A Feasibility Study of a Novel Cone-Beam CT Approach for Image Guided Radiotherapy in Cancer Patients
Summary
Cone beam computed tomography (CBCT) is an imaging technology that is incorporated into many modern radiation therapy systems. The quality of conventional CBCT is good enough to align patients for their daily radiation therapy but CBCT images have poor contrast and are susceptible to imaging artefacts that limit their usability for other tasks in the radiation therapy workflow. Varian Medical Systems, the sponsor of this study, has developed new CBCT imaging technology called HyperSight that so far has demonstrated increased image quality compared with conventional CBCT images. This new HyperSight CBCT imager has previously been built into Varian Halcyon and Ethos treatment machines, where the imager is enclosed in a ring that rotates around the patient. Now, HyperSight has been built into a Varian treatment machine, called TrueBeam, where the imager is mounted on a C-shaped arm that rotates around you to acquire an image. This study is being done to evaluate the image quality of HyperSight CBCT compared to conventional CBCT images, and to determine whether HyperSight CBCT can improve the process of delivering radiation treatments. The goal of this study is to collect images from this new HyperSight-TrueBeam CBCT imager from a variety of patients and locations in the body. The images will be analyzed to determine whether their quality is high enough to use for tasks other than positioning patients for treatment. For example, the study will determine whether the HyperSight images could be used to calculate a radiation plan.
Arms & interventions
- DeviceComparison of HyperSight CBCT imaging to conventional CBCT imaging.
Participants will receive their daily radiation treatment on a radiation therapy system equipped with HyperSight CBCT imaging. For at least 1 and up to 3 treatment fractions, participants will receive their daily radiation treatment on a system equipped with conventional CBCT imaging.
Outcome measures
Primary
Comparison of Image Contrast Resolution
The difference in contrast resolution will be evaluated between a standard CBCT image, a CBCT image acquired using HyperSight technology, and a standard fan-beam CT acquired as part of the treatment simulation and planning process
Time frame: End of radiation treatment at 9 weeks.
Comparison of Image Uniformity
The difference in image uniformity will be evaluated between a standard CBCT image, a CBCT image acquired using HyperSight technology, and a standard fan-beam CT acquired as part of the treatment simulation and planning process.
Time frame: End of radiation treatment at 9 weeks.
Qualitative Image Comparison
Qualitative comparison of HyperSight CBCT to conventional CBCT to determine preferred imaging for patient localization for daily treatment. Clinician observers will rank their preference using a 5-point Likert scale, where 1 represents strong preference of one imaging modality and 5 represents strong preference for the other modality.
Time frame: End of radiation treatment at 9 weeks.
Secondary
Reduction of Metal Artifacts
Time frame: End of radiation treatment at 9 weeks.
Imaging Time for Large Treatment Volumes
Time frame: End of radiation treatment at 9 weeks.
Imaging Time for Breath Hold Imaging
Time frame: End of radiation treatment at 9 weeks.
Patient Tolerance of Breath Hold Imaging
Time frame: End of radiation treatment at 9 weeks.
Feasibility of HyperSight CBCT for Treatment Planning
Time frame: End of radiation treatment at 9 weeks.
Eligibility criteria
Study locations (4)
James Outpatient Center
Columbus, Ohio, 43210
Ohio State University, Brain and Spine Hospital
Columbus, Ohio, 43210
The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
Columbus, Ohio, 43210
Stefanie Spielman Comprehensive Breast Center
Columbus, Ohio, 43212