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RecruitingInterventionalPhase 4

Quadratus Lumborum Block to Improve Postoperative Pain Management After Laparoscopic Myomectomies: a Double-blinded and Prospective Randomized Clinical Trial.

NCT ID: NCT05979493Sponsor: Joseph Findley MDLast updated: 2025-08-06

Summary

This study aims to determine the efficacy of a quadratus lumborum (QL) block in decreasing postoperative pain in patients undergoing myomectomy for uterine fibroids. A QL block is a temporary anesthetic injection in the quadratus lumborum muscle, a muscle in the lower back, that has been previously shown to significantly reduce postoperative pain levels in patients undergoing abdominal and pelvic surgery. Because of its demonstrated effects, the QL block is becoming a standard of anesthesia and surgical care. Since participants will be undergoing a myomectomy procedure, the investigators believe that participants may qualify to participate in this study. The investigators will be comparing patients who receive the QL block (in addition to standard anesthesia and postoperative pain care) with patients who do not receive the QL block (in addition to standard care). The participants will be randomly assigned to one of the two groups and may or may not actually receive the block.

Arms & interventions

  • DrugBupivacain

    30cc IM injection in each quadratus lumborum muscle (60cc total).

  • DrugSaline

    30cc IM injection in each quadratus lumborum muscle (60cc total).

Outcome measures

Primary

  • Time in minutes from first analgesic request as measured by medical chart review

    Time frame: Up to 24 hours

  • Total number of doses of rescue analgesics given as measured by medical chart review

    Time frame: Up to 24 hours

Secondary

  • Pain as measured by visual analog scale (VAS)

    Time frame: Up to 48 hours after discharge from hospital.

  • Patient satisfaction with perioperative pain management measured on a scale of 1-10

    Time frame: Up to 48 hours after discharge from hospital.

Eligibility criteria

Sex: FemaleAge: 18 Years to 45 YearsHealthy volunteers: No
Inclusion Criteria: * Presence of uterine fibroids requiring surgical excision with preservation of the uterus * Stated willingness to comply with all study procedures and availability for the duration of the study * Provision of signed and dated informed consent form Exclusion Criteria: * Pre-existing diagnoses of anxiety or depression * Pre-existing coagulopathies * Pre-existing neuropathic or chronic pelvic pain * Chronic opioid use * Illiteracy due to inability to read and understand plain questionnaire * Non-English speaking * BMI \>38

Study locations (1)

University Hospitals Ahuja Medical Center

Beachwood, Ohio, 44122

Recruiting
Catherine P Haering, BA · Contact