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RecruitingObservational

Extracellular Vesicles and Particles (EVP) as Biomarkers of Recurrence in Non-Small Cell Lung Cancer

NCT ID: NCT05424029Sponsor: Memorial Sloan Kettering Cancer CenterLast updated: 2025-07-03

Summary

The purpose of this study is to find out if fluid rinsed from peoples' airways (bronchial washing samples) during routine surgery to remove (resect) their non-small cell lung cancer (NSCLC) tumors contains enough vesicles to do testing that may help the researchers learn more about their NSCLC.

Outcome measures

Primary

  • to isolate exosomes from bronchial washings

    every patient from whom the essential specimens have been acquired will be evaluated to determine if more than 100,000 microvesicles can be isolated for exosome purification

    Time frame: day 1

Eligibility criteria

Sex: AllAge: 18 Years and olderHealthy volunteers: No
Inclusion Criteria: * All patients ≥ 18 years of age undergoing consideration of surgical resection, including lobar resections, sublobar resections, and pneumonectomies, for primary lung cancer will be eligible. * Patients with previously resected disease and/or previous radiation therapy will be considered on a case by case basis. Exclusion Criteria: * Patients with active infection or pneumonia which may impact exosome makeup * Additionally, if at the discretion of the operating surgeon, obtaining bronchial washings would lead to undue morbidity, the patient would be excluded and replaced

Study locations (7)

Memorial Sloan Kettering Basking Ridge (Consent Only)

Basking Ridge, New Jersey, 07920

Recruiting
David Jones, MD · Contact

Memorial Sloan Kettering Monmouth (Consent Only)

Middletown, New Jersey, 07748

Recruiting
David Jones, MD · Contact

Memorial Sloan Kettering Bergen (Consent Only)

Montvale, New Jersey, 07645

Recruiting
David Jones, MD · Contact

Memorial Sloan Kettering Suffolk - Commack (Consent Only)

Commack, New York, 11725

Recruiting
David Jones, MD · Contact

Memorial Sloan Kettering Westchester (Consent Only)

Harrison, New York, 10604

Recruiting
David Jones, MD · Contact

Memorial Sloan Kettering Cancer Center

New York, New York, 10065

Recruiting
David Jones, MD · Contact
Yuan Liu, MD, PhD · Contact
David Jones, PhD · Principal Investigator

Memorial Sloan Kettering Nassau (Consent Only)

Uniondale, New York, 11553

Recruiting
David Jones, MD · Contact
Extracellular Vesicles and Particles (EVP) as Biomarkers of Recurrence in Non-Small Cell Lung Cancer | Cancerify