Specimen Banking With Clinical and Genomic Data Registry With the Establishment of Tumor Models for Pediatric Cancers

Primary

• Create a data registry of clinical and molecular/genomic data

  Create a data registry of clinical and molecular/genomic data from cancer patients who have undergone biopsy or surgical resection for clinical care to better understand the relationship between genomic and molecular information and clinical outcomes.

  Time frame: 10 Years

• Determine number and types of genomic alterations within tumor types/subtypes

  Define genomic landscape of pediatric cancers through the determination of the number and types of genomic alterations within tumor types/subtypes, across tumor types, and tumor evolution over time.

  Time frame: 10 Years

• Evaluate the rate of actionable genomic alternations

  Evaluate the rate of actionable genomic alternations resulting in associated targeted therapies relative to all actionable genomic alterations.

  Time frame: 10 Years

• Evaluate the correlation of baseline genomic alterations with clinical outcome.

  Evaluate the correlation of baseline genomic alterations with clinical outcome.

  Time frame: 10 Years

• Identify biomarkers that predict risk of adverse outcomes that occur following pediatric cancer therapy.

  Identify biomarkers that predict risk of adverse outcomes that occur following pediatric cancer therapy.

  Time frame: 10 Years