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RecruitingObservational

The T-cell Lymphoma Master Repository (TCLMR): A Prospective Databank of Patients With T-cell Lymphoma With Clinical Annotation and Matched Tumor Specimens

NCT ID: NCT05978141Sponsor: Memorial Sloan Kettering Cancer CenterLast updated: 2026-05-20

Summary

The purpose of this registry study is to create a database-a collection of information-for better understanding T-cell lymphoma. Researchers will use the information from this database to learn more about how to improve outcomes for people with T-cell lymphoma.

Arms & interventions

  • OtherOptional Blood Sample and Nail Sample

    Participants may provide optional research blood and nail samples for biobanking and future use

Outcome measures

Primary

  • Number of participants populating the T-cell Lymphoma Master Repository/TCLMR

    To develop and populate a secure database comprised of patients with T-cell lymphomas with curated clinical characteristics and treatment outcomes matched to pathological biospecimens.

    Time frame: 10 years

Eligibility criteria

Sex: AllAge: All agesHealthy volunteers: No
Inclusion Criteria: * Written informed consent * Adequate fresh or archival tumor biopsy or intent to obtain fresh tumor biopsy. * Pathologically-confirmed mature T- or natural killer (NK)-cell lymphoma meeting one of the following diagnostic criterion (based on WHO classification and NCCN guidelines): * T-cell prolymphocytic leukemia * T-cell large granular lymphocytic leukemia * Chronic lymphoproliferative disorder of NK cells * Aggressive NK-cell leukemia * Systemic Epstein-Barr virus (EBV)-positive T-cell lymphoma of childhood * Chronic active EBV infection of T- and NK-cell type, systemic form * Hydroa vacciniforme-like lymphoproliferative disorder * Adult T-cell leukemia/lymphoma * Extranodal NK/T-cell lymphoma, nasal type * Enteropathy-associated T-cell lymphoma * Monomorphic epitheliotropic intestinal T-cell lymphoma * Intestinal T-cell lymphoma, not otherwise specified (NOS) * Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract * Hepatosplenic T-cell lymphoma * Subcutaneous panniculitis-like T-cell lymphoma * Mycosis fungoides (limited to those with ≥ stage IB disease and those receiving active therapy) * Sézary syndrome * Primary cutaneous anaplastic large cell lymphoma (receiving systemic therapy) * Primary cutaneous Gamma-Delta T-cell lymphoma * Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma * Primary cutaneous acral CD8+ T-cell lymphoma (receiving systemic therapy) * Peripheral T-cell lymphoma, not otherwise specified * Angioimmunoblastic T-cell lymphoma * Follicular T-cell lymphoma * Nodal peripheral T-cell lymphoma with TFH phenotype * Anaplastic large cell lymphoma, ALK-positive * Anaplastic large cell lymphoma, ALK-negative * Breast-implant associated anaplastic large cell lymphoma. * NOTE: Patients with diagnoses of mycosis fungoides, primary cutaneous anaplastic large cell lymphoma, and/or primary cutaneous acral CD8+ T-cell lymphoma must be receiving systemic therapy. Exclusion Criteria: * Patients with of mycosis fungoides, primary cutaneous anaplastic large cell lymphoma, and/or primary cutaneous acral CD8+ T-cell lymphoma not receiving systemic therapy. * Inability to collect prospective data, measure response, or perform adequate follow-up assessments in the clinical judgment of the treating physician. NOTE: Repository participation does not exclude participation in clinical trials, nor does existing clinical trial participation exclude enrollment in the study herein outlined.

Study locations (26)

City of Hope Cancer Center (Data collection only)

Duarte, California, 91010

Not Yet Recruiting
Jasmine Zain, MD · Contact

UNIVERSITY OF CALIFORNIA SAN DIEGO (Data collection only)

San Diego, California, 92103

Not Yet Recruiting
Aaron Goodman, MD · Contact

University of California San Francisco (Data collection only)

San Francisco, California, 94143

Not Yet Recruiting
Weiyun Ai, MD · Contact

Stanford University Medical Center (Data collection only)

Stanford, California, 94305-5408

Not Yet Recruiting
Michael Khodadoust, MD · Contact

University of Colorado (Data Collection Only)

Aurora, Colorado, 80045

Not Yet Recruiting
Bradley Haverkos, MD · Contact

Yale University (Data Collection Only)

New Haven, Connecticut, 06511

Not Yet Recruiting
Francine Foss, MD · Contact

University of Miami (Data Collection Only)

Miami, Florida, 33136

Not Yet Recruiting
Jonathan Schatz, MD · Contact

Moffitt Cancer Center (Data Collection Only)

Tampa, Florida, 33612

Not Yet Recruiting
Lubomir Sokol, MD, PhD · Contact

Emory University (Data Collection Only)

Atlanta, Georgia, 30322

Not Yet Recruiting
Pamela Allen, MD, MSc · Contact

Northwestern Medicine (Data Collection)

Chicago, Illinois, 60611

Not Yet Recruiting
Jaehyuk Choi, MD, PhD · Contact

Massachusetts General Hospital (Data Collection Only)

Boston, Massachusetts, 02114

Not Yet Recruiting
Salvia Jain, MD · Contact

Dana Farber Cancer Institute (Data Collection Only)

Boston, Massachusetts, 02115

Not Yet Recruiting
Eric D Jacobsen, MD · Contact

Mayo Clinic (Data Collection Only)

Rochester, Minnesota, 55905

Not Yet Recruiting
Nora Bennani, MD · Contact

Washington University (Data Collection Only)

St Louis, Missouri, 63110

Not Yet Recruiting
Neha Mehta-Shah, MD, MSCI · Contact

University of Nebraska (Data collection only)

Omaha, Nebraska, 68198-7680

Not Yet Recruiting
Matthew Lunning, DO, FACP · Contact

Memorial Sloan Kettering at Basking Ridge (All protocol activities)

Basking Ridge, New Jersey, 07920

Recruiting
Steven Horwitz, MD · Contact

Memorial Sloan Kettering Monmouth (All protocol activities)

Middletown, New Jersey, 07748

Recruiting
Steven Horwitz, MD · Contact

Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (All protocol activities)

Commack, New York, 11725

Recruiting
Steven Horwitz, MD · Contact

Memorial Sloan Kettering Westchester (All protocol activities)

Harrison, New York, 10604

Recruiting
Steven Horwitz, MD · Contact

Weill Cornell Medical Center (Data Collection Only)

New York, New York, 10021

Not Yet Recruiting
Jia Ruan, MD, PhD · Contact

Memorial Sloan Kettering Cancer Center (All Protocol Activities)

New York, New York, 10065

Recruiting
Steven Horwitz, MD · Contact

Memorial Sloan Kettering Nassau (All protocol activities)

Uniondale, New York, 11553

Recruiting
Steven Horwitz, MD · Contact

Ohio State University (Data Collection Only)

Columbus, Ohio, 43210

Not Yet Recruiting
John Reneau, MD, PhD · Contact

University of Pennsylvania (Data Collection Only)

Philadelphia, Pennsylvania, 19104

Not Yet Recruiting
Stefan Barta, MD, MS, MRCPCUK · Contact

Thomas Jefferson University Hospital (Data collection only)

Philadelphia, Pennsylvania, 19107

Not Yet Recruiting
Pierluigi Porcu, MD · Contact

MD Anderson Cancer Center (Data Collection Only)

Houston, Texas, 77030

Not Yet Recruiting
Swami Iyer, MD · Contact