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Mechanisms for Laser-Induced Rejuvenation

NCT ID: NCT06489301Sponsor: Wright State UniversityLast updated: 2026-05-22

Summary

It has shown that laser wounding of geriatric skin protects it against skin cancer. The purpose of this study is to determine the origin of cells called fibroblasts which are present after treatment with Fractionated Laser Resurfacing (FLR). These cells restore a youth-like ultraviolet B (UVB) response, but where they come from is currently unknown. The study recruits subjects who are scheduled to undergo abdominoplasties to investigate the origin of those cells stimulated by laser treatment.

Arms & interventions

  • DeviceFractionated Laser Resurfacing

    A rejuvenating laser that makes tiny holes in the very superficial part of the skin.

Outcome measures

Primary

  • To test if the new fibroblasts that develop in response to fractionated laser resurfacing (FLR) wounding are derived from blood-derived monocytes.

    Identify cells in the skin that have been wounded by FLR at 2 weeks and 1 week previously, for cells that co-express markers for both fibroblasts and monocytes by using single cell RNA-sequencing

    Time frame: 2 weeks prior to skin removal and 1 week prior to skin removal

  • To test if possible cells transitioning from monocytes to fibroblasts are found in the top part of the dermis (papillary dermis).

    Using tissue RNA-seq, PI will define if co-expressing cells are in the papillary dermis.

    Time frame: 2 weeks prior to skin removal and 1 week prior to skin removal

Secondary

  • To define the number and types of cells populating the skin following fractionated laser resurfacing (FLR) wounding

    Time frame: 2 weeks prior to skin removal and 1 week prior to skin removal

  • To define the locations of the number of cells populating in the skin following fractionated laser resurfacing (FLR) wounding

    Time frame: 2 weeks prior to skin removal and 1 week prior to skin removal

  • To define the locations of the types of cells populating in the skin following fractionated laser resurfacing (FLR) wounding

    Time frame: 2 weeks prior to skin removal and 1 week prior to skin removal

Eligibility criteria

Sex: AllAge: 18 Years and olderHealthy volunteers: No
Inclusion Criteria: * Adult males and females 18 and older * Able to comprehend procedures and risks * Planning to undergo abdominoplasty surgery * Minimum amount of skin to be removed is 50 x 20cm Exclusion Criteria: * Medical history of not well-controlled diabetes. This is defined as a subject who needs high doses of insulin, recent history of hospitalization for diabetes-related complications, or poor wound health as evidenced by diabetic ulcers. Subjects who have been deemed healthy enough for abdominoplasty surgery would tend to suggest that their diabetes should not be an issue. However, if the subjects have diabetic complications as outlined above, they could affect the wound healing which is the object of this protocol so they would be excluded. * Pregnant or nursing * History of pathologically abnormal wound healing such as keloidal scars * Existing tattoos on the abdomen that are so extensive that they could interfere with the study

Study locations (1)

Pharmacology Translational Unit

Fairborn, Ohio, 45324

Recruiting
Pharmacology Translational Unit · Contact
937-245-7500pturesearch@wrightstatephysicians.org
Mechanisms for Laser-Induced Rejuvenation | Cancerify