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RecruitingObservational

CanScan; Community-based Registry to Assess, Address and advaNce SCreening for cANcer Prevention and Management

NCT ID: NCT06804395Sponsor: Hackensack Meridian HealthLast updated: 2026-05-26

Summary

Early diagnosis of cancer allows for better treatment outcomes, higher survival rates, and lower costs of care. It is shown that cancer monitoring for cancer in at-risk populations is a key component in early diagnosis. The HMH Hennessey Institute for Cancer prevention and Applied Molecular Science (HICAP) is a newly founded institute, providing clinical services for cancer screening and risk assessment to the community, as well as research in cancer risk and prevention. The CanScan registry will prospectively collect data from participants in the form of questionnaires. The registry will also capture data that is collected as per non-research assessments, for participants who consent to participate. The registry will facilitate better understanding of cancer risk, screening, and diagnostics.

Outcome measures

Primary

  • Rate of Pathogenic Germline Variants (PGV)

    Compare the number of detected PGVs as measured by a universal multi-gene panel, proactively, in a diverse community-based population of individuals. PGV rate will be compared to NCCN genetic testing criteria at baseline, and to longitudinal cancer outcomes.

    Time frame: 10 years from study initiation as defined based on the date the first patient was enrolled.

Secondary

  • Incidence of Cancer

    Time frame: 10 years from study enrollment.

  • Genetic Risk Score (GRS)

    Time frame: 10 years from study enrollment

  • Environmental and Lifestyle Factors

    Time frame: 10 years from study enrollment

  • Impact of Early Detection and Prevention on Cancer Outcomes

    Time frame: 10 years from study enrollment

Eligibility criteria

Sex: AllAge: 18 Years and olderHealthy volunteers: Yes
* Adults ( 18 and older) * Ability to provide own consent * Must meet at least one of the below criteria, Indicating an increased risk for cancer, any of the following: * Family or personal history suggests a familial/hereditary disorder known or suspected of predisposition to cancer. * Personal factors associated with an increased risk for cancer include benign breast disease, polyps, tobacco use, etc.as defined by the investigator. * Family members of participating individuals. * Any participant in the HICAP program regardless of cancer risk

Study locations (1)

Hennessy Institute for Cancer Prevention and Applied Molecular Medicine

Totowa, New Jersey, 07462

Recruiting
Lee Ifhar, MSs, CCRP · Contact
862-657-4227Lee.ifhar@hmhn.org