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Aromatherapy Inhaler Use for Hematopoietic Stem Cell Transplant Patient Distress

NCT ID: NCT05302583Sponsor: Stanford UniversityLast updated: 2026-06-02

Summary

This randomized controlled trial will evaluate the feasibility and acceptability of an inhaled aromatherapy stick for patients during the acute inpatient phase after hematopoietic cell transplantation (HCT) . The study will also explore whether aromatherapy use is associated with short-term changes in patient-reported cancer-related distress and coping self-efficacy.

Detailed description

Patients undergoing hematopoietic cell transplantation (HCT) commonly experience high levels of distress and other symptoms during the acute inpatient period. Inhaled aromatherapy is a low-burden, patient-directed supportive care strategy that may be feasible to deliver during hospitalization. This randomized, parallel-group study will evaluate the feasibility and acceptability of an aromatherapy inhaler ("aromatherapy stick") during the early post-transplant inpatient period and will explore short-term changes in patient-reported outcomes.

Arms & interventions

  • OtherAromatherapy Stick

    Participants receive aromatherapy inhaler education and an aromatherapy stick for self-administered inhalation during the early post-transplant inpatient period. Aromatherapy use occurs on the assigned Inhaler Use Day (targeted for Transplant Day +1, +2, or +3) and is documented using an inhaler use log. Total exposure is limited to a maximum of 2 hours.

  • OtherStandard of Care

    Participants receive standard inpatient supportive care during the acute post-HCT period. No aromatherapy inhaler is provided.

Outcome measures

Primary

  • Change in cancer distress (NCCN Distress Thermometer)

    Change in NCCN Distress Thermometer score (0-10 visual analog scale). Calculated as follow-up score minus baseline score.

    Time frame: Baseline: SOC/Inhaler Use Day (Transplant Day +1, +2, or +3); Follow-up: Study Completion Day (Transplant Day +2, +3, or +4)

Secondary

  • Change in cancer coping self-efficacy (Cancer Behavior Inventory-Brief Form, modified)

    Time frame: Baseline: SOC/Inhaler Use Day (Transplant Day +1, +2, or +3); Follow-up: Study Completion Day (Transplant Day +2, +3, or +4)

  • Aromatherapy Inhaler Use Log (Inhaler Use Log)

    Time frame: 1 day (Inhaler Use Day)

  • Aromatherapy experience (Final Evaluation of Aromatherapy)

    Time frame: Study Completion Day (Transplant Day +4, +5, or +6)

Eligibility criteria

Sex: AllAge: 18 Years and olderHealthy volunteers: No
Inclusion Criteria: * Autologous and Allogeneic patients admitted to E1 for planned HSCT * Patients with hematologic malignancies requiring HSCT * No allergies to lavender or peppermint essential oils * Must have received chemotherapy during preparative regimen (single or multi-agent regimen) * Adult patient over 18 years of age * Able to speak, read, and comprehend English * Willing and capable of providing informed consent Exclusion Criteria: * Patients admitted for Chimeric Antigen Receptor T cell (CART) infusion * Patients receiving a transplant for a germ cell tumor diagnosis * Unexpected/unplanned admission (e.g., neutropenic fever, confusion, clinical deterioration) * Immune effector cell-associated neurotoxicity syndrome (ICANS) grade 1 through 4 * History of scleroderma * History of atrial fibrillation * Known history of G6PD deficiency * Allergic to lavender or peppermint essential oils * Pediatric patient 18 years of age or less * Unable to speak, read, and comprehend English * Unwilling or incapable of providing informed consent

Study locations (1)

Stanford University

Stanford, California, 94305

Recruiting
Anna Oh, PhD, MPH, RN · Contact
Anna Oh, PhD, MPH, RN · Principal Investigator
Aromatherapy Inhaler Use for HSCT Distress | Cancerify