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RecruitingInterventional
Exercise Prehabilitation for Locoregional Esophageal Cancer: A Pilot Study
NCT ID: NCT06430346Sponsor: H. Lee Moffitt Cancer Center and Research InstituteLast updated: 2025-12-04
Summary
The purpose of the study is to examine the feasibility and acceptability of exercise "prehabilitation" for patients preparing for esophageal cancer resection (removal).
Arms & interventions
- BehavioralExercise
Physical activity and resistance training
Outcome measures
Primary
Retention
The number of participants who complete T0 and T1 measures.
Time frame: Up to 11 weeks
Secondary
Exploratory outcomes and changes
Time frame: Up to 17 weeks
Clinical and treatment outcomes
Time frame: Up to 17 weeks
Eligibility criteria
Sex: AllAge: 18 Years and olderHealthy volunteers: No
Inclusion Criteria:
* Biopsy-proven locoregional esophageal cancer (LEC)
* Eastern Cooperative Oncology Group (ECOG) performance status 0-2
* Treatment plan including neoadjuvant chemoradiation therapy and surgical resection
* Ability to read and speak English
Exclusion Criteria:
* Regular engagement in resistance training (2x/week targeting all major muscle groups)
* Screen failure for exercise safety based on PAR-Q
* Underlying unstable cardiac or pulmonary disease or symptomatic cardiac disease
* Recent fracture or acute musculoskeletal injury that precludes ability to participate in resistance training safely
* Numeric pain rating scale of 7 or more out of 10
* Myopathic or rheumatologic disease that impacts physical function
Study locations (1)
Moffitt Cancer Center
Tampa, Florida, 33612
Nathan Parker, PhD · Principal Investigator
Jose Pimiento, MD · Principal Investigator