Pediatric Acute Leukemia (PedAL) Screening Trial - Developing New Therapies for Relapsed Leukemias
Summary
This study aims to use clinical and biological characteristics of acute leukemias to screen for patient eligibility for available pediatric leukemia sub-trials. Testing bone marrow and blood from patients with leukemia that has come back after treatment or is difficult to treat may provide information about the patient's leukemia that is important when deciding how to best treat it, and may help doctors find better ways to diagnose and treat leukemia in children, adolescents, and young adults.
Detailed description
PRIMARY OBJECTIVES: I. To utilize clinical and biological characteristics of acute leukemias to screen for patient eligibility for available phase I/II Pediatric Acute Leukemia (PedAL) sub-trials. II. To maintain a longitudinal and comprehensive registry, as well as a specimen bank, from relapse in children and young adults with acute leukemias. OUTLINE: Patients undergo collection of blood and/or bone marrow samples at baseline, end of treatment cycle(s), and at relapse/refractory disease status (if applicable). After completion of study, patients are followed up every 3 months for 2 years, and then every 6 months for 3 years.
Arms & interventions
- ProcedureBiospecimen Collection
Undergo collection of blood and/or bone marrow samples
Outcome measures
Primary
Proportion of patients with identification of a priori specified genomic and immunophenotypic targets who enroll on a sub-trial
The proportion will be calculated as the percent of eligible patients who are identified to have an a priori specified genomic or immunophenotypic target and who enroll on at least one of the sub-trials. The corresponding confidence interval will be constructed.
Time frame: Up to 5 years
Maintain a longitudinal and comprehensive registry, as well as specimen bank of children and young adults with acute leukemias
The number of patients with at least one specimen submitted to the bank will be reported.
Time frame: Up to 5 years
Eligibility criteria
Study locations (164)
Children's Hospital of Alabama
Birmingham, Alabama, 35233
USA Health Strada Patient Care Center
Mobile, Alabama, 36604
Providence Alaska Medical Center
Anchorage, Alaska, 99508
Banner Children's at Desert
Mesa, Arizona, 85202
Phoenix Childrens Hospital
Phoenix, Arizona, 85016
Banner University Medical Center - Tucson
Tucson, Arizona, 85719
Arkansas Children's Hospital
Little Rock, Arkansas, 72202-3591
Kaiser Permanente Downey Medical Center
Downey, California, 90242
Loma Linda University Medical Center
Loma Linda, California, 92354
Miller Children's and Women's Hospital Long Beach
Long Beach, California, 90806
Children's Hospital Los Angeles
Los Angeles, California, 90027
Valley Children's Hospital
Madera, California, 93636
UCSF Benioff Children's Hospital Oakland
Oakland, California, 94609
Kaiser Permanente-Oakland
Oakland, California, 94611
Children's Hospital of Orange County
Orange, California, 92868
Lucile Packard Children's Hospital Stanford University
Palo Alto, California, 94304
Rady Children's Hospital - San Diego
San Diego, California, 92123
UCSF Medical Center-Mission Bay
San Francisco, California, 94158
Children's Hospital Colorado
Aurora, Colorado, 80045
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center
Denver, Colorado, 80218
Connecticut Children's Medical Center
Hartford, Connecticut, 06106
Yale University
New Haven, Connecticut, 06520
Alfred I duPont Hospital for Children
Wilmington, Delaware, 19803
MedStar Georgetown University Hospital
Washington D.C., District of Columbia, 20007
Children's National Medical Center
Washington D.C., District of Columbia, 20010
Broward Health Medical Center
Fort Lauderdale, Florida, 33316
Golisano Children's Hospital of Southwest Florida
Fort Myers, Florida, 33908
UF Health Cancer Institute - Gainesville
Gainesville, Florida, 32610
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood, Florida, 33021
Nemours Children's Clinic-Jacksonville
Jacksonville, Florida, 32207
Nicklaus Children's Hospital
Miami, Florida, 33155
Arnold Palmer Hospital for Children
Orlando, Florida, 32806
Nemours Children's Hospital
Orlando, Florida, 32827
Nemours Children's Clinic - Pensacola
Pensacola, Florida, 32504
Sacred Heart Hospital
Pensacola, Florida, 32504
Johns Hopkins All Children's Hospital
St. Petersburg, Florida, 33701
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa, Florida, 33607
Saint Mary's Medical Center
West Palm Beach, Florida, 33407
Children's Healthcare of Atlanta - Arthur M Blank Hospital
Atlanta, Georgia, 30329
Memorial Health University Medical Center
Savannah, Georgia, 31404
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii, 96826
Saint Luke's Cancer Institute - Boise
Boise, Idaho, 83712
Lurie Children's Hospital-Chicago
Chicago, Illinois, 60611
University of Illinois
Chicago, Illinois, 60612
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, 60637
Loyola University Medical Center
Maywood, Illinois, 60153
Advocate Children's Hospital-Oak Lawn
Oak Lawn, Illinois, 60453
Advocate Children's Hospital-Park Ridge
Park Ridge, Illinois, 60068
Saint Jude Midwest Affiliate
Peoria, Illinois, 61637
Southern Illinois University School of Medicine
Springfield, Illinois, 62702
Northwestern Medicine Central DuPage Hospital
Winfield, Illinois, 60190
Riley Hospital for Children
Indianapolis, Indiana, 46202
Ascension Saint Vincent Indianapolis Hospital
Indianapolis, Indiana, 46260
Blank Children's Hospital
Des Moines, Iowa, 50309
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa, 52242
University of Kentucky/Markey Cancer Center
Lexington, Kentucky, 40536
Norton Children's Hospital
Louisville, Kentucky, 40202
Children's Hospital New Orleans
New Orleans, Louisiana, 70118
Ochsner Medical Center Jefferson
New Orleans, Louisiana, 70121
Eastern Maine Medical Center
Bangor, Maine, 04401
Maine Children's Cancer Program
Scarborough, Maine, 04074
Sinai Hospital of Baltimore
Baltimore, Maryland, 21215
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, 21287
Walter Reed National Military Medical Center
Bethesda, Maryland, 20889-5600
Dana-Farber Cancer Institute
Boston, Massachusetts, 02215
C S Mott Children's Hospital
Ann Arbor, Michigan, 48109
Children's Hospital of Michigan
Detroit, Michigan, 48201
Michigan State University
East Lansing, Michigan, 48823
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
Grand Rapids, Michigan, 49503
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007
Corewell Health Children's
Royal Oak, Michigan, 48073
Children's Hospitals and Clinics of Minnesota - Minneapolis
Minneapolis, Minnesota, 55404
University of Minnesota/Masonic Cancer Center
Minneapolis, Minnesota, 55455
Mayo Clinic in Rochester
Rochester, Minnesota, 55905
University of Mississippi Medical Center
Jackson, Mississippi, 39216
University of Missouri Children's Hospital
Columbia, Missouri, 65212
Children's Mercy Hospitals and Clinics
Kansas City, Missouri, 64108
Cardinal Glennon Children's Medical Center
St Louis, Missouri, 63104
Washington University School of Medicine
St Louis, Missouri, 63110
Mercy Hospital Saint Louis
St Louis, Missouri, 63141
Children's Hospital and Medical Center of Omaha
Omaha, Nebraska, 68114
University of Nebraska Medical Center
Omaha, Nebraska, 68198
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas, Nevada, 89135
Summerlin Hospital Medical Center
Las Vegas, Nevada, 89144
Renown Regional Medical Center
Reno, Nevada, 89502
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire, 03756
Hackensack University Medical Center
Hackensack, New Jersey, 07601
Morristown Medical Center
Morristown, New Jersey, 07960
Jersey Shore Medical Center
Neptune City, New Jersey, 07753
Saint Peter's University Hospital
New Brunswick, New Jersey, 08901
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
New Brunswick, New Jersey, 08903
Saint Joseph's Regional Medical Center
Paterson, New Jersey, 07503
University of New Mexico Cancer Center
Albuquerque, New Mexico, 87106
Albany Medical Center
Albany, New York, 12208
Maimonides Medical Center
Brooklyn, New York, 11219
NYU Langone Hospital - Long Island
Mineola, New York, 11501
The Steven and Alexandra Cohen Children's Medical Center of New York
New Hyde Park, New York, 11040
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York, 10016
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York, 10032
Memorial Sloan Kettering Cancer Center
New York, New York, 10065
University of Rochester
Rochester, New York, 14642
Stony Brook University Medical Center
Stony Brook, New York, 11794
State University of New York Upstate Medical University
Syracuse, New York, 13210
Montefiore Medical Center - Moses Campus
The Bronx, New York, 10467
New York Medical College
Valhalla, New York, 10595
Mission Hospital
Asheville, North Carolina, 28801
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, 27599
Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina, 28203
Novant Health Presbyterian Medical Center
Charlotte, North Carolina, 28204
Duke University Medical Center
Durham, North Carolina, 27710
East Carolina University
Greenville, North Carolina, 27834
Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157
Sanford Broadway Medical Center
Fargo, North Dakota, 58122
Children's Hospital Medical Center of Akron
Akron, Ohio, 44308
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229
Rainbow Babies and Childrens Hospital
Cleveland, Ohio, 44106
Cleveland Clinic Foundation
Cleveland, Ohio, 44195
Nationwide Children's Hospital
Columbus, Ohio, 43205
Dayton Children's Hospital
Dayton, Ohio, 45404
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo, Ohio, 43606
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104
Legacy Emanuel Children's Hospital
Portland, Oregon, 97227
Oregon Health and Science University
Portland, Oregon, 97239
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania, 18103
Geisinger Medical Center
Danville, Pennsylvania, 17822
Penn State Children's Hospital
Hershey, Pennsylvania, 17033
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104
Saint Christopher's Hospital for Children
Philadelphia, Pennsylvania, 19134
Children's Hospital of Pittsburgh of UPMC
Pittsburgh, Pennsylvania, 15224
Rhode Island Hospital
Providence, Rhode Island, 02903
Medical University of South Carolina
Charleston, South Carolina, 29425
Prisma Health Richland Hospital
Columbia, South Carolina, 29203
BI-LO Charities Children's Cancer Center
Greenville, South Carolina, 29605
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, 57117-5134
East Tennessee Childrens Hospital
Knoxville, Tennessee, 37916
Saint Jude Children's Research Hospital
Memphis, Tennessee, 38105
The Children's Hospital at TriStar Centennial
Nashville, Tennessee, 37203
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, 37232
Dell Children's Medical Center of Central Texas
Austin, Texas, 78723
Driscoll Children's Hospital
Corpus Christi, Texas, 78411
Medical City Dallas Hospital
Dallas, Texas, 75230
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, 75390
El Paso Children's Hospital
El Paso, Texas, 79905
Cook Children's Medical Center
Fort Worth, Texas, 76104
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas, 77030
M D Anderson Cancer Center
Houston, Texas, 77030
Covenant Children's Hospital
Lubbock, Texas, 79410
UMC Cancer Center / UMC Health System
Lubbock, Texas, 79415
Children's Hospital of San Antonio
San Antonio, Texas, 78207
Methodist Children's Hospital of South Texas
San Antonio, Texas, 78229
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78229
Primary Children's Hospital
Salt Lake City, Utah, 84113
University of Virginia Cancer Center
Charlottesville, Virginia, 22908
Inova Fairfax Hospital
Falls Church, Virginia, 22042
Children's Hospital of The King's Daughters
Norfolk, Virginia, 23507
VCU Massey Comprehensive Cancer Center
Richmond, Virginia, 23298
Carilion Children's
Roanoke, Virginia, 24014
Seattle Children's Hospital
Seattle, Washington, 98105
Providence Sacred Heart Medical Center and Children's Hospital
Spokane, Washington, 99204
Mary Bridge Children's Hospital and Health Center
Tacoma, Washington, 98405
Madigan Army Medical Center
Tacoma, Washington, 98431
West Virginia University Healthcare
Morgantown, West Virginia, 26506
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, 53792
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin, 54449