Role of Gut Microbiome in Cancer Therapy
Summary
This study examines how gut microbiome can affect cancer therapy in cancer patients undergoing cancer therapy or stem cell transplant. The human microbiome affects the way some cancer drugs are metabolized in the human body. Information from this study may help doctors improve the way cancer treatment is delivered, and increase its effectiveness and success.
Detailed description
PRIMARY OBJECTIVE: I. To correlate gut microbiome with specific cancer diagnoses and the clinical response (efficacy), and adverse effects of cancer therapy (single or multiple) and stem cell transplant. OUTLINE: Patients undergo collection of blood and stool samples and have their medical records reviewed.
Arms & interventions
- ProcedureBiospecimen Collection
Undergo collection of blood and stool samples
- OtherElectronic Health Record Review
Review of medical records
Outcome measures
Primary
Gut microbiome associations with cancer diagnoses
Will be done using Shogun pipeline for metagenomics data followed by analysis using Quantitative Insights Into Microbial Ecology (QIIME) 2.0.
Time frame: Through study completion, average of 1 year
Associations between microbial community abundances and clinical outcomes
Will use a linear multivariate regression model specifically developed for microbiome data (MaAsLin, Multivariate microbial Association by Linear models.
Time frame: Through study completion, average of 1 year
Eligibility criteria
Study locations (3)
Mayo Clinic in Arizona
Scottsdale, Arizona, 85259
Mayo Clinic in Florida
Jacksonville, Florida, 32224
Mayo Clinic in Rochester
Rochester, Minnesota, 55905