahospital.org
Charles W. Drescher · Principal Investigator

Providence Newberg Medical Center

Newberg, Oregon, 97132

Recruiting
Site Public Contact · Contact
503-215-2614CanRsrchStudies@providence.org
Charles W. Drescher · Principal Investigator

Saint Alphonsus Medical Center-Ontario

Ontario, Oregon, 97914

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Providence Willamette Falls Medical Center

Oregon City, Oregon, 97045

Recruiting
Site Public Contact · Contact
503-215-2614CanRsrchStudies@providence.org
Charles W. Drescher · Principal Investigator

Providence Portland Medical Center

Portland, Oregon, 97213

Recruiting
Site Public Contact · Contact
503-215-2614CanRsrchStudies@providence.org
Charles W. Drescher · Principal Investigator

Providence Saint Vincent Medical Center

Portland, Oregon, 97225

Recruiting
Site Public Contact · Contact
503-215-2614CanRsrchStudies@providence.org
Charles W. Drescher · Principal Investigator

Saint Charles Health System-Redmond

Redmond, Oregon, 97756

Recruiting
Site Public Contact · Contact
541-706-2909
Charles W. Drescher · Principal Investigator

University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, 15232

Recruiting
Site Public Contact · Contact
412-647-8073
Yana Najjar · Principal Investigator

Avera Cancer Institute

Sioux Falls, South Dakota, 57105

Active Not Recruiting

Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112

Recruiting
Site Public Contact · Contact
888-424-2100cancerinfo@hci.utah.edu
Joanne M. Jeter · Principal Investigator

Providence Regional Cancer System-Aberdeen

Aberdeen, Washington, 98520

Recruiting
Site Public Contact · Contact
360-412-8958deidre.dillon@providence.org
Charles W. Drescher · Principal Investigator

PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, 98225

Recruiting
Site Public Contact · Contact
360-788-8223
Charles W. Drescher · Principal Investigator

Providence Regional Cancer System-Centralia

Centralia, Washington, 98531

Recruiting
Site Public Contact · Contact
360-412-8958deidre.dillon@providence.org
Charles W. Drescher · Principal Investigator

Swedish Cancer Institute-Edmonds

Edmonds, Washington, 98026

Recruiting
Site Public Contact · Contact
206-215-3086PCRC-NCORP@Swedish.org
Charles W. Drescher · Principal Investigator

Providence Regional Cancer Partnership

Everett, Washington, 98201

Recruiting
Site Public Contact · Contact
425-261-3529marilyn.birchman@providence.org
Charles W. Drescher · Principal Investigator

Swedish Cancer Institute-Issaquah

Issaquah, Washington, 98029

Recruiting
Site Public Contact · Contact
206-215-3086PCRC-NCORP@Swedish.org
Charles W. Drescher · Principal Investigator

Kadlec Clinic Hematology and Oncology

Kennewick, Washington, 99336

Recruiting
Site Public Contact · Contact
509-783-4637research@kadlecmed.org
Charles W. Drescher · Principal Investigator

Providence Regional Cancer System-Lacey

Lacey, Washington, 98503

Recruiting
Site Public Contact · Contact
360-412-8958deidre.dillon@providence.org
Charles W. Drescher · Principal Investigator

PeaceHealth Saint John Medical Center

Longview, Washington, 98632

Recruiting
Site Public Contact · Contact
360-514-2016kmakin-bond@peacehealth.org
Charles W. Drescher · Principal Investigator

Jefferson Healthcare

Port Townsend, Washington, 98368

Recruiting
Site Public Contact · Contact
360-344-3091
Nicholas DiBella · Principal Investigator

Pacific Gynecology Specialists

Seattle, Washington, 98104

Suspended

Swedish Medical Center-Ballard Campus

Seattle, Washington, 98107

Recruiting
Site Public Contact · Contact
206-215-3086PCRC-NCORP@Swedish.org
Charles W. Drescher · Principal Investigator

Swedish Medical Center-Cherry Hill

Seattle, Washington, 98122-5711

Recruiting
Site Public Contact · Contact
206-215-3086PCRC-NCORP@Swedish.org
Charles W. Drescher · Principal Investigator

Swedish Medical Center-First Hill

Seattle, Washington, 98122

Recruiting
Site Public Contact · Contact
206-215-3086PCRC-NCORP@Swedish.org
Charles W. Drescher · Principal Investigator

PeaceHealth United General Medical Center

Sedro-Woolley, Washington, 98284

Recruiting
Site Public Contact · Contact
360-788-8238lkey@peacehealth.org
Charles W. Drescher · Principal Investigator

Providence Regional Cancer System-Shelton

Shelton, Washington, 98584

Recruiting
Site Public Contact · Contact
360-412-8958deidre.dillon@providence.org
Charles W. Drescher · Principal Investigator

PeaceHealth Southwest Medical Center

Vancouver, Washington, 98664

Recruiting
Site Public Contact · Contact
360-514-3940kmakin-bond@peacehealth.org
Charles W. Drescher · Principal Investigator

Providence Saint Mary Regional Cancer Center

Walla Walla, Washington, 99362

Recruiting
Site Public Contact · Contact
509-897-5993Cheryl.Dodd@providence.org
Charles W. Drescher · Principal Investigator

Providence Regional Cancer System-Yelm

Yelm, Washington, 98597

Recruiting
Site Public Contact · Contact
360-412-8958deidre.dillon@providence.org
Charles W. Drescher · Principal Investigator

Langlade Hospital and Cancer Center

Antigo, Wisconsin, 54409

Recruiting
Site Public Contact · Contact
715-623-9869Juli.Alford@aspirus.org
Andrew J. Huang · Principal Investigator

Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Chady A. Leon · Principal Investigator

Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601

Recruiting
Site Public Contact · Contact
608-775-2385cancerctr@gundersenhealth.org
David E. Marinier · Principal Investigator

University of Wisconsin Carbone Cancer Center

Madison, Wisconsin, 53792

Recruiting
Site Public Contact · Contact
800-622-8922
Vincent T. Ma · Principal Investigator

Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Chady A. Leon · Principal Investigator

Aspirus Medford Hospital

Medford, Wisconsin, 54451

Recruiting
Site Public Contact · Contact
715-847-2353Beth.Knetter@aspirus.org
Andrew J. Huang · Principal Investigator

Marshfield Clinic-Minocqua Center

Minocqua, Wisconsin, 54548

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Chady A. Leon · Principal Investigator

Cancer Center of Western Wisconsin

New Richmond, Wisconsin, 54017

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
David M. King · Principal Investigator

Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Chady A. Leon · Principal Investigator

Ascension Saint Michael's Hospital

Stevens Point, Wisconsin, 54481

Recruiting
Site Public Contact · Contact
715-847-2353Beth.Knetter@aspirus.org
Andrew J. Huang · Principal Investigator

Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Chady A. Leon · Principal Investigator

Aspirus Regional Cancer Center

Wausau, Wisconsin, 54401

Recruiting
Site Public Contact · Contact
877-405-6866
Andrew J. Huang · Principal Investigator

Marshfield Medical Center - Weston

Weston, Wisconsin, 54476

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Chady A. Leon · Principal Investigator

Aspirus Cancer Care - Wisconsin Rapids

Wisconsin Rapids, Wisconsin, 54494

Recruiting
Site Public Contact · Contact
715-422-7718
Andrew J. Huang · Principal Investigator

Cheyenne Regional Medical Center-West

Cheyenne, Wyoming, 82001

Recruiting
Site Public Contact · Contact
303-777-2663ccrp@co-cancerresearch.org
Nicholas DiBella · Principal Investigator

Billings Clinic-Cody

Cody, Wyoming, 82414

Recruiting
Site Public Contact · Contact
800-996-2663research@billingsclinic.org
John M. Schallenkamp · Principal Investigator

Welch Cancer Center

Sheridan, Wyoming, 82801

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator