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RecruitingInterventional

Cancer Prevention by Reducing Tobacco With Informatics and Chronic Care Approaches Trial (CONNECT)

NCT ID: NCT07020273Sponsor: Washington University School of MedicineLast updated: 2026-01-08

Summary

The purpose of this study is to evaluate the comparative effectiveness of two different informatics-enabled implementation strategies on increasing tobacco treatment and improving smoking cessation rates for cancer control and prevention. This will be done via a two-arm pragmatic cluster randomized trial (CRT) to test the effectiveness of nudges to change (ELEVATE-S) vs. quit-focused usual care (ELEVATE) in increasing tobacco treatment (use of medication, brief advice, or referral to external counseling) and smoking cessation.

Arms & interventions

  • BehavioralELEVATE

    ELEVATE uses implementation strategies to support clinicians (support clinicians by revising professional roles to enable point of care tobacco treatment with a team are approach and support clinicians by providing clinical decision support tools).

  • BehavioralELEVATE-S

    ELEVATE-S uses implementation strategies to support clinicians (support clinicians by revising professional roles to enable point of care tobacco treatment with a team are approach and support clinicians by providing clinical decision support tools) and implementation strategies to support patients with chronic care model-informed self-management support (patient centered flexible goals and patient-generated health data).

Outcome measures

Primary

  • Patient receipt of tobacco use treatment, i.e. Tobacco use treatment (TUT) Reach

    This will be quantified by the proportion of enrolled patients who receive tobacco use treatment (either medication or behavioral intervention (brief advice or referral to counseling)).

    Time frame: Up to 6 months post-enrollment

Secondary

  • Patient receipt of tobacco use treatment - behavioral intervention.

    Time frame: Up to 6 months post-enrollment

  • Patient receipt of tobacco use treatment - medication.

    Time frame: Up to 6 months post-enrollment

  • Patient smoking abstinence

    Time frame: Up to 6 months post-enrollment

Eligibility criteria

Sex: AllAge: 18 Years and olderHealthy volunteers: Yes
Eligibility Criteria: * Be receiving care at a participating clinic * Report current tobacco use (assessed by the rooming staff during the index visit) * Have a completed appointment with a participating clinic * Be an adult (at least 18 years old).

Study locations (1)

Washington University School of Medicine

St Louis, Missouri, 63110

Recruiting
Li-Shiun Chen, M.D., MPH, ScD · Contact
Nina Smock · Contact
Li-Shiun Chen, M.D., MPH, ScD · Principal Investigator
Aimee James, Ph.D. · Sub Investigator
Ramaswamy Govindan, M.D. · Sub Investigator
Jeff Michalski, M.D. · Sub Investigator
Premal Thaker, M.D. · Sub Investigator
Esther Lu, Ph.D. · Sub Investigator
Alex Ramsey, Ph.D. · Sub Investigator
Laura Bierut, M.D. · Sub Investigator
Thomas Kannampallil, Ph.D. · Sub Investigator