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Intraoperative Identification and Stimulation of the Ansa Cervicalis Nerve Plexus

NCT ID: NCT05650710Sponsor: Vanderbilt University Medical CenterLast updated: 2026-01-12

Summary

Recently published data suggest that stimulation of the infrahyoid strap muscles increases pharyngeal patency in patients with obstructive sleep apnea, but the innervation of these muscles by the ansa cervicalis is variable. The investigators propose a study examining the anatomic variation of the ansa cervicalis and the effect of neurostimulation on muscle recruitment.

Detailed description

This is a single-arm physiology study. Consenting patients undergoing neck dissection (ND) for cervical lymphadenectomy of level IV will undergo dissection of the ansa cervicalis nerves to the infrahyoid strap muscles. Per routine care, a large incision is made across the neck to provide surgeons access to the cervical lymph nodes for extirpation. During this dissection, the branch(es) of the ansa cervicalis nerve plexus descending from the loop of the plexus and innervating the infrahyoid strap muscles (the "common trunk") are dissected uni- or bilaterally. For this study, measurements and photos/videos of the common trunks will be taken. An electrode will be placed on one or both common trunks to stimulate infrahyoid muscles.

Arms & interventions

  • DeviceNerve stimulation using nerve stimulation device and sterile wire electrode.

    A nerve stimulator device will be used in this study as a research tool to investigate whether a future (currently nonexistent) medical device might be able to stimulate desired infrahyoid musculature in a therapeutic manner.

Outcome measures

Primary

  • Primary Objective

    Anatomic measurements of the length, diameter, and comformation of the common trunk of the ansa cervicalis to the sternothyroid muscle and it's dependent branches, measured in mm with a flexible ruler.

    Time frame: Collected during a single operative procedure, taking about 15 minutes

Secondary

  • Secondary Objective

    Time frame: Collected during a single operative procedure, taking about 15 minutes.

  • Secondary Objective

    Time frame: Collected during a single operative procedure, taking about 15 minutes.

Eligibility criteria

Sex: AllAge: 18 Years and olderHealthy volunteers: No
Inclusion Criteria: * Adult patient (≥18 years old). * Scheduled for uni- or bilateral neck dissection (BND) for cervical lymphadenectomy of level IV and other indicated procedures for management of head and neck cancer. Exclusion Criteria: * Unable to consent for research due to a pre-existing neurologic condition as determined by PI. * Unable to consent for research due to language barriers. * History of prior neck surgery with transection of the infrahyoid strap muscles as determined by clinical history.

Study locations (1)

Vanderbilt University Medical Center

Nashville, Tennessee, 37232

Recruiting
Katie Hartley-Estes, RPSGT · Contact
Nicole L Jones, MS · Contact
David T Kent, MD · Principal Investigator
Intraoperative Ansa Cervicalis Nerve (ACN) Stimulation | Cancerify