Cancerify Logo
Log inSign up
Back to clinical trials
RecruitingInterventionalPhase 2

Acupuncture for Adolescent and Young Adult Cancer Patients: (AcuAYA)

NCT ID: NCT06915116Sponsor: Memorial Sloan Kettering Cancer CenterLast updated: 2026-04-14

Summary

The purpose of this study is to find out whether it is practical (feasible) to use acupuncture to treat period loss (amenorrhea) caused by chemotherapy treatment in people with cancer. The researchers will look at how many participants enroll and complete the study. The researchers will also study how treatment with acupuncture affects the amount of time for the menstrual cycle to return and symptoms and quality of life related to amenorrhea.

Arms & interventions

  • ProcedureAcupuncture

    Acupuncture will be delivered by licensed experienced acupuncturists at MSK. The intervention includes 12 treatments of acupuncture over 12 weeks (i.e. one treatment a week) with a +/- 14-day window. This window applies to the 12-week treatment period rather than to individual visits. The minimum required time between each treatment is 48 hours. When patients experience menses recovery during the treatment period, they have the option to discontinue treatment or continue receiving up to 12 acupuncture sessions for symptom management over 12 weeks.

  • OtherNo Acupuncture

    Will have the option to receive the same acupuncture treatment as the acupuncture group after a 16-week waiting period

Outcome measures

Primary

  • Enrollment rate

    This is the proportion of patients who enroll in the study among those who are eligible and offered participation. Reason for not participating will be documented (e.g. time/commitment, not wanting to be randomized, does not want the study intervention).

    Time frame: 1 year

  • Acupuncture treatment adherence rate.

    adherence rate is the proportion of patients randomized to the Acupuncture arm who are treatment adherent, defined as completing 10 or more of the 12 acupuncture sessions.

    Time frame: up to 16 weeks

Secondary

  • Menses recovery

    Time frame: 1 year

Eligibility criteria

Sex: FemaleAge: 15 Years to 40 YearsHealthy volunteers: No
Inclusion Criteria: * English speaking woman between the ages of 15 and 40 * History of stage I, II, or III cancer OR stage IV or unstaged hematologic malignancy (e.g. lymphoma, leukemia, myeloma) that is stable, as assessed by care team * Premenopausal status with regular menstruation at the time of diagnosis by patient report * Completed cytotoxic chemotherapy within the past year * Premenopausal status with regular menstruation at the time of diagnosis by patient report for females ages 18 or older * Report cessation of menses during or after chemotherapy and have not experienced menses recovery at the time of enrollment. * Have reached menarche prior to therapy or during therapy for females between 15 and 17 years old * Patient reports cessation of menses during or after chemotherapy and have not experienced menses recovery at the time of enrollment. * Have been without menses for at least 3 months 64 following the completion of cytotoxic chemotherapy * Willing to adhere to all study-related procedures, including randomization to one of the two possible arms: acupuncture and WLC Exclusion Criteria: * Had been pregnant or lactating within 3 months prior to enrollment * History of hysterectomy or bilateral oophorectomy * Ongoing or planned radiation or surgery within 4 months from randomization * Use of acupuncture for menses recovery within 3 months of enrollment * Had been or will be receiving ovarian suppression medicine, such as leuprolide (Lupron) and goserelin (Zoladex), or hormonal contraception drugs within 3 months of enrollment or during the study period

Study locations (7)

Memorial Sloan Kettering Basking Ridge (All Protocol Activities)

Basking Ridge, New Jersey, 07920

Recruiting
Jun Mao, MD, MSCE · Contact

Memorial Sloan Kettering Monmouth (All protocol activities)

Middletown, New Jersey, 07748

Recruiting
Jun Mao, MD, MSCE · Contact

Memorial Sloan Kettering Bergen (All Protocol Activities)

Montvale, New Jersey, 07645

Recruiting
Jun Mao, MD, MSCE · Contact

Memorial Sloan Kettering Suffolk- Commack (All Protocol Activities)

Commack, New York, 11725

Recruiting
Jun Mao, MD, MSCE · Contact

Memorial Sloan Kettering Westchester (All Protocol Activities)

Harrison, New York, 10604

Recruiting
Jun Mao, MD, MSCE · Contact

Memorial Sloan Kettering Cancer Center (All Protocol Activities)

New York, New York, 10065

Recruiting
Jun Mao, MD, MSCE · Contact
William Tap, MD · Contact

Memorial Sloan Kettering Nassau (All Protocol Activities)

Rockville Centre, New York, 11553

Recruiting
Jun Mao, MD, MSCE · Contact