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RecruitingObservational

Optimizing Preoperative Surgical Decision-making for Intraductal Papillary Mucinous Neoplasms: The Role of Intent of Surgery

NCT ID: NCT07216521Sponsor: NYU Langone HealthLast updated: 2025-10-14

Summary

This multicenter retrospective observational cohort study seeks to: 1. Classify surgical intent in patients with resected Intraductal Papillary Mucinous Neoplasms (IPMN) and quantify the proportion of IPMN-associated cancers diagnosed as overt pancreatic cancer with incidental IPMN association on pathology. 2. Compare clinicopathologic features and outcomes between surveillance-detected and incidentally detected IPMN-derived pancreatic cancers. 3. Revise and redefine risk features limited to patients undergoing surgery for IPMN-related indications, identifying optimal predictors of malignant IPMN (high-grade dysplasia or invasive cancer).

Arms & interventions

Outcome measures

Primary

  • Grade of IPMN on Final Pathology

    Time frame: Day 0 (Retrospective Analysis)

Secondary

  • Recurrence Free Survival

    Time frame: Day 0 (Retrospective Analysis)

  • Overall Survival

    Time frame: Day 0 (Retrospective Analysis)

Eligibility criteria

Sex: AllAge: 18 Years and older
Inclusion Criteria: * All patients (18 years old of greater) who underwent surgical resection for IPMN (including low-, high-grade dysplasia, or invasive carcinoma) between July 1, 2015 and July 1, 2025. Exclusion Criteria: * Patients with concomitant pancreatic ductal adenocarcinoma (PDAC)

Study locations (8)

Mayo Clinic

Phoenix, Arizona, 85054

Recruiting
Zhi Fong, MD, PhD · Principal Investigator

Johns Hopkins University

Baltimore, Maryland, 21287

Recruiting
Jin He, MD, PhD · Principal Investigator

Massachusetts General Hospital

Boston, Massachusetts, 02114

Recruiting
Carlos Fernandez-del Castillo, MD · Principal Investigator

Mayo Clinic

Rochester, Minnesota, 55905

Recruiting
Cornelius Thiels, D.O., MBA · Principal Investigator

NYU Langone Health

New York, New York, 10016

Recruiting
Greg Sacks, MD MPH PhD · Principal Investigator

Memorial Sloan Kettering

New York, New York, 10022

Recruiting
Kevin Soares, MD · Principal Investigator

Duke University

Durham, North Carolina, 27710

Recruiting
Daniel Nussbaum, MD · Principal Investigator

MD Anderson Cancer Center

Houston, Texas, 77030

Recruiting
Michael Kim, MD · Principal Investigator