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RecruitingObservational

Characterization of the Genomic Risk Underlying Retroperitoneal Liposarcoma

NCT ID: NCT06436846Sponsor: Fox Chase Cancer CenterLast updated: 2024-05-31

Summary

The protocol intends to explore the biology which may underlie recurrences of retroperitoneal liposarcoma. Surgery remains the only curative intent intervention for this disease. Often, tumors recur in locations within the retroperitoneum remote from the original primary tumor. This study hypothesizes that normal appearing retroperitoneal fat actually harbors underlying genetic changes which predispose to development of future liposarcoma. To accomplish this goal, retroperitoneal fat is sampled from quadrants within and remote from the primary tumor and is subsequently subjected to genetic analyses looking for such predisposing factors.

Arms & interventions

  • OtherBiospecimen sample collection during standard-of-care surgery

    Patients in this observational study are undergoing planned surgical resection of their retroperitoneal sarcoma as prescribed by their primary surgeon and treatment team. In addition to removal of the primary tumor, surgeons remove 4 samples of retroperitoneal fat and a sample of subcutaneous fat for further study at the time of the operation.

Outcome measures

Primary

  • Presence of MDM2 amplification in "normal" retroperitoneal fat

    MDM2 amplification of primary tumors and fat samples will be tested by immunohistochemistry and/or fluorescence in situ hybridization.

    Time frame: Through study completion, an average of 3 years

Eligibility criteria

Sex: AllAge: 18 Years and olderHealthy volunteers: Yes
Inclusion Criteria: * Adult patients (age ≥18 years). * Histologically confirmed retroperitoneal liposarcoma via preoperative biopsy, or cross-sectional imaging suspicious for liposarcoma with planned surgical resection * Will be undergoing surgical resection for treatment of primary or recurrent disease * Have provided informed consent to participate in this study Exclusion Criteria: • Prior surgical anatomy which makes sampling of remote areas of the retroperitoneum technically impossible or clinically undesirable for safety reasons

Study locations (1)

Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111

Recruiting
Anthony Villano, MD · Contact
215-728-3686anthony.villano@fccc.edu
Margaret vonMehren, MD · Sub Investigator
Andres Correa, MD · Sub Investigator
Jeffrey Farma, MD, FACS · Sub Investigator
Stephanie Greco, MD, FACS · Sub Investigator
Alexander Kutikov, MD, FACS · Sub Investigator
Sanjay Reddy, MD, FACS · Sub Investigator
Lori Rink, PhD · Sub Investigator
Marc Smaldone, MD, MSHP, FACS · Sub Investigator
Robert Uzzo, MD, MBA, FACS · Sub Investigator
Rosalia Viterbo, MD, FACS · Sub Investigator
Shuanzeng Wei, MD, PhD · Sub Investigator
Johnathan Whetstine, PhD · Sub Investigator
Margaret von Mehren, MD · Sub Investigator