Assessing Radiation Induced Alterations in Resting State Brain Networks in Pediatric Brain Tumor Patients
Summary
With modern therapy, the survival rate for pediatric brain tumor patients has significantly improved, with over 70% of patients surviving their disease. However, this progress often comes at the cost of substantial morbidity, with cognitive deficits being the primary obstacle to independent living. Robust predictors of cognitive decline and a comprehensive understanding of the underlying mechanisms of cognitive injury remain elusive. This study will prospectively investigate alterations in brain resting state networks following radiation therapy using functional imaging. The hypothesis is that radiation therapy leads to dose-dependent alterations in functional connectivity in the networks associated with higher level cognition, ultimately leading to cognitive decline.
Arms & interventions
- OtherCognitive testing
NIH Toolbox Cognitive Battery and the Novel Cognitive Measure (NCM)
- DeviceResting State MRI/Precision functional mapping
At baseline (before the end of radiation therapy) and approximately 12 months after the completion of radiation therapy.
Outcome measures
Primary
Radiation induced effects on functional brain resting state connectivity
The investigators will compare resting state maps of each patient pre- and post-radiation therapy. The investigators will evaluate changes in the resting state architecture and compare to the average results that would be expected from a patient in the same age and sex.
Time frame: Through 1 year follow-up
Baseline characteristics of functional network architecture
The investigators will assess the unique architecture of brain networks at diagnosis and how significantly this architecture diverges from average healthy controls.
Time frame: At baseline (day 1)
Change in characteristics of functional network architecture
The investigators will assess brain system segregation which is measure of the connection and disconnection between different brain networks. These will be compared within individuals and compared to healthy controls.
Time frame: Baseline and 1 year follow-up
Secondary
Correlation of radiation dose to changes in cognitive performance and resting state network connectivity
Time frame: At 1 year follow-up
Eligibility criteria
Study locations (1)
Washington University School of Medicine/Saint Louis Children's Hospital
St Louis, Missouri, 63110