Lung Cancer Screening of Family Members of Patients With Mutation-Driven Lung Cancer

Cohort A: Inclusion Criteria: * Current diagnosis of lung cancer with a driver mutation. * Known driver mutation (e.g. via NGS, PCR, IHC, FISH, RT-PCR etc.) * Able and willing to give informed consent. * Able and willing to complete the screening questionnaire. Cohort A: Exclusion Criteria: * There are no exclusion criteria for Cohort A. Cohort B: Inclusion Criteria: * Age 40 - 80. * Must have a first degree relative (mother, father, sibling, biological child) eligible for Cohort A. Note: Multiple first degree relatives of a Cohort A eligible participant may be approached for participation into the trial. * Smoked \< 20 pack years; a. Pack years = numbers of packs per day × number of years smoked; b. One pack year is the equivalent of smoking an average of 20 cigarettes (1 pack) per day for a year. * Be able to undergo a low dose chest CT scan. * If an upper respiratory infection (pneumonia, COVID19, flu, etc.) occurred in the last 3 months, this infection must have resolved by time of enrollment. * Able and willing to provide informed consent. * Able and willing to comply with the protocol requirements Cohort B: Exclusion Criteria: * Previous history of lung cancers. * Symptoms suggestive of presence of current lung cancer, including (but not limited to): unexplained weight loss of over 15 pounds within the last 12 months or unexplained hemoptysis. * Pregnant at time of enrollment. * History of any type of cancer within 5 years, with the exception of in situ carcinomas and non-melanoma skin cancers (if excised). * Current smoker. * Smoked ≥ 20 pack years. * Had a chest CT scan within 1 year of study entry.