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RecruitingInterventionalPhase 2

A Randomized Trial of Neratinib, A Pan-ERBB Inhibitor, Alone or in Combination With Palbociclib, a CDK4/6 Inhibitor, in Patients With HER2+ Gynecologic Cancers and Other Solid Tumors: A ComboMATCH Treatment Trial

NCT ID: NCT06126276Sponsor: National Cancer Institute (NCI)Last updated: 2026-06-17

Summary

This phase II ComboMATCH treatment trial compares the effect of neratinib to the combination of neratinib and palbociclib in treating patients with HER2 positive solid tumors. Neratinib and palbociclib are in a class of medications called kinase inhibitors. They work by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of tumor cells. Giving neratinib and palbociclib in combination may shrink or stabilize cancers that over-express a specific biomarker called HER2.

Detailed description

PRIMARY OBJECTIVE: I. To investigate the efficacy of neratinib plus palbociclib (PD-0332991) compared to neratinib maleate (neratinib) alone in patients with HER2+ gynecologic cancers and HER2+ solid tumors by evaluating progression-free survival (PFS). SECONDARY OBJECTIVES: I. To investigate outcome in terms of objective response rate (ORR) by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. II. To investigate clinical benefit rate (ORR + stable disease at 16 weeks). III. To evaluate overall (OS) survival. IV. To evaluate the ORR of patients who crossed over from neratinib monotherapy to neratinib-palbociclib combination. V. To investigate adverse events especially grade 3 and 4 toxicities by Common Terminology Criteria for Adverse Events (CTCAE) version (v) 5.0. VI. Collect tissue and provide it to the ComboMATCH Registration Protocol to assess concordance between the diagnostic tumor mutation profile generated by the Designated Laboratories, the pre-treatment biopsy mutation profile, and the pre-treatment circulating tumor-derived deoxyribonucleic acid (ctDNA) mutation profile from plasma, as described in ComboMATCH Registration Protocol. EXPLORATORY TRANSLATIONAL OBJECTIVES: I. To investigate the role of ctDNA-HER2 status at baseline and during follow up to assess if it predicts response to therapy and disease progression and if it does correlate with tumor tissue based HER2 status. II. To investigate if activation of the pathways of interest (PI3K/mTOR and RB1, CCND1-CDK4/6 CDK and RAS/RAF/MAPK) in tumor tissue as well as blood/ctDNA correlate with response or resistance to therapy. III. To correlate extent of HER2 amplification with response to treatment and with HER2 expression by immunohistochemistry or fluorescence in situ hybridization (FISH). IV. To correlate the extent of HER2 amplification with HER2 expression by RNA and protein immunohistochemistry (IHC) analyses and FISH. V. To correlate expression of Rb1, CCND1, CCNE1, CDK4/6 protein expression with response to treatment. VI. Assess alteration in RB1-CDK pathway in neratinib resistant patients at time of progression on monotherapy compared to combination neratinib-palbociclib. OUTLINE: Patients are randomized to 1 of 2 arms. ARM I: Patients receive neratinib maleate orally (PO) once daily (QD) on days 1-14 of cycle 0 in the absence of disease progression or unacceptable toxicity. Patients then receive neratinib maleate PO QD on days 1-28 of each subsequent cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients who experience progression may crossover to Arm II. Patients undergo echocardiogram (ECHO) or multi-gated acquisition scan (MUGA) during screening and on study, and computed tomography (CT) or magnetic resonance imaging (MRI) and collection of blood samples throughout the trial. Patients may also undergo tumor biopsy during screening and on study. ARM II: Patients receive neratinib maleate PO QD on days 1-14 of cycle 0 in the absence of disease progression or unacceptable toxicity. Patients then receive neratinib maleate PO QD on days 1-28 and palbociclib PO QD on days 1-21 of each subsequent cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo ECHO or MUGA during screening and on study, and CT or MRI and collection of blood samples throughout the trial. Patients may also undergo tumor biopsy during screening and on study. After completion of study treatment, patients are followed up every 3 months for 2 years.

Arms & interventions

  • ProcedureBiopsy Procedure

    Undergo tumor biopsy

  • ProcedureBiospecimen Collection

    Undergo collection of blood samples

  • ProcedureComputed Tomography

    Undergo CT scan

  • ProcedureEchocardiography Test

    Undergo ECHO

  • ProcedureMagnetic Resonance Imaging

    Undergo MRI

  • ProcedureMultigated Acquisition Scan

    Undergo MUGA

  • DrugNeratinib Maleate

    Given PO

  • DrugPalbociclib

    Given PO

Outcome measures

Primary

  • Progression free survival

    The stratified log-rank statistic will be used to draw inferences about the relative activity of the two regimens. Characterized by medians and Kaplan-Meier (KM) curves.

    Time frame: From study entry to time of progression or death, whichever occurs first, or date of last contact if neither progression nor death has occurred, assessed up to 2 years

Secondary

  • Overall survival

    Time frame: Up to 2 years

Eligibility criteria

Sex: AllAge: 18 Years and olderHealthy volunteers: No
Inclusion Criteria: * Patient must have enrolled onto EAY191 and must have been given a treatment assignment to ComboMATCH to EAY191-N5 based on the presence of an actionable mutation as defined in EAY191 * Patients must have a HER2 amplified solid tumor except breast cancer. * If IHC is 0 or 1+, patient (pt) is NOT ELIGIBLE regardless of in situ hybridization (ISH)/FISH or next generation sequencing (NGS) status * If IHC is 3+, pt IS ELIGIBLE regardless of ISH/FISH or NGS status * If IHC is 2+, ISH/FISH OR NGS must be positive for the patient to be ELIGIBLE. Otherwise, pt is NOT ELIGIBLE * If IHC is unknown and… * ISH/FISH is positive, independent of NGS results, the patient IS ELIGIBLE * ISH/FISH is negative and NGS positive with ≥ 7 copies, the patient IS ELIGIBLE * Patients must have recurrent or persistent disease * No known evidence of RB1 loss or deletion including copy number loss or deleterious mutation * Patients must have disease that can be safely biopsied and agree to a pre-treatment biopsy or, if disease cannot be safely biopsied, have archival tissue available from within 12 months prior to the date of registration on the ComboMATCH Registration Trial (EAY191) * Patients must have measurable disease based on RECIST 1.1. A second measurable lesion outside of the biopsiable lesion is required * Patients with treated brain metastases are eligible if follow up brain imaging after central nervous system (CNS) directed therapy shows no evidence of progression for 3 months or more and patient is not on steroids and is asymptomatic * No known leptomeningeal disease * Patients may have received up to 5 prior lines of systemic therapy * Prior therapy with trastuzumab or pertuzumab, either alone or in combination, antibody drug conjugates (ADC) such as DS8201a or T-DM1 is allowed * No prior therapy with HER2 targeting tyrosine kinase inhibitors (TKI) such as neratinib or tucatinib * No prior therapy with CDK4/6 inhibition * No cancer directed therapy within 3 weeks prior to registration. For oral therapy, the washout can be reduced to greater than or equal to 5 half lives of the drug. No HER2 targeting ADCs within 30 days prior to registration * Age ≥ 18 * Eastern Cooperative Oncology Group (ECOG) Performance Status of ≤ 2 * Not pregnant and not nursing * Absolute neutrophil count (ANC) ≥ 1,500 cells/mm\^3 * Platelets ≥ 100,000 cells/mm\^3 * Hemoglobin ≥ 9 g/dl (Note: The use of transfusion or other intervention to achieve hemoglobin (Hgb) ≥ 9 g/dl is acceptable) * Creatinine clearance (CrCL) of ≥ 30 mL/min by the Cockcroft-Gault formula * Total bilirubin level ≤ 1.5 x institutional upper limit of normal (ULN) (patients with known Gilbert's disease who have bilirubin level ≤ 3 x institutional ULN may be enrolled) * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3 x institutional upper limit of normal (ULN) * Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better * No active infection requiring parenteral antibiotics * No current evidence of intra-abdominal abscess, abdominal/pelvic fistula (not diverted), gastrointestinal perforation, gastrointestinal (GI) obstruction, and/or need for drainage nasogastric or gastrostomy tube * No current evidence of malabsorption or chronic diarrhea or any other significant gastro-intestinal disease (e.g gastrectomy, ileal bypass, Crohn's disease, gastroparesis), associated with moderate to severe diarrhea (grade 2 or more) or inability to tolerate oral therapy * No lung disease causing dyspnea at rest * No interstitial lung disease with ongoing signs and symptoms at the time of registration * No history of allergic reaction to the study agents, compound of similar chemical or biologic composition of the study agents or any of their excipients

Study locations (186)

University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233

Recruiting
Site Public Contact · Contact
gingerreeves@uabmc.edu
Rebecca C. Arend · Principal Investigator

University of South Alabama Mitchell Cancer Institute

Mobile, Alabama, 36688

Recruiting
Site Public Contact · Contact
251-445-9870pfrancisco@usouthal.edu
Ahmed Abdalla · Principal Investigator

Alaska Women's Cancer Care

Anchorage, Alaska, 99508

Recruiting
Site Public Contact · Contact
907-212-6871AKPAMC.OncologyResearchSupport@providence.org
Dan S. Zuckerman · Principal Investigator

UC San Diego Health System - Encinitas

Encinitas, California, 92024

Recruiting
Site Public Contact · Contact
760-536-7700
Peter Vu · Principal Investigator

UC San Diego Moores Cancer Center

La Jolla, California, 92093

Recruiting
Site Public Contact · Contact
858-822-5354cancercto@ucsd.edu
Peter Vu · Principal Investigator

The Angeles Clinic and Research Institute - West Los Angeles Office

Los Angeles, California, 90025

Recruiting
Site Public Contact · Contact
888-823-5923ctsucontact@westat.com
Omid Hamid · Principal Investigator

Cedars-Sinai Medical Center

Los Angeles, California, 90048

Recruiting
Site Public Contact · Contact
310-423-2133Cancer.trial.info@cshs.org
Omid Hamid · Principal Investigator

UC San Diego Medical Center - Hillcrest

San Diego, California, 92103

Recruiting
Site Public Contact · Contact
rhabbaba@health.ucsd.edu
Peter Vu · Principal Investigator

UM Sylvester Comprehensive Cancer Center at Aventura

Aventura, Florida, 33180

Recruiting
Site Public Contact · Contact
954-461-2180
Matthew P. Schlumbrecht · Principal Investigator

UM Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables, Florida, 33146

Recruiting
Site Public Contact · Contact
305-243-2647
Matthew P. Schlumbrecht · Principal Investigator

UM Sylvester Comprehensive Cancer Center at Coral Springs

Coral Springs, Florida, 33065

Recruiting
Site Public Contact · Contact
305-243-2647
Matthew P. Schlumbrecht · Principal Investigator

UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, 33442

Recruiting
Site Public Contact · Contact
305-243-2647
Matthew P. Schlumbrecht · Principal Investigator

University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136

Recruiting
Site Public Contact · Contact
305-243-2647
Matthew P. Schlumbrecht · Principal Investigator

UM Sylvester Comprehensive Cancer Center at Kendall

Miami, Florida, 33176

Recruiting
Site Public Contact · Contact
305-243-2647
Matthew P. Schlumbrecht · Principal Investigator

University of Miami Sylvester Comprehensive Cancer Center at Sole Mia

North Miami, Florida, 33181

Recruiting
Site Public Contact · Contact
kginnity@med.miami.edu
Matthew P. Schlumbrecht · Principal Investigator

UM Sylvester Comprehensive Cancer Center at Plantation

Plantation, Florida, 33324

Recruiting
Site Public Contact · Contact
305-243-2647
Matthew P. Schlumbrecht · Principal Investigator

Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, 83706

Recruiting
Site Public Contact · Contact
734-712-3671stephanie.couch@stjoeshealth.org
Tareq Al baghdadi · Principal Investigator

Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712

Recruiting
Site Public Contact · Contact
208-381-2774eslinget@slhs.org
Dan S. Zuckerman · Principal Investigator

Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, 83605

Recruiting
Site Public Contact · Contact
734-712-3671stephanie.couch@stjoeshealth.org
Tareq Al baghdadi · Principal Investigator

Kootenai Health - Coeur d'Alene

Coeur d'Alene, Idaho, 83814

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, 83619

Recruiting
Site Public Contact · Contact
208-381-2774eslinget@slhs.org
Dan S. Zuckerman · Principal Investigator

Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642

Recruiting
Site Public Contact · Contact
208-381-2774eslinget@slhs.org
Dan S. Zuckerman · Principal Investigator

Saint Alphonsus Cancer Care Center-Nampa

Nampa, Idaho, 83687

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
Tareq Al baghdadi · Principal Investigator

Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83687

Recruiting
Site Public Contact · Contact
208-381-2774eslinget@slhs.org
Dan S. Zuckerman · Principal Investigator

Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, 83854

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Kootenai Clinic Cancer Services - Sandpoint

Sandpoint, Idaho, 83864

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

SIH Cancer Institute

Carterville, Illinois, 62918

Recruiting
Site Public Contact · Contact
618-985-3333clinical.research@sih.net
Bryan A. Faller · Principal Investigator

John H Stroger Jr Hospital of Cook County

Chicago, Illinois, 60612

Suspended

University of Illinois

Chicago, Illinois, 60612

Recruiting
Site Public Contact · Contact
312-355-3046
Ryan Nguyen · Principal Investigator

Carle at The Riverfront

Danville, Illinois, 61832

Recruiting
Site Public Contact · Contact
800-446-5532Research@Carle.com
Maria T. Grosse-Perdekamp · Principal Investigator

Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526

Recruiting
Site Public Contact · Contact
217-876-4762morganthaler.jodi@mhsil.com
Bryan A. Faller · Principal Investigator

Decatur Memorial Hospital

Decatur, Illinois, 62526

Recruiting
Site Public Contact · Contact
217-876-4762morganthaler.jodi@mhsil.com
Bryan A. Faller · Principal Investigator

Carle Physician Group-Effingham

Effingham, Illinois, 62401

Recruiting
Site Public Contact · Contact
800-446-5532Research@carle.com
Maria T. Grosse-Perdekamp · Principal Investigator

Crossroads Cancer Center

Effingham, Illinois, 62401

Recruiting
Site Public Contact · Contact
217-876-4762morganthaler.jodi@mhsil.com
Bryan A. Faller · Principal Investigator

NorthShore University HealthSystem-Evanston Hospital

Evanston, Illinois, 60201

Recruiting
Site Public Contact · Contact
847-570-2109
Mary T. Jenkins Vogel · Principal Investigator

NorthShore University HealthSystem-Glenbrook Hospital

Glenview, Illinois, 60026

Recruiting
Site Public Contact · Contact
847-570-2109
Mary T. Jenkins Vogel · Principal Investigator

NorthShore University HealthSystem-Highland Park Hospital

Highland Park, Illinois, 60035

Recruiting
Site Public Contact · Contact
847-570-2109
Mary T. Jenkins Vogel · Principal Investigator

Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938

Recruiting
Site Public Contact · Contact
800-446-5532Research@carle.com
Maria T. Grosse-Perdekamp · Principal Investigator

Carle BroMenn Medical Center

Normal, Illinois, 61761

Recruiting
Site Public Contact · Contact
800-446-5532Research@Carle.com
Maria T. Grosse-Perdekamp · Principal Investigator

Carle Cancer Institute Normal

Normal, Illinois, 61761

Recruiting
Site Public Contact · Contact
800-446-5532Research@Carle.com
Maria T. Grosse-Perdekamp · Principal Investigator

Cancer Care Center of O'Fallon

O'Fallon, Illinois, 62269

Recruiting
Site Public Contact · Contact
217-876-4762morganthaler.jodi@mhsil.com
Bryan A. Faller · Principal Investigator

Mercyhealth Cancer Institute - Rockford

Rockford, Illinois, 61114

Recruiting
Site Public Contact · Contact
815-971-5858oncologyclinicaltrials@mhemail.org
Mayur Narkhede · Principal Investigator

Southern Illinois University School of Medicine

Springfield, Illinois, 62702

Recruiting
Site Public Contact · Contact
217-545-7929
Bryan A. Faller · Principal Investigator

Springfield Clinic

Springfield, Illinois, 62702

Recruiting
Site Public Contact · Contact
800-444-7541
Bryan A. Faller · Principal Investigator

Springfield Memorial Hospital

Springfield, Illinois, 62781

Recruiting
Site Public Contact · Contact
217-528-7541pallante.beth@mhsil.com
Bryan A. Faller · Principal Investigator

Carle Cancer Center

Urbana, Illinois, 61801

Recruiting
Site Public Contact · Contact
800-446-5532Research@carle.com
Maria T. Grosse-Perdekamp · Principal Investigator

Woodland Cancer Care Center

Michigan City, Indiana, 46360

Recruiting
Site Public Contact · Contact
219-861-5800Anna.Huron@franciscanalliance.org
William H. Bae · Principal Investigator

UI Health Care Mission Cancer and Blood - Ankeny Clinic

Ankeny, Iowa, 50023

Recruiting
Site Public Contact · Contact
515-241-3305
Richard L. Deming · Principal Investigator

UI Health Care Mission Cancer and Blood - Des Moines Clinic

Des Moines, Iowa, 50309

Recruiting
Site Public Contact · Contact
515-241-3305
Seema Harichand-Herdt · Principal Investigator

UI Health Care Mission Cancer and Blood - Laurel Clinic

Des Moines, Iowa, 50314

Recruiting
Site Public Contact · Contact
515-241-3305
Seema Harichand-Herdt · Principal Investigator

UI Health Care Mission Cancer and Blood - Waukee Clinic

Waukee, Iowa, 50263

Recruiting
Site Public Contact · Contact
515-241-3305
Seema Harichand-Herdt · Principal Investigator

Saint Joseph Hospital East

Lexington, Kentucky, 40509

Recruiting
Site Public Contact · Contact
720-874-1881ResearchInstituteInquiries@CommonSpirit.org
Shahzad Siddique · Principal Investigator

University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536

Recruiting
Site Public Contact · Contact
859-257-3379
Susanne M. Arnold · Principal Investigator

Harold Alfond Center for Cancer Care

Augusta, Maine, 04330

Recruiting
Site Public Contact · Contact
207-626-4855
Leslie S. Bradford · Principal Investigator

Lafayette Family Cancer Center-EMMC

Brewer, Maine, 04412

Recruiting
Site Public Contact · Contact
800-987-3005
Sarah J. Sinclair · Principal Investigator

MaineHealth Maine Medical Center- Scarborough

Scarborough, Maine, 04074

Recruiting
Site Public Contact · Contact
207-396-8670clinicalresearch@mainehealth.org
Leslie S. Bradford · Principal Investigator

University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201

Recruiting
Site Public Contact · Contact
800-888-8823
Ranee Mehra · Principal Investigator

Walter Reed National Military Medical Center

Bethesda, Maryland, 20889-5600

Recruiting
Site Public Contact · Contact
301-319-2100
Christopher Tarney · Principal Investigator

National Institutes of Health Clinical Center

Bethesda, Maryland, 20892

Recruiting
Site Public Contact · Contact
800-411-1222
Sarah Shin · Principal Investigator

UPMC Western Maryland

Cumberland, Maryland, 21502

Recruiting
Site Public Contact · Contact
240-964-1400
Sarah E. Taylor · Principal Investigator

Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, 48106

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Tareq Al baghdadi · Principal Investigator

Trinity Health IHA Medical Group Hematology Oncology - Brighton

Brighton, Michigan, 48114

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Tareq Al baghdadi · Principal Investigator

Trinity Health IHA Medical Group Hematology Oncology - Canton

Canton, Michigan, 48188

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Tareq Al baghdadi · Principal Investigator

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

Chelsea, Michigan, 48118

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Tareq Al baghdadi · Principal Investigator

Corewell Health Dearborn Hospital

Dearborn, Michigan, 48124

Suspended

OSF Saint Francis Hospital and Medical Group

Escanaba, Michigan, 49829

Recruiting
Site Public Contact · Contact
920-433-8889WI_research_admin@hshs.org
Matthew L. Ryan · Principal Investigator

Corewell Health Farmington Hills Hospital

Farmington Hills, Michigan, 48336

Suspended

Cancer Hematology Centers - Flint

Flint, Michigan, 48503

Recruiting
Site Public Contact · Contact
810-762-8038wstrong@ghci.org
Tareq Al baghdadi · Principal Investigator

Genesee Hematology Oncology PC

Flint, Michigan, 48503

Suspended

Genesys Hurley Cancer Institute

Flint, Michigan, 48503

Recruiting
Site Public Contact · Contact
810-762-8038wstrong@ghci.org
Tareq Al baghdadi · Principal Investigator

Hurley Medical Center

Flint, Michigan, 48503

Recruiting
Site Public Contact · Contact
810-762-8038wstrong@ghci.org
Tareq Al baghdadi · Principal Investigator

University of Michigan Health - Sparrow Lansing

Lansing, Michigan, 48912

Recruiting
Site Public Contact · Contact
517-364-3712harsha.trivedi@umhsparrow.org
Tareq Al baghdadi · Principal Investigator

Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, 48154

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Tareq Al baghdadi · Principal Investigator

Trinity Health Saint Joseph Mercy Oakland Hospital

Pontiac, Michigan, 48341

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Tareq Al baghdadi · Principal Investigator

Corewell Health William Beaumont University Hospital

Royal Oak, Michigan, 48073

Suspended

Corewell Health Beaumont Troy Hospital

Troy, Michigan, 48085

Suspended

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

Ypsilanti, Michigan, 48197

Recruiting
Site Public Contact · Contact
734-712-7251MCRCwebsitecontactform@stjoeshealth.org
Tareq Al baghdadi · Principal Investigator

Sanford Joe Lueken Cancer Center

Bemidji, Minnesota, 56601

Recruiting
Site Public Contact · Contact
218-333-5000OncologyClinicalTrialsFargo@sanfordhealth.org
Daniel Almquist · Principal Investigator

Essentia Health - Deer River Clinic

Deer River, Minnesota, 56636

Recruiting
Site Public Contact · Contact
218-786-3308CancerTrials@EssentiaHealth.org
Bret E. Friday · Principal Investigator

Essentia Health Cancer Center

Duluth, Minnesota, 55805

Recruiting
Site Public Contact · Contact
218-786-3308CancerTrials@EssentiaHealth.org
Bret E. Friday · Principal Investigator

Essentia Health Hibbing Clinic

Hibbing, Minnesota, 55746

Recruiting
Site Public Contact · Contact
218-786-3308
Bret E. Friday · Principal Investigator

Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
Yan Ji · Principal Investigator

Mayo Clinic in Rochester

Rochester, Minnesota, 55905

Recruiting
Site Public Contact · Contact
855-776-0015
Grace M. Choong · Principal Investigator

Essentia Health Sandstone

Sandstone, Minnesota, 55072

Recruiting
Site Public Contact · Contact
218-786-3308CancerTrials@EssentiaHealth.org
Bret E. Friday · Principal Investigator

Essentia Health Virginia Clinic

Virginia, Minnesota, 55792

Recruiting
Site Public Contact · Contact
218-786-3308CancerTrials@EssentiaHealth.org
Bret E. Friday · Principal Investigator

Saint Francis Medical Center

Cape Girardeau, Missouri, 63703

Recruiting
Site Public Contact · Contact
573-334-2230sfmc@sfmc.net
Bryan A. Faller · Principal Investigator

Community Hospital of Anaconda

Anaconda, Montana, 59711

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Billings Clinic Cancer Center

Billings, Montana, 59101

Recruiting
Site Public Contact · Contact
800-996-2663research@billingsclinic.org
John M. Schallenkamp · Principal Investigator

Bozeman Health Deaconess Hospital

Bozeman, Montana, 59715

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Benefis Sletten Cancer Institute

Great Falls, Montana, 59405

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Logan Health Medical Center

Kalispell, Montana, 59901

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

Community Medical Center

Missoula, Montana, 59804

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
John M. Schallenkamp · Principal Investigator

OptumCare Cancer Care at Charleston

Las Vegas, Nevada, 89102

Recruiting
Site Public Contact · Contact
702-384-0013research@sncrf.org
John A. Ellerton · Principal Investigator

OptumCare Cancer Care at Fort Apache

Las Vegas, Nevada, 89183

Recruiting
Site Public Contact · Contact
702-384-0013research@sncrf.org
John A. Ellerton · Principal Investigator

Jersey City Medical Center

Jersey City, New Jersey, 07302

Recruiting
Site Public Contact · Contact
412-339-5294Roster@nrgoncology.org
Eugenia Girda · Principal Investigator

Monmouth Medical Center Southern Campus

Lakewood, New Jersey, 08701

Recruiting
Site Public Contact · Contact
732-923-6564mary.danish@rwjbh.org
Eugenia Girda · Principal Investigator

Monmouth Medical Center

Long Branch, New Jersey, 07740

Recruiting
Site Public Contact · Contact
732-923-6564mary.danish@rwjbh.org
Eugenia Girda · Principal Investigator

Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903

Recruiting
Site Public Contact · Contact
732-235-7356
Eugenia Girda · Principal Investigator

Community Medical Center

Toms River, New Jersey, 08755

Recruiting
Site Public Contact · Contact
732-557-8294Lennette.Gonzales@rwjbh.org
Eugenia Girda · Principal Investigator

Roswell Park Cancer Institute

Buffalo, New York, 14263

Recruiting
Site Public Contact · Contact
800-767-9355askroswell@roswellpark.org
Ellis G. Levine · Principal Investigator

State University of New York Upstate Medical University

Syracuse, New York, 13210

Recruiting
Site Public Contact · Contact
315-464-5476
Mary J. Cunningham · Principal Investigator

Cone Health MedCenter Asheboro

Asheboro, North Carolina, 27205

Recruiting
Site Public Contact · Contact
336-832-0836stacey.phelps@conehealth.com
Ni Gorsuch · Principal Investigator

Cone Health Cancer Center at Alamance Regional

Burlington, North Carolina, 27215

Recruiting
Site Public Contact · Contact
336-832-0836stacey.phelps@conehealth.com
Ni Gorsuch · Principal Investigator

Southeastern Medical Oncology Center-Clinton

Clinton, North Carolina, 28328

Recruiting
Site Public Contact · Contact
919-587-9084jfields@cancersmoc.com
Samer S. Kasbari · Principal Investigator

Duke University Medical Center

Durham, North Carolina, 27710

Recruiting
Site Public Contact · Contact
888-275-3853
Angeles A. Secord · Principal Investigator

Southeastern Medical Oncology Center-Goldsboro

Goldsboro, North Carolina, 27534

Recruiting
Site Public Contact · Contact
919-587-9084jfields@cancersmoc.com
Samer S. Kasbari · Principal Investigator

Cone Health Cancer Center

Greensboro, North Carolina, 27403

Recruiting
Site Public Contact · Contact
336-832-0836stacey.phelps@conehealth.com
Ni Gorsuch · Principal Investigator

Cone Health Cancer Center at Drawbridge Parkway

Greensboro, North Carolina, 27410

Recruiting
Site Public Contact · Contact
336-832-0836stacey.phelps@conehealth.com
Ni Gorsuch · Principal Investigator

Southeastern Medical Oncology Center-Jacksonville

Jacksonville, North Carolina, 28546

Recruiting
Site Public Contact · Contact
910-587-9084jfields@cancersmoc.com
Samer S. Kasbari · Principal Investigator

Duke Women's Cancer Care Raleigh

Raleigh, North Carolina, 27607

Recruiting
Site Public Contact · Contact
919-785-4878
Angeles A. Secord · Principal Investigator

Annie Penn Memorial Hospital

Reidsville, North Carolina, 27320

Recruiting
Site Public Contact · Contact
336-832-0836stacey.phelps@conehealth.com
Ni Gorsuch · Principal Investigator

Sanford Bismarck Medical Center

Bismarck, North Dakota, 58501

Recruiting
Site Public Contact · Contact
701-323-5760OncologyClinicalTrialsFargo@sanfordhealth.org
Daniel Almquist · Principal Investigator

Sanford Broadway Medical Center

Fargo, North Dakota, 58122

Recruiting
Site Public Contact · Contact
701-323-5760OncologyClinicalTrialsFargo@sanfordhealth.org
Daniel Almquist · Principal Investigator

Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58122

Recruiting
Site Public Contact · Contact
701-234-6161OncologyClinicalTrialsFargo@sanfordhealth.org
Daniel Almquist · Principal Investigator

OhioHealth O'Bleness Hospital

Athens, Ohio, 45701

Recruiting
Site Public Contact · Contact
614-788-3860Jennifer.Sexton@ohiohealth.com
Aine E. Clements · Principal Investigator

Miami Valley Hospital South

Centerville, Ohio, 45459

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Tarek M. Sabagh · Principal Investigator

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210

Recruiting
Site Public Contact · Contact
800-293-5066Jamesline@osumc.edu
Floor Backes · Principal Investigator

Columbus Oncology and Hematology Associates Inc

Columbus, Ohio, 43214

Recruiting
Site Public Contact · Contact
614-788-3860Jennifer.Sexton@ohiohealth.com
Aine E. Clements · Principal Investigator

Riverside Methodist Hospital

Columbus, Ohio, 43214

Recruiting
Site Public Contact · Contact
614-788-3860Jennifer.Sexton@ohiohealth.com
Aine E. Clements · Principal Investigator

Grant Medical Center

Columbus, Ohio, 43215

Recruiting
Site Public Contact · Contact
614-788-3860Jennifer.Sexton@ohiohealth.com
Aine E. Clements · Principal Investigator

Doctors Hospital

Columbus, Ohio, 43228

Recruiting
Site Public Contact · Contact
614-788-3860Jennifer.Sexton@ohiohealth.com
Aine E. Clements · Principal Investigator

Miami Valley Hospital

Dayton, Ohio, 45409

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Tarek M. Sabagh · Principal Investigator

Premier Blood and Cancer Center

Dayton, Ohio, 45409

Recruiting
Site Public Contact · Contact
937-276-8320
Tarek M. Sabagh · Principal Investigator

Dayton Physician LLC - Englewood

Dayton, Ohio, 45415

Suspended

Miami Valley Hospital North

Dayton, Ohio, 45415

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Tarek M. Sabagh · Principal Investigator

Delaware Health Center-Grady Cancer Center

Delaware, Ohio, 43015

Recruiting
Site Public Contact · Contact
614-788-3860Jennifer.Sexton@ohiohealth.com
Aine E. Clements · Principal Investigator

Grady Memorial Hospital

Delaware, Ohio, 43015

Recruiting
Site Public Contact · Contact
614-788-3860Jennifer.Sexton@ohiohealth.com
Aine E. Clements · Principal Investigator

Columbus Oncology and Hematology Associates

Dublin, Ohio, 43016

Recruiting
Site Public Contact · Contact
614-788-3860Jennifer.Sexton@ohiohealth.com
Aine E. Clements · Principal Investigator

Dublin Methodist Hospital

Dublin, Ohio, 43016

Recruiting
Site Public Contact · Contact
614-788-3860Jennifer.Sexton@ohiohealth.com
Aine E. Clements · Principal Investigator

Atrium Medical Center-Middletown Regional Hospital

Franklin, Ohio, 45005-1066

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Tarek M. Sabagh · Principal Investigator

Miami Valley Cancer Care and Infusion

Greenville, Ohio, 45331

Recruiting
Site Public Contact · Contact
937-569-7515
Tarek M. Sabagh · Principal Investigator

Kettering Medical Center

Kettering, Ohio, 45429

Suspended

OhioHealth Mansfield Hospital

Mansfield, Ohio, 44903

Recruiting
Site Public Contact · Contact
614-788-3860Jennifer.Sexton@ohiohealth.com
Aine E. Clements · Principal Investigator

OhioHealth Marion General Hospital

Marion, Ohio, 43302

Recruiting
Site Public Contact · Contact
614-788-3860Jennifer.Sexton@ohiohealth.com
Aine E. Clements · Principal Investigator

OhioHealth Pickerington Methodist Hospital

Pickerington, Ohio, 43147

Recruiting
Site Public Contact · Contact
614-788-3860Jennifer.Sexton@ohiohealth.com
Aine E. Clements · Principal Investigator

Upper Valley Medical Center

Troy, Ohio, 45373

Recruiting
Site Public Contact · Contact
937-528-2900clinical.trials@daytonncorp.org
Tarek M. Sabagh · Principal Investigator

OhioHealth Westerville Medical Campus/Westerville Cancer Center

Westerville, Ohio, 43082

Recruiting
Site Public Contact · Contact
610-788-3860Jennifer.Sexton@ohiohealth.com
Aine E. Clements · Principal Investigator

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104

Recruiting
Site Public Contact · Contact
405-271-8777ou-clinical-trials@ouhsc.edu
Lauren E. Dockery · Principal Investigator

Saint Alphonsus Cancer Care Center-Ontario

Ontario, Oregon, 97914

Recruiting
Site Public Contact · Contact
406-969-6060mccinfo@mtcancer.org
Tareq Al baghdadi · Principal Investigator

Providence Portland Medical Center

Portland, Oregon, 97213

Recruiting
Site Public Contact · Contact
503-215-2614CanRsrchStudies@providence.org
Dan S. Zuckerman · Principal Investigator

Providence Saint Vincent Medical Center

Portland, Oregon, 97225

Recruiting
Site Public Contact · Contact
503-215-2614CanRsrchStudies@providence.org
Dan S. Zuckerman · Principal Investigator

UPMC Altoona

Altoona, Pennsylvania, 16601

Recruiting
Site Public Contact · Contact
412-339-5294Roster@nrgoncology.org
Sarah E. Taylor · Principal Investigator

UPMC Hillman Cancer Center Erie

Erie, Pennsylvania, 16505

Recruiting
Site Public Contact · Contact
412-864-7716ClinicalResearchServices@upmc.edu
Sarah E. Taylor · Principal Investigator

UPMC Cancer Centers - Arnold Palmer Pavilion

Greensburg, Pennsylvania, 15601

Recruiting
Site Public Contact · Contact
724-838-1900
Sarah E. Taylor · Principal Investigator

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion

Mechanicsburg, Pennsylvania, 17050

Recruiting
Site Public Contact · Contact
412-389-5208haneydl@upmc.edu
Sarah E. Taylor · Principal Investigator

UPMC Hillman Cancer Center - Monroeville

Monroeville, Pennsylvania, 15146

Recruiting
Site Public Contact · Contact
412-864-7716ClinicalResearchServices@upmc.edu
Sarah E. Taylor · Principal Investigator

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107

Recruiting
Site Public Contact · Contact
215-600-9151ONCTrialNow@jefferson.edu
Mitchell I. Edelson · Principal Investigator

UPMC-Magee Womens Hospital

Pittsburgh, Pennsylvania, 15213

Recruiting
Site Public Contact · Contact
412-647-2811
Sarah E. Taylor · Principal Investigator

University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, 15232

Recruiting
Site Public Contact · Contact
412-647-8073
Sarah E. Taylor · Principal Investigator

UPMC-Passavant Hospital

Pittsburgh, Pennsylvania, 15237

Recruiting
Site Public Contact · Contact
412-367-6454
Sarah E. Taylor · Principal Investigator

Asplundh Cancer Pavilion

Willow Grove, Pennsylvania, 19090

Recruiting
Site Public Contact · Contact
215-600-9151ONCTrialNow@jefferson.edu
Mitchell I. Edelson · Principal Investigator

Women and Infants Hospital

Providence, Rhode Island, 02905

Recruiting
Site Public Contact · Contact
401-274-1122
Paul A. DiSilvestro · Principal Investigator

Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, 57104

Recruiting
Site Public Contact · Contact
605-312-3320OncologyClinicTrialsSF@sanfordhealth.org
Daniel Almquist · Principal Investigator

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134

Recruiting
Site Public Contact · Contact
605-312-3320OncologyClinicalTrialsSF@SanfordHealth.org
Daniel Almquist · Principal Investigator

Bristol Regional Medical Center

Bristol, Tennessee, 37620

Recruiting
Site Public Contact · Contact
423-431-5654charles.mays@balladhealth.org
Asheesh Shipstone · Principal Investigator

Regional Cancer Center at Johnson City Medical Center

Johnson City, Tennessee, 37604

Recruiting
Site Public Contact · Contact
423-431-5654charles.mays@balladhealth.org
Asheesh Shipstone · Principal Investigator

Ballad Health Cancer Care - Kingsport

Kingsport, Tennessee, 37660

Recruiting
Site Public Contact · Contact
423-431-5654charles.mays@balladhealth.org
Asheesh Shipstone · Principal Investigator

Wellmont Holston Valley Hospital and Medical Center

Kingsport, Tennessee, 37660

Recruiting
Site Public Contact · Contact
423-431-5654charles.mays@balladhealth.org
Asheesh Shipstone · Principal Investigator

Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232

Recruiting
Site Public Contact · Contact
800-811-8480
Jennifer H. Choe · Principal Investigator

UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390

Recruiting
Site Public Contact · Contact
214-648-7097canceranswerline@UTSouthwestern.edu
James L. Wilder · Principal Investigator

UT MD Anderson Cancer Center

Houston, Texas, 77030

Recruiting
Site Public Contact · Contact
866-632-6789askmdanderson@mdanderson.org
Sarina A. Piha-Paul · Principal Investigator

Scott and White Memorial Hospital

Temple, Texas, 76508

Recruiting
Site Public Contact · Contact
254-724-5407
Lucas Wong · Principal Investigator

Ballad Health Cancer Care - Bristol

Bristol, Virginia, 24201

Recruiting
Site Public Contact · Contact
423-431-5654charles.mays@balladhealth.org
Asheesh Shipstone · Principal Investigator

University of Virginia Cancer Center

Charlottesville, Virginia, 22908

Recruiting
Site Public Contact · Contact
434-243-6303uvacancertrials@hscmail.mcc.virginia.edu
Matthew J. Reilley · Principal Investigator

Inova Schar Cancer Institute

Fairfax, Virginia, 22031

Recruiting
Site Public Contact · Contact
703-720-5210Stephanie.VanBebber@inova.org
Timothy L. Cannon · Principal Investigator

Inova Fairfax Hospital

Falls Church, Virginia, 22042

Recruiting
Site Public Contact · Contact
703-208-6650Stephanie.VanBebber@inova.org
Timothy L. Cannon · Principal Investigator

VCU Massey Comprehensive Cancer Center

Richmond, Virginia, 23298

Recruiting
Site Public Contact · Contact
804-628-6430CTOclinops@vcu.edu
Chelsea Salyer · Principal Investigator

Carilion Roanoke Memorial Hospital

Roanoke, Virginia, 24033

Recruiting
Site Public Contact · Contact
540-981-7377
Chelsea Salyer · Principal Investigator

Swedish Cancer Institute-Edmonds

Edmonds, Washington, 98026

Recruiting
Site Public Contact · Contact
206-215-2343PCRC-NCORP@Swedish.org
Dan S. Zuckerman · Principal Investigator

Swedish Cancer Institute-Issaquah

Issaquah, Washington, 98029

Recruiting
Site Public Contact · Contact
206-215-2343PCRC-NCORP@Swedish.org
Dan S. Zuckerman · Principal Investigator

Swedish Medical Center-First Hill

Seattle, Washington, 98122

Recruiting
Site Public Contact · Contact
206-215-2343PCRC-NCORP@Swedish.org
Dan S. Zuckerman · Principal Investigator

West Virginia University Healthcare

Morgantown, West Virginia, 26506

Recruiting
Site Public Contact · Contact
304-293-7374cancertrialsinfo@hsc.wvu.edu
Mohammed Almubarak · Principal Investigator

Duluth Clinic Ashland

Ashland, Wisconsin, 54806

Recruiting
Site Public Contact · Contact
218-786-3308CancerTrials@EssentiaHealth.org
Bret E. Friday · Principal Investigator

Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Adedayo A. Onitilo · Principal Investigator

Saint Vincent Hospital Cancer Center Green Bay

Green Bay, Wisconsin, 54301

Recruiting
Site Public Contact · Contact
920-433-8889WI_research_admin@hshs.org
Matthew L. Ryan · Principal Investigator

Saint Vincent Hospital Cancer Center at Saint Mary's

Green Bay, Wisconsin, 54303

Recruiting
Site Public Contact · Contact
920-433-8889wi_research_admin@hshs.org
Matthew L. Ryan · Principal Investigator

Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601

Recruiting
Site Public Contact · Contact
608-775-2385cancerctr@gundersenhealth.org
Collin D. Driscoll · Principal Investigator

Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Adedayo A. Onitilo · Principal Investigator

Marshfield Medical Center - Minocqua

Minocqua, Wisconsin, 54548

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Adedayo A. Onitilo · Principal Investigator

Cancer Center of Western Wisconsin

New Richmond, Wisconsin, 54017

Recruiting
Site Public Contact · Contact
952-993-1517mmcorc@healthpartners.com
Yan Ji · Principal Investigator

Saint Vincent Hospital Cancer Center at Oconto Falls

Oconto Falls, Wisconsin, 54154

Recruiting
Site Public Contact · Contact
920-433-8889WI_research_admin@hshs.org
Matthew L. Ryan · Principal Investigator

Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Adedayo A. Onitilo · Principal Investigator

Saint Vincent Hospital Cancer Center at Sheboygan

Sheboygan, Wisconsin, 53081

Recruiting
Site Public Contact · Contact
920-433-8889wi_research_admin@hshs.org
Matthew L. Ryan · Principal Investigator

Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Adedayo A. Onitilo · Principal Investigator

Saint Vincent Hospital Cancer Center at Sturgeon Bay

Sturgeon Bay, Wisconsin, 54235-1495

Recruiting
Site Public Contact · Contact
920-433-8889wi_research_admin@hshs.org
Matthew L. Ryan · Principal Investigator

Marshfield Medical Center - Weston

Weston, Wisconsin, 54476

Recruiting
Site Public Contact · Contact
800-782-8581oncology.clinical.trials@marshfieldresearch.org
Adedayo A. Onitilo · Principal Investigator