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RecruitingInterventional

A Multi-Disciplinary Approach to the Opportunistic Salpingectomy for Primary Prevention of Ovarian Cancer

NCT ID: NCT06312124Sponsor: Memorial Sloan Kettering Cancer CenterLast updated: 2026-01-23

Summary

The purpose of this study is to find out how many participants are interested in a surgical preventive procedure after watching an educational video. Before and after watching the video, participants will complete questionnaires in the clinic.

Arms & interventions

  • BehavioralEducational Module

    Part 1 consists of an education module with premodule and postmodule assessment questionnaires.

  • ProcedureSalpingectomy

    Part 2 consists of incorporating opportunistic salpingectomy /OS into non-gynecologic surgery

Outcome measures

Primary

  • Rate of Opportunistic Salpingectomy/OS after completion of educational module

    Evaluate the acceptance of Opportunistic Salpingectomy/OS among nongynecologic surgical patients after completion of an educational module

    Time frame: up to 2 years

Eligibility criteria

Sex: FemaleAge: 45 Years and olderHealthy volunteers: Yes
Inclusion Criteria: Part I * Age ≥45 years * Scheduled visit with a nongynecologic surgeon * Female or assigned female at birth Part II * Age ≥45 years * At least one in situ fallopian tube * No desire or plan to have children in the future * Average risk of developing ovarian cancer ° Note: Average risk patients are defined as patients with no known genetic risk factor for developing ovarian cancer. Patients who, after obtaining family history, are suspected to have a hereditary ovarian cancer syndrome but have not yet been tested, will be referred for genetic evaluation. * Planned nongynecologic, intraabdominal, or pelvic surgery * Deemed to be a suitable candidate by gynecologic surgeon and primary nongynecologic surgeon (for example, on the basis of surgical history and current malignancy status) * Approved and signed informed consent Exclusion Criteria: Part I * Not fluent in English or Spanish ° If there is a non-english or non-spanish speaking participant who is a strong candidate and meets all other criteria for Part 2, they are able to go directly onto Part 2 without completing Part 1. (Please see additional details in section 4.1 and 7.0.) * Known inherited ovarian cancer susceptibility Part II * Personal history of a gynecologic malignancy * Carrier of a hereditary breast or ovarian cancer variant (e.g., BRCA1, BRCA2, BRIP1, PALB2, RAD51C, RAD51D, MLH1, MSH2, MSH6, PMS2) * Suspicious ovarian, fallopian tube, or uterine lesion on preoperative imaging * Previous bilateral salpingectomy or bilateral salpingo-oophorectomy * Presence of ESSURE, or other tubal-implanted birth control at the time of surgery * Current pregnancy * Emergent procedure or emergency procedure that has to be completed within 24 hours where clinical consent occurs in the inpatient setting or where the patient's immediate well-being is in danger or condition may be life threatening * Primary surgeon anticipates that OS will add significant time (\>30-40min) to the planned procedure. * Inability to access the pelvis (ex., patient prone/lateral position) during the planned procedure. * Known history of pelvic fibrosis or significant adhesions. * Procedures with palliative intent only

Study locations (10)

Johns Hopkins University (Data Collection Only)

Baltimore, Maryland, 21287

Recruiting
Rebecca Stone, MD · Contact

Dana Farber Cancer Institute (Data Collection Only)

Boston, Massachusetts, 02115

Not Yet Recruiting
Michelle Davis, MD · Contact

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)

Basking Ridge, New Jersey, 07920

Recruiting
Kara Long Roche, MD · Contact

Memorial Sloan Kettering Monmouth (Limited protocol activities)

Middletown, New Jersey, 07748

Recruiting
Kara Long Roche, MD · Contact

Memorial Sloan Kettering Bergen (Limited Protocol Activities)

Montvale, New Jersey, 07645

Recruiting
Kara Long Roche, MD · Contact

Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (Limited protocol activities)

Commack, New York, 11725

Recruiting
Kara Long Roche, MD · Contact

Memorial Sloan Kettering Westchester (Limited Protocol Activities)

Harrison, New York, 10604

Recruiting
Kara Long Roche, MD · Contact

Memorial Sloan Kettering Cancer Center (All Protocol Activities)

New York, New York, 10065

Recruiting
Kara Long Roche, MD · Contact

Memorial Sloan Kettering Nassau (Limited Protocol Activities)

Uniondale, New York, 11553

Recruiting
Kara Long Roche, MD · Contact

MD Anderson Cancer Center (Data Collection Only)

Houston, Texas, 77030

Recruiting
Larissa Meyer, MD · Contact