RecruitingObservational

Utilizing Long-read Sequencing to Investigate the EGFR Landscape of EGFR Positive Lung Cancer Patients

NCT ID: NCT06659458Sponsor: Our Lady of the Lake HospitalLast updated: 2025-03-20

Summary

EGFR gene mutations are some of the most commonly occurring mutations in non-small cell lung cancer. Investigators have developed a DNA instability model that estimates a risk score to assess the likelihood of an individual acquiring a cancer-linked mutation. The aim of this study is to collect blood from both those diagnosed with EGFR positive lung cancer and healthy individuals, evaluate their gene sequence surrounding the EGFR landscape and use the cancer positive and healthy sequences to validate the risk assessment model, which may one day be used to provide insight on susceptibility of getting EGFR positive lung cancer or potentially other cancer types.

Arms & interventions

Otherblood draw
A 10ml Blood sample will be taken and used to sequence the EGFR gene and surrounding DNA.
OtherGene sequencing
Subjects will have their DNA sequenced within and around the EGFR gene.

Outcome measures

Primary

Differences in DNA sequence of EGFR gene
Subjects who have EGFR positive lung cancer will have their gene sequence compared to those that are EGFR negative and do not have lung cancer to look for differences in the sequence.
Time frame: From enrollment to end of data analysis at 6 months

Eligibility criteria

Sex: FemaleAge: 18 Years to 100 YearsHealthy volunteers: Yes

Inclusion Criteria: * 18-100 years old * Biologically born female * Diagnosed with EGFR positive lung cancer (Arm 1-Cancer group) * No cancer diagnosis (Arm 2-health control) Exclusion Criteria: * less than 18 years of age * Biologically born male * Incarcerated at the time of participation

Study locations (1)

Our Lady of the Lake Regional Medical Center

Baton Rouge, Louisiana, 70808

Recruiting