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RecruitingObservational

Identification of Metabolic Phenotypes Associated With Melanoma Metastasis

NCT ID: NCT06400550Sponsor: University of Texas Southwestern Medical CenterLast updated: 2026-06-02

Summary

The goal of this study is to observe metabolic features associated with human melanoma tumors.

Detailed description

This is a single center, correlative study designed to assess metabolic features of melanoma tumors in patients. The study will involve the collection of melanoma tissue at the time of surgical biopsy or excision. All samples will be assessed by mass spectrometry for metabolomic analysis. A subset of patients will have received \[U-13C\]glucose infusions which will be utilized for isotope tracing metabolic analysis. Relevant clinical data (eg survival, metastasis) will be correlated with metabolic findings.

Arms & interventions

Outcome measures

Primary

  • Glucose Utilisation in the TCA cycle

    In patients receiving a \[U-13C\]Glucose infusion, assess glucose utilization in the TCA cycle by melanoma tumors (defined as fractional enrichment of 13C-label in TCA metabolites)

    Time frame: 5 years

Secondary

  • Relapse free survival

    Time frame: 5 years

  • Overall Survival

    Time frame: 5 years

  • Development of Lymph Node or Distant Metastasis

    Time frame: 5 years

Eligibility criteria

Sex: AllAge: 18 Years and olderHealthy volunteers: No
Inclusion Criteria: * Patients with known or probable malignant melanoma lesions requiring surgical biopsy or excision. * Subjects of all races and ethnic origins over age 18. Exclusion Criteria: * Not a surgical candidate * Poorly controlled diabetes

Study locations (1)

University of Texas Southwestern Medical Center

Dallas, Texas, 75390

Recruiting
Aleuna Lee · Contact
2146458968aleuna.lee@utsouthwestern.edu
Identification of Metabolic Phenotypes Associated With Melanoma Metastasis | Cancerify