Defining Mechanisms of Surgical Site Infection After Oral Cancer Surgery
Summary
The study design is an observational cohort study of patients undergoing standard of care oral cavity reconstruction. An observational study is required to prospectively evaluate microbial and antibiotic mechanisms underlying surgical site infection after oral cavity reconstruction.
Detailed description
This is a single institution study at the Medical College of Wisconsin, given the feasibility of projected sample size accrual as well as the clinical and translational expertise at this location for investigating surgical site infection after oral cavity reconstruction. Biospecimens collected will include oral, nasal, pharyngoesophageal, and skin microbial swabs, blood, and discard tissue samples obtained during standard of care oral cavity reconstruction surgery and an oral swab and nasal swab obtained post-operatively.
Arms & interventions
- ProcedureOral Cavity Reconstruction
This procedure includes a planned surgical connection from the oral cavity to the neck soft tissues which is repaired through free or pedicled flap reconstruction.
Outcome measures
Primary
Source of bacteria leading to a surgical site infection
This is the number of subjects with surgical site infections with bacteria that originates from the oral cavity. This will be determined by metagenomic mapping of bacterial strains causing surgical site infection back on to the metagenomic samples from their anatomic source (oral cavity, nasal cavity, pharyngoesophagus, donor site skin).
Time frame: Up to 30 days
Secondary
Tissue antibiotic correlations
Time frame: Up to 30 days
Plasma antibiotic correlations
Time frame: Up to 30 days
Eligibility criteria
Study locations (1)
Froedtert & the Medical College of Wisconsin
Milwaukee, Wisconsin, 53226