Cancerify Logo
Log inSign up
Back to clinical trials
RecruitingObservational

Pulmonary Segmentectomy for Lung Cancer: A Real-World International Registry-TSOG 108

NCT ID: NCT06424327Sponsor: Memorial Sloan Kettering Cancer CenterLast updated: 2026-06-01

Summary

Participants will complete questionnaires before surgery, between 2 to 4 weeks after surgery, and 6 months after surgery.

Arms & interventions

  • OtherPatient-Reported Outcomes Measurement Information System

    Participants-reported outcomes will be collected using the Patient-Reported Outcomes Measurement Information System (PROMIS). PROMIS is a web-based platform developed by the National Institutes of Health. Scoring is standardized on a scale from 0 to 100, with a population mean of 50 and standard deviation of 10 units. High scores mean more of the concept being measured. This study will use PROMIS surveys assessing three domains: physical function (PROMIS bank version 2.0), pain interference (PROMIS bank version 1.1), and dyspnea severity (PROMIS bank version 1.0)

Outcome measures

Primary

  • Determine 3-year disease-free survival/DFS among patients undergoing pulmonary segmentectomy for lung cancer.

    DFS is measured from the date of surgery to the date of recurrence or death

    Time frame: 3 years

  • Determine 5-year disease-free survival/DFS among patients undergoing pulmonary segmentectomy for lung cancer.

    DFS is measured from the date of surgery to the date of recurrence or death

    Time frame: 5 years

Eligibility criteria

Sex: AllAge: 18 Years and olderHealthy volunteers: No
Inclusion Criteria: * Age ≥18 years * Clinical Stage I with suspected NSCLC, classified preoperatively based on the AJCC TNM staging manual, 9th edition o Note: Tissue diagnosis of NSCLC is not required before enrollment. A pathologic diagnosis of NSCLC may be confirmed preoperatively with biopsy, intraoperatively with frozen section, or postoperatively on final pathology Exclusion Criteria: * Actively receiving lung cancer treatment or a history of lung cancer in the previous 5 years * History of chemotherapy or radiation therapy for a previous lung cancer * Synchronous secondary cancer in the lung or elsewhere in the body at the time of surgery * Carcinoid tumors * History of other malignancies within the past 3 years, with the exception of non-melanoma skin cancer, superficial bladder cancer, and carcinoma in situ of the cervix * Actively receiving treatment for other malignancies * Cases of lobectomy in conjunction with segmentectomy from another lobe and ≥2 segmentectomies from different lobes either en bloc or separate will be excluded from the primary analysis. * Multi-segmental resection from the same lobe is not a criterion for exclusion.

Study locations (15)

University of Arizona (Data Collection Only)

Tucson, Arizona, 85704

Recruiting
Praveen Sridhar, MD · Contact
520-694-2873psridhar@arizona.edu

Rush University Medical Center (Data collection only)

Chicago, Illinois, 606012

Recruiting
Christopher Seder, MD · Contact
312-738-3732

Endeavor Health

Evanston, Illinois, 60201

Recruiting
Seth Krantz, MD · Contact
847-570-2868

University of Michigan (Data Collection Only)

Ann Arbor, Michigan, 48109

Recruiting
Jules Lin, MD · Contact
734-936-8857

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)

Basking Ridge, New Jersey, 07920

Recruiting
David Jones, MD · Contact
212-639-6428

Memorial Sloan Kettering Monmouth (Limited Protocol Activities)

Middletown, New Jersey, 07748

Recruiting
David Jones, MD · Contact
212-639-6428

Memorial Sloan Kettering Bergen (Limited Protocol Activities)

Montvale, New Jersey, 07645

Recruiting
David Jones, MD · Contact
212-639-6428

Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)

Commack, New York, 11725

Recruiting
David Jones, MD · Contact
212-639-6428

Memorial Sloan Kettering Westchester (Limited Protocol Activities)

Harrison, New York, 10604

Recruiting
David Jones, MD · Contact
212-639-6428

Memorial Sloan Kettering Cancer Center (All Protocol Activities)

New York, New York, 10065

Recruiting
David Jones, MD · Contact
212-639-6428
Yuan Liu, MD, PhD · Contact
646-888-3640
David Jones, PhD · Principal Investigator

Memorial Sloan Kettering Nassau (Limited Protocol Activities)

Uniondale, New York, 11553

Recruiting
David Jones, MD · Contact
212-639-6428

Thomas Jefferson University Hospital (Data Collection Only)

Philadelphia, Pennsylvania, 19107

Recruiting
Nathaniel Evans III, MD · Contact
nathaniel.evans@jefferson.edu

ALLEGHENY HEALTH NETWORK (Data Collection Only)

Pittsburgh, Pennsylvania, 15212

Recruiting
Benny Weksler, MD · Contact
412-359-6137

Baylor University Medical Center (Data Collection Only)

Dallas, Texas, 75246

Recruiting
Shanda Blackmon, MD, MPH · Contact
713-198-6376sshanda.blackmon@bcm.edu

MD Anderson Cancer Center (Data Collection Only)

Houston, Texas, 77030

Recruiting
David Rice, MD · Contact
800-392-1611