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RecruitingInterventional

Pilot Study of Line-Field Confocal Optical Coherence Tomography for Detection of Mohs Micrographic Surgery Margins of Basal Cell Carcinomas

NCT ID: NCT07182240Sponsor: Roswell Park Cancer InstituteLast updated: 2026-06-01

Summary

To assess the feasibility and provide information on the utility of noninvasive line field confocal optical coherence tomography (LC-OCT) for the presurgical assessment of Mohs micrographic surgery sites in patients undergoing removal of cutaneous basal cell carcinomas (BCC).

Arms & interventions

  • DeviceLC-OCT Imaging

    handheld imaging device will take high resolution images of lesion

Outcome measures

Primary

  • Number of cases with fully evaluable images

    cases were the image evaluator can assess the margins based on image quality

    Time frame: 1.5 years

Secondary

  • Patient interest in study

    Time frame: 1.5 years

  • Patients overall experience

    Time frame: one office visit - immediately after imaging procedure

  • Determine LC-OCT imaging's impact on surgical workflow

    Time frame: To be filled out immediately after finishing Mohs procedure

  • Accuracy of LC-OCT findings

    Time frame: 1.5 years

  • Accuracy of LC-OCT in detectng location of tumor

    Time frame: 1.5 years

Eligibility criteria

Sex: AllAge: 18 Years and olderHealthy volunteers: No
Inclusion Criteria: * Age ≥ 18 years * Participant must understand the investigational nature of this study and provide written consent prior to receiving any study-related procedure. * Participant must be clinically eligible for Mohs surgery as determined by their referring dermatologist and the Mohs surgeon. * The participant must have a BCC with superficial histology or a BCC with multiple histological features that also include superficial histology, which is appropriate for Mohs surgery. Exclusion Criteria: * Known or reported allergy to mineral oil, the optical agent used during imaging. * Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements. * . Any condition which in the investigator's opinion deems the subject an unsuitable candidate to undergo imaging procedure. * Unwilling or unable to follow protocol requirements

Study locations (1)

Roswell Park Comprehensive Cancer Center

Buffalo, New York, 14263

Recruiting
Pilot Study of Line-Field Confocal Optical Coherence Tomography for Detection of Mohs Micrographic Surgery Margins of Basal Cell Carcinomas | Cancerify