StableEyes With Active Neurophysiological Feedback
Summary
The investigators have developed a self-administered rehabilitation tool that incrementally guides the user to increase head motion to mitigate motion sickness and enhance postural recovery following centrifugation or unilateral vestibular nerve deafferentation surgery.
Detailed description
The rehabilitation device guides users to perform sinusoidal head rotations, matched to a metronome, about the yaw, pitch, and roll axes (60 sec epochs, 5 minutes per axis, 15 min total). The assessment for each axis consists of the number of completed epochs with each epoch requiring head rotations of a different amplitude. Subjects are instructed to begin with an 'easy' amplitude (i.e. small) and increase or decrease amplitude depending on the subject's perception of motion sickness - which is input from 0 (absent motion sick) to 11 (vomit) using a handheld controller. Video-oculography captures eye and head velocity as well as tracks the number of blinks and saccades, metrics that can indicate worsening nausea.
Arms & interventions
- BehavioralTraditional Therapy
Exercises that teaches subjects to move their heads while viewing still or moving targets.
- DeviceSWAN
The SWAN device uses video-oculography to monitor head motion while guiding participants to move their head in yaw, pitch, roll planes for 15 minutes. Feedback is provided regarding frequency and plane of head rotation
Outcome measures
Primary
Change in Motion sickness intensity as assessed by subjective rating
Subjective rating of motion sickness intensity from 0 to 10. Zero denotes absent motion sickness while 10 denote vomiting.
Time frame: Daily for up to 4 weeks
Secondary
Change in Vestibulo-Ocular Reflex (VOR) gain as measured by video-oculography
Time frame: Daily for up to 4 weeks
Change in Number of blinks as measured by video-oculography
Time frame: Daily for up to 4 weeks
Change in Heart rate as measured by a monitor worn over the forearm
Time frame: Daily for up to 4 weeks
Change in Timed Up and Go Plus
Time frame: Daily for up to 4 weeks
Change in Foam Stance - Eyes Open
Time frame: Daily for up to 4 weeks
Change in Foam Stance - Eyes Closed
Time frame: Daily for up to 4 weeks
Change in Foam Stance - Eyes Open with head motion
Time frame: Daily for up to 4 weeks
Change in Foam Stance - Eyes Closed with head motion
Time frame: Daily for up to 4 weeks
Change in Gait speed
Time frame: Daily for up to 4 weeks
Change in Gait endurance
Time frame: Daily for up to 4 weeks
Change in Vertical and torsional alignment nulling test (VAN and TAN)
Time frame: Daily for up to 4 weeks
Change in Rod and Frame Test
Time frame: Daily for up to 4 weeks
Change in Rod and Disk Test
Time frame: Daily for up to 4 weeks
Change in Subjective Visual Vertical
Time frame: Daily for up to 4 weeks
Change in Daily Activity as assessed by an activity monitor
Time frame: Daily for up to 4 weeks
Eligibility criteria
Study locations (2)
Johns Hopkins University
Baltimore, Maryland, 21287
Naval Medical Research Unit
Dayton, Ohio, 45433
References
- Todd CJ, Schubert MC, Rinaudo CN, Migliaccio AA. Unidirectional Vertical Vestibuloocular Reflex Adaptation in Humans Using 1D and 2D Scenes. Otol Neurotol. 2022 Oct 1;43(9):e1039-e1044. doi: 10.1097/MAO.0000000000003684. Epub 2022 Sep 9.(PubMed)