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RecruitingObservational
Nanosecond Pulsed Field Ablation in the Management of Benign Thyroid Nodules
NCT ID: NCT07226804Sponsor: M.D. Anderson Cancer CenterLast updated: 2026-06-01
Summary
To observe the outcomes of nsPFA therapy to treat benign thyroid nodules.
Detailed description
Primary Objectives • To evaluate the thyroid nodule volume changes over time in participants undergoing nsPFA as part of routine clinical care Secondary Objectives * To determine changes in health-related quality of life changes following ultrasound-guided nsPFA * To evaluate the ultrasound features of thyroid nodules over time following ultrasound-guided nsPFA. * To assess the incidence and nature of complications following ultrasound-guided nsPFA, categorized into Minor and Major complications.
Arms & interventions
- OtherQuestionnaire
patient-reported outcomes questionnaire
Outcome measures
Primary
Quality-of-life Questionnaire
Time frame: Through study completion; an average of 1 year
Eligibility criteria
Sex: AllAge: 18 Years and olderHealthy volunteers: No
Eligibility Criteria
* Scheduled to undergo ultrasound guided nsPFA as standard of care
* Age 18 to 80 years.
* Capable of providing independent consent.
* Presence of biopsy-confirmed benign thyroid nodule , defined as one of the following:
* Benign FNA X 2 or
* Benign US guided FNA X 1 + benign thyroid nodule ultrasound appearance (TI-RADS 2) or
* Benign FNA X 1 and radiographic/laboratory evidence of functional nature
* Nodule measuring \>2cm in greatest dimension
* Presence of compressive symptoms reasonably attributable to thyroid nodule (i.e. pressure sensation, dysphagia, dysphonia, respiratory distress)
* No abnormal cervical lymph nodes during screening visit .
Exclusion Criteria
* Age \<18
* Patients considered unsuitable for nsPFA by the treating physician
Study locations (1)
MD Anderson Cancer Center
Houston, Texas, 77030
Victoria E Banuchi, MD · Principal Investigator