Postoperative Heme Oxygenase Induction and Carbon Monoxide Production as a Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy
Summary
the investigators will pursue two specific aims: (1) to monitor the extent of heme oxygenase induction (by measuring endogenous CO production) in relationship to the extent of hepatic resection (2) to assess the production of CO in patients following liver resection and correlate these findings to the rate of liver regeneration and liver function.
Arms & interventions
- Othercarbon monoxide measurement via smokerlyzer
participants in this study will provide breath samples for carbon monoxide measurements pre and post liver resection
Outcome measures
Primary
correlation of carbon monoxide levels in exhaled breath with quantity and quality of liver regeneration
patients will be asked to donate exhaled breath into a smokerlyzer device
Time frame: measurements will be taken pre, then 4 hours and 24 hours post resection
Secondary
level of carbon monoxide in exhaled air of patients
Time frame: measurements will be taken pre, then 4 hours and 24 hours post resection
quantity of liver regeneration, liver volume (ml)
Time frame: one and three months after resection
quality of hepatic regeneration, normalized liver function
Time frame: one and three months post resection
Eligibility criteria
Study locations (1)
Englewood Hospital
Englewood, New Jersey, 07631