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RecruitingObservational

Biomarkers to Predict Cancer Therapy-Related Cardiotoxicity

NCT ID: NCT06353191Sponsor: Mayo ClinicLast updated: 2026-02-27

Summary

This study evaluates why some cancer patients but not others experience changes in heart function following treatment with chemotherapy.

Detailed description

PRIMARY OBJECTIVE: I. To collect biospecimens from 1) patients who developed chemotherapy related cardiac toxicity (CRCT) and 2) patients who are at a high risk for developing CRCT. OUTLINE: This is an observational study. Patients undergo blood sample collection and have their medical records reviewed on study.

Arms & interventions

  • OtherNon-Interventional Study

    Non-interventional study

Outcome measures

Primary

  • Collection of biospecimens from patients who developed cardiac toxicity (CRCT) or who are at high risk for developing CRCT

    Assessed by the number of participants who participate and consent to have their specimen (blood draw) retained for future research.

    Time frame: Baseline

Eligibility criteria

Sex: AllAge: 18 Years and olderHealthy volunteers: No
Inclusion Criteria: * 18 years of age or older * Treated for any malignancy with any type of chemotherapy including oral, parenteral therapy and immunotherapy * One of the following: * Diagnosed with cardiotoxicity defined as; cardiomyopathy, symptomatic heart failure, asymptomatic reduced systolic function, acute coronary syndrome, myocardial infarction, critical limb ischemia, cardiac arrhythmias or myocarditis possibly related to prior cancer treatment * Completed chemotherapy with no cardiotoxicity at least two years post treatment * Patients with cancer who will be initiating systemic therapy with potentially cardiotoxic medications. This will include chemotherapy, immunotherapy, targeted therapy that have been associated with cardiac toxicity * An understanding of the protocol and its requirements, risks, and discomforts * The ability and willingness to sign an informed consent Exclusion Criteria: \- Inability on the part of the patient to understand the informed consent or be compliant with the protocol

Study locations (4)

Mayo Clinic in Arizona

Scottsdale, Arizona, 85259

Recruiting
Clinical Trials Referral Office · Contact
Myrah Manuel · Contact
Lida A. Mina, MD · Principal Investigator

Mayo Clinic in Florida

Jacksonville, Florida, 32224-9980

Recruiting
Clinical Trials Referral Office · Contact
Pamela Williamson · Contact
Nadine Norton, PhD · Principal Investigator

Moffitt Cancer Center

Tampa, Florida, 33612

Recruiting
Aixa Soyano, MD · Contact
Aixa Soyano, MD · Principal Investigator

Mayo Clinic in Rochester

Rochester, Minnesota, 55905

Suspended