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RecruitingObservational

A Long-Term Follow-up Study for Subjects Previously Treated With A Century Therapeutics Cellular Therapy Product

NCT ID: NCT05768269Sponsor: Century Therapeutics, Inc.Last updated: 2025-06-25

Summary

This study is designed to collect long-term safety and survival data from participants previously treated in an eligible Century-sponsored index trial. This is an observational study, and the elements of the study design allow for important follow-up for safety, survival, and the continued evaluation of any late adverse events (AEs) that may appear after treatment with such cellular products. Additionally, collection of persistence data from participants will support the identification of any long-term risks or late AEs that may be causally related to treatment with such cellular products.

Arms & interventions

  • OtherNo Intervention

    As this is a non-interventional rollover, long-term safety follow-up study, no intervention will be administered.

Outcome measures

Primary

  • Number of Participants With any Adverse Events of Special Interest (AESI)

    Time frame: Up to 180 months

Secondary

  • Number of Participants With Cellular Product-related Serious Adverse Events (SAEs)

    Time frame: Up to 180 months

  • Overall Survival (OS)

    Time frame: From first dose of study drug up to end of the study or death whichever occurs first (up to 180 months)

  • Percentage of Participants With Persistent Product

    Time frame: Up to 180 months

Eligibility criteria

Sex: AllAge: 18 Years and olderHealthy volunteers: No
Inclusion Criteria: * Participant has provided written informed consent prior to any long-term follow-up (LTFU) study-specific procedures. * Participants received at least one treatment with a cellular therapy product in an eligible index trial. * Participant was withdrawn, early discontinued or completed an eligible index trial. * Participant is willing and able to comply with scheduled visits, study plan, and other study procedures. Exclusion Criteria: -This study has no exclusion criteria.

Study locations (7)

Banner MD Anderson Cancer Center

Gilbert, Arizona, 85234

Not Yet Recruiting
Dr Matthew Ulrickson · Contact

University of Southern California - Norris Comprehensive Cancer Center

Los Angeles, California, 90033

Not Yet Recruiting
Dr Yaghmour · Contact

University of Maryland Medical Center

Baltimore, Maryland, 21201

Recruiting
Dr Nancy Hardy · Contact

Corewell Health

Grand Rapids, Michigan, 49503

Not Yet Recruiting

Levine Cancer Institute

Charlotte, North Carolina, 28204

Recruiting
Dr Moyo · Contact

University of Cincinnati Medical Center

Cincinnati, Ohio, 45229

Recruiting
Dr Latif · Contact

Swedish Cancer Institute

Seattle, Washington, 98104

Recruiting
Dr. Krish Patel · Contact