Optimizing Preoperative Surgical Decision-making for Intraductal Papillary Mucinous Neoplasms: The Role of Intent of Surgery
Summary
This multicenter retrospective observational cohort study seeks to: 1. Classify surgical intent in patients with resected Intraductal Papillary Mucinous Neoplasms (IPMN) and quantify the proportion of IPMN-associated cancers diagnosed as overt pancreatic cancer with incidental IPMN association on pathology. 2. Compare clinicopathologic features and outcomes between surveillance-detected and incidentally detected IPMN-derived pancreatic cancers. 3. Revise and redefine risk features limited to patients undergoing surgery for IPMN-related indications, identifying optimal predictors of malignant IPMN (high-grade dysplasia or invasive cancer).
Arms & interventions
Outcome measures
Primary
Grade of IPMN on Final Pathology
Time frame: Day 0 (Retrospective Analysis)
Secondary
Recurrence Free Survival
Time frame: Day 0 (Retrospective Analysis)
Overall Survival
Time frame: Day 0 (Retrospective Analysis)
Eligibility criteria
Study locations (8)
Mayo Clinic
Phoenix, Arizona, 85054
Johns Hopkins University
Baltimore, Maryland, 21287
Massachusetts General Hospital
Boston, Massachusetts, 02114
Mayo Clinic
Rochester, Minnesota, 55905
NYU Langone Health
New York, New York, 10016
Memorial Sloan Kettering
New York, New York, 10022
Duke University
Durham, North Carolina, 27710
MD Anderson Cancer Center
Houston, Texas, 77030