RecruitingInterventional

Improving Oral Chemotherapy Adherence in Maintenance for Adolescents and Adults With Acute Lymphoblastic Leukemia Using Text Messages

NCT ID: NCT06446661Sponsor: University of ChicagoLast updated: 2026-06-15

Summary

The purpose of this section is to learn how text message reminders might help with regularly taking chemotherapy medications for Adolescents and Adults with Acute Lymphoblastic leukemia (ALL).

Detailed description

This study aims to compare adherence to oral mercaptopurine and methotrexate during the first 84-day cycle of maintenance therapy for adolescent and young adult patients with Acute Lymphoblastic Leukemia on pediatric-based regimens between those who receive the high intensity text message intervention and those who receive standard-of-care. It is believed that high-intensity text messages will increase patient adherence within cycle 1.

Arms & interventions

OtherHigh Intensity
Daily texts
OtherNo Text Messagings
Standard Care
OtherLow Intensity Text Messaging
Weekly Texts

Outcome measures

Primary

To compare adherence to oral chemotherapy with mercaptopurine and methotrexate
To compare adherence to oral mercaptopurine and methotrexate during the first 84-day cycle of maintenance therapy for patients with ALL on pediatric-based regimens between those who receive the high intensity text message intervention and those who receive standard of care.
Time frame: 84 days

Secondary

To describe the relationship between oral chemotherapy adherence and patient factors
Time frame: 1 year

Eligibility criteria

Sex: AllAge: 15 Years to 39 YearsHealthy volunteers: No

Inclusion Criteria: * Age of 15-39 years-old at the time of initial ALL diagnosis * Diagnosed with ALL * Currently receiving treatment with pediatric-based regimen that includes maintenance with mercaptopurine and methotrexate (e.g., CALGB 10403). Study participation begins with the start of maintenance, so enrollment occurs prior to the start of maintenance. Exclusion Criteria: * Patient or caregiver who would receive text message reminders does not have a cell phone that receives text messages * Patient does not wish to participate * Text messages will be crafted in the patient's preferred language for medical communication, so English fluency is not an enrollment requirement.

Study locations (1)

University of Chicago Medicine Comprehensive Cancer Center

Chicago, Illinois, 60637

Recruiting

Clinical Trials Intake · Contact

1-855-702-8222 cancerclinicaltrials@bsd.uchicago.edu

Wendy Stock · Principal Investigator