Perioperative Versus Adjuvant Systemic Therapy in Patients With Resectable Non-Small Cell Lung Cancer - PROSPECT LUNG
Summary
This phase III trial compares standard therapy given after surgery (adjuvant) to standard therapy given before and after surgery (perioperative) in treating patients with stage II-IIIB non-small cell lung cancer (NSCLC) that can be removed by surgery (resectable). The usual approach for patients with resectable NSCLC is chemotherapy and/or immunotherapy before surgery, after surgery, or both before and after surgery. This study is being done to find out which approach is better at treating patients with lung cancer. Treatment will be administered according to the current standard of care at the time of enrollment. Chemotherapy options may include cisplatin, carboplatin, pemetrexed, gemcitabine, docetaxel, and vinorelbine at standard doses according to the treating physician. Cisplatin is in a class of medications known as platinum-containing compounds. It works by killing, stopping or slowing the growth of tumor cells. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of tumor cells. Pemetrexed is in a class of medications called antifolate antineoplastic agents. It works by stopping cells from using folic acid to make deoxyribonucleic acid (DNA) and may kill tumor cells. Gemcitabine is a chemotherapy drug that blocks the cells from making DNA and may kill tumor cells. Docetaxel is in a class of medications called taxanes. It stops tumor cells from growing and dividing and may kill them. Other chemotherapy drugs, such as vinorelbine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading . Immunotherapy with monoclonal antibodies, such as nivolumab, pembrolizumab, and atezolizumab, may help the body's immune system attack the tumor, and may interfere with the ability of tumor cells to grow and spread. Starting treatment with chemotherapy and immunotherapy prior to surgery and continuing treatment after surgery may be a more effective treatment option than adjuvant therapy alone in patients with stage II-IIIB resectable NSCLC.
Detailed description
The primary and secondary objectives of the study: PRIMARY OBJECTIVE: I. To compare the 3-year real-world event-free survival (rwEFS) rate and overall survival (OS) between perioperative and adjuvant immunotherapy-based treatment for patients with resectable non-small cell lung cancer (dual endpoints). SECONDARY OBJECTIVES: I. To compare the rates of surgical resection between the two arms. II. To compare the rates of complete resection (R0) between the two arms. III. To summarize and compare rates of adverse events (AEs) resulting in permanent treatment discontinuation, hospitalization, or death between the two arms. IV. To evaluate the association between locally defined pathological complete response (pCR) and rwEFS in patients randomized to the perioperative arm (arm 2). V. To compare the rwEFS post 3-years from randomization between the two arms among patients who do not experience an event by 3 years. EXPLORATORY OBJECTIVES: I. To compare outcomes according to the systemic therapy administered on each arm. II. To compare the sites of relapse between the two treatment arms. OUTLINE: Patients are randomized to 1 of 2 arms. ARM 1: SURGERY: Patients undergo surgery within 28 days of registration. ADJUVANT THERAPY: Patients receive platinum-based doublet chemotherapy (cisplatin, carboplatin, pemetrexed, gemcitabine, docetaxel, and/or vinorelbine) for up to 4 cycles and immune checkpoint inhibitor therapy (nivolumab, pembrolizumab, and/or atezolizumab) for up to 1 year in the absence of disease progression or unacceptable toxicity according to current approved guidelines. ARM 2: NEOADJUVANT THERAPY: Within 28 days of registration, patients receive platinum-based doublet chemotherapy (cisplatin, carboplatin, pemetrexed, gemcitabine, docetaxel, and/or vinorelbine) for up to 4 cycles in combination with immune checkpoint inhibitor (nivolumab, pembrolizumab, and/or atezolizumab) according to current approved guidelines. SURGERY: Patients undergo surgery. ADJUVANT THERAPY: Patients receive immune checkpoint inhibitor therapy (nivolumab, pembrolizumab, and/or atezolizumab) for up to 1 year in the absence of disease progression or unacceptable toxicity according to current approved guidelines. Patients also undergo computed tomography (CT) throughout the study and may undergo magnetic resonance imaging (MRI) and/or positron emission tomography (PET)/CT at screening. After completion of study treatment, patients are followed up every 6 months for up to 10 years.
Arms & interventions
- ProcedureSurgical Procedure
undergo surgery
- DrugCisplatin
Give cisplatin
- DrugCarboplatin
Give Carboplatin
- DrugPemetrexed
Give Pemetrexed
- DrugGemcitabine
Give Gemcitabine
- DrugDocetaxel
Give Docetaxel
- DrugVinorelbine
Give Vinorelbine
- DrugNivolumab
Give Nivolumab
- DrugPembrolizumab
Give Pembrolizumab
- DrugAtezolizumab
Give Atezolizumab
- ProcedureComputed Tomography
Undergo CT and/or PET/CT
- ProcedureMagnetic Resonance Imaging
Undergo MRI
- ProcedurePositron Emission Tomography
Undergo PET/CT
Outcome measures
Primary
3-year real-world event-free survival (rwEFS)
Time to event analyses will be summarized using the Kaplan-Meier method, where both the stratified and unstratified log-rank test will be used to compare the distributions across the treatment arms. For the primary analysis of 3-year rwEFS rate, we will compare the rwEFS curves at 3 years, using the difference in Kaplan-Meier estimates for the survival functions. The test statistic will be derived from the difference in the estimated Kaplan-Meier values between two arms at 3 years, using the Greenwood estimate of the variances. rwEFS rates at 1 year, 2 years, and 5 years will also be reported, along with 95% confidence intervals. The comparison of the rwEFS post 3-years between the two arms among patients who do not experience an event by 3 years, will involve assessing the probability of a longer rwEFS on the perioperative arm. Non-parametric estimation and inference methods will be used for analysis.
Time frame: From the date of randomization to the date of the first of the following events: failure to undergo resection for any reason, recurrence or progression at any time after surgery, or death from any cause, assessed at 3 years
Overall survival (OS)
Time to event analyses will be summarized using the Kaplan-Meier method, where both the stratified and unstratified log-rank test will be used to compare the distributions across the treatment arms. OS rates at 1 year, 2 years, and 5 years will also be reported, along with 95% confidence intervals.
Time frame: From randomization until death from any cause, assessed up to 10 years
Secondary
Rates of surgical resection
Time frame: Up to 10 years.
Rates of complete resection (R0)
Time frame: Up to 10 years.
Incidence of adverse events (AEs)
Time frame: Up to 10 years.
Pathological complete response (pCR)
Time frame: Up to 10 years
Eligibility criteria
Study locations (378)
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, 35233
Cancer Center at Saint Joseph's
Phoenix, Arizona, 85004
Mayo Clinic Hospital in Arizona
Phoenix, Arizona, 85054
Mercy Hospital Fort Smith
Fort Smith, Arkansas, 72903
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro, Arkansas, 72401
CARTI Cancer Center
Little Rock, Arkansas, 72205
Kaiser Permanente-Deer Valley Medical Center
Antioch, California, 94531
Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande, California, 93420
Mercy Cancer Center - Carmichael
Carmichael, California, 95608
Mercy San Juan Medical Center
Carmichael, California, 95608
Enloe Medical Center
Chico, California, 95926
Kaiser Permanente Dublin
Dublin, California, 94568
Mercy Cancer Center - Elk Grove
Elk Grove, California, 95758
Kaiser Permanente-Fremont
Fremont, California, 94538
Fresno Cancer Center
Fresno, California, 93720
Kaiser Permanente Fresno Orchard Plaza
Fresno, California, 93720
Kaiser Permanente-Fresno
Fresno, California, 93720
UC San Diego Moores Cancer Center
La Jolla, California, 92093
Fremont - Rideout Cancer Center
Marysville, California, 95901
Mercy Cancer Center
Merced, California, 95340
Kaiser Permanente- Modesto MOB II
Modesto, California, 95356
Kaiser Permanente-Modesto
Modesto, California, 95356
Kaiser Permanente Oakland-Broadway
Oakland, California, 94611
Kaiser Permanente-Oakland
Oakland, California, 94611
Kaiser Permanente-Rancho Cordova Cancer Center
Rancho Cordova, California, 95670
Kaiser Permanente- Marshall Medical Offices
Redwood City, California, 94063
Kaiser Permanente-Richmond
Richmond, California, 94801
Mercy Cancer Center - Rocklin
Rocklin, California, 95765
Rohnert Park Cancer Center
Rohnert Park, California, 94928
Kaiser Permanente-Roseville
Roseville, California, 95661
The Permanente Medical Group-Roseville Radiation Oncology
Roseville, California, 95678
Kaiser Permanente Downtown Commons
Sacramento, California, 95814
Mercy Cancer Center - Sacramento
Sacramento, California, 95816
University of California Davis Comprehensive Cancer Center
Sacramento, California, 95817
Kaiser Permanente-South Sacramento
Sacramento, California, 95823
South Sacramento Cancer Center
Sacramento, California, 95823
Kaiser Permanente-San Francisco
San Francisco, California, 94115
Kaiser Permanente-Santa Teresa-San Jose
San Jose, California, 95119
Kaiser Permanente San Leandro
San Leandro, California, 94577
Pacific Central Coast Health Center-San Luis Obispo
San Luis Obispo, California, 93401
Kaiser San Rafael-Gallinas
San Rafael, California, 94903
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, 95051
Mission Hope Medical Oncology - Santa Maria
Santa Maria, California, 93444
Kaiser Permanente-Santa Rosa
Santa Rosa, California, 95403
Kaiser Permanente Cancer Treatment Center
South San Francisco, California, 94080
Kaiser Permanente-South San Francisco
South San Francisco, California, 94080
Saint Joseph's Medical Center
Stockton, California, 95204
Kaiser Permanente-Stockton
Stockton, California, 95210
Kaiser Permanente Medical Center-Vacaville
Vacaville, California, 95688
Kaiser Permanente-Vallejo
Vallejo, California, 94589
Kaiser Permanente-Walnut Creek
Walnut Creek, California, 94596
Woodland Memorial Hospital
Woodland, California, 95695
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado, 80907
Rocky Mountain Cancer Centers-Penrose
Colorado Springs, Colorado, 80907
Saint Francis Cancer Center
Colorado Springs, Colorado, 80923
CommonSpirit Cancer Center Mercy
Durango, Colorado, 81301
Mercy Medical Center
Durango, Colorado, 81301
CommonSpirit Saint Anthony Hospital Cancer Center
Lakewood, Colorado, 80228
Longmont United Hospital
Longmont, Colorado, 80501
Saint Mary Corwin Medical Center
Pueblo, Colorado, 81004
Saint Anthony North Hospital
Westminster, Colorado, 80023
Beebe Medical Center
Lewes, Delaware, 19958
Beebe South Coastal Health Campus
Millville, Delaware, 19967
Helen F Graham Cancer Center
Newark, Delaware, 19713
Medical Oncology Hematology Consultants PA
Newark, Delaware, 19713
Christiana Care Health System-Christiana Hospital
Newark, Delaware, 19718
Beebe Health Campus
Rehoboth Beach, Delaware, 19971
Christiana Care Health System-Wilmington Hospital
Wilmington, Delaware, 19801
MedStar Georgetown University Hospital
Washington D.C., District of Columbia, 20007
MedStar Washington Hospital Center
Washington D.C., District of Columbia, 20010
Orlando Health Cancer Institute - Lake Mary
Lake Mary, Florida, 32746
The Watson Clinic
Lakeland, Florida, 33805
Health Central
Ocoee, Florida, 34761
Orlando Health Cancer Institute
Orlando, Florida, 32806
CTCA at Southeastern Regional Medical Center
Newnan, Georgia, 30265
Kaiser Permanente Moanalua Medical Center
Honolulu, Hawaii, 96819
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho, 83706
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho, 83605
Kootenai Health - Coeur d'Alene
Coeur d'Alene, Idaho, 83814
Idaho Urologic Institute-Meridian
Meridian, Idaho, 83642
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho, 83687
Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho, 83854
Kootenai Clinic Cancer Services - Sandpoint
Sandpoint, Idaho, 83864
OSF Saint Anthony's Health Center
Alton, Illinois, 62002
Rush-Copley Medical Center
Aurora, Illinois, 60504
Illinois CancerCare-Bloomington
Bloomington, Illinois, 61704
Illinois CancerCare-Canton
Canton, Illinois, 61520
Memorial Hospital of Carbondale
Carbondale, Illinois, 62902
SIH Cancer Institute
Carterville, Illinois, 62918
Illinois CancerCare-Carthage
Carthage, Illinois, 62321
Centralia Oncology Clinic
Centralia, Illinois, 62801
Saint Mary's Hospital
Centralia, Illinois, 62801
Northwestern University
Chicago, Illinois, 60611
John H Stroger Jr Hospital of Cook County
Chicago, Illinois, 60612
University of Illinois
Chicago, Illinois, 60612
Carle at The Riverfront
Danville, Illinois, 61832
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, 62526
Decatur Memorial Hospital
Decatur, Illinois, 62526
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois, 60115
Illinois CancerCare-Dixon
Dixon, Illinois, 61021
Carle Physician Group-Effingham
Effingham, Illinois, 62401
Crossroads Cancer Center
Effingham, Illinois, 62401
Illinois CancerCare-Eureka
Eureka, Illinois, 61530
Illinois CancerCare-Galesburg
Galesburg, Illinois, 61401
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois, 60134
Northwestern Medicine Glenview Outpatient Center
Glenview, Illinois, 60026
Northwestern Medicine Grayslake Outpatient Center
Grayslake, Illinois, 60030
Edward Hines Jr VA Hospital
Hines, Illinois, 60141
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois, 61443
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois, 60045
Illinois CancerCare-Macomb
Macomb, Illinois, 61455
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois, 61938
SSM Health Good Samaritan
Mount Vernon, Illinois, 62864
Cancer Care Center of O'Fallon
O'Fallon, Illinois, 62269
HSHS Saint Elizabeth's Hospital
O'Fallon, Illinois, 62269
Northwestern Medicine Oak Brook
Oak Brook, Illinois, 60523
Northwestern Medicine Orland Park
Orland Park, Illinois, 60462
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois, 61350
Illinois CancerCare-Pekin
Pekin, Illinois, 61554
Illinois CancerCare-Peoria
Peoria, Illinois, 61615
Methodist Medical Center of Illinois
Peoria, Illinois, 61636
Illinois CancerCare-Peru
Peru, Illinois, 61354
Valley Radiation Oncology
Peru, Illinois, 61354
Illinois CancerCare-Princeton
Princeton, Illinois, 61356
UW Health Carbone Cancer Center Rockford
Rockford, Illinois, 61114
Memorial Hospital East
Shiloh, Illinois, 62269
Southern Illinois University School of Medicine
Springfield, Illinois, 62702
Springfield Clinic
Springfield, Illinois, 62702
Springfield Memorial Hospital
Springfield, Illinois, 62781
Carle Cancer Center
Urbana, Illinois, 61801
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, 60555
Illinois CancerCare - Washington
Washington, Illinois, 61571
Rush-Copley Healthcare Center
Yorkville, Illinois, 60560
Midwestern Regional Medical Center
Zion, Illinois, 60099
Goshen Center for Cancer Care
Goshen, Indiana, 46526
Reid Health
Richmond, Indiana, 47374
Mercy Hospital
Cedar Rapids, Iowa, 52403
Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa, 52403
Central Care Cancer Center - Garden City
Garden City, Kansas, 67846
Central Care Cancer Center - Great Bend
Great Bend, Kansas, 67530
HaysMed
Hays, Kansas, 67601
Lawrence Memorial Hospital
Lawrence, Kansas, 66044
The University of Kansas Cancer Center - Olathe
Olathe, Kansas, 66061
Mercy Hospital Pittsburg
Pittsburg, Kansas, 66762
Salina Regional Health Center
Salina, Kansas, 67401
University of Kansas Health System Saint Francis Campus
Topeka, Kansas, 66606
King's Daughter's Medical Center
Ashland, Kentucky, 41101
Flaget Memorial Hospital
Bardstown, Kentucky, 40004
Commonwealth Cancer Center-Corbin
Corbin, Kentucky, 40701
Saint Joseph Hospital
Lexington, Kentucky, 40504
Saint Joseph Radiation Oncology Resource Center
Lexington, Kentucky, 40504
Saint Joseph Hospital East
Lexington, Kentucky, 40509
Saint Joseph London
London, Kentucky, 40741
Saint Joseph Mount Sterling
Mount Sterling, Kentucky, 40353
Owensboro Health Mitchell Memorial Cancer Center
Owensboro, Kentucky, 42303
Tulane University School of Medicine
New Orleans, Louisiana, 70112
University Medical Center New Orleans
New Orleans, Louisiana, 70112
Eastern Maine Medical Center
Bangor, Maine, 04401
Lafayette Family Cancer Center-EMMC
Brewer, Maine, 04412
MedStar Franklin Square Medical Center/Weinberg Cancer Institute
Baltimore, Maryland, 21237
MedStar Good Samaritan Hospital
Baltimore, Maryland, 21239
Christiana Care - Union Hospital
Elkton, Maryland, 21921
Beverly Hospital
Beverly, Massachusetts, 01915
Tufts Medical Center
Boston, Massachusetts, 02111
Lahey Hospital and Medical Center
Burlington, Massachusetts, 01805
Addison Gilbert Hospital
Gloucester, Massachusetts, 01930
Lahey Medical Center-Peabody
Peabody, Massachusetts, 01960
Tufts Medical Center Cancer Center Stoneham
Stoneham, Massachusetts, 02180
OSF Saint Francis Hospital and Medical Group
Escanaba, Michigan, 49829
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota, 56601
Minnesota Oncology - Burnsville
Burnsville, Minnesota, 55337
Cambridge Medical Center
Cambridge, Minnesota, 55008
Minnesota Oncology Hematology PA-Chaska
Chaska, Minnesota, 55318
Mercy Hospital
Coon Rapids, Minnesota, 55433
Minnesota Oncology - Coon Rapids
Coon Rapids, Minnesota, 55433
Fairview Southdale Hospital
Edina, Minnesota, 55435
Minnesota Oncology - Edina
Edina, Minnesota, 55435
Fairview Clinics and Surgery Center Maple Grove
Maple Grove, Minnesota, 55369
Minnesota Oncology - Maple Grove
Maple Grove, Minnesota, 55369
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota, 55109
Saint John's Hospital - Healtheast
Maplewood, Minnesota, 55109
Abbott-Northwestern Hospital
Minneapolis, Minnesota, 55407
Hennepin County Medical Center
Minneapolis, Minnesota, 55415
Health Partners Inc
Minneapolis, Minnesota, 55454
Monticello Cancer Center
Monticello, Minnesota, 55362
New Ulm Medical Center
New Ulm, Minnesota, 56073
Fairview Northland Medical Center
Princeton, Minnesota, 55371
North Memorial Medical Health Center
Robbinsdale, Minnesota, 55422
Mayo Clinic in Rochester
Rochester, Minnesota, 55905
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota, 56303
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota, 55416
Regions Hospital
Saint Paul, Minnesota, 55101
United Hospital
Saint Paul, Minnesota, 55102
Saint Francis Regional Medical Center
Shakopee, Minnesota, 55379
Lakeview Hospital
Stillwater, Minnesota, 55082
Sanford Thief River Falls Medical Center
Thief River Falls, Minnesota, 56701
Ridgeview Medical Center
Waconia, Minnesota, 55387
Rice Memorial Hospital
Willmar, Minnesota, 56201
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota, 55125
Sanford Cancer Center Worthington
Worthington, Minnesota, 56187
Fairview Lakes Medical Center
Wyoming, Minnesota, 55092
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus, Mississippi, 39705
Baptist Cancer Center-Grenada
Grenada, Mississippi, 38901
Baptist Memorial Hospital and Cancer Center-Union County
New Albany, Mississippi, 38652
Baptist Memorial Hospital and Cancer Center-Oxford
Oxford, Mississippi, 38655
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, Mississippi, 38671
Mercy Oncology and Hematology - Clayton-Clarkson
Ballwin, Missouri, 63011
Central Care Cancer Center - Bolivar
Bolivar, Missouri, 65613
Cox Cancer Center Branson
Branson, Missouri, 65616
Mercy Cancer Center - Cape Girardeau
Cape Girardeau, Missouri, 63703
Saint Francis Medical Center
Cape Girardeau, Missouri, 63703
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, Missouri, 63376
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri, 63141
Parkland Health Center - Farmington
Farmington, Missouri, 63640
Freeman Health System
Joplin, Missouri, 64804
Mercy Hospital Joplin
Joplin, Missouri, 64804
University Health Truman Medical Center
Kansas City, Missouri, 64108
Lake Regional Hospital
Osage Beach, Missouri, 65065
Mercy Clinic-Rolla-Cancer and Hematology
Rolla, Missouri, 65401
Phelps Health Delbert Day Cancer Institute
Rolla, Missouri, 65401
Heartland Regional Medical Center
Saint Joseph, Missouri, 64506
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri, 63670
Mercy Hospital Springfield
Springfield, Missouri, 65804
CoxHealth South Hospital
Springfield, Missouri, 65807
Mercy Infusion Center - Chippewa
St Louis, Missouri, 63109
Washington University School of Medicine
St Louis, Missouri, 63110
Veteran's Affairs Medical Center - Saint Louis
St Louis, Missouri, 63125
Mercy Hospital South
St Louis, Missouri, 63128
Siteman Cancer Center-South County
St Louis, Missouri, 63129
Missouri Baptist Medical Center
St Louis, Missouri, 63131
Siteman Cancer Center at Christian Hospital
St Louis, Missouri, 63136
Mercy Hospital Saint Louis
St Louis, Missouri, 63141
Missouri Baptist Sullivan Hospital
Sullivan, Missouri, 63080
BJC Outpatient Center at Sunset Hills
Sunset Hills, Missouri, 63127
Mercy Hospital Washington
Washington, Missouri, 63090
Community Hospital of Anaconda
Anaconda, Montana, 59711
Billings Clinic Cancer Center
Billings, Montana, 59101
Bozeman Health Deaconess Hospital
Bozeman, Montana, 59715
Benefis Sletten Cancer Institute
Great Falls, Montana, 59405
Great Falls Clinic
Great Falls, Montana, 59405
Hi-Line Sletten Cancer Center
Havre, Montana, 59501
Benefis Helena Specialty Center
Helena, Montana, 59601
Logan Health Medical Center
Kalispell, Montana, 59901
Community Medical Center
Missoula, Montana, 59804
CHI Health Saint Francis
Grand Island, Nebraska, 68803
CHI Health Good Samaritan
Kearney, Nebraska, 68847
Alegent Health Immanuel Medical Center
Omaha, Nebraska, 68122
Alegent Health Bergan Mercy Medical Center
Omaha, Nebraska, 68124
Alegent Health Lakeside Hospital
Omaha, Nebraska, 68130
Creighton University Medical Center
Omaha, Nebraska, 68131
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire, 03756
Dartmouth Cancer Center - Manchester/ DCC Manchester
Manchester, New Hampshire, 03104
Dartmouth Cancer Center - Nashua
Nashua, New Hampshire, 03063
Cooper Hospital University Medical Center
Camden, New Jersey, 08103
Englewood Hospital and Medical Center
Englewood, New Jersey, 07631
Cooper CyberKnife Center
Mount Laurel, New Jersey, 08054
Jersey Shore Medical Center
Neptune City, New Jersey, 07753
The Valley Hospital - Luckow Pavilion
Paramus, New Jersey, 07652
Neurosurgeons of New Jersey-Ridgewood
Ridgewood, New Jersey, 07450
Valley Health System Ridgewood Campus
Ridgewood, New Jersey, 07450
MD Anderson Cancer Center at Cooper-Voorhees
Voorhees Township, New Jersey, 08043
Valley Health System-Hematology/Oncology
Westwood, New Jersey, 07675
University of New Mexico Cancer Center
Albuquerque, New Mexico, 87106
Memorial Medical Center-Las Cruces
Las Cruces, New Mexico, 88011
Glens Falls Hospital
Glens Falls, New York, 12801
Upstate Cancer Center at Oswego
Oswego, New York, 13126
University of Rochester
Rochester, New York, 14642
State University of New York Upstate Medical University
Syracuse, New York, 13210
SUNY Upstate Medical Center-Community Campus
Syracuse, New York, 13215
James J Peters VA Medical Center
The Bronx, New York, 10468
Upstate Cancer Center at Verona
Verona, New York, 13478
Wilmot Cancer Institute at Webster
Webster, New York, 14580
Sanford Bismarck Medical Center
Bismarck, North Dakota, 58501
Sanford South University Medical Center
Fargo, North Dakota, 58103
Southpointe-Sanford Medical Center Fargo
Fargo, North Dakota, 58103
Sanford Medical Center Fargo
Fargo, North Dakota, 58104
Sanford Broadway Medical Center
Fargo, North Dakota, 58122
Sanford Roger Maris Cancer Center
Fargo, North Dakota, 58122
Indu and Raj Soin Medical Center
Beavercreek, Ohio, 45431
Saint Elizabeth Boardman Hospital
Boardman, Ohio, 44512
Dayton Physicians LLC-Miami Valley South
Centerville, Ohio, 45459
Good Samaritan Hospital - Cincinnati
Cincinnati, Ohio, 45220
Oncology Hematology Care Inc-Kenwood
Cincinnati, Ohio, 45236
Bethesda North Hospital
Cincinnati, Ohio, 45242
TriHealth Cancer Institute-Westside
Cincinnati, Ohio, 45247
TriHealth Cancer Institute-Anderson
Cincinnati, Ohio, 45255
Dayton Physician LLC - Englewood
Dayton, Ohio, 45415
Armes Family Cancer Center
Findlay, Ohio, 45840
Blanchard Valley Hospital
Findlay, Ohio, 45840
Orion Cancer Care
Findlay, Ohio, 45840
Dayton Physicians LLC-Atrium
Franklin, Ohio, 45005
Dayton Physicians LLC-Wayne
Greenville, Ohio, 45331
Wayne Hospital
Greenville, Ohio, 45331
Greater Dayton Cancer Center
Kettering, Ohio, 45409
Kettering Medical Center
Kettering, Ohio, 45429
Dayton Physicians LLC - Troy
Troy, Ohio, 45373
Saint Joseph Warren Hospital
Warren, Ohio, 44484
Saint Elizabeth Youngstown Hospital
Youngstown, Ohio, 44501
Cancer Centers of Southwest Oklahoma Research
Lawton, Oklahoma, 73505
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104
Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma, 73120
Saint Alphonsus Cancer Care Center-Baker City
Baker City, Oregon, 97814
Legacy Mount Hood Medical Center
Gresham, Oregon, 97030
Saint Alphonsus Cancer Care Center-Ontario
Ontario, Oregon, 97914
Legacy Good Samaritan Hospital and Medical Center
Portland, Oregon, 97210
Salem Hospital
Salem, Oregon, 97301
Legacy Meridian Park Hospital
Tualatin, Oregon, 97062
Christiana Care Health System-Concord Health Center
Chadds Ford, Pennsylvania, 19317
Geisinger Medical Center
Danville, Pennsylvania, 17822
Geisinger Cancer Center Dickson City
Dickson City, Pennsylvania, 18519
Geisinger Medical Center-Cancer Center Hazleton
Hazleton, Pennsylvania, 18201
Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania, 17837
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania, 18711
Medical University of South Carolina
Charleston, South Carolina, 29425
McLeod Regional Medical Center
Florence, South Carolina, 29506
Gibbs Cancer Center-Gaffney
Gaffney, South Carolina, 29341
Saint Francis Hospital
Greenville, South Carolina, 29601
Saint Francis Cancer Center
Greenville, South Carolina, 29607
Self Regional Healthcare
Greenwood, South Carolina, 29646
Gibbs Cancer Center-Pelham
Greer, South Carolina, 29651
North Grove Medical Park
Spartanburg, South Carolina, 29303
Spartanburg Medical Center
Spartanburg, South Carolina, 29303
Spartanburg Medical Center - Mary Black Campus
Spartanburg, South Carolina, 29307
SMC Center for Hematology Oncology Union
Union, South Carolina, 29379
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota, 57104
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, 57117-5134
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville, Tennessee, 38017
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee, 38120
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, 75390
Lyndon Baines Johnson General Hospital
Houston, Texas, 77026-1967
Dartmouth Cancer Center - North
Saint Johnsbury, Vermont, 05819
University of Virginia Cancer Center
Charlottesville, Virginia, 22908
Saint Joseph Medical Center Hematology and Oncology - Silverdale
Silverdale, Washington, 98383
Legacy Cancer Institute Medical Oncology and Day Treatment
Vancouver, Washington, 98684
Legacy Salmon Creek Hospital
Vancouver, Washington, 98686
Langlade Hospital and Cancer Center
Antigo, Wisconsin, 54409
ThedaCare Regional Cancer Center
Appleton, Wisconsin, 54911
ThedaCare Cancer Care - Berlin
Berlin, Wisconsin, 54923
Marshfield Clinic-Chippewa Center
Chippewa Falls, Wisconsin, 54729
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin, 54701
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin, 54301
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin, 54303
Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601
Marshfield Medical Center - Ladysmith
Ladysmith, Wisconsin, 54848
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin, 54449
Aspirus Medford Hospital
Medford, Wisconsin, 54451
Froedtert Menomonee Falls Hospital
Menomonee Falls, Wisconsin, 53051
Medical College of Wisconsin
Milwaukee, Wisconsin, 53226
Zablocki Veterans Administration Medical Center
Milwaukee, Wisconsin, 53295
Marshfield Medical Center - Minocqua
Minocqua, Wisconsin, 54548
ProHealth D N Greenwald Center
Mukwonago, Wisconsin, 53149
ThedaCare Regional Medical Center - Neenah
Neenah, Wisconsin, 54956
Marshfield Medical Center - Neillsville
Neillsville, Wisconsin, 54456
ThedaCare Cancer Care - New London
New London, Wisconsin, 54961
Cancer Center of Western Wisconsin
New Richmond, Wisconsin, 54017
Drexel Town Square Health Center
Oak Creek, Wisconsin, 53154
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin, 53066
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls, Wisconsin, 54154
ThedaCare Cancer Care - Oshkosh
Oshkosh, Wisconsin, 54904
Aspirus Cancer Care - James Beck Cancer Center
Rhinelander, Wisconsin, 54501
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin, 54868
ThedaCare Cancer Care - Shawano
Shawano, Wisconsin, 54166
Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan, Wisconsin, 53081
Sheboygan Physicians Group
Sheboygan, Wisconsin, 53081
Aspirus Cancer Care - Stevens Point
Stevens Point, Wisconsin, 54481
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin, 54482
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, Wisconsin, 54235-1495
ProHealth Waukesha Memorial Hospital
Waukesha, Wisconsin, 53188
UW Cancer Center at ProHealth Care
Waukesha, Wisconsin, 53188
ThedaCare Cancer Care - Waupaca
Waupaca, Wisconsin, 54981
Aspirus Regional Cancer Center
Wausau, Wisconsin, 54401
Marshfield Clinic-Wausau Center
Wausau, Wisconsin, 54401
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, Wisconsin, 53095
Marshfield Medical Center - Weston
Weston, Wisconsin, 54476
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids, Wisconsin, 54494
Marshfield Clinic - Wisconsin Rapids Center
Wisconsin Rapids, Wisconsin, 54494
Memorial Hospital of Laramie County
Cheyenne, Wyoming, 82001
Billings Clinic-Cody
Cody, Wyoming, 82414
References
- Booth A, Hillman S, Laumann K, Zhao YQ, LeBlanc M, Chansky K, Giri S, Dill J, Johnson J, Kelley K, Martin L, Osarogiagbon RU, Morris MJ, Chiang AC, Kozono DE, Blanke CD, Galanis E, Gray JE, Stinchcombe TE, Aljumaily R, Morgensztern D, Mandrekar SJ. PROSPECT-LUNG: A National Clinical Trials Network Trial Advancing Pragmatic Innovation in Cancer Clinical Trials. J Thorac Oncol. 2026 Feb 24:103650. doi: 10.1016/j.jtho.2026.103650. Online ahead of print.(PubMed)