Patient-centered, Optimal Integration of Survivorship and Palliative Care
Summary
The goal of this study is to develop and test the feasibility of a supportive care model (POISE) for patients with metastatic Non-small Cell Lung Cancer (NSCLC). The main questions are * is POISE feasible to deliver and acceptable to patients * what is the effect of POISE on the distress patients feel related to their uncertain future, their confidence in their ability to manage cancer, and their understanding about what to expect Participants in the randomized controlled trial will receive either the new supportive care model, POISE, which consists of four visits with a trained palliative care clinician, or care as usual, and will be asked to complete three surveys.
Detailed description
This research study involves an intervention consisting of four sessions with palliative care specialists who have been additionally trained to evaluate and address the specific psychosocial issues and health-promoting behaviors of patients with NSCLC. The research study procedures include: * Four 60-minute visits with a trained palliative care clinician * Questionnaires and an exit interview * Chart Review It is expected that about 70 participants currently receiving targeted therapy at Massachusetts General Hospital for lung cancer will take part in this research study: 10 patients in an open pilot study, followed by 60 patients in a randomized controlled trial.
Arms & interventions
- BehavioralPOISE
POISE (Patient-centered, Optimal Integration of Survivorship and palliative carE) is a brief, population-specific intervention that consists of four sessions with palliative care specialists who have been additionally trained to evaluate and address the specific psychosocial issues and health-promoting behaviors of patients with long, uncertain cancer trajectories.
Outcome measures
Primary
Feasibility of POISE - enrollment
≥60% enrollment among eligible patientsamong patients in the POISE group
Time frame: 20 weeks
Feasibility of POISE - completion of all sessions among patients in intervention group
≥70% completion of all sessions in the intervention arm
Time frame: 20 weeks
Feasibility of POISE - completion of surveys in both arms
≥70% completion of all surveys in both arms
Time frame: 20 weeks
Secondary
Acceptability
Time frame: 20 Weeks
Emotional coping with prognosis and prognostic awareness
Time frame: 12 weeks
Emotional coping with prognosis and prognostic awareness
Time frame: 20 weeks
Self efficacy
Time frame: 12 weeks
Self efficacy
Time frame: 20 weeks
Documentation of Goals and Values
Time frame: 20 weeks
Eligibility criteria
Study locations (1)
Massachusetts General Hospital
Boston, Massachusetts, 02115
References
- Richard HA, Sarathy R, Rabideau DJ, Feldman J, Cartagena L, Patel H, Sequist LV, Park E, Jackson V, Greer JA, Temel JS, Petrillo LA. Blended palliative and survivorship care intervention (POISE) for patients with metastatic oncogene-driven non-small cell lung cancer: study protocol for a pilot randomised controlled trial. BMJ Open. 2025 Aug 13;15(8):e098075. doi: 10.1136/bmjopen-2024-098075.(PubMed)