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RecruitingObservational

Collection of Specimens and Clinical Data for Patients With Recurrent or Metastatic Breast Cancer or Male Breast Cancer

NCT ID: NCT06217874Sponsor: Mayo ClinicLast updated: 2026-02-25

Summary

This study is being done to create a resource of samples and information that can be used to improve our understanding of the development, progression and treatment of recurrent or metastatic breast cancer or male breast cancer.

Detailed description

PRIMARY OBJECTIVE: I. To collect blood samples and fresh tissue from biopsies of metastatic lesions from Mayo Clinic patients with metastatic breast cancer. OUTLINE: This is an observational study. Patients undergo blood sample collection, provide clinical residual tissue samples and have their medical records reviewed on study.

Arms & interventions

  • OtherNon-Interventional Study

    Non-interventional study

Outcome measures

Primary

  • Response to targeted therapies

    Response to targeted therapies will be evaluated in organoid or mouse xenograft models derived from tumor biospecimens obtained from participants.

    Time frame: Baseline

  • Change in tumor cells

    Changes in tumor cells will be evaluated following metastasis to other organs and after various treatments.

    Time frame: Baseline

Eligibility criteria

Sex: AllAge: 18 Years and olderHealthy volunteers: No
Inclusion Criteria: * Female participants must have histologically or cytologically confirmed invasive breast cancer. * Male participants must have biopsy proven breast cancer. * Age must be \>= 18 years, and all must be able to understand and willing to sign an informed consent document. Exclusion Criteria: * Dementia, altered mental status, or any psychiatric condition that would prohibit the understanding or rendering of informed consent; a history of serious or life-threatening allergic reaction to local anesthetics (i.e. lidocaine, xylocaine). * Any other condition, which in the opinion of the patient's treating oncologist, or the physician performing the biopsy procedure, would make participation in this protocol unreasonably hazardous for the patient.

Study locations (1)

Mayo Clinic in Rochester

Rochester, Minnesota, 55905

Recruiting
Clinical Trials Referral Office · Contact
Fergus J. Couch, Ph.D. · Principal Investigator
Kathryn J. Ruddy, M.D. · Principal Investigator
Karthik V. Giridhar, M.D. · Sub Investigator
Collection of Specimens and Clinical Data for Patients With Recurrent or Metastatic Breast Cancer or Male Breast Cancer | Cancerify