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Cultural Tailoring and Pilot Testing of an Inpatient Yoga Therapy Program for Cancer Patients Undergoing Hematopoietic Stem Cell Transplantation in India, Tanzania, and the United States

NCT ID: NCT05681026Sponsor: M.D. Anderson Cancer CenterLast updated: 2026-02-27

Summary

To develop and measure the effects of a culturally sensitive yoga program for inpatients

Detailed description

Primary Objective: 1\. To develop a culturally tailored yoga therapy (YT) program for HSCT patients. We will conduct semi-structured interviews with patients from each center to examine cultural norms, culturally sensitive language, and specific factors relevant to yoga and psychosocial support. Secondary Objectives: 1. To optimize the HSCT YT program using an iterative process. Fifteen patients from each center (or until thematic saturation based on exit interviews) will participate in the yoga program two weeks prior to the transplant and throughout the first 30 days of the HSCT. Sessions will be delivered in person, via telehealth (Zoom), or in combination. 2. To examine the feasibility of adherence and follow-up completion. We will declare the intervention feasible if: (a) at least 50% of patients complete a minimum of 50% of the 12 YT sessions, and (b) at least 60% of participants complete follow-up measures at 2 months after transplant (± 7 days).

Arms & interventions

  • BehavioralYoga Sessions

    Participants will have up to 12 sessions, 3 sessions per week starting two weeks before the transplant and throughout the first 30 days of your hospitalization.

  • BehavioralQuestionnaries

    Participants will complete 4 questionnaires about any symptoms you may be having, any anxiety and/or depression you may be having, your quality of life, and your expectations about your treatment.

  • BehavioralInterviews

    Participants will have an exit interview last about 30-45 minutes. The interview will be conducted over the phone or remotely over Zoom, FaceTime, or other approved video call methods.). The interview will be audio and video recorded and transcribed (typed).

Outcome measures

Primary

  • Patient Health Questionnaire-8 (PHQ-8)

    The PHQ-8 is a 8-item self-report questionnaire used to assess bother of depressive symptoms over the past 2 weeks. The PHQ-8 is a 8-item questionnaire to screen for degree of depressive symptoms scored on a 0-24 scale with higher scores indicating greater distress and impairment

    Time frame: through study completion; an average of 1 year

Eligibility criteria

Sex: AllAge: 18 Years and olderHealthy volunteers: No
Inclusion Criteria: 1. Cancer patients scheduled to undergo an autologous or allogeneic HSCT at MD Anderson, HCG, or MNH; 2. Age 18 or older; 3. English, Hindi, or Swahili speaking; 4. Able to sign a written informed consent and be willing to follow protocol requirements. Exclusion Criteria: * Extreme mobility issues that preclude participating in the YT; * Major thought disorders such as schizophrenia or uncontrolled bipolar disorder; * HCT comorbidity score of 3 or higher, excluding cancer diagnoses

Study locations (1)

M D Anderson Cancer Center

Houston, Texas, 77030

Recruiting
Lorenzo Cohen, PHD · Contact
Lorenzo Cohen, PHD · Principal Investigator

References

  • Mallaiah S, Majumdar V, Mama SK, Olson AL, Daher M, Badgare Y, Kolar Srinivasrao N, Rwezaula S, Muhoka P, Rao R, Jadav S, Wagner R, Wilson A, Nandi Krishnamurthy M, Cohen L. Adapting Yoga Therapy to Meet the Needs of Inpatients Undergoing Hematopoietic Stem Cell Transplantation: Insights From an International, Multisite, Qualitative Study. JCO Glob Oncol. 2026 Mar;12(3):e2500567. doi: 10.1200/GO-25-00567. Epub 2026 Mar 6.(PubMed)
Cultural Tailoring and Pilot Testing of an Inpatient Yoga Therapy Program for Cancer Patients Undergoing Hematopoietic Stem Cell Transplantation in India, Tanzania, and the United States | Cancerify